CCeezzaarr SSttrrooeessccuu,, mmeeddiicc pprriimmaarr cchhiirruurrgg,, ddooccttoorr iinn mmeeddiicciinnaa DDaattaa ssii llooccuull nnaasstteerriiii:: 1133 aapprriilliiee 11997700,, BBuuccuurreessttii,, RRoommaanniiaa

EE--mmaaiill: cceezzaarr..ssttrrooeessccuu@@ggmmaaiill..ccoomm

PPOOZZIITTIIEE AACCTTUUAALLAA:: MMEEDDIICC PPRRIIMMAARR CCHHIIRRUURRGG IINN CCAADDRRUULL SSEECCTTIIEEII CCLLIINNIICCEE

CCHHIIRRUURRGGIIEE GGEENNEERRAALLAA IIII –– CCHHIIRRUURRGGIIEE OONNCCOOLLOOGGIICCAA ((MMEEDDIICC SSEEFF SSEECCTTIIEE:: CCOONNFF..DDRR.. MMIIHHNNEEAA IIOONNEESSCCUU)),, CCEERRCCEETTAATTOORR SSTTIIIINNTTIIFFIICC CCHHIIRRUURRGGIIEE GGEENNEERRAALLAA SSII TTRRAANNSSPPLLAANNTT IINN CCAADDRRUULL CCEENNTTRRUULLUUII DDEE CCHHIIRRUURRGGIIEE GGEENNEERRAALLAA SSII TTRRAANNSSPPLLAANNTT HHEEPPAATTIICC DDIINN CCAADDRRUULL IINNSSTTIITTUUTTUULLUUII CCLLIINNIICC DDEE BBOOLLII DDIIGGEESSTTIIVVEE SSII TTRRAANNSSPPLLAANNTT HHEEPPAATTIICC FFUUNNDDEENNII ((SSEEFF CCLLIINNIICCAA:: PPRROOFF..DDRR.. IIRRIINNEELL PPOOPPEESSCCUU)),, DDOOCCTTOORR IINN MMEEDDIICCIINNAA

EEDDUUCCAATTIIEE MMEEDDIICCAALLAA,, TTRRAAIINNIINNGG SSII EEXXPPEERRIIEENNTTAA PPRROOFFEESSIIOONNAALLAA:: •• 11999955,, aabbssoollvveenntt aall UUnniivveerrssiittaattiiii ddee MMeeddiicciinnaa ssii FFaarrmmaacciiee CCaarrooll DDaavviillaa,, BBuuccuurreessttii,,

FFaaccuullttaatteeaa ddee MMeeddiicciinnaa GGeenneerraallaa • 1996 – 2001 medic rezident în specialitatea Chirurgie Generală la Institutul Clinic

Fundeni • 2000 Asistent cercetare în Clinica de Chirurgie Generală a Institutului Clinic Fundeni • 2001 Medic specialist chirurgie generală • 1999 Curs de perfectionare cu participare internaţională “Chirurgie Pancreatică” in

cadrul International Gastro-Surgical Club, Mai 1999, Bucureşti, România • 2000 Curs de Chirurgie Laparoscopică a Colonului şi Rectului la Clinica de Chirurgie

Generală a Institutului Clinic Fundeni , Bucureşti, România • 2000 Curs de perfecţionare cu participare internatională “ Cancerul Tubului Digestiv

Superior – Esofag, Stomac – in cadrul International Gastro-Surgical Club, Bucuresti, Romania

• 2000 Curs de Tehnici Avansate în Chirurgia Laparoscopică a Splinei, Suprarenalei şi joncţiunii Gastro-Esofagiene, Bucureşti, România

• 2001 Iulie – septembrie Stagiu de pregătire în cadrul Departamentului de Chirurgie Generala a Universităţii din Ulm prin bursa oferită de Fundaţia Alexander von Humboldt in cadrul Programului de Stabilitate pentru Ţările Est – Europene, Proiect de cercetare: Expresia receptorilor “ Toll–like” TLR 2,3,4 la nivelul pancresului si tractului digestive – utilizare tehnici imunohistochimie, extragere ARN din ţesuturi, reverstranscriere, polimerizare în lanţ

• 2001 Minimal Invasive Surgery on the way to the Standard Surgery Departmentul Chirurgie Generală, Prof HG Beger, Universitatea Ulm, 16-18 July, 2001

• XIIIth Postgraduate Course of Pancreatic Surgery: PANCREATIC SURGERY: BENEFITS, RISKS AND FAILURE Departmentul Chirurgie Generala, Prof HG Beger, Universitatea Ulm, 3-5 September, 2001

• 2002 Mai-august - Stagiu de pregătire la Universitatea Maryland, SUA prin bursa oferită de Agenţia Spaţială Americană (NASA) cu tema “Telemedicina, Sanatate la nivel

mondial, Politica Şiinţelor Spaţiale, Telecomunicaţii şi Intenet în Practica Medicală” East West Space Science Center, Computer and Space Sciences Building, University of Maryland

• Combined humanitarian assistance response training” (“CHART” course), la Centrul de Excelenţă în Managementul Dezastrelor şi Asistenţă Umanitară de la National Naval Medical Center, Bethesda, Maryland

• Curs teoretic şi practic de telemedicină la Medical Informatics and Technology Application Consortium (Meditac) Virginia Commonwealth University partener al NASA pe probleme de telemedicină

• 2002 Septembrie – octombrie Stagiu de pregătire în cadrul Departamentului de Chirurgie Generala a Universităţii din Ulm prin bursa oferită de Fundaţia Alexander von Humboldt in cadrul Programului de Stabilitate pentru Ţările Est – Europene

• Proiect de cercetare: Expresia receptorilor “ Toll–like” TLR 2,3,4 la nivelul pancresului si tractului digestive – utilizare tehnici imunohistochimie, extragere ARN din ţesuturi, reverstranscriere, polimerizare în lanţ

• 2003 Februarie Stagiu de pregătire în cadrul Departamentului de Chirurgie Generala a Universităţii din Ulm prin bursa oferită de Fundaţia Alexander von Humboldt in cadrul Programului de Stabilitate pentru Ţările Est – Europene in cadrul proiectului descris anterior.

• 2003 Curs de perfecţionare cu participare internatională “ Actualitati in bolile ficatului” in cadrul International Gastro-Surgical Club, Bucuresti, Romania

• Proiectul Pilot de Telemedicină între Institutul Clinic Fundeni si Agenţia Spaţială Română

• 2005 Medic primar chirurgie generală • 2005 Proiect de cercetare: Studiul profilului expresiei genice si biomarkerilor corelat cu

parametrii clinicopatologici in cancerul de pancreas (GENOPACT) • 2006 Proiect CNCSIS Markeri imunohistochimici de diagnostic si prognostic in tumorile

hepatice primitive si secundare • In desfasurare: Proiect de cercetare “Studiul mecanismelor moleculare in pancreatita

cronica comparativ cu adenocarcinomul ductal” • In desfasurare: Proiect de cercetare “Intracellular signaling in gastric and oesophageal

adenocarcinoma”

DDooccttoorr iinn mmeeddiicciinnaa –– UUnniivveerrssiittaatteeaa ddee MMeeddiicciinnaa ssii FFaarrmmaacciiee CCaarrooll DDaavviillaa,, BBuuccuurreessttii::

•• TTiittlluull tteezzeeii ddee ddooccttoorraatt:: Markeri imunohistochimici de diagnostic şi prognostic şi apoptoza celulara în tumorile hepatice maligne primitive CCoooorrddoonnaattoorr ssttiiiinnttiiffiicc tteezzaa ddee ddooccttoorraatt:: PPrrooff.. DDrr.. II.. PPooppeessccuu

MMEEMMBBRRUU SSOOCCIIEETTAATTII SSTTIIIINNTTIIFFIICCEE:: NN aa tt ii oo nn aa ll ee

•• CCoolleeggiiuull MMeeddiicciilloorr ddiinn RRoommaanniiaa •• SSoocciieettaatteeaa RRoommaannaa ddee CChhiirruurrggiiee •• SSoocciieettaatteeaa RRoommaannaa ddee CChhiirruurrggiiee EEnnddoossccooppiiccaa (( mmeemmbbrruu ffoonnddaattoorr)) •• FFuunnddaattiiaa ppeennttrruu CChhiirruurrggiiaa FFiiccaattuulluuii

II nn tt ee rr nn aa tt ii oo nn aa ll ee •• IInntteerrnnaattiioonnaall AAssssoocciiaattiioonn ooff SSuurrggeeoonnss,, GGaassttrrooeenntteerroollooggiissttss aanndd OOnnccoollooggiissttss ((IIAASSGGOO)) •• IInntteerrnnaattiioonnaall AAssssoocciiaattiioonn ooff PPaannccrreeaattoollooggyy

AA CC TT II VV II TT AA TT EE SS TT II II NN TT II FF II CC AA (( AA RR TT II CC OO LL EE PP UU BB LL II CC AA TT EE ,, CC OO MM UU NN II CC AA RR II SS TT II II NN TT II FF II CC EE )) ::

1. Pseudomyxoma peritonei of appendiceal origin. Ionescu M, Diculescu M, Popovici

D, Herlea V, Stroescu C. Annals of Fundeni Hospital 1999, 3-4: 85-89

2. Pancreatectomia distală cu prezervarea splinei. Ionescu M, Stroescu C, Bărbuţă S,

Ciurea S, Popescu I. Chirurgia, vol 98 nr. 1:69 – 74, 2003

3. Duodenopancreatectomia cefalica – operatie de rutina? Ionescu M, Stroescu C,

Bărbuţă S, Ciurea S, Popescu I. Chirurgia, vol 98 nr.2:103 – 108, 2003

4. Resection for Klatskin tumors. M. Ionescu , T. Dumitrascu , C. Stroescu , S. Ciurea

, I. Popescu . Archives of Balkan Medical Union , 38 ( 1 ) : 15-20 , March 2003

5. Aggressive surgery in advanced gallbladder cancer. M. Ionescu , T. Dumitrascu ,

C. Stroescu , S. Ciurea , I. Popescu . Rev Rom of Oncology , 40 ( 3 ) : 1-9 , 2003

6. Restorative proctocolectomy for colonic diffuse polyposis and ulcerative colitis.

M. Ionescu , T. Dumitrascu , C. Stroescu , I. Popescu . Oral presentation at National

Surgical Conference (Colorectal Surgery), May 16 - 18 , 2003 , Sinaia , Romania

7. Restorative proctocolectomy as an alternative in prevention ant treatment of

malignisation in ulcerative colitis and diffuse colic polyposis. M. Ionescu , V.

Tomulescu , C. Stroescu , S. Barbuta , T. Dumitrascu . Oral presentation at 6-th

Symposium and Course of Romanian Section of IASG, April 14 - 16 , 2004 , Bucharest,

Romania

8. Surgical treatment of ulcerative colitis. M. Ionescu , T. Dumitrascu , C. Stroescu ,

S. Barbuta , V. Tomulescu , I. Popescu . Chirurgia , 99 ( 3 ) : 125-135 , 2004

9. Resection value in pancreatic cancer. M. Ionescu , C. Stroescu , S. Ciurea , A.

Dragnea , T. Dumitrascu , Anna-Maria Tanase , I. Popescu . Chirurgia , 99 ( 4 ) : 211-220

, 2004

10. Pancreatic pleomorf osteoclast like carcinoma with portal fistula. M. Ionescu, T.

Dumitrascu, C. Stroescu, V. Herlea, Ioana Lupescu . Chirurgia , 100 ( 2) : 163-168 , 2005

11. Klatskin tumors; Fundeni Hospital experience. M. Ionescu, C. Stroescu, T.

Dumitrascu, I. Popescu . Oral presentation at 7-th Symposium and Course of Romanian

Section of IASG, April 20 – 22 , 2005 , Bucharest, Romania

12. Surgical treatment in pancreatic head cancer. I. Popescu, M. Ionescu, C.

Vasilescu, S. Ciurea, D. Pietrareanu, V. Brasoveanu, C. Stroescu, P. Boeti-Sarbu, D.

Hrehoret, A. Dragnea, T. Dumitrascu . Oral presentation at National Surgical Conference

( Pancreatic Surgery ) , May 25 - 29 , 2005 , Iasi , Romania

13. Surgical treatment of acute severe pancreatitis. M. Ionescu, C. Vasilescu, S.

Ciurea, C. Stroescu, A. Dragnea, T. Dumitrascu, S. Georgescu, M. Boros, I. Popescu .

Oral presentation at National Surgical Conference ( Pancreatic Surgery ) , May 25 - 29 ,

2005 , Iasi , Romania

14. Conservative Surgery in benign tumors of the corporeal pancreas. M. Ionescu, C.

Stroescu, T. Dumitrascu, A. Dragnea, I. Popescu . Oral presentation at National Surgical

Conference ( Pancreatic Surgery ) , May 25 - 29 , 2005 , Iasi , Romania

15. Central pancreatectomy. M. Ionescu, T. Dumitrascu, C. Stroescu, S. Ciurea, D.

Pietrareanu, G. Mitulescu, A. Dragnea, I. Popescu . Chirurgia 100 ( 5 ) : 429 – 435 , 2005.

16. Cytokeratins value in differentiating between hepatocellular carcinoma and

perifferal type of cholangiocarcinoma C. Stroescu, A. Dragnea, V. Herlea, I. Popescu

- J Gastrointest Liver Dis (15) 1: 914 2006

17. Factori prognostici in cancerul pancreatic- analiza preliminara a unui lot de 38

de pacienti. I. Popescu, C. Stroescu, A. Dragnea, M. Ionescu, O.Sgarbura – Radiologie

si Oncologie Medicala 2006

18. Resection of The Celiac Trunk increase resectability rate in locally advanced

pancreatic body and gastric tumor . M. Ionescu, T. Dumitrascu, C. Stroescu, S. Ciurea,

I. Popescu . Chirurgia , 101 ( 3) : 297- 305 , 2006

19. The diagnostic value of cytokeratins and carcinoembryonic antigen

immunostaining in differentiating hepatocellular carcinomas from intrahepatic

cholangiocarcinomas. C. Stroescu, V. Herlea, A. Dragnea, and I. Popescu J

Gastrointestin.Liver Dis. 15 (1):9-14, 2006.

20. Klatskin tumors – experience of Center of General Surgery and Liver

Transplantation, Fundeni Clinical Institute. M. Ionescu, T. Dumitrascu, C. Stroescu, S.

Ciurea, I. Popescu . Oral presentation at The First Romanian – Serbian Conference of

Surgery , November 17 – 19 , 2006 , Drobeta Turnu Severin , Romania

21. Digestive tumor bank protocol: from surgical specimens to genomic studies of

digestive cancers . I. Popescu, C. Stroescu, T. Dumitrascu, V. Herlea, Liliana Paslaru, V.

Lazar, H. Boissin, J. Taieb, Ionela Horeanga . Chirurgia , 101 ( 5 ) : 471-475 , 2006

22. Liver resection after downstaging with systemic chemotherapy in a case of a

multicentric hepatocellular carcinoma with virus B cirrhosis. M. Ionescu, T.

Dumitrascu, C. Stroescu . Chirurgia , 102 ( 3 ) : 337-343, 2007

23. Prognostic factors after resection of Klatskin tumors: A retrospective analysis of

50 cases. T. Dumitrascu, M. Ionescu, C. Stroescu, B. Ivanov, I. Popescu. Oral

presentation at The Second International Conference of Serbian and Romanian surgeons,

November 15 – 17 , 2007 , Kladovo , Serbia

24. R0 resection for Klatskin tumors is critical for postoperative long-term survival:

a retrospective analysis of 50 cases. T. Dumitrascu, M. Ionescu, C. Stroescu, B. Ivanov,

I. Popescu. Oral presentation at 15th International Postgraduate Course of IASGO, 2007,

Athens, Greece (abstract in Hepatogastroenterology , Volume 54, December 2007,

Supplement 1, A30)

25. Spleen-preserving distal pancreatectomy for benign diseases of the body and tail

of the pancreas. M. Ionescu, C. Stroescu, T. Dumitrascu, A. Dragnea, B. Dorobantu, G.

Mitulescu. Oral presentation at 17th World Congress of IASGO, 2007, Bucharest,

Romania (abstract in Hepatogastroenterology , Volume 54, September 2007, Supplement

1, A29)

26. Recurrent benign cystic peritoneal mesothelioma. C. Stroescu, R. Negulescu, V.

Herlea, L. David, B. Ivanov, C. Nitipir, and I. Popescu. Chirurgia (Bucur.) 103 (6):715-

718, 2008.

27. Expression of p53, Bcl-2, VEGF, Ki67 and PCNA and prognostic significance in

hepatocellular carcinoma. C. Stroescu, A. Dragnea, B. Ivanov, C. Pechianu, V. Herlea,

O. Sgarbura, A. Popescu, and I. Popescu. J Gastrointestin.Liver Dis. 17 (4):411-417,

2008.

28. Pancreatoduodenectomy in the elderly – a safe operation? C. Stroescu, B. Ivanov,

A. Dragnea, T. Dumitrascu, M. Ionescu, I. Popescu. Chirurgia, 103 ( 3 ) : 275-282, 2008

29. Expression of p53, Bcl-2, VEGF, ki67 and PCNA and prognostic significance in

hepatocellular carcinoma Stroescu C., Dragnea A., Ivanov B., Pechianu C., Herlea V.,

Popescu I. Oral presentation at 18th World Congress of IASGO, 2008, Istanbul, Turkey

(abstract in Hepatogastroenterology , Volume 55, October 2008, Supplement 1, A269)

30. Clinico-pathological features of a cystic stromal tumor of the duodeno-jejunal

angle – case report. T. Dumitrascu, M. Mihai, C. Stroescu, I. Lupescu, M. Ionescu.

Poster presentation at 18th World Congress of IASGO, 2008, Istanbul, Turkey (abstract in

Hepatogastroenterology , Volume 55, October 2008, Supplement 1, A300)

31. The role of life-long feeding with different dietary lipid sources on the

development of non-alcoholic steatoliepatitis (nash) in aged rats. V. Herlea, C.

Pechianu, C. Stroescu, L. Paslaru, M. Hortopan, E. Stoica-Mustafa, M. Mihai, A.

Vacarasteanu, I. Sobaru, L. Driu, C. Vasilescu, M. Ionescu, V. Tomulescu, S. D.

Dragnea, and I. Popescu.Virchows Archiv 452:S128-S129, 2008.

32. Expression of p53, Bcl-2, VEGF, Ki67 and PCNA and Prognostic Significance in

Hepatocellular Carcinoma. C. Stroescu,A. Dragnea, B. Ivanov, C.Pechianu, V.Herlea,

Olivia Sgarbura, Andra Popescu, I. Popescu J Gastrointestin Liver Dis (17) 40 411-417,

2008

33. Mezoteliom multichistic peritoneal recidivat. C.Stroescu, Raluca Negulescu, V.

Herlea, L. David, B. Ivanov, Cornelia Nitipir, I. Popescu Chirurgia, 103 (6): 715-718,

2008

34. An accurate diagnosis of hepatocellular carcinoma and cholangiocarcinoma with

immunohistochemistry? V. Herlea, C. Pechianu, E. Stoica-Mustafa, C. Stroescu, M.

Hortopan, L. Paslaru, A. Iorgescu, I. Sobaru, O. Balan, D. Moldovan, A. Poteca, C.

Vasilescu, M. Ionescu, V. Tomulescu, D. Hrehoret, S. Dima, V. Brasoveanu, S.

Alexandrescu, C. Ungureanu, G. Mitulescu, S. Ciurea, A. Croitoru, C. Gheorghe, and I.

Popescu. Virchows Archiv 455:113, 2009.

35. Immunohistochemical and morphometrical analysis in ductal pancreatic

carcinoma. V. Herlea, E. Stoica-Mustafa, C. Pechianu, C. Vasilescu, L. Paslaru, M.

Sajin, M. Hortopan, A. Iorgescu, I. Sobaru, M. Ionescu, C. Stroescu, V. Tomulescu, S.

Dima, V. Brasoveanu, C. Ungureanu, G. Mitulescu, S. Ciurea, L. Gheorghe, C.

Gheorghe, A. Croitoru, D. Cretoiu, and I. Popescu Virchows Archiv 455:119, 2009.

36. Tratamentul chirurgical in pancreatita cronica –o experienta de 14 ani C.

Stroescu, A. Popescu, B. Ivanov, S. Dima, M. Ionescu, C. Vasilescu, I. Popescu,

Prezentare orala la A XXXI-a Reuniune a Chirurgilor din Moldova , oct 2009

CCAAPPIITTOOLLEE DDEE CCAARRTTEE PPUUBBLLIICCAATTEE::

• Tumorile esofagului - M. Ionescu, I. Lica, C. Stroescu in „Manual de chirurgie”, I. Popescu, M. Beuran, vol. I, pp. 441-458, Ed. Universitara „Carol Davila” Bucuresti, 2007

• Cancerul rectal - M. Ionescu, C. Stroescu in „Manual de chirurgie”, I. Popescu, M. Beuran, vol. II, pp. 617-630, Ed. Universitara „Carol Davila” Bucuresti, 2007

• Icterul colestatic - M. Ionescu, C. Stroescu in „Manual de chirurgie”, I. Popescu, M. Beuran, vol. II, pp. 789-806, Ed. Universitara „Carol Davila” Bucuresti, 2007

• Anatomia pancreasului – C. Stroescu in „Tratat de chirurgie” (Textbook of surgery), I. Popescu, vol. IX, General Surgery, pp. 399-404, Ed. Academiei Romane Bucuresti, 2009

• Cancerul de pancreas – I. Popescu, M. Ionescu, C. Stroescu in „Tratat de chirurgie” (Textbook of surgery), I. Popescu, vol. IX, General Surgery, pp. 476-495, Ed. Academiei Romane Bucuresti, 2009

AARRIIII PPRRIINNCCIIPPAALLEE DDEE IINNTTEERREESS::

•• CChhiirruurrggiiaa oonnccoollooggiiccaa ddiiggeessttiivvaa •• CChhiirruurrggiiaa ppaannccrreeaassuulluuii •• CChhiirruurrggiiaa ffiiccaattuulluuii ssii ccaaiilloorr bbiilliiaarree

AALLTTEELLEE::

•• LLiimmbbii ssttrraaiinnee ccuunnoossccuuttee:: eenngglleezzaa,, ggeerrmmaannaa,, ffrraanncceezzaa

•• MMeemmbbrruu iinn ccoommiitteettuull llooccaall ddee oorrggaanniizzaarree aall 1177tthh WWoorrlldd CCoonnggrreessss ooff tthhee IInntteerrnnaattiioonnaall AAssssoocciiaattiioonn ooff SSuurrggeeoonnss,, GGaassttrrooeenntteerroollooggiissttss aanndd OOnnccoollooggiissttss,, BBuucchhaarreesstt,, 55--88 ooff SSeepptteemmbbeerr 22000077