Technology Advances

Mark Fornalik & Brian Aylward

Technical Prowess & Innovation Technical Prowess & Innovation

Our historical success has been based on the Our historical success has been based on the design and manufacture of precision, multi-layered design and manufacture of precision, multi-layered films consisting of high-performance, engineered films consisting of high-performance, engineered materials with unique physical and chemical materials with unique physical and chemical propertiesproperties

Small Particle Manufacturing

Ag Antimicrobials Ag Antimicrobials TechnologyTechnology

Effectiveness of any Ag AM will Effectiveness of any Ag AM will depend on three factors:depend on three factors:

1. Ag form (solubility, chemistry, size, etc.)1. Ag form (solubility, chemistry, size, etc.)

2. Delivery vehicle (polymer permeability, Ag release 2. Delivery vehicle (polymer permeability, Ag release rate, surface properties, etc.)rate, surface properties, etc.)

3. Microbial environment (water content, pH, ionic 3. Microbial environment (water content, pH, ionic nature/strength, viscosity, flow, etc.)nature/strength, viscosity, flow, etc.)

Knowledge of all three factors is needed Knowledge of all three factors is needed to design effective productsto design effective products

P

Ribosom

PM

Protein

SH

NH2

Gram NegativeBacteria

P

OL

P

CMDNA

RNA

Gram PositiveBacteria

PTA

O

MycobacteriaA M

Yeast

G

OMP.G.C.

TA

AgAg++/Cell Interaction/Cell Interaction

• Most biocides only impact one cellular functionMost biocides only impact one cellular function

• Silver can disrupt cell growth by multiple meansSilver can disrupt cell growth by multiple means

P

Ribosom

PM

Protein

SH

NH2

Gram NegativeBacteria

P

OL

P

CMDNA

RNA

Gram PositiveBacteria

PTA

O

MycobacteriaA M

Yeast

G

OMP.G.C.

TA

AgAg++/Cell Interaction/Cell Interaction

• Most biocides only impact one cellular functionMost biocides only impact one cellular function

• Silver can disrupt cell growth by multiple meansSilver can disrupt cell growth by multiple means

Modification of Plasma MembraneModification of Plasma Membrane

P

Ribosom

PM

Protein

SH

NH2

Gram NegativeBacteria

P

OL

P

CMDNA

RNA

Gram PositiveBacteria

PTA

O

MycobacteriaA M

Yeast

G

OMP.G.C.

TA

AgAg++/Cell Interaction/Cell Interaction

• Most biocides only impact one cellular functionMost biocides only impact one cellular function

• Silver can disrupt cell growth by multiple meansSilver can disrupt cell growth by multiple means

Interferes with DNA and RNA functionalityInterferes with DNA and RNA functionality

P

Ribosom

PM

Protein

SH

NH2

Gram NegativeBacteria

P

OL

P

CMDNA

RNA

Gram PositiveBacteria

PTA

O

MycobacteriaA M

Yeast

G

OMP.G.C.

TA

AgAg++/Cell Interaction/Cell Interaction

• Most biocides only impact one cellular functionMost biocides only impact one cellular function

• Silver can disrupt cell growth by multiple meansSilver can disrupt cell growth by multiple means

Blocking of Thiol groups on proteins and Blocking of Thiol groups on proteins and enzymes enzymes

Biocides, Biostats & BiofilmsBiocides, Biostats & Biofilms

Killing Microbes

Ag+

biostatic

Stopping Biogrowth

planktonicAg+

Ag+

Ag+

biocidalAg

+

Ag+

Ag+

Ag+

Ag+

Ag+

Ag+

Time

Antimicrobial Contamination

(colony forming units)

Surface Concentration of Microbial Species

With Time

Time

Surfaceconcentration

of silver species

Surface Concentration of Silver Species

With Time

Time

Antimicrobial Contamination

(colony forming units)

Surface Concentration of Microbial Species

With Time

Time

Surfaceconcentration

of silver species

Surface Concentration of Silver Species

With Time

SilpureAg-Antimicrobial

Old Generation Ag-Antimicrobial

Silpure FormulationSilpure Formulation• ActiveActive

– Specially formulated silver chemistry for Specially formulated silver chemistry for controlled ion release in microbial controlled ion release in microbial environment (textiles)environment (textiles)

– Manufactured to specific particle size, Manufactured to specific particle size, shape and morphology for optimal shape and morphology for optimal surface coverage and antimicrobial surface coverage and antimicrobial efficacyefficacy

Silpure Formulation…Silpure Formulation…• Binder SystemBinder System

– Polymeric binder system to provide adhesion of silver Polymeric binder system to provide adhesion of silver to fabric materialsto fabric materials

– Co developed with silver technology to provide Co developed with silver technology to provide additional control of ion release for long lasting additional control of ion release for long lasting antimicrobial efficacyantimicrobial efficacy

– Designed for optimal performance in padding processes Designed for optimal performance in padding processes

– Compatible with a wide range of textile auxiliaries Compatible with a wide range of textile auxiliaries

Untreated Fabric- A Untreated Fabric- A Closer LookCloser Look

Treated FabricTreated Fabric Topically adhered Topically adhered

Uniform CoverageUniform Coverage

Maximum DurabilityMaximum Durability

Target application will be 1-3% Target application will be 1-3% (performance dependent)(performance dependent)

Active (silver) concentration in blended Active (silver) concentration in blended product will be 0.24%product will be 0.24%

Final goods will therefore contain Final goods will therefore contain between 0.0024 and 0.0072% active between 0.0024 and 0.0072% active (24-72 ppm)(24-72 ppm)

Product InformationProduct Information

Silpure FBR-5 Performance Evaluation

• Eliminates bacteria growth

• Highly durable antimicrobial performance

1 10 100 1000 10000 100000 1000000 10000000

Log(Bacteria Colony Forming Units)

0

10

20

30

40

50

Wash Cycles

Bacterial Growth on Treated and Untreated Polyester Articles

UntreatedArticle

TreatedArticle