Proton Pump Inhibitor (PPI)

Md. Saiful IslamExecutive

PMD REPHCO Pharmaceuticals Ltd.

What is PPI???

• Proton Pump Inhibitors (PPI) are a group of drugs whose main action is a pronounced and long-lasting reduction of gastric acid production.

USE OF PPI

Main GIT problem↓

1. Gastritis2. Dyspepsia

3. Peptic ulcer diseases (PUD)4. Gastroesophageal reflux disease (GERD)

Causes & Symptoms

Causes & Symptoms

Gastritis Dyspepsia

Gastritis is an inflammation,

irritation or erosion of the

lining of the stomach. It

can occur suddenly (acute)

or gradually (chronic).

Dyspepsia is an uncomfortable feeling in the upper middle

part of the stomach.

Causes & SymptomsPeptic Ulcer GERDPeptic ulcer

disease refers to painful sores or

ulcers in the lining of

the stomach or first part of the small intestine,

called the duodenum.

Gastroesophageal reflux disease, or GERD, is a

digestive disorder that affects the

lower esophageal sphincter (LES), the

ring of muscle between

the esophagus and stomach.

Gastritis Dyspepsia Peptic ulcer GERD

• Bloating• Unexpected

weight loss• Yellow, green

or bloody vomiting.

• Belly pain or discomfort.• Bloating• Feeling

uncomfortably full after eating• Nausea

• Loss of appetite• Heartburn

• Burping up food or liquid

(regurgitation)• Burping.

• A feeling of fullness

• Difficulty drinking as

much liquid as usual

• Hunger and an empty

feeling in the stomach soon

after eating• Mild nausea• Stomach pain that wakes up

at night.

• Heartburn• Asthma false

symptoms• Chest pain• Bad breath

• Nausea• Increased

salivation• Feeling as if

there is a lump in the

throat.

How deal with that???Life Style Neutralizing

AcidsBlocking acid production

1. Smoking2. Weight loss3. Eating habits4. Alcohol5. Posture after meal

1. Antacid(Very temporary

treatment)

1. H2 blockers2. PPI

PPI

Proton Pump Inhibitor

Clinically Used PPIs

Omeprazole Lansoprazole Esomeprazole Pantoprazole Rabeprazole

Esomeprazole(Esolin-20,40)

Unique Selling Propositions (USP)

Market share of Esomeprazole

Thanking you

Have a good day………………. 19

REPHCO