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  • PURINE METABOLISM IN M A N - I I I Biochemical, Immunological, and Cancer Research

    E d i t e d by

    Aurelio Rapado Fundacion Jimenez Diaz Madrid, Spain

    R.W.E. Watts M.R.C. Clinical Research Centre Harrow, England

    a n d

    Chris H.M.M. De Bruyn Department of Human Genetics University of Nijmegen Faculty o f Medicine Nijmegen, The Netherlands

    PLENUM PRESS NEW YORK AND LONDON

  • Contents of Part

    I . PURINE METABOLISM PATHWAYS AND REGULATION

    A. De Novo S y n t h e s i s ; P r e c u r s o r s and R e g u l a t i o n

    De Novo P u r i n e S y n t h e s i s i n C u l t u r e d Human F i b r o b l a s t s 1

    R.B. Gordon, L. Thompson, L.A. Johnson, and B.T. Emmerson

    Comparative M e t a b o l i s m o f a New A n t i l e i s h m a n i a l A g e n t , A l l o p u r i n o l R i b o s i d e , i n t h e P a r a s i t e and t h e Host C e l l 7

    D. J. N e l s o n , S.W. LaFon, G.B. E l i o n , J . J . Ma r r , and R.L. Berens

    P u r i n e M e t a b o l i s m i n Rat S k e l e t a l Muscle 13 E. R. T u l l y and T.G. Sheehan

    A l t e r a t i o n s i n P u r i n e M e t a b o l i s m i n C u l t u r e d F i b r o b l a s t s w i t h HGPRT D e f i c i e n c y and w i t h PRPPP S y n t h e t a s e S u p e r a c t i v i t y 19

    E. Z o r e f - S h a n i and 0. S p e r l i n g

    P u r i n e M e t a b o l i s m i n C u l t u r e d E n d o t h e l i a l C e l l s 25 S. Nees, A.L. Gerbes, B. Willershausen-Znnchen, and E. G e r l a c h

    D e t e r m i n a n t s o f 5 - P h o s p h o r i b o s y l - l - P y r o p h o s p h a t e (PRPP) S y n t h e s i s i n Human F i b r o b l a s t s 31

    K.0, R a i v i o , Ch. L a z a r , H. Krumholz, and M.A. Becker

    X a n t h i n e O x i d o r e d u c t a s e I n h i b i t i o n by NADH as a R e g u l a t o r y F a c t o r o f P u r i n e M e t a b o l i s m 35

    M.M. Jezewska and Z.W. K a m i n s k i

    vii

  • viii C O N T E N T S OF P A R T

    . N u c l e o t i d e M e t a b o l i s m

    Human P l a c e n t a l Adenosine K i n a s e : P u r i f i c a t i o n and C h a r a c t e r i z a t i o n 41

    CM. Andres, T.D. P a l e l l a , and I.H. Fox

    Long-Term E f f e c t s o f Ribose on Adenine N u c l e o t i d e M e t a b o l i s m i n I s o p r o t e r e n o l - S t i m u l a t e d H e a r t s . . 45

    H.-G. Zimmer, . I b e l , G. S t e i n k o p f f , and H. Kosc h i n e

    C. Salvage Pathways

    P u r i n e Salvage Enzymes i n Man and L e i s h m a n i a d o n o v a n i . . . 51 T.A. K r e n i t s k y , G.W. K o s z a l k a , J.V. T u t t l e , D. L. Adamczyk, G.B. E l i o n , and J . J . Marr

    R e g u l a t i o n o f P u r i n e Salvage Enzymes i n . c o l i 57

    R.A. L e v i n e and M.W. T a y l o r

    D. C a t a b o l i s m

    P u r i n e T r a n s p o r t and t h e C e l l C y c l e 61 M.P. R i v e r a , M.R. Grau, J. R i g a u , and A. Goday

    H y p o x a n t h i n e T r a n s p o r t i n Human E r y t h r o c y t e s 69 C. S a l e r n o and G i a c o m e l l o

    Uptake o f Adenosine i n Human E r y t h r o c y t e s 73 M. Kraupp, P. Chiba, and M.M. Mller

    E f f e c t o f A c t i n o m y c i n D on i n v i v o P u r i n e B i o s y n t h e s i s i n Hamster C e l l s 79

    M.W. T a y l o r , K.C. Gupta, and L. Z a w i s t o w i c h

    P u r i n e C a t a b o l i s m i n I s o l a t e d H e p a t o c y t e s : I n f l u e n c e o f C o f o r m y c i n 85

    G. Van den Berghe, F. Bontemps, and H.G. Hers

    I I . ENZYMOLOGY AND PURINE METABOLISM

    A. P h o s p h o r i b o s y l t r a n s f e r a s e s

    I n a c t i v a t i o n o f H y p o s a n t h i n e Guanine Phospho-r i b o s y l t r a n s f e r a s e by Guanosine D i a l d e h y d e : An A c t i v e S i t e D i r e c t e d I n h i b i t o r 87

    L.A, Johnson, R.B, Gordon, and B.T. Emmerson

  • C O N T E N T S O F P A R T ix

    Role o f Human H y p o x a n t h i n e Guanine P h o s p h o r i b o s y l -t r a n s f e r a s e i n N u c l e o t i d e I n t e r c o n v e r s i o n . . . . 93

    A. G i a c o m e l l o and C. S a l e r n o

    P u r i f i c a t i o n and C h a r a c t e r i z a t i o n o f Mammalian Adenine P h o s p h o r i b o s y l t r a n s f e r a s e 103

    M.W. T a y l o r and H.V. Hershey

    The E f f e c t o f P h o s p h o r i b o s y l p y r o p h o s p h a t e on S t a b i l i t y and C o n f i g u r a t i o n o f Hypoxan-t h i n e g u a n i n e p h o s p h o r i b o s y l t r a n s f e r a s e and A d e n i n e p h o s p h o r i b o s y l t r a n s f e r a s e f r o m Human E r y t h r o c y t e s I l l

    W. Grbner and N. Zllner

    C h e m i c a l M o d i f i c a t i o n o f Hypoxanthine-phospho-r i b o s y l t r a n s f e r a s e and I t s P r o t e c t i o n by S u b s t r a t e s and P r o d u c t s 117

    W.. Gutensohn and H. Jahn

    .. N u c l e o s i d e P h o s p h o r i b o s y l a t i n g Enzymes

    S t r u c t u r a l S t u d i e s o f Human Adenine P h o s p h o r i b o s y l -t r a n s f e r a s e P u r i f i e d by A f f i n i t y Chromatography 123

    J,A. H olden, G.S. M e r e d i t h , and W.N. K e l l e y

    P h o s p h o r i b o s y l p y r o p h o s p h a t e (PRPP) S y n t h e t a s e M utant i n S a l m o n e l l a t y p h i m u r i u m 131

    B,. Jochimsen, . Garber, and J.S. Gots

    C. N u c l e o s i d e C l e a v i n g Enzymes

    M e t h y l m e r e a p t o p u r i n e R i b o n u c l e o s i d e T o x i c i t y i n Human F i b r o b l a s t s : I n h i b i t i o n o f Phosphor i b o s y l p y r o p h o s p h a t e S y n t h e t a s e as w e l l as A m i d o p h o s p h o r i b o s y l t r a n s f e r a s e 137

    R..C.K. Yen and M.A. Becker

    A d e n o s i n e K i n a s e : R e g u l a t i o n by S u b s t r a t e s , Magnesium, and pH 145

    R..L. M i l l e r and D.L. Adamczyk

    A d e n o s i n e and Deoxyadenosine K i n a s e f r o m Rat L i v e r . . . . 151 N.. Ogasawara, Y. Yamada, and H. Goto

    D- D e a m i n a t i n g Enzymes

    R a d i o immunochemical A n a l y s i s o f Human E r y t h r o c y t e Adenosine Deaminase

    P..E. Daddona, M.A. Frohman, and W.N. K e l l e y 157

  • C O N T E N T S O F P A R T

    Adenosine Deaminase C o n v e r s i o n P r o t e i n s : A P o t e n t i a l Role 163

    P.P. T r o t t a and M.E. B a l i s

    R e g u l a t o r y P r o p e r t i e s o f AMP Deaminase Isozymes 169 N. Ogasawara, H. Goto, and Y. Yamada

    Human Adenosine Deaminase: S t o i c h i o m e t r y o f t h e Large Form Complex 177

    P.E. Daddona and W.N. K e l l e y

    Guanase f r o m Human L i v e r - P u r i f i c a t i o n and C h a r a c t e r i z a t i o n 183

    R. K u z m i t s , H. Stemberger, and M.M. Mller

    . O x i d a t i n g Enzymes

    N i c o t i n a m i d e and L i v e r X a n t h i n e Oxidase 189 A. D i S t e f a n o , . P i z z i c h i n i , and . M a r i n e l l o

    X a n t h i n e Oxidase A c t i v i t y i n Human I n t e s t i n e s . H i s t o c h e m i c a l and R a d i o c h e m i c a l Study 197

    C. Auseher, . Amory, P. van der Kemp, and F. D e l b a r r e

    I I I . PYRIMIDINE METABOLISM

    P u r i n e and P y r i m i d i n e M e t a b o l i s m i n H e r e d i t a r y O r o t i c a c i d u r i a D u r i n g a 15-Year Follow-Up Study 203

    D. R. Webster, H.A. Simmonds, C.F. P o t t e r , and D.M.O. B e c r o f t

    E f f e c t o f A l l o p u r i n o l on P y r i m i d i n e M e t a b o l i s m i n Human Whi t e B l o o d C e l l s : Role o f t h e Salvage Pathway 209

    P. B a n h o l z e r , W. Grbner, and N. Zllner

    K i n e t i c s and Co m p a r t m e n t a t i o n o f E r y t h r o c y t e P y r i m i d i n e M e t a b o l i s m 217

    E. H. H a r l e y , P. Z e t l e r , and S. Ne a l

    S i m u l t a n e o u s D e t e r m i n a t i o n o f Rates o f P u r i n e and P y r i m i d i n e S y n t h e s i s i n C u l t u r e d Human Lymphoblasts and F i b r o b l a s t s 223

    W.H. Huisman, K.O. R a i v i o , and M.A. Becker

    A c t i v i t i e s o f Enzymes o f P u r i n e and P y r i m i d i n e M e t a b o l i s m i n Nine Mycoplasma Species 231

    M. Hamet, C. B o n i s s o l , and P. C a r t i e r

  • CONTENTS O F P A R T x

    I V . LYMPHOCYTE PURINE METABOLISM RESEARCH

    I n c r e a s e s i n P u r i n e E x c r e t i o n and Rate o f S y n t h e s i s by Drugs I n h i b i t i n g IMP Dehydrogenase o r A d e n y l o s u c c i n a t e S y n t h e t a s e A c t i v i t i e s 237

    R.C. W i l l i s and J.E. S e e g m i l l e r

    P o s s i b l e Role f o r 5 T - N u c l e o t i d a s e i n Deoxyadenosine S e l e c t i v e T o x i c i t y t o C u l t u r e d Human Lymp h o b l a s t s 243

    R.L. Wortmann, B.S. M i t c h e l l , N.L. Edwards, and I.H. Fox

    C y c l i c N u c l e o t i d e L e v e l s and Mechanism o f I n h i b i t i o n o f L e u c o c y t e F u n c t i o n by Adenosine Deaminase I n h i b i t i o n 251

    A.D. M e i s e l , Ch. N a t a r a j a n , G. S t e r b a , and H.S. Diamond

    P u r i n e R i b o n u c l e o s i d e and D e o x y r i b o n u c l e o s i d e M e t a b o l i s m i n Thymocytes 259

    F.F. Snyder and T. Lukey

    M o l e c u l a r Mechanism(s) o f D e o x y r i b o n u c l e o s i d e i n T-Lymphoblasts 265

    J.M. W i l s o n , B.S. M i t c h e l l , and W.N. K e l l e y

    I n h i b i t i o n o f Immune C e l l F u n c t i o n by Adenosine: B i o c h e m i c a l S t u d i e s 271

    T.P. Zimmerman, G. WoIberg, G.S. Duncan, R.D. Deeprose, and R.J. Harvey

    I n t e r a c t i o n s Between Energy M e t a b o l i s m and Adenine N u c l e o t i d e M e t a b o l i s m i n Human Lym

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