Jessica Tatiana Reyes

Medicine Student3rd Semester

The discovery of new mechanisms of cellular function and it’s process is a great aid to all researchers specially community health as an great progress in etiology understanding and development of treatments of different organic entities

The discovery of new mechanisms of cellular function and it’s process is a great aid to all researchers specially community health as an great progress in etiology understanding and development of treatments of different organic entities

The development of new tools in medical genetics study are of great importance for the understanding and learning the different processes involved, thus facilitating its study and accessibility

SWEET GENES: new way found by which metabolism is linked to the regulation of

DNA (July 3, 2014)

SWEET GENES: new way found by which metabolism is linked to the regulation of

DNA (July 3, 2014)

The DNA has a special configuration, which allows not only the maintenance and stability but also conducive to the different processes to be performed for proper operation.

The DNA has a special configuration, which allows not only the maintenance and stability but also conducive to the different processes to be performed for proper operation.

Among the fate of the DNA to its operation is the relaxation of chromatin which consists of genetic material and proteins mainly histones, this relaxation promotes replication and development of the central dogma of molecular biology

Among the fate of the DNA to its operation is the relaxation of chromatin which consists of genetic material and proteins mainly histones, this relaxation promotes replication and development of the central dogma of molecular biology

SWEET GENES: new way found by which metabolism is linked to the

regulation of DNA

SWEET GENES: new way found by which metabolism is linked to the

regulation of DNA

This process is made by a molecule known acetyl-CoA. This relaxes the DNA, allowing for DNA replication and gene expression. This mechanism is called "epigenetic regulation of DNA" is very important for normal functions

This process is made by a molecule known acetyl-CoA. This relaxes the DNA, allowing for DNA replication and gene expression. This mechanism is called "epigenetic regulation of DNA" is very important for normal functions

The way which the nucleus generates acetyl-CoA for histone acetylation and DNA relaxation had remained elusive, until these days

The way which the nucleus generates acetyl-CoA for histone acetylation and DNA relaxation had remained elusive, until these days

SWEET GENES: new way found by which metabolism is linked to the regulation of

DNA

SWEET GENES: new way found by which metabolism is linked to the regulation of

DNA

SWEET GENES: new way found by which metabolism is linked to the

regulation of DNA

SWEET GENES: new way found by which metabolism is linked to the

regulation of DNA

A research team discovered of an enzyme which thought to reside only with in mitochondria for energy production by acetil CoA, called Pyruvate Dehydrogenase Complex (PDC), actually also has been find it into the nucleus and maybe have responsibility in epigenetic regulation

A research team discovered of an enzyme which thought to reside only with in mitochondria for energy production by acetil CoA, called Pyruvate Dehydrogenase Complex (PDC), actually also has been find it into the nucleus and maybe have responsibility in epigenetic regulation

This work bring to us different implications for many physiological and pathological conditions with this

enzyme discovered into the nucleus is comprehended the way what is produced and can participate in the

regulation of DNA specifically epigenetic

STUDENT OBSERVATION

SWEET GENES: new way found by which metabolism is linked to the

regulation of DNA

SWEET GENES: new way found by which metabolism is linked to the

regulation of DNA

DNA 'replication fork' reconstituted for the first time

 (July 9, 2014)

DNA 'replication fork' reconstituted for the first time

 (July 9, 2014)

The genetic material undergoes different processes of great importance to properly perform its functions, including DNA replication, the first step of the central molecular biology dogma

The genetic material undergoes different processes of great importance to properly perform its functions, including DNA replication, the first step of the central molecular biology dogma

DNA 'replication fork' reconstituted for the first time

 

DNA 'replication fork' reconstituted for the first time

 

Replication fork is the region of active DNA synthesis, is the place where the parental strands are separated and are synthesized two new daughter strands

Replication fork is the region of active DNA synthesis, is the place where the parental strands are separated and are synthesized two new daughter strands

DNA 'replication fork' reconstituted for the first time

 

DNA 'replication fork' reconstituted for the first time

 

To create his replication fork model, researchers used enzymes from yeast. Like human cells, yeast cells are eukaryotic, meaning a membrane encloses their nucleus

To create his replication fork model, researchers used enzymes from yeast. Like human cells, yeast cells are eukaryotic, meaning a membrane encloses their nucleus

Researchers at Rockefeller University have built the first model system about "replication fork" to decipher what goes on here and understanding the complete process

Researchers at Rockefeller University have built the first model system about "replication fork" to decipher what goes on here and understanding the complete process

They were able to purify and reconstitute the central components that propel the eukaryotic replication fork

They were able to purify and reconstitute the central components that propel the eukaryotic replication fork

That's why they said "for the first time enables us to study the process and its regulation by the cell in fine detail" and it was presented as a research tool, which could allow scientists to better understand what occurs in DNA replication and some disease states

That's why they said "for the first time enables us to study the process and its regulation by the cell in fine detail" and it was presented as a research tool, which could allow scientists to better understand what occurs in DNA replication and some disease states

DNA 'replication fork' reconstituted for the first time

 

DNA 'replication fork' reconstituted for the first time

 

This model as a study tool allow researches and medical people better understand the process of DNA

replicaton and what goes wrong in disease states

DNA 'replication fork' reconstituted for the first time

 

DNA 'replication fork' reconstituted for the first time

 

STUDENT OBSERVATION

Understand the different biological processes, compounds and pathways involved followed by the genetic material are of great impotence to understand both normal and abnormal procedures that are held for proper operation or pathological states

The discovery of the enzyme PDC within the nucleus and its possible relationship to epigenetic regulation is a huge advance understanding different etiological processes or to think of possible medical interventions

Creating a model that outlines the replication fork eukaryotic cell with its components and processes serves as a research tool to study in more detail the mechanisms involved, normal versus abnormal operating states and develop a possible medical treatment

The era of molecular biology and genetics with broader developments, discoveries and study tools have facilitated and improved medical work to contribute their knowledge in the diagnostic aids and treatments developed

University of Alberta Faculty of Medicine & Dentistry. "Sweet genes: New way found by which metabolism is linked to the regulation of DNA." ScienceDaily. www.sciencedaily.com/releases/2014/07/140703151821.htm (accessed July 26, 2014).

Rockefeller University. "DNA 'replication fork' reconstituted for the first time." ScienceDaily. www.sciencedaily.com/releases/2014/07/140709100106.htm (accessed July 25, 2014)

MARTINEZ SÁNCHEZ, Lina María. Biología molecular. 7. ed. Medellín: UPB. Fac. de Medicina, 2012.

TATACOA DESERTVILLA VIEJA – HUILA