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PRE-CLINICAL PEDIATRIC DENTISTRY
DSV 342 Pain perception control and LA
(Pinkham, Ch.7, Pg 108, Ch.28,Pg 447) 9
update 5/5/2012
Professor Othman Al-Ajlouni Salman Bin Abdul Aziz University
Tuesday 8/5/2012 9:00 -10:00 am
Sunday, November 09, 2014 1 Professor Othman Al-Ajlouni
PAIN PERCEPTION CONTROL • General anesthesia
• Local anesthesia:
Mechanisms of action
Local anesthetic agents
Local anesthetic properties
toxicity
• Analgesics
Nonnarcotic analgesics
Narcotic analgesic
Sunday, November 09, 2014 Professor Othman Al-Ajlouni 2
PAIN PERCEPTION CONTROL
General anesthesia
unconscious through depression of CNS.
Very young, precooperative, mentally retarded.
Anesthesiologist
Sunday, November 09, 2014 Professor Othman Al-Ajlouni 3
PAIN PERCEPTION CONTROL • Local anesthesia:
Mechanisms of action: primary effect is to penetrate
nerve cell membrane and block receptor sites that control the influx of Na associated with membrane depolarization.
Local anesthetic agents.
Small nerve fibers > susceptible to the onset of LA>large fibers.
Sensations modalities blocked firstly pain, cold, warmth, touch,
and pressure.
LA agents are weak chemical bases.
Salts added as uncharged free-base form (lipid soluble) to
penetrate nerve cell membrane.
Sunday, November 09, 2014 Professor Othman Al-Ajlouni 4
PAIN PERCEPTION CONTROL Local anesthetic agents:
ESTERS: cocaine, benzoic acid ester derivatives:
benzocaine,
procaine(Novocain),
tetracaine(Pontocaine), and
chloroprocaine(Nesacaine)
Allergic reactions
AMIDES: lidocaine synthesis, diethylaminoacetic acid derivatives:
mepivacaine(Carbocaine),
prilocaine(Citanest),
bupivaine(Marcaine), and
etidocaine(Duranest).
Free from allergic reactions Sunday, November 09, 2014 Professor Othman Al-Ajlouni 5
PAIN PERCEPTION CONTROL Local anesthetic properties
Potency
Onset Time
Duration
Regional Technique
Other Factors:Dose, Vasoconstricors,
Sunday, November 09, 2014 Professor Othman Al-Ajlouni 6
PAIN PERCEPTION CONTROL Toxicity
Toxic reactions due to: Overdose, accidental intravascular injection, idiosyncratic response, allergic reaction, or interactive effects with other agents.
Maximal safe dose (mg\kg):
Central nervous system reactions
Cardiovascular system reactions
Sunday, November 09, 2014 Professor Othman Al-Ajlouni 7
GENEREC NAME
BRAND NAME
TYPE CONCENTRATION
VASOCONSTRICTOR
MAX. REC. DOSE (MG\KG)
ABSOLUTE MAX.(MG\KG)
AV. DURATION PUPLAL TISSUE (MIN)
AV.DURATION SOFT TISSUE(HR)
PROXYCAINE WITH PROCAINE
RAVOCAINE ESTER 0.4% 1;20.000 6.6 400 30-60 23
LIDOCAINE XYLOCAINE AMIDE 2% 1;100.000 EPINEPHRINE
4.4 300 60 3-5
MEPIVACAINE CARBOCAINE AMIDE 3% AND 2%
1;20.000 LEVONORDEFRIN (NEO-COBERFIN)
4.4 300 60 2% 60-90 3%
2-3 3% 3-5 2%
PRILOCAINE CITANEST AMIDE 4% 6.0 400 10 (INFIL) 1\12-2
PRILOCAINE FORTE
CITANEST FORTE
AMIDE 4% 1;200.000 EPINEPHRINE
6.0 400 60-90 3-8
Sunday, November 09, 2014 Professor Othman Al-Ajlouni 8
LA IN CHILDREN • HIGHER CARDIAC OUTPUT
• HIGHER BASAL METABOLIC RATE
• HIGHER DEGREE OF TISSUE PERFUSUION
• LA AGENTS ABSORBED MORE RAPIDLY
• DETOXIFY CHEMICALS SLOWER RATE THAN ADULTS DUE TO LESS MATURE LIVER ENZYME SYSTEM
• MORE SUSCEPTLE TO TOXICITY AT LOWER DRUG LEVEL THAN ADULT DUE TO IMMATURE CENTRAL NERVOUS AND CARDIOVASCULAR SYSTEMS
FOR THESE REASONS;
PRECISE LA TECHNIUE SHOULD BE USED
ASPIRATION TECHNIUES SHOULD BE PRACTICED
VASOCONSTRICTOR IS NECESSARY
KNOWLEDGE OF PROPERTIES OF LA AGENT IS ESSENTIAL
RECOMMENDED MAXIMAL SAFE DOSE OF LA SHOULD BE CALCULATED PRECISELY FOR EACH PT. AND MUST NEVER EXCEEDED.
Sunday, November 09, 2014 Professor Othman Al-Ajlouni 9
PAIN PERCEPTION CONTROL • General anesthesia
• Local anesthesia:
Mechanisms of action
Local anesthetic agents
Local anesthetic properties
toxicity
• Analgesics
Nonnarcotic analgesics
Narcotic analgesic
Sunday, November 09, 2014 Professor Othman Al-Ajlouni 10
LOCAL ANESTHESIA AND ORAL SURGERY IN CHILDREN
• Topical anesthesia.
• General considerations for local anesthesia.
• Operator technique
• Maxillary primary and permanent molar anesthesia.
• Maxillary primary and permanent incisor and canine anaesthesia.
• Palatal tissue anesthesia.
• Mandibular tooth anesthesia.
• Complications of local anesthesia.
• Alternative anesthesia systems
Sunday, November 09, 2014 Professor Othman Al-Ajlouni 11
LOCAL ANESTHESIA AND ORAL SURGERY IN CHILDREN
• Topical anesthesia:
is used to exclude the discomfort associated with needle insertion into mucosal membrane.
Benzocaine is good tasting and easy to control gel.
Use gel and apply to a very dry mucosal surface for at least 2 minutes.
Patch type (lidocaine patches) 46.1 mg lidocaine with minimum 10 minutes on a very dry mucosa.
Sunday, November 09, 2014 Professor Othman Al-Ajlouni 12
LOCAL ANESTHESIA AND ORAL SURGERY IN CHILDREN
• General considerations for local anesthesia: changes of Na receptors of neural membrane, LA block Na channels result in inhibition of neural excitability, reduces action potential transmission distal to the anesthetic block and fail to transmit information to the central nervous system (CNS).
• Failure due to operator error or anatomic aberrations.
• Local infection causing release of neuroactive substances (histamine, leukotrienes, kinins, and prostaglandins) and lowering pH.
• These changes reduce lipid solubility and interfere with its ability to penetrate the nervous tissue.
• Nerve block, Field block, Local infiltration
Sunday, November 09, 2014 Professor Othman Al-Ajlouni 13
MAXIMUM RECOMMENDED DOSES OF LA FOR CHILDREN
PATIENT WEIGHT KG\LB 1KG=2.3LBS
MILLIGRAMS 36.4 mg\cartridge
NO.OF CARTRIDGES 1.8 ml\cartridge
10\23 44 1.2
15\34.5 66 1.8
20\46 88 2.4
25\57.5 100 2.7
30\69 132 3.6
40\92 176 4.8
50\115 220 6.1
60\138 264 7.3
70\161 300 8.3
Sunday, November 09, 2014 Professor Othman Al-Ajlouni 14
LOCAL ANESTHESIA AND ORAL SURGERY IN CHILDREN
Operator technique:
GOING TO SLEEP AFTER A LITTLE PINCH
COUNTERIRRITATION
DISTRACTION
SLOW RATE ADMINISTRATION 1 MINUTE AT LEAST
DENTAL ASSISSTANT
REFLEXIVE MOVEMENTS SHOULD BE ANTICIPATED
SHORT (20 MM) OR LONG (32 MM ), 27OR30 GAUGE NEEDLE
Sunday, November 09, 2014 Professor Othman Al-Ajlouni 15
LOCAL ANESTHESIA AND ORAL SURGERY IN CHILDREN
• Maxillary primary and permanent molar anesthesia:
POSTERIOR SUPERIOR ALVEOLAR NERVE (PERMENET MOLARS)
AND MIDLE SUPERIOR ALVEOLAR NERVE (MESIOBUCCAL ROOT OF 1ST PERMANENT MOLAR, PRIMARY MOLARS, AND PREMOLARS.
Sunday, November 09, 2014 Professor Othman Al-Ajlouni 16
LOCAL ANESTHESIA AND ORAL SURGERY IN CHILDREN
• Topical anesthesia.
• General considerations for local anesthesia.
• Operator technique
• Maxillary primary and permanent molar anesthesia.
• Maxillary primary and permanent incisor and canine anaesthesia.
• Palatal tissue anesthesia.
• Mandibular tooth anesthesia.
• Complications of local anesthesia.
• Alternative anesthesia systems
Sunday, November 09, 2014 Professor Othman Al-Ajlouni 17
LOCAL ANESTHESIA AND ORAL SURGERY IN CHILDREN
• Topical anesthesia.
• General considerations for local anesthesia.
• Operator technique
• Maxillary primary and permanent molar anesthesia.
• Maxillary primary and permanent incisor and canine anaesthesia.
• Palatal tissue anesthesia.
• Mandibular tooth anesthesia.
• Complications of local anesthesia.
• Alternative anesthesia systems
Sunday, November 09, 2014 Professor Othman Al-Ajlouni 18
LOCAL ANESTHESIA AND ORAL SURGERY IN CHILDREN
• Topical anesthesia.
• General considerations for local anesthesia.
• Operator technique
• Maxillary primary and permanent molar anesthesia.
• Maxillary primary and permanent incisor and canine anaesthesia.
• Palatal tissue anesthesia.
• Mandibular tooth anesthesia.
• Complications of local anesthesia.
• Alternative anesthesia systems
Sunday, November 09, 2014 Professor Othman Al-Ajlouni 19
• Local anesthesia temporarily blocks the normal generation and conduction action of the nerve impulses.
• Local anesthesia is obtained by injecting the anesthetic agent near the nerve in the area intended for dental treatment.
• Induction time is the length of time from the injection of the anesthetic solution to complete and effective conduction blockage.
Method of Action
• Length of time from induction until the reversal process is complete.
• Short-acting:
– Local anesthetic agent lasts less than 30 minutes.
• Intermediate-acting:
– Local anesthetic agent lasts about 60 minutes.
• Long-acting:
– Local anesthetic agent lasts longer than 90 minutes.
Duration
• Criteria for use:
– Prolongs the duration of an anesthetic agent by decreasing the blood flow in the immediate area of the injection.
– Decreases bleeding in the area during surgical procedures.
• Types:
– Epinephrine
– Levonordefrin
– Norepinephrine
Vasoconstrictor
• Ratio of vasoconstrictor to anesthetic solution:
• 1:20,000
• 1:50,000
• 1:100,000
• 1:200,000
Vasoconstrictor- cont’d
• Contraindications for the use of vasoconstrictors
– Unstable angina.
– Recent myocardial infarction.
– Recent coronary artery bypass surgery.
– Untreated or uncontrolled severe hypertension.
– Untreated or uncontrolled congestive heart failure.
Vasoconstrictor- cont’d
• Infiltration is achieved by injecting the solution directly into the tissue at the site of the dental procedure.
– Most frequently used to anesthetize the maxillary teeth.
– Used as a secondary injection to block gingival tissues surrounding the mandibular teeth.
Types of Local Anesthesia Injections
• Block anesthesia – The solution is injected near a major nerve, and the
entire area served by that nerve is numbed. • Type of injection required for most mandibular
teeth. • Inferior alveolar nerve block
– Obtained by injecting the anesthetic solution near the branch of the inferior alveolar nerve close to the mandibular foramen. • Type of injection for half of the lower jaw, including
the teeth, tongue, and lip.
Types of Local Anesthesia Injections- cont’d
• Incisive nerve block
– Injection given at the site of the mental foramen.
• Used when the mandibular anterior teeth or premolars require anesthesia.
• Periodontal ligament
– Alternative infiltration anesthesia method by which the anesthetic solution is injected directly into the periodontal ligament and surrounding tissues.
Types of Local Anesthesia Injections- cont’d
Table 37-2 Local Anesthesia Setup: Anesthetic Syringe
• Anesthetic carpule: Care and caution of use – Cartridges should be stored at room temperature and
protected from direct sunlight. – Never use a cartridge that has been frozen. – Do not use a cartridge if it is cracked, chipped, or
damaged in any way. – Never use a solution that is discolored or cloudy or
has passed the expiration date. – Do not leave the syringe preloaded with the needle
attached for an extended period of time. – Never save a cartridge for reuse.
Local Anesthesia Setup
• Injection into a blood vessel
• Infected area
• Localized toxic reaction
• Systemic toxic reaction
• Temporary numbness
• Paresthesia
Local Anesthetic Cautions
• A noninvasive method to block pain electronically by using a low current of electricity through contact pads that target a specific electronic waveform directly to the nerve bundle at the root of the tooth.
• Benefits to the patient: – No needles. – No post-operative numbness or swelling. – Chemical-free method of anesthesia. – No risk of cross-contamination. – Reduces fear and anxiety. – Patients have control over their own comfort level.
Electronic Anesthesia