digital pathology virtual microscope slides for hematologycls2.ahc.umn.edu/case studies.pdf ·...
TRANSCRIPT
© 2011 Regents of the University of Minnesota. All rights reserved.
Digital Pathology Virtual Microscope Slides for Hematology
PATIENT DATA &
CASE STUDIES
Written by Stephen M. Wiesner, Ph.D., MT(ASCP) Updated 8/15/2011
1
The University of Minnesota, founded in the belief that all people are enriched by understanding, is dedicated to the advancement of learning and the search for truth; to the sharing of this knowledge through education for a diverse community; and to the application of this knowledge to benefit the people of the state, the nation and the world. The University's threefold mission of research and discovery, teaching and learning, and outreach and public service is carried out on multiple campuses and throughout the state. The University of Minnesota is an equal opportunity educator and employer.
This material is available in alternative formats upon request. Please contact:
Center for Allied Health Programs MMC 714, 516 Delaware St. SE Room 15-194, PWB Tel: (877) 334-2659 / email: [email protected] / Web: www.cahp.umn.edu
2
Slide Index
Description/Slide Label Specimen Type Comment/Condition Slide ID Page
Slide 002 Peripheral Blood Acute Lymphocytic Leukemia L1 305 1
Slide 003 Peripheral Blood Erythrocytosis; Cyanotic congenital heart disease 297 2
Slide 004 Peripheral Blood Iron Deficiency Anemia 338 3
Slide 005 Peripheral Blood Diffuse histiocytic lymphoma 337 4
Slide 006 Peripheral Blood Sezary Syndrome 429 5
Slide 007 Peripheral Blood Iron Deficiency Anemia 6 days post therapy 203 6
Slide 011 Peripheral Blood Metastatic Carcinoma 307
Slide 013 Peripheral Blood Hereditary Elliptocytosis 306
Slide 014 Peripheral Blood AML-M2 with basophilic stippling 169
Slide 014 Peripheral Blood Acute myelocytic leukemia (M2) w/basophilic stippling 475
Slide 015 Bone Marrow Concentrate Sideroblastic Anemia 207 7
Slide 015 Bone Marrow Concentrate Sideroblastic Anemia 359 7
Slide 016 Peripheral Blood Chronic Lymphcytic Leukemia w/hemolytic anemia 345 8
Slide 017 Peripheral Blood Autoimmune Hemolytic Anemia 336 9
Slide 018 Bone Marrow Concentrate Erythroleukemia (M6) w/ megakaryocytic involvement 251 10
Slide 019 Peripheral Blood Acute Myeloid Leukemia (M1) 458 11
Slide 020 Peripheral Blood Microcytic Anemia 440 12
Slide 020 Peripheral Blood Microcytic anemia 479 12
Slide 021 Peripheral Blood Macrocytic Anemia, hepatic failure 205 13
Slide 022 Peripheral Blood Chronic Lymphocytic Leukemia 348
Slide 023 Peripheral Blood Normal Peripheral Blood 493
Slide 024 Peripheral Blood Possible Infectious Hepatitis/Infectious mono 219 14
Slide 025 Peripheral Blood Chronic Lymphocytic Leukemia 450 15
Slide 026 Peripheral Blood Leukoerythroblastic Reaction (SLE) 166 16
Slide 027 Peripheral Blood Hemolytic Anemia; DIC 303 17
Slide 028 Peripheral Blood Kidney Transplant; Red cell fragmentation 360 18
Slide 029 Peripheral Blood CML, accelerated megakaryocytic 165 19
Slide 029 Peripheral Blood Chronic Myelogenous Leukemia; Accelerated megakaryocytic 477 19
Slide 030 Peripheral Blood Sideroblastic Anemia 304 20
Slide 031 Bone Marrow Concentrate Sideroblastic Anemia 459 20
Slide 032 Peripheral Blood Hairy Cell Leukemia 449 21
Slide 033 Peripheral Blood Iron Deficiency Anemia 248 22
Slide 033 Peripheral Blood Iron Deficiency Anemia (infancy) 340 22
Slide 034 Peripheral Blood Macrovascular/cardiac hemolytic anemia 334 23
Slide 035 Peripheral Blood Chronic Myelogenous Leukemia 457 24
Slide 036 Peripheral Blood Chronic Lymphocytic Leukemia 448 25
Slide 037 Peripheral Blood Thrombotic thrombocytopenic purpura 250 26
Slide 038 Peripheral Blood Macrocytic Anemia 361
Slide 039 Peripheral Blood Megaloblastic Anemia 302
Slide 040 Peripheral Blood Sickle Cell Anemia 301 27
Slide 041 Peripheral Blood Multiple Myeloma 335 28
Slide 042 Bone Marrow Concentrate Multiple Myeloma 419 29
Slide 043 Peripheral Blood Pelger-Huet Anomaly 332 30
Slide 044 Peripheral Blood Leukoerythroblastic Reaction 447 31
Slide 045 Peripheral Blood Acute Myelogenous Leukemia (M1) 331 32
Slide 046 Peripheral Blood Multiple Myeloma 247 33
Slide 047 Peripheral Blood Beta thalassemia minor; Omenn's Syndrome Immunodeficiency 330 34
Slide 048 Peripheral Blood Small cleaved cell lymphoma 242 35
Slide 049 Body Fluid_Cerebral Spinal Fluid 204
Slide 050 Peripheral Blood Infectious mononucleosis 491 36
Slide 051 Peripheral Blood Rheumatic Fever w/valve replacement 246 37
Slide 052 Peripheral Blood Leukoerythroblastic Reaction; Polychromasia 456 38
Slide 053 Peripheral Blood Hereditary Pyropoikilocytosis 455 39
Slide 054 Peripheral Blood Malaria, P. vivax 490 40
Slide 055 Peripheral Blood CML 220 41
Slide 057 Peripheral Blood Sickle Cell Anemia 346 42
Slide 058 Peripheral Blood Red Cell Fragmentation Syndrome 445
Slide 059 Peripheral Blood Acute Myeloid Leukemia M1 312 43
Slide 060 Peripheral Blood Post Splenectomy/Kidney Transplant 300 44
Slide 060 Peripheral Blood Kidney Transplant; post splenectomy 313 44
Slide 061 Peripheral Blood Acute Renal Failure; echinocytosis 314 45
Slide 062 Peripheral Blood Megaloblastic anemia 294 46
Slide 063 Peripheral Blood Multiple organ failure w/ Candidiasis; toxic neutrophilia, macrophages present 241 47
Slide Index
Description/Slide Label Specimen Type Comment/Condition Slide ID Page
Slide 064 Peripheral Blood Monocytosis, pancytopenia 347 48
Slide 065 Peripheral Blood Sickle Cell Anemia 446
Slide 066 Peripheral Blood Iron Deficiency Anemia 240 49
Slide 067 Peripheral Blood Erythroleukemia (M6) 453 50
Slide 068 Peripheral Blood Malaria, P. falciparum 492 51
Slide 069 Peripheral Blood Lead Poisoning 329 52
Slide 070 Peripheral Blood Thalassemia, alpha 202 53
Slide 071 Peripheral Blood Chediak-Higashi Syndrome 452 54
Slide 072 Peripheral Blood Agnogenic Myeloid Metaplasia 299 55
Slide 073 Peripheral Blood ALL L2 164 56
Slide 073 Peripheral Blood Acute Lymphocytic Leukemia (L2) 472 56
Slide 074 Bone Marrow Concentrate Metastatic Carcinoma 328
Slide 075 Peripheral Blood SLE; Cold Agglutinin Disease 295 57
Slide 076 Peripheral Blood Mucopolysaccarhidosis Type III (Sanfillipo) 327 58
Slide 077 Peripheral Blood Infectious Mononucleosis 163 59
Slide 077 Peripheral Blood Infectious Mononucleosis 481 59
Slide 078 Peripheral Blood Infectious Mononucleosis 162 60
Slide 078 Peripheral Blood Infectious Mononucleosis 478 60
Slide 079 Peripheral Blood Pneumococcal septicemia 244 61
Slide 080 Peripheral Blood Auto-immune hemolytic anemia 245 62
Slide 081 Peripheral Blood Chronic Myelogenous Leukemia 316 63
Slide 082 Peripheral Blood Acute Myeloid Leukemia (M1) 451 64
Slide 084 Peripheral Blood Hereditary Spherocytosis 326 65
Slide 085 Peripheral Blood Acute myelocytic leukemia M1 324 66
Slide 086 Bone Marrow Concentrate Acute Myelogenous Leukemia M1 315 67
Slide 087 Peripheral Blood Autoimmune Hemolytic Anemia 350 68
Slide 088 Peripheral Blood AIDS 354 69
Slide 089 Peripheral Blood Sickle Cell Anemia 161 70
Slide 089 Peripheral Blood Sickle Cell Anemia 480 70
Slide 090 Peripheral Blood Reticulocytosis; Sickle Cell Anemia 349 71
Slide 091 Peripheral Blood Chronic myelogenous leukemia 323 72
Slide 092 Peripheral Blood Thalassemia Alpha; HbE Disease 286 73
Slide 093 Bone Marrow Concentrate Normal Bone Marrow 100x 199
Slide 093 Bone Marrow Concentrate Normal Bone Marrow 83x 200
Slide 093 Bone Marrow Concentrate Normal Bone Marrow 201
Slide 094 Peripheral Blood Epstein Platelet Syndrome 287 74
Slide 095 Peripheral Blood Babesia microti 288 75
Slide 096 Peripheral Blood Infectious Mononucleosis 320 76
Slide 097 Peripheral Blood Thalassemia Minor; Beta 289
Slide 098 Peripheral Blood Acute Lymphocytic Leukemia L1 321 77
Slide 099 Peripheral Blood Benign Monoclonal Gammopathy; Heinz Body Positive 290 78
Slide 100 Peripheral Blood Sickle Cell Anemia 285 79
Slide 101 Peripheral Blood Normal; excess anticoagulant 284 80
Slide 102 Peripheral Blood Acute myeloid leukemia (M6) w/ autoagglutination 322 81
Slide 103 Peripheral Blood Immune Reaction/Monocytosis 319 82
Slide 104 Bone Marrow Concentrate Normal Bone Marrow 213 83
Slide 105 Peripheral Blood Relapse CML 283 84
Slide 106 Peripheral Blood Acute Myeloid Leukemia (M1) 412 85
Slide 107 Peripheral Blood Multple Myeloma 282 86
Slide 108 Peripheral Blood Chronic Myelogenous Leukemia 318 87
Slide 109 Bone Marrow Concentrate Chronic Myelogenous Leukemia 281 88
Slide 110 Peripheral Blood Acute Myelomonocytic Leukemia (M4) 413 89
Slide 111 Peripheral Blood Pyropoikilocytosis 421 90
Slide 113 Peripheral Blood Hemolytic Uremic Syndrome 420 91
Slide 114 Peripheral Blood Infectious Mononucleosis 280 92
Slide 115 Peripheral Blood Chronic Myelogenous Leukemia 352 93
Slide 116 Bone Marrow Concentrate Megaloblastic Anemia 414 94
Slide 117 Peripheral Blood Alder-Reilly Anomaly 317 95
Slide 118 Peripheral Blood Beta Thalassemia Minor 416 96
Slide 119 Peripheral Blood Megaloblastic Anemia 173 97
Slide 119 Peripheral Blood Megaloblastic Anemia 483 97
Slide 120 Bone Marrow Concentrate Megaloblastic Anemia 172 98
Slide 120 Bone Marrow Concentrate Megaloblastic Anemia 471 98
Slide Index
Description/Slide Label Specimen Type Comment/Condition Slide ID Page
Slide 120 Bone Marrow Concentrate Megaloblastic Anemia 476 98
Slide 121 Peripheral Blood CML 171
Slide 121 Peripheral Blood Chronic Myelogenous Leukemia 291
Slide 121 Peripheral Blood Chronic Myelogenous Leukemia 484
Slide 122 Peripheral Blood Chronic Myelogenous Leukemia 417
Slide 122 Peripheral Blood Chronic Myelogenous Leukemia 418
Slide 123 Bone Marrow_Trephine Section 279
Slide 124 Peripheral Blood Immune Reaction 170 99
Slide 124 Peripheral Blood Atypical polyclonal lymphoproliferative disease 325 99
Slide 124 Peripheral Blood Immune Reaction 482 99
Slide 125 Peripheral Blood Acute Myelomonocytic Leukemia (M4) 415 100
Slide 126 Peripheral Blood Hemolyitic anemia 489 101
Slide 127 Peripheral Blood Bernard-Soullier Syndrome 442
Slide 128 Peripheral Blood Monocytosis 278
Slide 129 Peripheral Blood Hypereosinophilic Syndrome 277 102
Slide 130 Peripheral Blood Acute Promyelocytic Leukemia (M3) 272 103
Slide 131 Peripheral Blood Hairy Cell Leukemia 275 104
Slide 132 Peripheral Blood Acute Myelomonocytic Leukemia w/Eosinophilia (M4) 273 105
Slide 132 Peripheral Blood Acute Myelomonocytic Leukemia w/eosinophilia (M4eos) 454 105
Slide 133 Bone Marrow Concentrate Acute Myelomonocytic Leukemia w/Eosinophilia (M4) 274 106
Slide 134 Bone Marrow Concentrate Megaloblastic Anemia 353
Slide 135 Peripheral Blood Congenital Erythropoietic porphyria 444 107
Slide 136 Peripheral Blood Platelet Satellitism 268 108
Slide 137 Peripheral Blood Siderblastic anemia 209 109
Slide 138 Peripheral Blood Sideroblastic Anemia 208 110
Slide 139 Peripheral Blood T Cell Acute Lymphocytic Leukemia 441 111
Slide 140 Peripheral Blood G6PD Deficiency - See Slide HB008 for Heinz Body Stain 439 112
Slide 142 Peripheral Blood Kidney Failure; Hemolytic Anemia 351 113
Slide 143 Peripheral Blood Idiopathic Thrombocytopenic Purpura 276 114
Slide 144 Bone Marrow Concentrate Idiopathic Thrombocytopenic Purpura 355
Slide 144 Bone Marrow Concentrate Idiopathic Thrombocytopenic Purpura 438
Slide 149 Peripheral Blood Juvenile Chronic Myeloid Leukemia (JMML) 437 115
Slide 150 Peripheral Blood Hemolytic Uremic Syndrome 269
Slide 151 Peripheral Blood Hemolytic Anemia w/ Heinz Bodies 270 116
Slide 152 Peripheral Blood Sickle Cell Anemia 271 117
Slide 153 Bone Marrow Concentrate Normoblastic hyperplasia 206 118
Slide 154 Peripheral Blood Infectious mononucleosis & immune suppression 426 119
Slide 155 Peripheral Blood CLL 168 120
Slide 155 Peripheral Blood Chronic Lymphocytic Leukemia 474 120
Slide 156 Bone Marrow Concentrate Chronic Lymphocytic Leukemia 266 121
Slide 157 Peripheral Blood Septicemia; Candida/Histoplasma 356 122
Slide 159 Peripheral Blood Hemolytic Uremic Syndrome 310 123
Slide 160 Peripheral Blood Leukoerythroblastic & immune reaction 425 124
Slide 161 Peripheral Blood Acute Myelomonocytic Leukemia (M4) 434 125
Slide 162 Peripheral Blood Acute Lymphocytic Leukemia (L2) 265 126
Slide 163 Peripheral Blood Acute Monocytic Leukemia M5b 309 127
Slide 164 Bone Marrow Concentrate Acute Monocytic Leukemia (M5b) 263 128
Slide 165 Peripheral Blood Acute Monocytic Leukemia (M5a) 264 129
Slide 166 Bone Marrow Concentrate Acute Monocytic Leukemia (M5a) 261 130
Slide 167 Peripheral Blood Megaloblastic Anemia; Folate Deficiency 267 131
Slide 168 Bone Marrow Concentrate Megaloblastic Anemia; Folate Deficiency 262 132
Slide 169 Peripheral Blood Immune Reaction - Castleman's Disease 259 133
Slide 170 Peripheral Blood Acute Promyelocytic Leukemia (M3) 435 134
Slide 171 Bone Marrow Concentrate Acute Promyelocytic Leukemia (M3) 260 135
Slide 172 Peripheral Blood Multiple Myeloma 308 136
Slide 173 Bone Marrow Concentrate Multiple Myeloma 436 137
Slide 174 Peripheral Blood Congenital Dyserythropoietic Anemia (Type III) 258 138
Slide 175 Peripheral Blood Congenital Dyserythropoietc Anemia (Type III) 257 139
Slide 176 Peripheral Blood Acute Lymphocytic Leukemia (L1) 432 140
Slide 177 Bone Marrow Concentrate Acute Lymphocytic Leukemia (L1) 433 141
Slide 178 Peripheral Blood Chronic Lymphocytic Leukemia 256 142
Slide 179 Peripheral Blood Chronic Myelogenous Leukemia 443 143
Slide 180 Bone Marrow Concentrate Immune thrombocytopenia 255 144
Slide Index
Description/Slide Label Specimen Type Comment/Condition Slide ID Page
Slide 181 Peripheral Blood Chronic myelogenous leukemia 254 145
Slide 182 Peripheral Blood Pneumococcal pneumonia and septicemia 253 146
Slide 183 Peripheral Blood Acute Myelomonocytic Leukemia (M4) 424 147
Slide 184 Peripheral Blood Agnogenic Myeloid Metaplasia 431 148
Slide 185 Peripheral Blood Thalassemia, Beta minor 167 149
Slide 185 Peripheral Blood Beta Thalassemia Minor 473 149
Slide 186 Bone Marrow Concentrate Niemann-Pick Disease 423 150
Slide 187 Peripheral Blood Agnogenic Myeloid Metaplasia 428 151
Slide 188 Peripheral Blood Beta thalassemia trait 252 152
Slide 188 Peripheral Blood Beta Thalassemia minor 339 152
Slide 189 Peripheral Blood Glucose phosphate isomerase deficiency 486 153
Slide 190 Peripheral Blood Small cleaved cell follicular lymphoma 298 154
Slide 191 Peripheral Blood Acute Lymphocytic Leukemia 430
Slide 192 Peripheral Blood Reactive neutrophilia post G-CSF therapy 249
Slide 192 Peripheral Blood Reactive Neutrophilia; G-CSF Therapy 358
Body Fluid 1 Body Fluid_Synovial Fluid 197
Body Fluid 3 Body Fluid_Ascites 196
Body Fluid 5 Body Fluid_Brochial Alveolar Lavage 195
CSF 2 Body Fluid_Cerebral Spinal Fluid 182
CSF 4 Body Fluid_Cerebral Spinal Fluid 181
Slide 193 Peripheral Blood Unknown Differential 311
Slide 193 Peripheral Blood Unknown Differential 344
Slide 194 Peripheral Blood Unknown Differential 357
Slide 195 Peripheral Blood Unknown Differential 488
Slide 305 Peripheral Blood Unknown Differential 547
Slide 306 Peripheral Blood Unknown Differential 541
Slide 307 Peripheral Blood Unknown Differential 544
Slide 310 Peripheral Blood Unknown Differential 543
Slide 317 Peripheral Blood Unknown Differential 548
Slide 318 Peripheral Blood Unknown Differential 545
Slide 319 Peripheral Blood Unknown Differential 546
Slide 320 Peripheral Blood Unknown Differential 542
Slide 321 Peripheral Blood Unknown Differential 564
Slide 322 Peripheral Blood Unknown Differential 565
Slide 832 Peripheral Blood Unknown Differential 343
Slide 1018 Peripheral Blood Unknown Differential 342
Slide 1203 Peripheral Blood Unknown Differential 212
Slide 1203 Peripheral Blood Unknown Differential 485
Slide 1221 Peripheral Blood Unknown Differential 210
Slide 1221 Peripheral Blood Unknown Differential 100X 211
Slide 1964 Bone Marrow Concentrate Hematogones 487
Slide HB008 Peripheral Blood Heinz Body Stain 341
Slide LAP2 Peripheral Blood Leukocyte Alkaline Phosphatase Stain 494
Hematology Case 01 Peripheral Blood Acute Monocytic Leukemia (M5a) 384 157
Hematology Case 02 Bone Marrow Direct Acute Myeloid Leukemia (M2) 386 160
Hematology Case 03 Bone Marrow Direct Acute Promyelocytic Leukemia (M3) 388 164
Hematology Case 04 Peripheral Blood Acute Myeloid Leukemia (M2) 390 167
Hematology Case 05 Peripheral Blood Acute Myelomonocytic Leukemia (M4) 392 171
Hematology Case 06 Peripheral Blood Acute Myelomonocytic Leukemia (M4eos) 394 174
Hematology Case 07 Bone Marrow Direct Acute Myeloid Leukemia (M2) 396 177
Hematology Case 08 Peripheral Blood Acute Myeloid Leukemia (M4) 398 180
Hematology Case 09 Bone Marrow Direct Erythroleukemia (M6) 400 183
Hematology Case 10 Peripheral Blood Acute Myeloid Leukemia (M2) 402 186
Hematology Case 11 Peripheral Blood Acute Lymphoblastic Leukemia 405 189
Hematology Case 12 Bone Marrow Direct Acute Lymphoblastic Leukemia 364 192
Hematology Case 13 Peripheral Blood Acute Myelomonocytic Leukemia (M4) 363 195
Hematology Case 14 Peripheral Blood Acute Promyelocytic Leukemia (M3) 365 198
Hematology Case 15 Peripheral Blood B Cell Lymphoma; Burkitts 379 201
Hematology Case 15 Bone Marrow Concentrate B Cell Lymphoma; Burkitts 381 202
Hematology Case 16 Peripheral Blood Hairy Cell Leukemia 376 205
Hematology Case 17 Bone Marrow Direct Acute Lymphoblastic Leukemia 372 208
Hematology Case 18 Peripheral Blood Myelodysplastic Syndrome 374 211
Hematology Case 19 Bone Marrow Direct Acute Monocytic Leukemia (M5b) 370 214
Slide Index
Description/Slide Label Specimen Type Comment/Condition Slide ID Page
Hematology Case 20 Peripheral Blood Chronic Myeloid Leukemia 368 217
Hematology Case 21 Bone Marrow Direct Chronic Lymphocytic Leukemia 366 220
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100
101
102
103
104
105
106
107
108
109
110
111
112
113
114
115
116
117
118
119
120
121
122
123
124
125
126
127
128
129
130
131
132
133
134
135
136
137
138
139
140
141
142
143
144
145
146
147
148
149
150
151
152
153
154
155