selenium metabolism and its clinical significance

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Selenium metabolism and its clinical significance Dr. Rohini C Sane

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SeleniummetabolismanditsclinicalsignificanceDr.Rohini CSane

Brazilnuts

DIETARYSOURCESOFSELENIUM

Seleniummetabolism• StimulantofGrowth• Requirement:50-100microgram/day• NormalserumSeleniumlevel:63-160micrograms/L(adults)and16-71(<2yrsofage)

Seleniumdependentenzymes SiteofenzymeGlutathioneperoxidase Human(RBC)Formatedehydrogenase E.ColiGlycinereductase Clostridium

RDAforSelenium

Functions of Selenium1.SynthesisofT₃fromT₄: T₄T₃Deiodinase +Selenium(seleniumdeficiency-Hypothyroidism)

2.Preventlivercirrhosis,musculardystrophy

3.Seleniumessentialfordevelopmentofspermatozoa(middlepiece)

4.Seleno –Cysteinerequiredforterminationofproteinbiosynthesis

5.Antioxidant(vitaminEdecreasesseleniu requirement )à preventslipidperoxidationà maintainscellmembraneintegrity )

6.SeleniumPreventscarcinogenesis(bindsMercury,cadmiumpreventstoxiceffect)

7.preventsKeshan’s diseaseàmultifocalmyocardialinfarction,cardiacenlargement

SeleniumfunctionsasanAntioxidant

SeleniumfunctionsasanAntioxidant

SeleniumMetabolism

SiteofabsorptionofSeleniuminhumanbody

Selenosis :SeleniumToxicityqSelenosis :dietaryintake>900micrograms/day• Causes :metalpolishes&antirustcompounds• Symptoms :hairloss,fallingofnails,weightloss,diarrhea,Garlicodor

methylation(AdenosylMethionine)H+Se HydrogenSeDimethylSelenide

vManagement of Selenosis with Halogenated Hydroselenium

EffectsofSelenosis inhumanbody

FunctionsofSelenocysteine

Keshan DiseaseassociatedwithSeleniumdeficiency

Keshan DiseaseassociatedwithSeleniumdeficiency