Spontaneous torque variations were significantly larger in patients.Strong correlations existed among these abnormal findings.Conclusions: The deficient ST patients' ability to manipulate normalpostural reactions is attributed to impairments of a long-latency slowfeedback mechanism. Modeling of this suppressive mechanism sug-gested further that patients may also have difficulties in switchingbetween feedforward and sensory-driven motor control. Similarfindings have been obtained from studying parkinsonian patients withaxial rigidity. Differences in impairment patterns between the twogroups help to understand altered sensorimotor control in basal gangliadisease leading to rigidity and abnormal postures.

doi:10.1016/j.jns.2013.07.533

Abstract — WCN 2013No: 1456Topic: 2 — Movement DisordersNon-motor symptoms in patients with early stages ofParkinson's disease

E. Gubanova, N. Fedorova. Russian Medical Academy for Post-GraduateEducation, Moscow, Russia

Parkinson's disease (PD) — one of the most frequent neurodegener-ative diseases.Objectives: To determine the influence of non-motor symptoms onquality of life and daily activities on PD patients in early stages.Material and methods: 80 patients with PD on the early stages wereincluded (male:female = 30:50). 20% of our patients had 1–1.5 stageof modified H&Y scale, 35% — 2nd and 45% — 2.5 stage. The mixedform of PD predominated over others (75%). We used Hoehn andYahr scale modified by Lindvall to assess PD severity (Hoehn M., YahrM., 1967, O. Lindvall, 1989); assess affective disorders – HamiltonRating Scale – (M. Hamilton, 1959, 1999); non-motor symptoms —

scale non-motor symptoms PD NMS (Chaudhuri K. R. et al., 2004).Results:Non-motor disturbances were observed in 80%. Hyposmia wasobserved in 30%; constipation — in 58.6% of patients; violation ofurination — in 73% of patients; 33% of patients reported increasedsweating; hypersalivation was observed in 27% of patients. Sleepdisorders were observed in 75% of patients: insomnia disorders in 44%of patients, excessive daytime sleepiness — 34%, pathological behaviorin REM-sleep phase— in 45.7% of patients. Muscle and joint pain in 33%of patients in the early stages. Affective disorders were diagnosed in80%. There was a positive correlation (р=0.047) of the quality of lifewith non-motor symptoms, affective and sleep disorders.Conclusions: Non-motor symptoms in the early stages of the diseasesignificantly deteriorate the quality of life and daily activities ofpatients with PD.

doi:10.1016/j.jns.2013.07.534

Abstract — WCN 2013No: 2245Topic: 2 — Movement DisordersSensitivity, specificity, positive and negative predictive values andaccuracy of datscan™ for prediction of clinical diagnosis of earlyparkinsonian syndromes

N. Bajaja, I.D. Grachevb, J. Seibylc, K. Marekc, A. Kupschd, M. Plotkine,R.A. Hauserf. aNottingham University Hospitals NHS Trust, Nottingham,UK; bGE Healthcare, Princeton, NJ; cThe Institute for NeurodegenerativeDisorders, New Haven, CT, USA; dOtto-von-Guericke-University, Magdeburg,Germany; eLeiter des Vivantes Instituts für Nuklearmedizin Mitte/Nord,Berlin, Germany; fUSF Byrd Parkinson's Disease and Movement DisordersCenter, Tampa, FL, USA

Objective: To assess the diagnostic efficacy data from clinical trialKupsch et al, 2012 (data not previously published) conducted usingDaTSCAN™ ([123I]Ioflupane Injection).Patients and methods: Study imaging group (n = 92) was used toassess the diagnostic accuracy of DaTSCAN™ in subjects with early,clinically uncertain Parkinsonian syndromes (PS) after 1 year follow-up. The reference standard was final clinical diagnosis 1 year afterimaging (with DaTSCAN™ results available), and it was compared tobaseline clinical diagnosis (without DaTSCAN™) and to baselineimaging diagnosis. Visual assessment of DaTSCAN™ images wasperformed by local nuclear medicine physicians, which is consistentwith current clinical practice. Acquisition of SPECT datawith DaTSCAN™and their reconstruction were performed using a standardized imagingprotocol.Results: The sensitivity of clinical diagnoses at baseline usingclinical data was 92% when compared to final clinical diagnosis at1 year, but the specificity was only 52.4%. For the comparison ofbaseline DaTSCAN™ images to the clinical diagnosis at 1 year, thesensitivity was 93.9%; specificity was 95.4% (p= 0.0005 as comparedto baseline clinical diagnosis). The PPV, NPV and diagnosticaccuracy for baseline clinical diagnosis or baseline imaging diagno-sis vs. final clinical diagnosis at 1 year (reference standard) wererespectively: 69.7% vs. 95.8% (p b 0.0001), 84.6% vs. 93.2%, and73.9% vs. 94.6%.Conclusion: High sensitivity and specificity, PPV, NPV and diagnosticaccuracy of DaTSCAN™ in diagnosis of early clinically uncertain PSwere demonstrated. Performance of DaTSCAN™ compares favorablyin this study to the performance of clinical diagnosis relative to finalclinical diagnosis.

doi:10.1016/j.jns.2013.07.535

Abstract — WCN 2013No: 1563Topic: 2 — Movement DisordersPure ataxia associated with N-methyl-d-aspartatereceptor antibodies

D. Aguiar de Sousa, P. Pita Lobo, A. Castro Caldas, M. Coelho,L. Albuquerque. Department of Neurology, Hospital de Santa Maria,University of Lisbon, Lisbon, Portugal

Introduction: Several movement disorders previously consideredidiopathic or degenerative are now recognized as immune-mediated.The N-methyl-d-aspartate receptor antibody (NMDA) encephalitishas been associated with movement disorders, frequently hyperki-netic. It is estimated that pure monosymptomatic syndromes occurin about 5% of patients. Ataxia is a rare manifestation of this type ofencephalitis.Case study: Male, 73 years old, Caucasian, resident in Mozambique.He presented with clinical picture of fever, anorexia and coughlasting two weeks and treated with gentamicin, azithromycin andmetronidazole for seven days with remission of complaints. Ten daysafter he started a rapidly progressive gait imbalance, being admitted3 weeks later. Neurological examination showed slight horizontalnystagmus, bilateral appendicular ataxia and ataxic gait with lossof postural reflexes. Psychiatric disorder or hyperkinesias were notobserved and patient and caregivers denied any other changes inprevious weeks. Examination of cerebrospinal fluid and cranial MRIwere unremarkable. The titer of anti-NMDAr antibodies in serumwas high (1/1000), while infectious serologies, other autoimmunitystudies and search for occult neoplasm, including positron emissiontomography scan, were negative. Remarkable clinical improvementfollowed treatment with high-dose corticosteroids, with completeremission of ataxia within 3 months and reduction of anti-NMDAr

Abstracts / Journal of the Neurological Sciences 333 (2013) e65–e108e74