Resurrecting Hippocrates: Food as Medicine Meets Modern Science

“Let food be thy medicine and medicine be thy food” ― Hippocrates

What Is Food? • That without which we can not

live(the molecular fabric and embedded Intelligence of our body is woven from food)

• Sacred/sacren (to make holy)• Holy/whole/health/heal

What Is Medicine? • Etymology: Latin ars

medicina, meaning the art of healing.

Asclepius, Greek godof medicine.

Are pharmaceuticalsmedicine?

• Etymology: "Pharmaceutical" derives from the Greek The term "pharmakos" later became the term "pharmakeus" which refers to "a drug, spell-giving potion, druggist, poisoner, by extension a magician or a sorcerer."

Food As Information“to put form into”

• Calories• Macro/Micronutrients

“Tell me what you eat, and I will tell you who you are” ~ Brillat-Savarin

The Protein Folding Mystery

Levinthal Paradox: There is not enough time in the universe to allow for a polypeptide to pass through all the degrees of freedom available to it to reach its native folded state.

Whole Food vs. Isolate Vitamin C is not reducible toIts chemical backbone Vs. whole food (food state) Whole food is bound to lipids,

sugars and proteins

The “nutraceutical” model Monochemical/isolated Palliative Modeled after similar

economics and placebo dynamic.

Reductionism/positivism/myopia

Food As Information Epigenetics/nutrigenomics Conformational diseases E.g. Cystic fibrosis; CFTR gene product

misfolded; corrected/rescued with Curcumin/Genistein/Resveratrol

Food Farmacy The body dialogs between food,

producing metabolites, and widely orchestrated chemistries, enabling it to absorb or neglect to absorb a wide range of compounds, as needed.

SNPs are not a ‘death sentence.’ E.g. gluten-digesting bacteria and 5-MTHF is produced via bacteria in gut.

Angiosperm-mammal coevolution

Food As Information: Dialog Gut Brain Axis Co-Evolutionary (broccoli/intestine) Food ‘pharmacy’ 5-MTHF via biotransformation The metabolome

Food As Information: Dialog Gut Brain Axis Co-Evolutionary (broccoli/intestine) Food ‘pharmacy’ 5-MTHF via biotransformation The metabolome

Tissue Regeneration via Nutrition

Heart Brain Skin Lung Liver

Germline Immortality/LUCA

Cephalic (Placebo-Nocebo) Commensalism Taste/Oral/Cortical Band Deficiency/Plenitude Phenomological Orthorexia vs. Being Present (the

nutritional value of pleasure and guiltlessness)