Radioactive cesium and potassium levels in human placenta: After the Fukushima nuclear power plant accident

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  • Abstracts / Placenta 35 (2014) A1eA23A22risk of stillbirth at GWNwas defined as a number of womenwith stillbirthat GW. N divided by number of women giving birth at GW N.Results: A total of 32 (29.4%) women experienced stillbirth at median GWof 31 (range, 2438). Preterm birth (GW37) occurred in 52 (67.5%) of the 77live born infants. Only 25 (22.9%) women had full-term (GW37) live-borninfants. The prospective risk of stillbirth was 29.4% (32/109), 27.5% (25/91),20.9% (14/67) and 13.0% (6/46) for womenwho reached GW 24, 28, 32, and36, respectively.Conclusions: As womenwith PMD faces at an extraordinary higher risk ofIUFD, early admission to the hospital and intensive monitoring of foetalstatus should be considered, although whether this policy improvesoutcome has not been validated.O-097.RADIOACTIVE CESIUM AND POTASSIUM LEVELS IN HUMAN PLACENTA:AFTER THE FUKUSHIMA NUCLEAR POWER PLANT ACCIDENT

    Makoto Kawamur a,b, Hiroshi Anbe b, Fujimori Keiya a. a Fukushima MedicalUniversity, Department of Obstetrics and Gynecology, Japan; bMinamisomaCity General Hospital, Department of Obstetrics and Gynecology, Japan

    Background: The Great East Japan earthquake (followed by large-scaletsunamis) struck Northeastern Pacific Coast of Japan on Mar 11, 2011. Itcaused TEPCO's Fukushima Daiichi Nuclear Power Plant (NPP) accident,accompanied by radioactive pollution in Fukushima prefecture. Minami-soma City General Hospital, just 23km away from the NPP, restarted theObstetric services in April 2012. We examined the placental radioactiveCesium and Potassium levels.

    Methods: We measured the radioactive contents of the 40samples ofplacenta after the delivery, using high-purity Germanium detectors forGamma-ray spectrometry (at National Institute of Public Health, Wako,Saitama). All the parturients underwent the Whole-Body Counting (WBC)test of radioactivity.Results: The radioactive content levels are as follows. 134Cs: 0.36Bq/kg,137Cs: 0.58Bq/kg, total-Cs: 0.94Bq/kg, 40K (natural radioactive): 53.1Bq/kg.Radioactive Cs (from the NPP accident) levels were about 1/50 of thenatural radioactive, and much lower than the '87 Italian data, 2years afterthe Chernobyl NPP accident (total-Cs:11.5Bq/kg). All of the parturientswere negative on the WBC test (with cut-off value of 250Bq/body).Conclusion: The Cs levels were much lower than natural radioactive (40K)level, which suggests the efforts to reduce external/internal radioactiveexposure in the area has been successful.O-102.DENTAL INFECTION OF PORPHYROMONAS GINGIVALIS INDUCESPRETERM BIRTH

    Mutsumi Miyauchi a, Hisako Furusho a, Atsuhiro Nagasaki a, SatoshiUrabe b, Haruhisa Konishi b, Hiroshi Miyoshi b, Yoshiki Kudo b, TakashiTakata a. aDepartment of Oral and Maxillofacial Pathobiology, Institute ofBiomedical and Health Sciences, Hiroshima University, Japan; bDepartmentof Obstetrics and Gynecology, Hiroshima University, Japan

    Objectives: Epidemiological studies revealed a link between periodontaldisease and preterm delivery, however, the mechanism of the link remainsunclear. The present study was aimed to examine the influence of Por-phyromonas gingivalis (Pg): one of main periodontal pathogens) on pre-term birth with a Pg dental infection mouse model and in vitro analyseswith trophoblasts and related cells Methods: In vivo experiment: 8-wks-old\C57Bl/6J mice were infected with Pg-w83-strain (108 CFU) from thepulp chamber (Pg group). Mating was started at 6-wks post-infectionwhen a periapical granuloma was established. Gestational day (gd) andbirth weight were examined.; At gd15, placental tissues were harvested forIHC staining and PCR. Serum, placental tissue and amniotic fluid werecollected for ELISA of cytokines. Uninfected mice were used as negativecontrol (NC). In vitro experiment: HTR-8 (trophoblast), HuhT1 (endothelialcell) and THP1 (monocyte) cell lines were used to assess the effects of Pgand Pg-LPS.Results: Pg group showed 2 days of preterm birth (p

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