proton pump inhibitor (ppi)

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Post on 16-Apr-2017



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Proton Pump Inhibitor

Proton Pump Inhibitor (PPI)Md. Saiful IslamExecutivePMD REPHCO Pharmaceuticals Ltd.

What is PPI???Proton Pump Inhibitors (PPI) are a group of drugs whose main action is a pronounced and long-lasting reduction of gastric acid production.

USE OF PPIMain GIT problemGastritisDyspepsiaPeptic ulcer diseases (PUD)Gastroesophageal reflux disease (GERD)

Causes & Symptoms

Causes & SymptomsGastritis DyspepsiaGastritisis aninflammation, irritation or erosion of the lining of thestomach. It can occur suddenly (acute) or gradually (chronic). Dyspepsia is an uncomfortable feeling in the upper middle part of the stomach.

Causes & SymptomsPeptic Ulcer GERDPeptic ulcer diseaserefers to painful sores or ulcers in the lining of thestomachor first part of the small intestine, called the duodenum. Gastroesophageal reflux disease, orGERD, is a digestive disorder that affects the lower esophageal sphincter (LES), the ring of muscle between theesophagusandstomach.

GastritisDyspepsiaPeptic ulcerGERD

BloatingUnexpected weight loss Yellow, green or bloody vomiting.Belly pain or discomfort.Bloating Feeling uncomfortably full after eatingNauseaLoss of appetiteHeartburnBurping up food or liquid (regurgitation)Burping. A feeling of fullness Difficulty drinking as much liquid as usual Hunger and an empty feeling in the stomach soon after eating Mild nausea Stomach pain that wakes up at night. Heartburn Asthma false symptoms Chest pain Bad breath Nausea Increased salivation Feeling as if there is a lump in the throat.

How deal with that???Life StyleNeutralizing AcidsBlocking acid productionSmokingWeight lossEating habitsAlcoholPosture after mealAntacid(Very temporary treatment)H2 blockersPPI


Proton Pump InhibitorClinically Used PPIs

Omeprazole Lansoprazole Esomeprazole Pantoprazole Rabeprazole


Unique Selling Propositions (USP)

Market share of Esomeprazole

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