Fall Semester 2012-13

Annotated Bibliography 2Roll Book.# 6 Name Juan Enrique Maldonado Weng

Date: October 19, 20012

Annotated Bibliography 2:SAUDER C, MU¨ LLER A, CUBITT B, MAYER J, STEINMETZ J, TRABERT W, ZIEGLER B, WANKE K, MUELLER-LANTZSCH K, CARLOS DE LA TORRE J, and GRA¨SSER A. 1996. Detection of Borna Disease Virus (BDV) Antibodies and BDV RNA in Psychiatric Patients: Evidence for High SequenceConservation of Human Blood-Derived BDV RNA. Journal of Virology, [Internet]; [Cited 2012 October 19]. DOI: 0022-538X/96/$04.0010:70: 7713–7724 Available at: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC190841/

In this German based study, 619 patients (416 psychiatric patients and 203 healthy patients) were

tested for seropositivity and traces of RNA of the Borna Disease Virus (BDV). Patients were taken

from the same geographical location, namely, the city of Homburg . Through Reverse Transmission

- Polymerase Chain Reaction (RT-PCR), traces of BDV RNA were found in the patients proving the

presence of the disease. Utilizing both methods of testing serum and RNA, the results provided a

link between mental disorders. The link was schizophrenia. Among the 416 psychiatric patients, 40

patients were found seropositive unlike the control which had only three cases. Of these

seropositive patients, 11 had schizophrenia and others had various different conditions. In the RT-

PCR tests, RNA strands were found in 7 of the 11 schizophrenics. The methodology utilized was

very effective because the experimental group was categorized by conditions facilitating the testing

of RNA. The interpretations also proved that it is valuable to test for RNA because it is a

reassurance of the existence of BDV. The article is important due to the association found

between schizophrenia and BDV. Most cases of BDV appeared in patients with this condition.