- Pathophysiology of the two conditions is different? Evidence from Doppler US studies that in a high proportion of cases of severe preeclampsia with associated FGR, unlike cases of mild disease without FGR, impedance to flow in the uterine arteries is increased.

- Consequence of inadequate trophoblastic invasion of the maternal spiral arteries and their conversion from narrow muscular vessels to wide nonmuscular channels

- It is possible that it improves placentation and, therefore, reduces the risk of severe preeclampsia.

- An alternative explanation is that in all cases of preeclampsia there is impaired placentation, but a spectrum of placental impairment is reflected in the severity of the clinical manifestations of the disease. In this case, the beneficial effect of aspirin on placentation could actually reduce substantially the risk of those cases that were destined to develop mild preeclampsia and convert the predestined severe to mild preeclamptic cases.

Referncia:

ROBERGE et al. Early Administration of Low-Dose Aspirin for Preeclampsia. American Journal of Perinatology. Vol. 29, No. 7/2012.

Obrigada!