Institute of Molecular Biology & BiotechnologyInstitute of Molecular Biology & Biotechnology

TechnologiesTechnologies ModelsModels ServicesServices

…in the postgenomic era

IMBB Investigates... Gene expression under

stress & in differentiation

The nervous system

aging& neurodegeneration

Development & differentiation

Protein trafficking &molecular machines

Mosquitoes andmalaria

IMBB Develops ... Insect control systems

(Minos Biosystems,Bayer)

DNA microchip prognostics ( Breast cancer)

New antibiotics (Pfitzer)

Gene silencing technologies (Crop protection)

Protein products (Enzymes &

Biopharmaceuticals) Acoustic biosensors

Computational Biology& Biomedical Informatics (IMBB-ICS)

Molecular imaging & tomography (IESL-IMBB)

Nano-biotechnology (ΙΜΒΒ-ICE/HT-IESL )

IMBBIMBB Promotes... Interdisciplinary research

IMBB-Industry collaborationsA variety of business models

SecA inhibitors Pfizer

Bayer

SmithKlein Beecham

BOEHRINGER MANNHEIM

BioLabsNEW ENGLAND

Chitin deacetylation

Secretion Biotechnology

Molecular Biology Enzymes

Chitin synthase inhibitorsChitozyme, Marine Biopolymers

The E. coli bacterium – 4.200 genes

“If we understand the biology of E. coli we will know the biology of the elephant”

[J. Monod]

H2Olipid

Bacterial secretion of proteins

H2O

T3SSec

Collaboration principles

Mutual benefit (access to know-how, agility - flexible funding, access to instrumentation)Reasonable charges (100-150% overhead on labor cost)Maintenance and transfer of new IPR (right of first refusal)Research collaboration rather than contractual workFurther development via national (?), European fundingKnowledge discovery and/or cutting edge technologies

Decision Diagramfor the Exploitation of Scientific Discoveries

ScientificDiscovery

ScientificDiscovery

Is itUseful?

Is itUseful? InventionInventionYesYes

No

No

Does it havean economicPotential?

Does it havean economicPotential? Y

esY

es

ScientificPublication

ScientificPublication NoNo

IntellectualProperty

IntellectualProperty

Does it needProtection?

Does it needProtection?YesYes

No

No

PatentApplication

PatentApplication

No No

BusinessSecrete

BusinessSecrete

Does is provideEntrepreneurial

Basis?

Does is provideEntrepreneurial

Basis?

No

No

No

No

YesYes

TechnologyTransfer

TechnologyTransfer

BusinessPlan

BusinessPlan

Drosophila and Genetics – life with 14.000 genes

Identification of insect chitin synthasesBAYER AG

Protection of IPR by patents (EPO, JPO, USPTO)

Chitin exists in the cuticle and the peritrophic membrane of insects

Chitin synthesis is a prime target for of pest control agents

{Epicuticle

(cuticulin layer) Exocuticle

{Endocuticle

{Epidermis

{Procuticle(chitin and proteins)

Synthesis zone

Hemolymph

Drug discovery is a excellent ground for fertile industry – academy research collaborations. Thus academy raises its social and technological awareness while industry overcomes its innovation deficit.Protection of intellectual property rights and technological awareness are vital for the success of innovation and essential for a balanced and a mutual benefit relation.

Understanding live and trying to tame it –basic and applied research – are no separate realms. They are mutually dependent.

Decision Diagramfor the Exploitation of Scientific Discoveries

ScientificDiscovery

ScientificDiscovery

Is itUseful?

Is itUseful? InventionInventionYesYes

No

No

Does it havean economicPotential?

Does it havean economicPotential? Y

esY

es

ScientificPublication

ScientificPublication NoNo

IntellectualProperty

IntellectualProperty

Does it needProtection?

Does it needProtection?YesYes

No

No

PatentApplication

PatentApplication

No No

BusinessSecrete

BusinessSecrete

Does is provideEntrepreneurial

Basis?

Does is provideEntrepreneurial

Basis?

No

No

No

No

YesYes

TechnologyTransfer

TechnologyTransfer

BusinessPlan

BusinessPlan

MINOS trangenesis technologies

Medfly SIT control

Minos + HGHInsect Protein Factories

larvae purification HGH

Mass rearing facility

500 tons / weekyields

HGH

The mouse – 35.000 genesTHE model for human disease

Genetic tranformation of mouse

IMBB-FORTHProducts & Services

MINOTECH BiotechnologyPRODUCTSDNA restriction enzymesDNA modification enzymesCytokines

SERVICESFermentationProtein expressionProtein purification

IMMUNOLOGYPRODUCTSHormonal immunodiagnosticsReproductive management of cowsProcedure employed by DELTA S.A.

MICROCHEMISTRYPRODUCTSCustom DNA oligonucleotides

SERVICESDNA sequencingGMO testing

Science & Technology Parks

and Innovation Policies in GreeceMyths and Reality

“Lefkippos” Technology Park of Attica

Technology & Culture Park - Lavrion

Thessaloniki Technology Park

Science & Technology Park - Epirus

Patras Science Park

Science & Technology Park of Crete

University of Ioannina

University of Patras

Foundation for Research & Technology - Hellas

The Centre for Research & Technology Hellas

NCRS “Demokritos”

National Technical University of Athens

0

1

2

3

4

5

6

7

8

9

10

Crete

Epirus

Lavrio

Lefki

ppos

Patra

s

Thessa

lonik

i

Information Technology-Telecomunications

Construction - Engineering

Commerce

Other

Can low-tech environments favor the Development of Science and Technology

Parks?

Main Objectives of Science and Technology Parks

Technology transfer

Regional or National Development

The Different Groups Interested in Science Parks

Universities-Research Centers

Government-Politicians

Industry

Venture Capital

Objectives of universities and Research Centers

-

-

-

-

Technology transfer

Scientific character

Financial aspect

Marketing

Prerequisites (situation in Greece)•Existing methods and centers of technology

transfer

•Number of centers of excellence

•Existing collaboration with the industry

•Funding of research

•Cultural attitude towards commercializing academic results

Objectives of the Government:

-

-

-

Creation of new jobs

Improve the image of an area

Increase the average income

Development

Prerequisit

esStrategy for regional development

Economic Incentives

Industrial situation

Degree of unemployment in area

Degree of education in area

Image of area

Local politicians

Objectives of the industry

Increase the number of suppliers, or potential clients

Increase the number of inhabitants in the region and their average income

Synergy with new firms

Possibility for the location of subsidiaries of existing companies

Improve image of area

Prerequisites

Type of industry in area (big industry which needs suppliers, or small industries which need more clients)

Size of companies

Degree of R&D in companies

Degree of high-tech of companies

Venture Capital

Spontaneous Development

Silicon ValleyMIT

Univ. of Stanford Route 128

-

-

-

-

Association with centers of excellence of different universities and Research Centers

Select locations that have commercial, geographical or financial advantages

Organization and management

Access to International Technology Transfer and Venture Capital