pharmaceutical organic chemistry department specification organic.pdf · pharmaceutical organic...

جامعة مصر للعلوم والتكنولوجیاCourse Specificationلوم والتكنولوجیا جامعة مصر للع2015ئى والتصنیع الدواعلوم الصیدلیةة الكلی - وحدة ضمان الجودة2016

Pharmaceutical Organic ChemistryDepartment





جامعة مصر للعلوم والتكنولوجیاCourse Specificationجامعة مصر للعلوم والتكنولوجیا وحدة ضمان الجودة2015-2016والتصنیع الدوائى علوم الصیدلیةة الكلی

PHCM111


PHCM111


PHCM111


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PharmaceuticalOrganicChemistryDepartment

A. Basic Information

Program(s) on which the course is given Bachelor of Pharm. SciencesDepartment offering the course Department of Pharmaceutical Organic

Chemistry

College offering the program College of Pharmaceutical Science & drugmanufacturing, MUST University

Dept. responsible for teaching the course Department of Pharmaceutical OrganicChemistry

Academic year / level First Year- First SemesterCourse title Pharmaceutical Organic Chemistry ICourse code PHCM 111Contact hours ( credit hours ) Lecture : ( 2 ) , Practical : (2), Total : 3 credit

hoursCourse coordinator Prof. Dr/ Khadiga Mohamed Attia

Ass. Prof. Dr/ Abd-Allah Shaaban El-EtrawyMajor or Minor element of programmes MajorDate of specification approval 1/9/2015

B- Professional InformationThe course aim and intended learning outcomes are based on that mentioned in the programspecifications, with more course-related specific details.

1- Overall aims of courseThe aim of the course is to provide students study of the fundamental principles of chemistry ofaliphatic compounds


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2- Intended learning outcomes of course (ILOs)

a- Knowledge and Understanding:By the end of the course the student should be able to demonstrate knowledge andunderstanding of :

a1- The basics of aliphatic organic chemistry.

a2- The mechanisms of aliphatic organic reactions.

a3- The principles of identification of organic compounds.

a4- The basic concepts of isomerism, spatial and three dimensional arrangement oforganic compounds and the stereochemical reactions.

b- Intellectual Skills:By the end of the course the student should be able to :b1-Recognize organic problems of different organic classes.

b2-Select methods for identification of organic compounds from both physical andchemical reactions ( reactions of functional groups).

b3- Solve stereochemical problems.

c- Professional and Practical Skills:By the end of the course the student should be able to:c1- Handle chemicals according to safety guidelines.

c2- Identify organic compounds from their physical and chemical properties.

c3- Analyze stereochemical problems and spectral data of organic compounds.

d- General and Transferable Skills:By the end of the course the student should be able to:d1-Retrieve information from libraries

d2- Work effectively as a part of a team and as an individual.


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3 .Course Contents

TotalTutorial/Practical

hours

Lecturehours

Topic

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Introduction to organic chemistry, type ofchemical bonds, hybridization and their types.

Introduction, safety& name of glassware &lab.tools and their uses.

Representation of organic compounds, type ofisomerism, and the principle of nomenclature

Classification of organic compounds.Saturatedhydrocarbons (Alkanes & Cycloalkanes).

Physical Character of organic compounds(Condition, Colour, Odour& Solubility).

Chemical Character of organic compounds (Sodalime, NaOH, FeCl3& Conc. H2SO4)

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Nomenclature of Alkenes and cycloalkenes&,geometrical isomerism (Z- or E- configuration)

Identification of alcohols. Preparations & reactions of Alkenes and

cycloalkenes. Identification of Aldehydes & Ketones. Alkynes.Representation of organic moleculesin

three dimensional& recognize the relative andabsolute configuration (D- or L-& R or S )

Identification of Liquid Aliphatic CarboxylicAcids.

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Alkyl halides. Determination of chairal molecules Identification ofSolid Aliphatic Carboxylic Acids. Alcohols&Ethers.Element of symmetry and

chairallty. Identification ofSalts of aliphatic carboxylic

Acids.(Amm., K+, Na+…..). Aliphatic aldehydes &Ketones.Calculation of

optical activities,of organic molecules Identification ofcarbamide ( Urea)


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3 .Course Contents


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3 .Course Contents


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Aliphatic carboxylic acids. Calculation of opticalpurity of organic molecules

Revision (General Scheme for Solid & LiquidUnknowns).

Derivatives of aliphatic of carboxylic acids.Enantiomers,diasereomersandmeso-compounds.

Aliphatic amines. Chairal molecules without achairal atom

Carbamide. Synthesis of enantiomers &importantbiologically active enantiomers.

4. Teaching and Learning Methods

4.1- Lectures (board, overhead projector, molecular models, software chemistry programsand data show)4.2- Tutorials and discussion sessions4.3- Practical sessions.

5. Student Assessment Methods5.1. Quiz to assess efficient study.5.2. Written exams to assess knowledge and understanding as well as intellectual skills.5.3. Practical exams to assess professional and practical skills.

Assessment ScheduleAssessment 1: Q Week: upon course progressionAssessment 2: Mid Term Week: 7-8thAssessment 3: Practical exam Week: 11-12thAssessment 4: Final exam Week: 14th

Weighting of AssessmentsQuiz I 6.667%Midterm 20 %Quiz II 6.667%First practical exam 6.677 %Second practical exam 20%Final exam 33.3%Other types of assessment 6.667 %Oral exam 0 %

Total 100%


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6. List of References

6.1- Course Notes Lecture notes on Basic organic Chemistry PHCM 111 by Prof. Dr. Khadiga

Mohamed Attia and Dr. Abd-Allah Shaaban El-Etrawy (University bookscenter).

Lecture notes on stereochemistry by Prof. Dr. Khadiga MohamedAttia(University books center).

6.2- Recommended Booksa. Essential organic chemistry, Paula YurkanisBruice, (2006).b. Fundamental of Organic Chemistry; J. McMurry and E. Simanek; 6thEdition Organic Chemistry; R.T. Morrison and R.N. Boyd; 6th Edition Chemistry for Pharmacy Students,Satyajit D. SarkerandLutfunNahar. 2007) Mechanisms in Advanced Organic Chemistry, R.P. Narain; (2008)c. Stereochemistry; V. M. POTAPOV, (1979)d. Organic Stereochemistry; Michael J. T. Robinson;(1999)2. VOGEL’s “Textbook of practical organic chemistry” Brian S. Furniss, Antony J.

Hannaford, Peter W. G. Smith and Austin R. Tatchell.5thEdition

3. Facilities Required for Teaching and Learning board, overhead projector, molecular models, software chemistry

programs and data show Laboratories equipped by, chemicals and glasswares

Coordinator: Signature:Prof. Dr. Khadiga Mohamed AttiaAss. Prof. Dr/ Abd-Allah Shaaban El-Etrawy

Head of Department:

Prof. Dr. Khadiga Mohamed AttiaSignature:

Date: 1/9/2015


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Head of Department:


Date: 1/9/2015


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Head of Department:


Date: 1/9/2015

جامعة مصر للعلوم والتكنولوجیاCourse Specificationجامعة مصر للعلوم والتكنولوجیا ضمان الجودةوحدة 2016-2015والتصنیع الدوائى علوم الصیدلیةة الكلی

PHCM112


PHCM112


PHCM112


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ChemistryCollege offering the program College of Pharmaceutical Science & drug

manufacturing, MUST UniversityDept. responsible for teaching the course Department of Pharmaceutical Organic

ChemistryAcademic year / level First Year- Second SemesterCourse title Pharmaceutical Organic Chemistry IICourse code PHCM 112Contact hours ( credit hours ) Lecture : (3) , Practical : (2), Total : 4 credit

hoursCourse coordinator Ass. Prof. Dr/ Abd-Allah Shaaban El-

EtrawyMajor or Minor element of programmes MajorDate of specification approval 1/9/2015

B.Professional InformationThe course aim and intended learning outcomes are based on that mentioned in the programspecifications, with more course-related specific details.

1- Overall Aims of Course:

The aim of the course is to provide the students with the fundamental principles of thechemistry of aromatic compounds. The course also involves a study of organic spectroscopyincluding infrared, nuclear magnetic resonance, ultra violet, and mass spectrometry, whichused in the elucidation of molecular structure of organic compounds. The laboratory workinvolves identification of aromatic compounds. In addition to spectroscopic study tocharacterize organic compounds such as IR, NMR, and UV-vis.


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2- Intended learning Outcomes of Course ( ILOs ):a- Knowledge and Understanding :By the end of the course the student should be able to demonstrate knowledge andunderstanding of :

a1- The basic concepts of aromaticity and chemistry of arenes.

a2- The characteristics of chemistry of benzenoids and polynuclear compounds

a3- The basics of spectroscopy and spectral analysis of organic compounds.

b- Intellectual Skills:By the end of the course the student should be able to :

b1- Recognize organic compounds from their physical and chemical properties.

b2- Discuss organic problems of different organic classes .

b3- Apply suitable methods for synthesis, purification, and identification ofchemical substances from different origins.

b4- Analyze and interpret experimental studies as well as data from publishedliterature using spectroscopy.

c- Professional and Practical Skills :By the end of the course the student should be able to :

c1- Select the appropriate methods for identification and synthesis of organiccompounds

c 2-Identify aromatic organic compounds and carbohydrates physically andchemically.


d- General and Transferable Skills :By the end of the course the student should be able to:

d1- Use the literature via different information sources including the library,internet….etc.

d2-Care about himself, his colleagues and all the tools and instruments of his labduring dealing with chemical organic compounds.


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3- Contents:TotalTutorial/

Practicalhours

Lecturehours

Topic

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Introduction to organic chemistry, structure of benzeneand its stability, (resonance), and the aromaticityphenomena.

Introduction to spectroscopy, relation between lightand organic compounds

Introduction, (safety, name of glassware &lab. toolsand their uses,physical& chemicalcharacter of organiccompounds

Classification and Nomenclature of aromaticcompounds. Preparation and addition reactions ofbenzene

Ultraviolet-and and visible U.V, Beer Lambert low,type of electronic transitions

Identification of Aromatic hydrocarbons. Electrophilic substitution reactions of benzene.

Orientation (o-,p-,m-directing group) of substitutedbenzene.

Calculate of λmax.fordienes by using (Woodward-Fisherrule).

Identification of Resorcinol & hydroquinone. Arenes and their derivatives Calculate of λmax, for α-, β- unsaturated carbonyl

compounds by Woodward-Fisher rule. Identification of1-naphthol & 2-naphthol.

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Aromatic halogen compounds Introduction infrared, Hook low, region of different

type of function groups. Identification of Aromatic alcohol & Tutorial Hydroxy compounds (Phenols). Problems on I.R. Identification of Aldehydes & Ketones& Tutorial. Aryl ether and aromatic alcohols Problems on I.R. Identification of aromatic Carboxylic Acids.


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Aromatic aldehydes and ketones. Introduction to NMR, type uses in life. H-NMR,

Chemical Shift and TMS.Chemical shift of differenttype of protons.

Identification of the Salts of aromaticCarboxylic Acids.(Amm., K+, Na+…..).

Aromatic carboxylic acids Factors affecting on chemical shift, Spin-spin splitting

and type of J-constant. Identification of Amines & their salts Nitro-compounds Problems on: H-NMR

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Aromatic amines and diazo-compounds. 13C-NMR (chemical shift. Problems on 13C-NMR) Revision (General Scheme forLiquid & Solid

Unknowns). Polynuclear aromatic hydrocarbons (Naphthalene,

Anthracene, phenanthrene, and anthrquinone and theirderivatives.

Introduction to mass spectroscopy, type offragmentation and Mc-Lafferty rearrangements.

4. Teaching and Learning Methods4.1- Lectures (board, overhead projector, molecular models, software chemistry programs anddata show)4.2- Tutorials and discussion sessions4.3- Practical sessions


Assessment ScheduleAssessment 1: Q Week: upon course progressionAssessment 2: Mid Term Week: 7-8thAssessment 3: Practical exam Week: 11-12thAssessment 4: Final exam Week: 14thAssessment 5: oral exam Week: 14th


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Weighting of Assessments

Quiz I 7.5 %Midterm 17.5 %Quiz II 7.5 %First practical exam 5 %Second practical exam 12.5 %Final exam 35 %Other types of assessment 5 %Oral exam 10 %

Total 100% 200 marks


6.1- Course Notes Lecture note on Organic Chemistry CHEM 201 by Prof. Dr. Khadiga Mohamed

Attia (University book center). Lecture note on Spectroscopy by Prof. Dr. Khadiga Mohamed Attia (University

book center).6.2- Recommended Books

Essential organic chemistry, Paula YurkanisBruice; (2006) Organic Chemistry, structure & reactivity, SeyhanEge; (2005) Chemistry for Pharmacy Students,Satyajit D. Sarker andLutfunNahar. 2007) Mechanisms in Advanced Organic Chemistry, R.P. Narain; (2008) Organic Chemistry; T.W. Graham Solomans and Craig B. Fryhle; 7th edition;

(2002) Spectroscopy of Organic Compounds; P.S.KALSI;5th edition (2002) Introduction to spectroscopy, A guide for student of organic chemistry; D. L.

Pavia, G.M. Lampman, G.S. Kriz; (1979) Handbook of Spectroscopy; Günter Gauglitz and Tuan Vo-Dinh, (2003) Nuclear Magnetic Resonance Spectroscopy, Joseph B. Lambert, 2002. VOGEL’s “Textbook of practical organic chemistry” Brian S. Furniss, Antony J.


7. Facilities Required for Teaching and Learning

Boards, overhead projector, molecular models, software chemistryprograms and data show.

Laboratories equipped by, chemicals and glasswaresCoordinator: Signature:Ass. Prof. Dr Abd-Allah Shaaban El-Etrawy

Head of Department: Signature:

Prof. Dr. Khadiga Mohamed Attia

Date : 1/9/2015


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Date : 1/9/2015


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Date : 1/9/2015

جامعة مصر للعلوم والتكنولوجیاCourse Specificationجامعة مصر للعلوم والتكنولوجیا ضمان الجودةوحدة 2015-2016والتصنیع الدوائعلوم الصیدلیةة الكلی

PHCM211


PHCM211


PHCM211


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Pharmaceutical Organic Chemistry Department


Program(s) on which the course is given Bachelor of Pharm. Sciences

Department offering the course Department of Pharmaceutical OrganicChemistry



Academic year / level Second Year- First Semester

Course title Pharmaceutical Organic Chemistry III

Course code PHCM 211

Contact hours ( credit hours ) Lecture: (2), Practical: (2), Total 3 credithours

Course coordinator Prof. Dr/ Mohammed Mohsen IsmailMajor or Minor element of programmes Major

Date of specification approval 1/9/2015

B- Professional Information

The course aim and intended learning outcomes are based on that mentioned in theprogram specification, with more course-related specific details.

1- Overall Aims of Course:The aim of the course is to provide students with the fundamental principles of chemistryof heterocyclic compounds with particular reference to heterocycles of biological interest.The laboratory work involves purification of organic compounds by different methods.Inaddition to synthesis of some selected examples of heterocyclic organic compounds.


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2- Intended learning Outcomes of Course ( ILOs ):a- Knowledge and Understanding:By the end of the course the student should be able to demonstrate knowledge of:

a1- The theoretical basis of chemistry of heterocyclic compounds.

a2- The methods of purification and preparation of some heterocyclic organic compounds.

b- Intellectual Skills:

By the end of the course the student should be able to :

b1-Sketch the structure and name the heterocyclic compounds.

b2- Apply the reaction mechanisms and employ the effect of condition on the type ofproducts.

b 3-Synthesize more complex classes of organic compounds.

c- Professional and Practical Skills :


c1- Synthesize preliminary heterocyclic compounds of different drug categories.

c2- Purify and identify the newly synthesized chemical compounds or drugs.

c3- Use spectral data to confirm the synthesized organic compounds.

d- General and Transferable Skills :

By the end of the course the student should be able to:

d1- Communicate clearly by verbal and written means

d2-Demonstrate self-learning needed for continuous professional development .


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Practicalhours

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Topic

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Introduction to heterocyclic compounds and theiruses as pro-drugs.

Introduction & safety.Calculation the nos. of molesof reactions and the % of yields.

Nomenclature of heterocyclic compounds(common and IUPAC of monocyclic)

Nomenclature of fused heterocyclic rings (common& IUPAC).

Purification of organic compounds bycrystallization and sublimation & determination ofits m.p.

Synthesis of 5-memberd rings contain one or morethan one heteroatom.

Preparation of some alcohol derivatives andaddition to carbonyl compounds.Determination ofm.p., and the % of yield of prepared compounds.

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Reaction, and biological activities of 5-memberdrings contain one heteroatom.

Preparation of some aldehydes and ketonesderivative &determination of their m.p. & the % ofyield.

Preparation of some phenols derivative & determinetheir m.p.,& the % of yield.

Reaction, and biological activities of 5-memberdrings contain more than one heteroatom.

Preparation of acids and amides derivative &determinetheir m.p., & the % of yield.


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Synthesis 6-memberd rings contain one or morethan one heteroatom (pyridine, pyradizines).

Preparation of some pyridine derivatives&determine theirb.p., orm.p., and the % of yield.

Reaction, and biological activities of 6-memberdrings contain one or more than oneheteroatom(pyridine, pyradizines).

Preparation of some diazine derivatives &determine their m.p., and the % of yield.

Synthesis fused five memberedheterocycles(indole).

Preparation of some imidazole derivatives &determinetheir m.p., and the % of yield.

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Reaction and biological activities of fused fivemembered heterocycles(indole).

Preparation ofCoumarin derivatives &determination of its m.p., the % of yield.

Synthesis fused sixe memberedheterocycles(quinoline and isoquinoline).

Reaction, and biological activities of fused sixemembered heterocycles(quinoline and isoquinoline).


4.1- Lectures (board, overhead projector, molecular models, software chemistry programs anddata show)4.2- Tutorials and discussion sessions4.3- Practical sessions

5. Student Assessment Methods5.1. Quiz to assess efficient study.5.2. Written exams to assess knowledge and understanding as well as intellectual skills.5.3. Practical exams to assess professional and practical skills.5.4. Oral exams to assess all types of skills and mainly general and transferrable skills



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Weighting of AssessmentsQuiz I 5%Midterm 10%Quiz II 5%First practical exam 15%Second practical exam 20%Final exam 25%Other types of assessment 10%Oral exam 10%


6. List of References6.1- Course Notes

Lecture notes on Heterocyclic Chemistry Prof. Dr. Khadiga Mohamed Attia(University book center).

6.2- Recommended Books Chemistry for Pharmacy Students,Satyajit D. Sarker andLutfunNahar. 2007) Handbook of Heterocyclic Chemistry; Alan R. Katritzky and Alexander F.

Pozharskii; 2nd Edition;(2000) R.R Gupta Heterocyclic Chemistry Principles ofChemical Nomenclature “A Guide toIUPAC Recommendations”

(2004) The Organic Chemistry of Drugs Synthesis “ Volume 3”; Daniel Lendnicer and

Lester A. Mitscher,(1984) Named Organic Reactions Thomas Laue and Andreas Plagens; 2ndEdition; (2005)a. VOGEL’s “Textbook of practical organic chemistry” Brian S. Furniss, Antony J.



programs and data show Laboratories equipped by, chemicals and glassware

Coordinator: Signature:Prof. Dr. Mohammed mohsen Ismail



Date: 1/9/2015


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Date: 1/9/2015


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Date: 1/9/2015

pharmaceutical organic chemistry department specification organic.pdf · pharmaceutical organic...

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