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Removes poisonous substances

Helps in digestion

Stores Energy

Purifies Blood

Manufactures new proteins

Processes Food

1 Organ that controls 6 vital functions of the body

Liver functions continued....

Liver functions continued....

Did you Know.... ???

The Liver is the Largest internal Organ & Largest gland in the human body.

The human Liver weighs approximately 3.5 – 5.5 lbs.

Alcohol abuse is the most common cause of liver disease in India.

Common Diseases of Liver

HEPATITIS: Inflamation of Liver caused due to Viral Infections. Its of three types.

CIRRHOSIS: Fibrosis of Liver tissues characterized by loss of Liver Function.

Launching Dabur Hepano – Everyday care for Liver

For everyday Liver Health

• Enriched with Herbs like Bhumiamlaki, Guduchi, Nimba, Haritaki, Kalmegh etc.

PRODUCT

• Pre Clinical studies have shown significant Hepato protective Action. Reduces SGOT, SGPT and Serum bilirubin levels to normal

KEY DIFFERENTIATOR

• 200 ml Pack with Monocarton

• 30 Units in one Case.

• Pack comes with QR code.

PACKAGING

• MRP : Rs.85/-. PRICING

DABUR HEPANO

DABUR HEPANO – BRAND DETAILS

DABUR HEPANO – COMPOSITION Bhumiamalaki Baheda Guduchi

Amla

Harad

Pippali Nimba

Kalmegh

Kutki

Parts used: Whole plant

Properties:

Taste inducer (Rocana) , useful in Amlapitta (Hyperacidity), Pandu (Anaemia), Hepato-

splenomegaly and Jaundice.

Scientific studies: Hepatoprotective acitivity on nimesulide- induced oxidative stress

in vivo etc

Bhumyamlaki (Phyllanthus niruri)

Guduchi (Tinospora cordifolia)

Parts used: Stem

Properties:

Strength promoting (Balya), Digestion promoter (Dipana), Rejuvenator (Rasayana),

Blood purifier (Raktasodhaka), useful in Jaundice (Kamala)and Anaemia (Pandu)

Scientific studies: Hepatoprotective acitivity by modulation of kupffer cell activity by

in liver damage, in CCl4 intoxicated mature albino rats etc

Neem (Azadirachta indica)

Parts used: Bark

Properties:

Neem is used for tastelessness conditions. It is having anti-parasitic, anti-inflammatory, anti-

ulcer and hepato-protective effects.

Scientific studies: Hepatoprotective acitivity paracetamol-induced hepatic damage in albino

rats, against diethylnitrosamine (NDEA) induced hepatotoxicity in mice etc

Kalmegh (Andrographis paniculata)

Parts used: Whole plant

Properties:

Digestion promoter properties and is used in Ajirna (dyspepsia), Jvara (fever), Kandu (itching),

Kamala (jaundice) and Yakrtvikara (disorders of liver..

Scientific studies: Hepatoprotective acitivity in acute hepatitis induced by galactosamine &

paracetamol intoxication in rats, against against carbon tetrachloride-induced liver damage

etc

Haritaki (Terminalia chebula)

Parts used: Pericarp

Properties:

Rejuvenator, Antioxidant, Laxative. It is used as appetizer and is used in tastelessness

conditions, jaundice, hepato-splenomegaly, Anaemia etc.

Amla (Emblica officinalis)

Parts used: Fruit

Properties:

Mild purgative, agni deepak (Digestion promoter), Skin diseases, inflammation, It is a potent

Rasayana (Rejuvenating agent) and Bulk promoting (Brmhaniya)

Scientific studies: Amla possess hepatoprotective, antioxidant, cholesterol lowering property

Vibhitaki (Terminalia belerica)

Parts used: Pericarp

Properties:

Laxative, diuretic and cardio tonic treatments.

Scientific studies: Amla possess hepato-protective, antioxidant property

Kutki (Picrorhiza kurroa)

Parts used: Roots and Rhizomes

Properties:

Digestion promoter properties and is used in Jaundice and tastelessness conditions.

Scientific studies: Hepatoprotective action against subacute liver damages

induced by carbon tetrachloride etc

Pre-Clinical Efficacy Study

• Study drug: Hepano

• Pre clinical efficacy study conducted at Jamia Hamdard, Hamdard University, New Delhi

(Third party independent centre).

• Model used

– D-galactosamine induced Hepatotoxicity

– Paracetamol induced Hepatotoxicity

• New Livfit and Liv 52 were used as reference standards used in the study.

• Paracetamol caused hepatotoxicity in the toxicant group, elevated levels of SGOT,

SGPT, serum bilirubin, ALP as well as increased lipid peroxidation and significantly

reduced level of serum albumin and tissue glutathione compared to toxicant.

• Liv 52 and New Livfit significantly improved these parameters

• Hepano at 120 mg/kg and 240 mg/kg also showed significant improvement in

comparison to toxicant.

Pre-Clinical Efficacy Study ….contd

HEPATOPROTECTIVE ACTIVITY OF HEPANO

Study drug and duration: :

• Hepano was administered orally once daily for 28 consecutive days.

Results

• No mortality and clinical signs of toxicities were observed in all the treated

group animals and control group animals throughout the study period.

• Hematological investigation & blood biochemistry parameters were found to

be within the normal range both in treated and control groups.

• Gross pathological examination of all the animals did not reveal any

abnormality and the mean values of absolute & relative organ weights were

comparable to their respective vehicle control.

• Histo-pathological examination did not reveal any test item related changes.

• The no observed adverse effect level (NOAEL) of HEPANO when administered

orally once daily for a period of 28 days in both the sexes of Wistar rats was

found to be 1000mg/kg body weight.

Pre-Clinical Safety Study

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