stroke incidence is reduced by antihypertensive therapy

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10 Stroke incidence is reduced by antihypertensive therapy In elderly patients with isolated systolic hypertension At 5-year follow-up, the incidence of stroke was reduced by 36% in elderly patients with isolated systolic hypertension who received antihypertensives compared with those who received placebo - a benefit of 30 events/IOOO participants. 4736 patients 60 years of age randomly received chlorthalidone 12.5 or 25 mg/day or placebo (step I) followed by atenolol 25 or 50 mg/day or reserpine 0.05 or 1 mg/day or placebo (step 2) for 5 years in a double-blind study. Patients only progressed to higher doses and/or step 2 when they failed to reach target BPs. Antihypertensive recipients had a reduced risk of cardiovascular events equal to 55 events/IOOO participants over 5 years and the death rate was 13% lower among antihypertensive recipients compared with placebo recipients. These benefits applied regardless of patient age or whether or not they were receiving antihypertensive medication on entry to the study. There was no excess incidence of dementia or depression among antihypertensive recipients compared to placebo· recipients. [See also Viewpoints section. this issue. p2] SHEP Cooperati ve Research Group. Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. Final results of the Systolic Hypertension in the Elderly Program (SHEP). Journal of the American Medical Association 265: 3255-3264, 26 Jun 1991 .." 6 lui 1991 INPHARMA® ISSN 0156-2703/91/0706-0010/0$01.00/0 © Adis International Ltd

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Page 1: Stroke incidence is reduced by antihypertensive therapy

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Stroke incidence is reduced by antihypertensive therapy In elderly patients with isolated systolic hypertension

At 5-year follow-up, the incidence of stroke was reduced by 36% in elderly patients with isolated systolic hypertension who received antihypertensives compared with those who received placebo - a benefit of 30 events/IOOO participants. 4736 patients ~ 60 years of age randomly received chlorthalidone 12.5 or 25 mg/day or placebo (step I) followed by atenolol 25 or 50 mg/day or reserpine 0.05 or 1 mg/day or placebo (step 2) for 5 years in a double-blind study. Patients only progressed to higher doses and/or step 2 when they failed to reach target BPs.

Antihypertensive recipients had a reduced risk of cardiovascular events equal to 55 events/IOOO participants over 5 years and the death rate was 13% lower among antihypertensive recipients compared with placebo recipients. These benefits applied regardless of patient age or whether or not they were receiving antihypertensive medication on entry to the study. There was no excess incidence of dementia or depression among antihypertensive recipients compared to placebo· recipients. [See also Viewpoints section. this issue. p2] SHEP Cooperati ve Research Group. Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. Final results of the Systolic Hypertension in the Elderly Program (SHEP). Journal of the American Medical Association 265: 3255-3264, 26 Jun 1991 .."

6 lui 1991 INPHARMA® ISSN 0156-2703/91/0706-0010/0$01.00/0 © Adis International Ltd