Proceedings of the 2012 Rheumatology Winter Clinical Symposia

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    004doiE OF MUSCULOSKELETALTRASOUND IN RHEUMATOLOGY

    ncreasing numbers of rheumatologists in NorthAmerica have begun to evaluate whether the use ofmusculoskeletal ultrasound will enhance the overall

    e of their patients. To date, this has been focusedinly on the diagnosis of patients with inflammatoryhritis such as rheumatoid arthritis (RA) as well as mon-ring the response to therapy. Similar to magnetic reso-nce imaging and computed tomography scanning, ul-sound is able to detect changes in the synovium,tilage, and bone but at a much lower cost and without

    the synovium and bone, musculoskeletal ultrasound is agreat clinical tool that may be used in the diagnosis andmonitoring of other rheumatic conditions. Some of theconditions include seronegative arthropathies (eg, psori-atic arthritis, enthesitis), crystalline arthritis (eg, gout,pseudogout), polymyalgia rheumatica, temporal arteritis,scleroderma, Sjgrens syndrome, and fibromyalgia.

    Although the use of ultrasound in some of the aboveconditions is still in the early stages of clinical develop-ment, the use of more sensitive ultrasound transducersand a portable ultrasound machine will make these andother rheumatic conditions more readily assessable to thepracticing rheumatologists and to other physicians treat-ing patients with musculoskeletal disorders.A.F. Wells

    APPROACH TO INFLAMMATORY MYOSITIS

    Idiopathic inflammatory myositis is a rare disorder thataffects 2 to 7 persons per million each year. Although thehistoric Bohan and Peter classification system remainsinstructive, new criteria and classifications have been fos-tered by the identification of well-characterized autoan-tibody subsets, including the antisynthetase antibodysyndrome. This overview also focuses on several un-usual myopathic disorders, including orbital myositis,

    SD Department of Medicine, La Jolla, CA.rmatology and Laser Center of Maui, Maui, Hawaii.partment of Medicine, Baylor Research University, Dallas, TX.partment of Medicine, Drexel University college of Medicine, Philadelphia, PA.partment of Medicine, University of Texas Southwestern Medical Center, Dallas,.C Medical School, Los Angeles, CA.ivision of Immunology/Rheumatology, Standford University, Palo Alto, CA.epartment of Medicine, Northwestern University School of Medicine, Chicago,

    osalind Franklin University of Medicine and Science, Chicago, IL.ddress reprint requests to John J. Cush, MD, Baylor Research Institute, 9900 N.tral Expressway, Suite 550, Dallas, TX 75231. E-mail: jjcush@gmail.com.

    9239-0172/12/$-see front matter 2012 Elsevier Inc. All rights reserved.Rheumatology Wint

    Arthur Kavanaugh, MD,* GeorgeMartin J. Bergman, MD,

    Orrin M. Troum, MD,Eric M. Ruderman, MD, an

    Recent years have witnessed important developmstratification approaches, and treatment paradigmof rheumatologic and autoimmune diseases. In amedical disciplines that are relevant to the care owith these many developments is a challenge,methods to educate themselves about these advatology Winter Clinical Symposium was held.discussions and exchanged knowledge about newrheumatology patients. Excerpts from some of tical Symposium 2012 are included in this reviewtheir entirety at http://www.r-w-c-s.com. 2012 Elsevier Inc. All rights reserved. Semin:10.1016/j.semarthrit.2012.03.002linical Symposia

    in, MD, John J. Cush, MD,

    Fleischmann, MD,

    eke Strand, MD,**in F. Wells, MD, PhD

    n rheumatology. Novel diagnostic methods,e been brought into the clinic for a numbern, there have been developments in relatedents with rheumatic diseases. Keeping paceclinical rheumatologists have used variousIn January 2012, the 5th annual Rheuma-is meeting, faculty and participants heldtific data and how it may impact the care of

    tures from the Rheumatology Winter Clin-se and other presentations can be viewed in

    itis Rheum 41:923-926

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    924 Proceedings of the 2012 rheumatology winter clinical symposiaans, and necrotizing myositis related to statin thera-s. Although statin-induced myopathic complaintsquite common, it has been estimated that up to 6%

    myositis patients may have statin-induced necrotiz-g myositis that appears to be associated with an an-ody against a 100-kDa autoantigen (3-hydroxy-3-thylglutaryl coenzyme reductase). Another novel

    tity is dermatomyositis sine myositis, also known as clini-ly amyopathic dermatomyositis. Such patients have a lowk (10%) of developing systemic myositis and weaknesst may be at risk for severe interstitial lung disease. Chronicg disease, serious infections (25% to 35%), and oppor-

    nistic infections (10%) may complicate the manage-nt of idiopathic inflammatory myositis patients.J. J.sh, MD

    D-10

    less changed by the US Congress, in October 2013ere will be a dramatic change in how physicians in the

    code for work done, specifically, in how the diagnosesreported. At that time, the official coding system will

    itch from the current ICD9-CM to ICD-10. Theange has been a long time coming, being legislated asrt of the Health Insurance Portability and Accountabil-Act of 1996. The change will bring the USA in line

    th most of Europe and parts of Canada.The reasons for adopting these changes are multiple.e current ICD9-CM has limited numbers of codesproximately 13,000), is often nonspecific, and reflects

    e state of the art as regards medical knowledge fromout the 1970s. The new coding system, by being up todigits long, will allow for 68,000 codes, will be morexible and specific, and will allow for laterality. For ex-ple, M05.761 is the code for Seropositive RA involving

    e right knee (M05.7 seropositive RA without otheran system involvement; plus 6 knee; plus 1 right)

    d MA1A.9820 would indicate chronic gout of left toethout tophi (M1A.9 chronic gout unspecified etiol-y; plus 8 toe; plus 2 left; plus 0 no tophi).Making the switch from ICD9 to ICD-10 will be cum-rsome, but not impossible. Office practices, superbills,mputer software, and billing systems will need to bedated. Staff will need to be trained, particularly thoseponsible for coding and billing. It is estimated that theitch will take up to 36 months to complete and may cost400$46,000 to implement, depending on the size of thectice. However, the implementation of ICD-10 will oc-

    r, whether you are ready or not. The best time to startparing is now.J. M. Bergman, MD

    VANCES IN RHEUMATOIDTHRITIS THERAPIES

    11 was an exciting year in the development of newerapeutics for the treatment of RA. Phase 3 results wereation with DMARDs and methotrexate, and com-red to adalimumab and in TNF inhibitor (TNFi)lures. Effects on radiographic inhibition were demon-ated. The safety profile has been better defined: therepears to be less liver test elevation when used as mono-erapy and the lipid elevation can be corrected with thee of lipid-lowering agents. Infections, including seriousd opportunistic, and herpes zoster have occurred. Theety of fostamatinib in phase 2 has been reported withreased diarrhea and hypertension noted, but no lipidvation. A report of a phase 2 study of another inhibitorJAK3/1, VX09-509-101, showed efficacy as mono-

    erapy with perhaps a slightly different safety profilean tofacitinib. The efficacy of tocilizumab as mono-erapy was presented; it is effective clinically and in in-iting radiographic progression, with less liver toxicity

    an when used with concomitant methotrexate. Phase 2ta were released on 2 new inhibitors of IL-6theircacy and safety appear to be similar to tocilizumab.e recently approved subcutaneous formulation of

    atacept has equivalent safety and efficacy as the IV for-lation. Screening for the JC virus, prior to rituximab

    atment, is not helpful in predicting the development ofL. It was reported from a French registry that IgG

    els do decrease over repetitive courses of RTX and thisy be related to increased frequency of serious infec-ns; this is different from what has been shown in thempany-sponsored long-term extensions.R. Fleisch-nn, MD

    ESITY: INFLAMMATORY ASPECTSD RELATED ISSUES IN RHEUMATOLOGY

    esity now affects more than 30% of the US adult pop-tion. The WHO reports that worldwide there are ap-

    oximately 1 billion adults who are overweight and 300llion who are obese; of note, these numbers are ex-cted to rise. Increased body mass index is a major com-nent of the metabolic syndrome (common in psoriasisd psoriatic arthritis) and is associated with an adversediovascular risk profile. Obesity is regarded as a sys-ic, low-grade inflammatory state, characterized by el-

    ated levels of C-reactive protein, TNF-, IL-6, IL-1,d PAI-1. It is an unequivocal risk factor for the onsetd progression of knee osteoarthritis. It increases cardio-scular risk in RA and increases the risk of developingoriatic arthritis, as reported at the 2011 American Col-e of Rheumatology national meeting.Adipose tissue is a dynamic endocrine organ that re-ses cytokines and adipokines, including adiponectin,tin, resistin, visfatin, and chemerin, promoting inflam-tion and metabolic dysfunction. Additionally, obesityds to in