How is REVIVAL PRP® Different?

Lasting, Natural Results

Available in both 11ml

and 22ml tube formats,

REVIVAL PRP® is an

Advanced Separator

Gel based, easy to use,

sterile system that is

used to prepare PRP in

a safe and effective

manner to maximize

the benefits of PRP

therapy.

References:

Araujo et al, (2010). "Biology of Human Hair: Know Your Hair to Control It" (PDF). Adv Biochem

Engin/Biotechnol. • Cervelli, V. Garcovich, S. Bielli, A. et al., “The Effect of Autologous Activated

Platelet Rich Plasma (AA-PRP) Injection on Pattern Hair Loss: Clinical and Histomorphometric

Evaluation,” BioMed Research International, vol. 2014, Article ID 760709, 9 pages, 2014.

doi:10.1155/2014/760709 • Gentile, P. Garcovich, P. Bielli, A. Scioli, MG. Orlandi, A. Cervelli, V. The

Effect of Platelet-Rich Plasma in Hair Regrowth: A Randomized Placebo-Controlled Trial. Stem Cells

Translational Medicine 2015; 4:1317–1323

XEDITON Pharmaceuticals Inc.2000 Argentia Road, Mississauga, Ontario. L5N 1W1 Canada

Tel: +1 905 286 9111 Fax: +1 905 286 9111

For more information visit our website: www.xediton.com

PRODUCTOF CANADA

RHDB01

Demonstrated

Efficacy

High Safety

Profile

Lasting Natural

Results

Platelet-Rich Plasma Therapy

for the Treatment of Hair Loss

The flexibility of the REVIVAL PRP® system enables the user to obtain

higher or lower platelet concentrations by simply adjusting the

amount of clear plasma removed from the tube

An accessories pack may be purchased with the REVIVAL PRP®

system which may include:

• Blood collection set

• Gauze pads

• Swabs

• Plasters

REVIVAL PRP® System

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on

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Media

@revivalprp

• Alcohol pads

• Tourniquets

• Tube holder

• Syringe

• 22G, 25G and 30G

needles

• Gloves

PRP can be combined with other therapies such as:

• Low-level Laser Therapy (LLLT)

• Hair Transplantation

• Hair Regrowth medications

BEFORE AFTER

Hair Loss: Causes and Treatment

THE HAIR GROWTH CYCLE

Hair grows from the follicle, or

root, underneath the skin. The hair

is ‘fed’ by blood vessels at the

base of the follicle, which gives it

the nourishment it needs to grow.

Each hair passes through four

stages of the hair growth cycle:

anagen, catagen, telogen and

exogen.

Every hair can be at a different

stage of the growth cycle at any

given time.

At the end of the 3 treatment cycles with

PRP, patients presented clinical

improvement in:

• Number of hairs (mean increase of

33.6 hairs in the target area)

• Total hair density (mean increase of

45.9 hairs/cm2 compared with

baseline values)

• Improvement of anagen/telogen ratios

(37.6%/62.4% vs 52.2%/47.8%, at

baseline)

• Increase in epidermal thickness

PRP injections have a positive effect on male pattern hair loss with absence of major side

effects, serving as a safe and effective treatment option against hair loss (Gentile et al, 2010).

PRP treatment induces proliferation of epidermal keratinocytes, hair follicular bulge cells

and a slight increase of small blood vessels around hair follicles in the treated area (Cervelli

et al, 2014).

Clinical Evidence Supporting the

Use of PRP to Treat Hair Loss

How Does PRP Stimulate Hair Growth?

PRP is a portion of the

patient’s own blood plasma

that is concentrated in

platelets and growth factors

which are critical in triggering

the body’s regenerative

mechanisms.

What is Platelet-Rich Plasma (PRP)?

Growth factors and

platelets play a central

role in the four stages of

the wound healing

process.

The key success factor of

PRP is the fact that it

uses the body’s own

regenerative pathways,

except that the process is

accelerated.

Current treatments for hair loss include:

• Medications such as Minoxidil and Finasteride

• Laser therapy

• Hair transplant surgery

• Platelet-Rich Plasma (PRP)

Figure 1: TrichoScan Digital images of before and after PRP treatment . Pre-

operative state w (A and B) vs post-operative state (C and D) with two

different markers.

0

2

4

6

BaselinePRP

treatment

Ki 67

+ep

iderm

al

cells (

%)

A*

0

2

4

6

BaselinePRP

treatment

Ki 67

+fo

llic

le c

ells (

%)

B

*

0

1

2

3

BaselinePRP

treatment

CD

31

+v

essels

(m

m2)

C

*

Figure 2: Morphometric analyses of: (A) Ki67+ cells of hair skin epidermis at baseline and after PRP treatment. (B) Percentage

of Ki67+ nuclei in hair follicles at baseline and after PRP treatment. (C) CD31+ small dermal vessels of hair skin at baseline

and after PRP treatment. * indicates p < 0.05.

Most recently, the use of autologous elements to

induce follicle regeneration has proven to be a

very effective alternative in increasing hair quality

and density naturally, with no risk of allergic

reactions or inflammation.

PRP which is rich in growth factors

is injected directly into the scalp at

the level of the hair follicles. The

injections are performed across the

scalp, approximately every half inch

over the area of thinning hair. These

growth factors can help stimulate

the activity of the hair follicles and

promote new hair growth.

If hair enters the resting (telogen) phase too

early, excess shedding and noticeable thinning

can occur. This is known as hair loss or

alopecia, which is categorized by a gradual

thinning and shedding of hair at the front and top

of the head.

This shorter hair growth cycle leads to a visible

reduction in hair density, quantity and quality.