Real-time 3D MR Respiratory Motion Acquisition for SimultaneousPET / MR Imaging

Liheng Guo1, Mark Ahlman3, Tao Feng2, Michael Guttman4, Elliot McVeigh1,David Bluemke3, Benjamin Tsui2, Daniel Herzka1

1Biomedical Engineering, Johns Hopkins University, Baltimore, MD2Department of Radiology, Johns Hopkins University, Baltimore, MD3Radiology and Imaging Sciences, National Institutes of Health, Bethesda, MD4Cardiology, School of Medicine, Johns Hopkins University, Baltimore, MD

Podium Presentation. Annual Meeting of the International Society for Nuclear Medicine and Molecular Imaging (SNMMI). St. Louis, MO. June 11, 2014.

Liheng GuoSNMMI 2014

Motivation• Breathing motion corrupts positron emission tomography (PET) images

Goerres, et al. %Respiration-induced Attenuation Artifact at PET/CT: Technical Considerations. Radiology. 2003; 226:906–910.

Liver

Lung

TimeHeart

http://www.siemens.com/press/en/presspicture/

Positron Emission Tomography (PET)

Motion-induced false signal void

Objective• To track breathing motion in 3D in real time, using simultaneous PET-MRI• To generate 3D motion vector field to correct PET images

http://www.siemens.com/press/en/events/healthcare/2010-11-Biograph-mMR.php

Method: Imaging Data Acquisition• Radial 3D MRI

Barger, et al. MRM 2002;48:297-305

• Golden Angle Sampling Pattern500 views

1000

2000

Early Late

Method: Image Reconstruction

Imaging Data Acquisition

. . .

• Sliding window frames• Iterative compressed-sensing reconstruction in 3D wavelet domain

Frame 1 Frame 2 Frame 3 Frame 4

Coronal View(slice 60 of 128)

Coronal Projection(all slices)

MotionVector Field

(slice 60 of 128)

3.1×3.1×3.1mm3 voxels 2s temporal res 4D registration

Results: Real-Time 3D Images• Sufficient Resolution for Motion Mapping