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Technology Advances. Mark Fornalik & Brian Aylward. Technical Prowess & Innovation. Our historical success has been based on the design and manufacture of precision, multi-layered films consisting of high-performance, engineered materials with unique physical and chemical properties. - PowerPoint PPT Presentation

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  • Technology AdvancesMark Fornalik & Brian Aylward

  • Technical Prowess & Innovation Our historical success has been based on the design and manufacture of precision, multi-layered films consisting of high-performance, engineered materials with unique physical and chemical propertiesSmall Particle Manufacturing

  • Ag Antimicrobials TechnologyEffectiveness of any Ag AM will depend on three factors:1. Ag form (solubility, chemistry, size, etc.)

    2. Delivery vehicle (polymer permeability, Ag release rate, surface properties, etc.)

    3. Microbial environment (water content, pH, ionic nature/strength, viscosity, flow, etc.)

  • PPMCMYeastGOMP.G.C.TAAg+/Cell Interaction Most biocides only impact one cellular function Silver can disrupt cell growth by multiple means

  • PPMCMYeastGOMP.G.C.TAAg+/Cell Interaction Most biocides only impact one cellular function Silver can disrupt cell growth by multiple means Modification of Plasma Membrane

  • PRibosomPMCMDNARNAYeastGOMP.G.C.TAAg+/Cell Interaction Most biocides only impact one cellular function Silver can disrupt cell growth by multiple meansInterferes with DNA and RNA functionality

  • PPMProteinSHNH2CMYeastGOMP.G.C.TAAg+/Cell Interaction Most biocides only impact one cellular function Silver can disrupt cell growth by multiple meansBlocking of Thiol groups on proteins and enzymes

  • Biocides, Biostats & Biofilms

  • TimeAntimicrobial Contamination(colony forming units)Surface Concentration of Microbial SpeciesWith TimeTimeSurfaceconcentrationof silver speciesSurface Concentration of Silver SpeciesWith TimeTimeAntimicrobial Contamination(colony forming units)Surface Concentration of Microbial SpeciesWith TimeTimeSurfaceconcentrationof silver speciesSurface Concentration of Silver SpeciesWith TimeSilpureAg-AntimicrobialOld Generation Ag-Antimicrobial

  • Silpure FormulationActiveSpecially formulated silver chemistry for controlled ion release in microbial environment (textiles)

    Manufactured to specific particle size, shape and morphology for optimal surface coverage and antimicrobial efficacy

  • Silpure FormulationBinder System

    Polymeric binder system to provide adhesion of silver to fabric materials

    Co developed with silver technology to provide additional control of ion release for long lasting antimicrobial efficacy

    Designed for optimal performance in padding processes

    Compatible with a wide range of textile auxiliaries

  • Untreated Fabric- A Closer Look

  • Treated Fabric Topically adhered Uniform Coverage Maximum Durability

  • Target application will be 1-3% (performance dependent)

    Active (silver) concentration in blended product will be 0.24%

    Final goods will therefore contain between 0.0024 and 0.0072% active (24-72 ppm)

  • Silpure FBR-5 Performance Evaluation Eliminates bacteria growth Highly durable antimicrobial performance

    Chart2

    503380000

    503830000

    753380000

    7633830000

    6635090000

    20805090000

    Treated Article

    Untreated Article

    Wash Cycles

    Log(Bacteria Colony Forming Units)

    Bacterial Growth on Treated and Untreated Polyester Articles

    Sheet1

    TreatedControls

    5.00E+0103.38E+06

    5.00E+01103.83E+06

    7.50E+01203.38E+06

    7.63E+02303.83E+06

    6.63E+02405.09E+06

    2.08E+03505.09E+06

    Sheet1

    Treated Article

    Untreated Article

    Wash Cycles

    Log(Bacteria Colony Forming Units)

    Bacterial Growth on Treated and Untreated Polyester Articles

    Sheet2

    Sheet3

    Silver is more efficient as a biocide because it attacks multiple cellular functions vs other biocides which impact one cell functionBy affecting multiple functions it is more difficult for microbes to become resistant to Ag Silver is more efficient as a biocide because it attacks multiple cellular functions vs other biocides which impact one cell functionBy affecting multiple functions it is more difficult for microbes to become resistant to Ag Silver is more efficient as a biocide because it attacks multiple cellular functions vs other biocides which impact one cell functionBy affecting multiple functions it is more difficult for microbes to become resistant to Ag Silver is more efficient as a biocide because it attacks multiple cellular functions vs other biocides which impact one cell functionBy affecting multiple functions it is more difficult for microbes to become resistant to Ag Silver ion concentration within the microbial environment largely impacts antimicrobial performance.For instance in a planktonic (free floating bacteria) environment silver will act as a biostat at low levels of silver ion. As ion concentration increases the silver will act as a biocide and completely eliminate bacteria growth.In an environment where bacteria can adhere to a surface Silver ion concentration at a interface where the bacteria attach themselves is important. At appropriate levels silver can prevent bacteria from forming a protective film.