research funding opportunities: the role of nida program

Research Funding Research Funding Opportunities:Opportunities:

The Role of NIDA ProgramThe Role of NIDA ProgramDavid Shurtleff, Ph.D.David Shurtleff, Ph.D.

DirectorDirector

Division of Basic Neuroscience Division of Basic Neuroscience and Behavioral Researchand Behavioral Research

National Institute on Drug AbuseNational Institute on Drug AbuseNational Institutes of HealthNational Institutes of Health

U.S. Department of Health and Human ServicesU.S. Department of Health and Human Services

CPDD-- June 2006CPDD-- June 2006

Who/What is a Program Officer?Who/What is a Program Officer? A Program Officer A Program Officer

is a scientist is a scientist andand administrator administrator manages grants, contracts, cooperative manages grants, contracts, cooperative

agreementsagreements identifies needs in scientific areasidentifies needs in scientific areas identifies scientific areas of special interest and identifies scientific areas of special interest and

communicates interestcommunicates interest monitors research progressmonitors research progress advocates for the best scienceadvocates for the best science

Attend study section Attend study section Listen to grant reviewsListen to grant reviews Observe review processObserve review process

Works with applicantsWorks with applicants

Make funding recommendationMake funding recommendation

Application & Funding ProcessApplication & Funding Process

The application processThe application process

Contacting the right personContacting the right person

““K” and “R” AwardsK” and “R” Awards

Writing and submitting your applicationWriting and submitting your application

After the application is reviewed: Now what?After the application is reviewed: Now what?

Funding Funding

ConclusionsConclusions

National Institutes of HealthNational Institutes of Health

The Application ProcessThe Application Process

Review Process for a Research Grant

PrincipalPrincipal

InvestigatorInvestigatorSchool or OtherSchool or OtherResearch CenterResearch Center

National Institutes of HealthNational Institutes of Health

InitiatesInitiatesResearch IdeaResearch Idea

Conducts ResearchConducts Research

SubmitsSubmitsapplicationapplication

AllocatesAllocatesFundsFunds

Center for Scientific ReviewCenter for Scientific Review

Scientific Review GroupScientific Review Group

InstituteInstitute

Advisory Council or BoardAdvisory Council or Board

Program staff/Program staff/

Assign to IC and IRG

Review for

ScientificMerit

Evaluate for Relevance

Recommend Action


The application processThe application process Contacting the right personContacting the right person ““K” and “R” AwardsK” and “R” Awards Writing and submitting your applicationWriting and submitting your application Submitting your applicationSubmitting your application After the application is reviewed: Now After the application is reviewed: Now

what?what? Funding Funding ConclusionsConclusions

Before you apply for an Before you apply for an NIH grant, contact a NIH grant, contact a Program OfficerProgram Officer

Who are you going to call?

A Program Officer

Before You Apply………..

Talk Talk WithWith NIDA Staff NIDA Staff

and learn about:and learn about:

•Funding MechanismsFunding Mechanisms•Program PrioritiesProgram Priorities•Grant ProcessGrant Process•Application ProcedureApplication Procedure•Review Process / CommitteesReview Process / Committees•New Initiatives-New Initiatives-

•RFAs, PAsRFAs, PAs

National Institute on Drug AbuseNational Institute on Drug Abuse

Special Populations OfficeSpecial Populations Office

Division of Division of Basic NeurosciencesBasic Neurosciences

& Behavior Research& Behavior Research

Office ofOffice ofExtramural Extramural

AffairsAffairs

Office of Office of Science Policy & Science Policy & CommunicationsCommunications

Intramural Intramural ResearchResearchProgramProgram

Division ofDivision ofEpidemiology, Epidemiology,

Services & Services & Prevention Research Prevention Research

Division ofDivision ofPharmacotherapies &Pharmacotherapies &Medical ConsequencesMedical Consequences

of Drug Abuseof Drug Abuse

Center for theCenter for theClinical Trials Clinical Trials

NetworkNetwork

Teresa Levitin, PhDTeresa Levitin, PhD Timothy Condon, PhDTimothy Condon, PhD Betty Tai, PhDBetty Tai, PhD

David Shurtleff, PhDDavid Shurtleff, PhD Frank Vocci, PhDFrank Vocci, PhD Wilson Compton, MD, MPEWilson Compton, MD, MPE Barry Hoffer, MD, PhDBarry Hoffer, MD, PhD

Office of the DirectorOffice of the DirectorNora D. Volkow, MDNora D. Volkow, MD

DirectorDirector

Timothy P. Condon, Ph.D.Timothy P. Condon, Ph.D.Deputy DirectorDeputy Director

Laura S. RosenthalLaura S. RosenthalAssociate DirectorAssociate Directorfor Managementfor Management

Division of ClinicalDivision of ClinicalNeuroscience Neuroscience & Behavioral& Behavioral

ResearchResearch

Joseph Frascella, PhDJoseph Frascella, PhD

Director, AIDS ResearchDirector, AIDS Research

Office of PlanningOffice of Planning& Resource& Resource

ManagementManagement

Laura RosenthalLaura Rosenthal

http://www.nida.nih.gov/about/organization/Organization.html

Framework to enhance cooperative activities Framework to enhance cooperative activities among 16 NIH Institutes and Centers among 16 NIH Institutes and Centers

Take on challenges in neuroscience that are Take on challenges in neuroscience that are best met collectively best met collectively

Develop research tools and infrastructure that Develop research tools and infrastructure that will serve the entire neuroscience communitywill serve the entire neuroscience community

Research Training ProgramsResearch Training Programs

NIH Roadmap FOR Medical Research

TransNIH initiative for a more efficient and productive system of medical research

Identifies in three main areas for support: New pathways to discoveryResearch teams of the futureRe-engineering the clinical research

enterprise


Grant success ratesGrant success rates The application processThe application process Contacting the right personContacting the right person ““K” and “R” AwardsK” and “R” Awards Writing and submitting your applicationWriting and submitting your application Submitting your applicationSubmitting your application After the application is reviewed: Now what?After the application is reviewed: Now what? Funding Funding The B/START mechanismThe B/START mechanism

Mentored Career Development Awards

Mentored Research Scientist Development Award Mentored Research Scientist Development Award (K01)(K01)

Mentored Clinical Scientist Development Award (K08)Mentored Clinical Scientist Development Award (K08)

Career Transition Award (K22)Career Transition Award (K22)

Mentored Patient-Oriented Research Career Mentored Patient-Oriented Research Career Development Award (K23)Development Award (K23)

Mentored Quantitative Research Career Development Mentored Quantitative Research Career Development Award (K25)Award (K25)

NIH Pathway to Independence (PI) Award (K99/R00) NIH Pathway to Independence (PI) Award (K99/R00)

Features of the Mentored Career Awards

Purpose:Purpose: Provide applicant with professional degree three-five years of Provide applicant with professional degree three-five years of

additional supervised researchadditional supervised research

Training must be in an area new to the applicantTraining must be in an area new to the applicant and/or one in and/or one in which additional supervised research experience will substantially which additional supervised research experience will substantially add to the research capabilities of the applicantadd to the research capabilities of the applicant

Focus on progression to independence: The candidate must provide Focus on progression to independence: The candidate must provide

a plan for achieving independent research support by the end of the a plan for achieving independent research support by the end of the award period award period

Allowable Costs:Allowable Costs: Annual Salary $48,000-$90,000 Annual Salary $48,000-$90,000

Research Development Support up to $50,000 per yearResearch Development Support up to $50,000 per year

“K”-- Review Criteria

Review Criteria for Mentored Career Review Criteria for Mentored Career Development AwardsDevelopment Awards

Candidate:Candidate: Quality of the candidate's research, academic and/ or clinical recordQuality of the candidate's research, academic and/ or clinical record Potential to develop as an independent researcher; and commitment Potential to develop as an independent researcher; and commitment

to a research career to a research career

Career Development Plan:Career Development Plan: The content, phasing, and duration of the planThe content, phasing, and duration of the plan Consistency with the candidate's career goalsConsistency with the candidate's career goals Likelihood the plan will contribute to achieving of scientific Likelihood the plan will contribute to achieving of scientific

independenceindependence

Research Plan:Research Plan: MethodologyMethodology Relevance to the candidate's career objectivesRelevance to the candidate's career objectives Appropriateness of the plan to the stage of research development Appropriateness of the plan to the stage of research development As a vehicle for developing research skills for career development As a vehicle for developing research skills for career development

Review Criteria for Mentored Career Review Criteria for Mentored Career Development AwardsDevelopment Awards

Mentor/Co-Mentor:Mentor/Co-Mentor: Research qualificationsResearch qualifications Quality and extent of mentor(s) role in providing guidance Quality and extent of mentor(s) role in providing guidance Previous experience in fostering the development of researchers Previous experience in fostering the development of researchers History of research productivityHistory of research productivity Adequacy of support for the proposed research project. Adequacy of support for the proposed research project.

Environment and Institutional CommitmentEnvironment and Institutional Commitment: : Adequacy of research facilities and training opportunitiesAdequacy of research facilities and training opportunities Quality of the environment for scientific and professional developmentQuality of the environment for scientific and professional development Institution's commitment to candidate--assurances that the institution intends the Institution's commitment to candidate--assurances that the institution intends the

candidate to be an integral part of its research programcandidate to be an integral part of its research program institution's commitment to an appropriate balance of research and other institution's commitment to an appropriate balance of research and other

responsibilities including 75% effort proposed by the candidate. responsibilities including 75% effort proposed by the candidate.

Mentored K AwardsSuccess Rates

Number of Mentored K-Awards Number of Mentored K-Awards Received and FundedReceived and Funded

(NIDA-FY 05)(NIDA-FY 05)

31

13

5 4

20

82

1

58

26

0

10

20

30

40

50

60

Nu

mb

er

of

Ap

plicati

on

s

K01 K08 K23 K25 Total

Funding Mechanism

Received

Funded

(42%) (80%) (45%)(40%) (50%)

Dollars Obligated Dollars Obligated New Mentored K-AwardsNew Mentored K-Awards

(NIDA-FY05)(NIDA-FY05)

1.8

0.621.2

0.12

3.7

0

1

2

3

4

Do

llars

in

Millio

ns

K01 K08 K23 K25 Total

Funding Mechanism

Research Funding Mechanismsto Become an Independent

Scientist

Research Mechanisms Investigator Initiated Research Grant (R01)Investigator Initiated Research Grant (R01)

NIDA B/START & I/STARTNIDA B/START & I/START One year award One year award Provide newly independent investigators an opportunity to conduct small Provide newly independent investigators an opportunity to conduct small

scale exploratory (i.e., pilot) researchscale exploratory (i.e., pilot) research Establish a rapid review and funding to “jump start” researchEstablish a rapid review and funding to “jump start” research

Small Grant Program (R03) Small Grant Program (R03) Pilot or feasibility studiesPilot or feasibility studies Secondary analysis of existing dataSecondary analysis of existing data Small, self-contained research projectsSmall, self-contained research projects Development of research methodology or new research technologyDevelopment of research methodology or new research technology

Exploratory/Developmental Research Grant Award (R21) Exploratory/Developmental Research Grant Award (R21) Test feasibility of a novel area of investigation Test feasibility of a novel area of investigation Studies may involve considerable risk but may lead to a breakthrough Studies may involve considerable risk but may lead to a breakthrough

that could have major impact on a field. that could have major impact on a field.

Review Criteria 1. 1. SignificanceSignificance Address an important problem? Will scientific knowledge Address an important problem? Will scientific knowledge

or clinical practice be advanced? What will be the effect of these studies on or clinical practice be advanced? What will be the effect of these studies on the field? the field?

2. 2. ApproachApproach Are the design, methods, etc. adequately developed, well Are the design, methods, etc. adequately developed, well integrated, reasoned, and appropriate to the project? Are potential problem integrated, reasoned, and appropriate to the project? Are potential problem areas considered and alternative tactics proposed? areas considered and alternative tactics proposed?

3. 3. InnovationInnovation Is the project original and innovative? Challenge existing Is the project original and innovative? Challenge existing paradigms; address an innovative hypothesis or critical barrier to progress in paradigms; address an innovative hypothesis or critical barrier to progress in the field? Employ novel concepts, approaches, etc?the field? Employ novel concepts, approaches, etc?

4. 4. InvestigatorsInvestigators Is the work proposed appropriate to the experience Is the work proposed appropriate to the experience level of the PI and other researchers? Does the team bring complementary level of the PI and other researchers? Does the team bring complementary and integrated expertise to the project (if applicable)? and integrated expertise to the project (if applicable)?

5. 5. EnvironmentEnvironment Does the scientific environment contribute to the Does the scientific environment contribute to the probability of success? Do the proposed studies benefit from the scientific probability of success? Do the proposed studies benefit from the scientific environment, or subject populations, or employ useful collaborative environment, or subject populations, or employ useful collaborative arrangements? Is there evidence of institutional support? arrangements? Is there evidence of institutional support?

Research Project FundingSuccess Rates

67

4653

8069

40 42

60

45

0

10

20

30

40

50

60

70

80

90

100

67

2531

0

10

20

30

40

50

60

70

80

90

100

B/START & I/START SuccessSuccess Rate

B/START 1995-2005 I/START 2003-2005

Fiscal Year

% F

un

ded

Funding Success Rate(FY 05)

0

10

20

30

40

% F

unde

d

P01 R01 R03 R21

Funding Mechanism

NIHNIDA

Dollars Obligated Dollars Obligated New and CompetingNew and Competing

AwardsAwards(NIDA-FY05)(NIDA-FY05)

4.1

98.3

3.8

12.3

118.5

1

10

100

1000

Dolla

rs in

Mill

ions

P01 R01 R03 R21

Funding Mechanism

Total

Percentage of New Funded R01 Applications Received from “New”

Principal Investigators to NIDA

0

25

50

75

% N

ew In

vest

igat

or

to N

IDA

2001 2002 2003 2004 2005

Fiscal Year


Grant success ratesGrant success rates The application processThe application process Contacting the right personContacting the right person ““K” and “R” AwardsK” and “R” Awards Writing and submitting your applicationWriting and submitting your application After the application is reviewed: Now After the application is reviewed: Now

what?what? Funding Funding ConclusionsConclusions

Before You Apply:Before You Apply:Developing the Research ConceptDeveloping the Research Concept

(one approach)(one approach) Find out about the institutional support that is available to Find out about the institutional support that is available to

youyou

Ask three senior colleagues to act as your “grant Ask three senior colleagues to act as your “grant committee.” Discussing your ideas for the application committee.” Discussing your ideas for the application with them before starting the writing processwith them before starting the writing process

Write three to five specific aims and discuss these with the Write three to five specific aims and discuss these with the committee before writing the application---by the time you committee before writing the application---by the time you tackle the bulk of the writing, the organization and content tackle the bulk of the writing, the organization and content of your proposal have received fairly detailed scrutiny and of your proposal have received fairly detailed scrutiny and critical consideration critical consideration

First steps in writing your application:First steps in writing your application:Start WorkStart Work

Generate preliminary data if needed–Most important for Generate preliminary data if needed–Most important for R01R01

Enlist collaborators Enlist collaborators include letters from theminclude letters from them clearly spell out the collaborations in your proposalclearly spell out the collaborations in your proposal

Look at successful proposals of colleagues in your fieldLook at successful proposals of colleagues in your field

Have a good idea! Have a good idea! Develop the conceptDevelop the conceptContact NIH by Web and by phone to reach peopleContact NIH by Web and by phone to reach people who can help youwho can help you

First steps in writing your application:First steps in writing your application:Start WritingStart Writing

Prepare your proposal early--Do not rush! Prepare your proposal early--Do not rush!

Make your first proposal your best proposal-- Convey Make your first proposal your best proposal-- Convey confidence and enthusiasm confidence and enthusiasm

Do your homework-- know the literature and issues, Do your homework-- know the literature and issues, questions, and controversies in your areaquestions, and controversies in your area Place your work in perspective Place your work in perspective Cite others—especially members of the review committee--if Cite others—especially members of the review committee--if

appropriateappropriate If there are two camps, make sure you cite both sidesIf there are two camps, make sure you cite both sides

Know the relevant review criteria Know the relevant review criteria Make your priorities clear Make your priorities clear Provide a timelineProvide a timeline Be focused and use a clear and concise writing style Be focused and use a clear and concise writing style

First steps in writing your application:First steps in writing your application:Start WritingStart Writing

Discuss potential problems and pitfalls-- Describe Discuss potential problems and pitfalls-- Describe alternate strategiesalternate strategies

Carefully consider your funding needs—Carefully consider your funding needs—

Keep in mind that the reviewers will judge your Keep in mind that the reviewers will judge your competence, in part, by how well your funding request competence, in part, by how well your funding request matches the scope of the projectmatches the scope of the project

Proofread!-- Reviewers and NIH Staff have Proofread!-- Reviewers and NIH Staff have zero tolerancezero tolerance

for typographical errors, misspellings, or sloppy for typographical errors, misspellings, or sloppy formatting.formatting.

Critique your own proposalCritique your own proposal

Have others read your final draftHave others read your final draft

Submitting Your Application:Submitting Your Application:““Dear CSR, …….”Dear CSR, …….”

Include a “cover letter” with applicationInclude a “cover letter” with application Request funding agency Request funding agency

Primary assignmentPrimary assignment Dual assignment if appropriateDual assignment if appropriate

Request review committee assignmentRequest review committee assignment NIDA Review groups:NIDA Review groups:

http://www.nida.nih.gov/IRGCouncil/IRGStructure.htmlhttp://www.nida.nih.gov/IRGCouncil/IRGStructure.html CSR Review GroupCSR Review Group

http://www.csr.nih.gov/Committees/rosterindex.asp#Ahttp://www.csr.nih.gov/Committees/rosterindex.asp#A

After all this….After all this….Concerned about your review committee or funding agency?Concerned about your review committee or funding agency?Be proactive!—Contact NIH —Be proactive!—Contact NIH —Ask questionsAsk questions



what? Will I get funds?what? Will I get funds? ConclusionsConclusions

After Your Application is Reviewed………..

Talk Talk withwith Program Staff Program Staff

about:about:

•Your Priority ScoreYour Priority Score

•Summary StatementSummary Statement

•Funding (?)Funding (?)

•Next Steps:Next Steps:•RevisionRevision•Other ideas & optionsOther ideas & options

Making Funding Decisions:Making Funding Decisions:Who Gets Paid and WhyWho Gets Paid and Why

Scientific MeritScientific Merit Priority scorePriority score Percentile scorePercentile score Summary statement-- reviewers commentsSummary statement-- reviewers comments

Programmatic RelevanceProgrammatic Relevance Gap area?Gap area? Submitted under an RFA?Submitted under an RFA?

New InvestigatorNew Investigator Availability of FundsAvailability of Funds Advisory Council RecommendationsAdvisory Council Recommendations Congressional Mandates Congressional Mandates (e.g., HIV/AIDS)(e.g., HIV/AIDS)



what? Will I get funds?what? Will I get funds? ConclusionsConclusions

Before You Apply………..

Talk Talk WithWith NIDA Staff……….. NIDA Staff………..

and learn about…and learn about…

•Funding MechanismsFunding Mechanisms•Program PrioritiesProgram Priorities•Grant ProcessGrant Process•Application ProcedureApplication Procedure•Review Process Review Process and Review Committeesand Review Committees•New Initiatives-New Initiatives-

•RFAs, PAsRFAs, PAs•Research InterestsResearch Interests•NIH Roadmap & NIH Neuroscience BlueprintNIH Roadmap & NIH Neuroscience Blueprint

Career Development Plan

YesYes

Do I have pilot data?NoNo

NoNo

Apply for R03, BSTART or ISTART

Do I need more training or changing career emphasis?

Institutional Pre-Doctoral Fellowship-T32

Pre-Doctoral Fellowship-F31

Post-Doctoral Fellowship-F32

Institutional Post-Doctoral Fellowship-T32

R01

YesYes

Apply for Mentored K

After Your Application is Reviewed………..

Talk Talk withwith Program Staff……….. Program Staff………..

about….….about….….

•Your Priority ScoreYour Priority Score•Summary StatementSummary Statement•Funding(?)Funding(?)•Next Steps:Next Steps:

•RevisionRevision•Other ideas & optionsOther ideas & options

BE BE PROACTIVEPROACTIVE!!!!!!BE BE PROACTIVEPROACTIVE!!!!!!

BE BE PPERSISTENTERSISTENT!!!!!!BE BE PPERSISTENTERSISTENT!!!!!!

ENGAGE A ENGAGE A PPROGRAM OFFICERROGRAM OFFICER!!!!!!

ENGAGE A ENGAGE A PPROGRAM OFFICERROGRAM OFFICER!!!!!!

research funding opportunities: the role of nida program

Documents

phd office

phd director

program officerprogram

phd david shurtleff

phd timothy condon

irg review

scientific reviewcenter

scientific areasidentifies