pharma & healthcare news june 2010

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Publisher: Alsiano A/SCirculation: 650 copies

Editor-in-chief: Anders Hager

Coordinator, text, lay-out: Dorthe Andersson

Contents

Organic ingredients ...............1

REBATEN - natural highintense sweetening ................2

Arolia - exclusive concentrated Acai extract ......3

Vitafoods 2010 - newsfrom our suppliers ..................4

4 effective trendy extracts from Afriplex ..........................5

New innovative ingredient for ODT .................7

News in brief ..........................8

The Alsiano Healthcareteam ........................................8

Organic ingredients

Pharma & Healthcare News is published twice a year and distributed to customers and other interested parties. Reproduction of articles appearing in Pharma & Healthcare News requires prior consent of the author. Alsiano is not responsible for the content of articles written by external authors.

Pharma & Healthcare News AlsianoNo. 12 • June 2010

Get an overview of our range of organic ingredi-ents for health supplements and nutraceuticals

Article 351

and sifted. It has a high pectin con-tent, useful for binding and thicken-ing, and is also high in dietary fibre. Applications: meal replacement, nu-tritional bars and drinks.

Organic rice starch The rice starch creates a soft and stable gel and is available in a native and a pregelatinised version. Appli-cations: starch-based excipients for tablets, sport nutrition (carbohydrate source).

Organic plant extracts We offer more than 50 different or-ganic extracts – e.g. rooibos, aloe vera, artichoke, green coffee, black-currant, milk thistle, and cranberry. Applications: food supplements.

Organic vegetable oilsWe offer a wide range of vegetable oils from different sources. They are also available in powder form for tablets and powders. Applications: health supplements, sports nutrition, meal replacements, nutrition bars, tablets, capsules.

If you require a specific product that is not listed here, please contact us, and we will do our best to support you. We may already be in touch with a potential supplier.

Alsiano is currently developing our product portfolio in accordance with the future needs and trends. We now see tendencies towards use of organ-ic ingredients in the health supple-ments and nutraceuticals industries. Therefore, we are presently expand-ing our range of organic ingredients. Right now, we can offer the ingredi-ents below in an organic version. This list will become more comprehensive in the years to come. Please do not hesitate to contact Alsiano if you have a need that isn’t on the list.

Organic inulin fibres from agave The agave fibres are made from or-ganically grown agave plants which naturally contain 25% inulin. It is a white powder with neutral taste and excellent solubility. Applications: slim-ming, digestive health.

Organic agave syrupThe agave syrup is made from the “quiote” (juice) of organically grown agave plants. The gentle production process makes sure that the “raw” properties of the agave syrup are pre-served. Agave sirup is available in 4 different grades. Applications: sport nutrition, nutrition bars.

Organic baobab fruit pulp powder Baobab is a superfruit. The natural fruit powder is free-flowing, milled

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Pharma & Healthcare News No. 12 • June 2010 Alsiano

REBATEN – natural high intense sweeteningWith a forthcoming European approval of stevia, Seppic is ready with an inter-esting range of this natural high intense sweetener, which is well suited for e.g. food supplements, drinks and pharmaceuticals

By Thierry Liot, Stevia Development Manager, Seppic

In September 2009, the French gov-ernment approved stevia extracts with 97 % purity Rebaudioside A (Reb A) as food and beverage sweet-eners by inter-ministerial decree, tak-ing advantage of a two year window that allows approval ahead of the rest of the EU. This has given the French company Seppic a great opportunity to achieve useful experience with the use of this natural high intense sweetener.

Legal status in EUStevia is not approved in EU yet, but just a few months ago the expert panel of the EFSA (European Food Safety Association) expressed a posi-tive recommendation on the use of steviol glycosides in foods and beve-rages, emphasizing quality standards as expressed by JECFA (Joint FAO/WHO Experts Committee on Food Additives). This document is paving the way to a European approval, ex-pected by end 2010 or early 2011.

The REBATEN rangeBased on the recommendations ex-pressed in this document, it is SEPPIC’s intention to propose 4 JECFA-com-pliant grades for industrial appli-

cations (food, beverages and phar-maceuticals) and one specific grade for a ready-to-use powder table top sweetener – see table below. With these 5 grades, Seppic covers the en-tire panel of applications that Euro-pean producers are looking for (taste profile, corresponding to application, manufacturing constraints, cost/sweetness ratio, …).

REBATEN 97% in food supplements and drinksDue to its great stability and solubil-ity, REBATEN 97%, Stevia extract, can easily be used in low-calorie or no sugar added food supplements. The maximum usage dosage (expressed in Rebaudioside A) authorised by French regulation is as follows:

• Liquid food supplements - 600 mg/kg

• Solid food supplements - 2000 mg/kg

• Vitamin- and/or mineral-based food supplements in syrup or chewable form - 5500 mg/kg

Likewise because of its great stabi-lity and solubility, REBATEN 97% Ste-via extract can be used as a natural sweetener in a wide range of drinks like slimming drinks, energy drinks,

vitamin-enriched drinks, etc. This also makes it ideal for formulating low calorie or no added sugar drinks.

REBATEN 97% advantages• Improved flavour • No sugar, fewer calories! Reduced

calorie content • Low glycaemic index • 100% natural origin (Stevia plant

extract) • Ideal for formulating sugar-free

food supplements

Industrial benefits• Intense sweetness• High stability in terms of pH, light

and heat• Water soluble• Non fermentable• Good digestibility

continues on page 3 >>

Rebaten 97

Rebaten 90

Rebaten 80

Steviten Light

Sweepia Light

Description

Premium grade

Standard high purity grade

Medium grade for applications with strong cost constraints and with other ingredients in the end-product formula that can hide off-taste

Blend of stevion glycosides

Blend of high purity Rebaten 97 with Erythritol and a natural aroma

Appearance

White crystalline powder





Reb. A (%) min.

97

90

80

10

3

total steviol glycosides %

97

95

95

95

3

Typical sweetness

factor

300

270

240

150

5

Applications

Beverages, dairy, table top sweeteners and other applica-tions wherein a premium taste is required

Beverages

Bakery, dietary supplements, pharmaceuticals

Pharmaceuticals, marinated products, pickles and seasoning

High quality table top sweet-ener in spoonable form

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Health benefits of AroliaAnthocyanins and proanthocyanidins are Arolia’s active principles. They be-long to a specific group of polyphe-nols called flavonoids and have a high antioxidant activity. ORAC (Oxygen Radical Absorbance Capacity) assay is the most commonly used method to evaluate the antioxidant activity of a product. This assay was performed to compare the antioxidant capacities of Arolia, its raw material (acai pulp) and several fruit pulps whose ORAC values are indicated in the Antioxi-dant U.S. Department of Agriculture database published in 2007.

Acai pulp has the highest ORAC value among other black/purple pig-mented fruits. Moreover, Arolia anti-oxidant capacity is respectively 2 and 27 times higher compared to freeze dried acai and acai pulp, respectively. These data show the importance of the extraction process designed to concentrate acai specific components responsible of the high antioxidant effects in Arolia.

In conclusion, one gram of Arolia is equivalent to 2,700 ORAC units and covers 65% of the recommended daily antioxidant intake.

Arolia – exclusive concentrated Acai extractOne gram of Arolia, which is equivalent to 2,700 ORAC units, covers 65% of the recommended daily antioxidant intake. Arolia can therefore easily complete the other antioxidant sources to reach the recommended level

Arolia is a natural exclusive extract of acai berries containing 2% proan-thocyanidins. The extraction process, developed by BIOPHYTIS, is specifi-cally designed to preserve and con-centrate the most interesting com-ponents of the acai berry. Arolia’s antioxidant capacity is triggered and its content in lipids is reduced in com-parison with acai berry and freeze-dried acai pulp.

Traceability and sustainability is to-tally implemented from the plant to the extract. Plants are strictly selected and the acai is harvested and pro-duced in Brazil. BIOPHYTIS extraction plant is located in Atibaïa, Brazil.

Being an alimentary extract of the ed-ible part of a food plant, Arolia has been approved as a food ingredient by French regulatory authorities, and can therefore be used for dietary sup-plements and functional foods.

About acaiAcai is the fruit of the palm tree acaizeiro which is typical from Ama-zonian lands. Acai berries have been traditionally consumed by native Americans from this region and have been recognised as healthy food due to their number of active principles with health benefits: fibres, mono- and poly-unsaturated fatty acids, phytosterols, phenolic compounds, vitamins and minerals.

Quality Commitment To ensure the confidence and satis-faction of its customers in accordance with regulatory requirements, SEPPIC has a sustainable progress policy fo-cused on the control of risks and a Quality Hygiene Safety and Environ-mental management system.

As a partner of the pharmaceutical, nutrition, and cosmetics industry, SEPPIC integrates and implements all relevant reference systems in its man-agement system.

About steviaBetter known simply as stevia, Stevia rebaudiana is a wild herb which originates from the sub-tropical forest located on the border of Paraguay and Brazil. However, today, stevia is also cultivated in East Asia, including China, Korea, Taiwan, Thailand, and Malaysia.

Steviol glycosides are what give Stevia leaves their sweet flavour. These compounds are 40 to 300 times sweeter than sucrose (table sugar). Among all steviol glycosides contained in the Stevia leaves, the following can be mentioned:

• Stevioside represents 5-10% of the dry matter (250 – 300 times sweeter than sugar). This substance has a bitter, mentholated taste.

• Rebaudioside A represents 2- 4% of the dry matter. This is the sweetest substance (200 to 400 times sweeter than sugar), and it has no bitter taste.

• Rebaudioside C represents 1- 2% of the dry matter.• Dulcoside A represents 0.5-1% of the dry matter.

Characteristics• Proanthocyanidins: 2%• ORAC: 2,700 µmol TE/g• Red-purple fine powder• Water soluble• Taste/odour is characteristic of the

fruit• Heat stable up to 80°C for a few

seconds• Labelling: acai extract, cassava flor

Applications• Beverages• Dairy products• Ice cream• Dietary supplements

Recommended dosage: 1g/day

Article 353

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Article 352

By Seppic

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Vitafoods 2010 - news from our suppliers

mune system, normal thyroid func-tion and normal spermogenesis. Lynside® Forte selenium has high bio-availability and is authorised in foods - including food supplements – at a European level.

Afriplex - rose hip & baobabAt Afriplex’s booth, the focus fell on two of their extracts: rosehip and baobab which are suitable for e.g. drinks. Baobab offers opportunities for improvements in the overall nu-tritional profile of various products. For instance, it contains higher levels of calcium than milk, other fruits and “superfruits”. Of other key nutrition-al properties it is also worth mention-ing that baobab has a high content of dietary fibre, antioxidants, iron, potassium and magnesium.

Rose hip is regarded as a natural herb and is an excellent source of vitamins A, D, E and C as well as a range of antioxidant bioflavonoids. Rose hip can be used in a wide range of appli-cations and is avail-able as powder ex-tract, finely milled powder, and oil. Read more about rose hip and other products from Afriplex on page 5.

New SEDOX® dry extract from EPOEPO introduced their brand new SE-DOX® dry extract with double stan-dardisation, i.e. 1% verbascoside and 5% total phenols.

This extract has been developed by EPO as a completion of their SEDOX® range, which already includes the fluid extracts available both with and without ethanol. Besides its antioxi-dating action, this extract is recom-mended ... continues on page 5 >>

Vitafoods 2010 offered many interesting products and news from Alsiano’s suppliers such as microencapsulated solubiliser, baobab and rosehip extract for e.g. beverages, selenium-enriched yeast and microalgae

Vitafoods 2010 is over for this time. Visitors came from all over the world to visit the exhibition which hosted over 500 international exhibiting companies. Here is a brief overview of what our suppliers chose to show-case at Vitafoods 2010:

Roquette: Much more than just ingredients The Roquette group presented its ingredients, active agents and ex-cipients. Reflecting the group’s well-known scientific and technical skills, they offer the nutraceutical industry the opportunity to achieve its ambi-tions both more creatively and more quickly.

Today, nutrition and health are every-one’s priorities. Always responsive to such priorities, Roquette is:

• Helping bring about better ba-lance in nutritional intakes with its range of NUTRALYS® proteins of vegetable origin (the pea) and its NUTRIOSE® fibres (from wheat and maize). Likewise its microalgae product ALGOMED®, and specifi-cally Chlorella, with its unique nu-tritional composition.

• Opening up new perspectives in the fields of satiety and digestive health with its NUTRIOSE® fibres. Its NUTRALYS® proteins also have a natural role to play in the satiety field.

• Contributing to the uptake of lutein, a pigment involved in ocu-lar health. Based on a new lutein-rich form, this Chlorella is a recent addition to the Roquette range.

• Offering a range of high-perform-ance excipients through its com-plete range of DC Polyols (manni-tol, maltitol, sorbitol, xylitol) newly completed with PEARLITOL® Flash, a mannitol compound made from two natural origin ingredients for orodispersible tablets technology, and LYCOAT® - a film-forming starch for original coating solu-tions.

New microencapsulated solubiliser from SeppicSEPPIC’s latest innovation is dedi-cated to oral solid drug formulations, in which solubilizers are needed. A new innovation is SEPITRAP™, mi-croencapsulated solubilizer (MES), which opens up new possibilities for utilising more effectively poorly water soluble drugs, by improving their so-lubility and thus their bioavailability.

SEPITRAP™ is supplied in powder form and can be used in direct com-pression. It is recommended for tablet formulations up to 20% (SEPITRAP™ 80) and 15% (SEPITRAP™ 4000). It is also possible to use this new MES to formulate capsules.

SEPITRAP™ meets all the require-ments of the current USP/NF regar-ding manufacturing of pharmaceuti-cal ingredients.

Lesaffre – EFSA approved selenium enriched yeastLesaffre showcased Lynside® Forte Se +1200 and Se +2000, selenium-enriched yeast, which is an excellent ingredient for antioxidative and im-mune formulations. The products contribute to the protection of body cell constituents from oxidative dam-age, the normal function of the im-


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4 effective trendy extracts from Afriplex Afriplex offers a wide range of plants extracts made from plants indigenous to the African continent. Among these are Buchu, Pelargonium sidoides and Irv-ingia, which - together with Rose hip - are of great interest at the moment for health supplements due to recently published studies

By Annette Strarup, Area Sales Ma-nager, Alsiano

Pelargonium sidoides for immune health/coldsThe Pelargonium is successfully em-ployed in the modern phyto-therapy in Europe to cure infection diseases in the respiratory tract. Until recently, a German company have had mo-nopoly on Pelargonium supple-ments, but their patent expired last year and Pelargonium extract is thus now available for use for everybody.

Pelargonium is a South African indigenous plant and has been used for centuries by the Zulu as a traditional remedy in the treat-ment of upper respiratory tract ir-ritations such as cough, fever and bronchitis. In the 19th century, the South African drug ‘Umckal abo’ became known in Europe where the pink-flowered Pelargo-nium renifine and the very similar but dark maroon-red flowers of Pel-argonium sidoides are ingredients in a German medicinal remedy called ‘Umckaloabo’.

Modern human studies comprise two relatively new ones: a study on com-mon colds from 20071) and a study from 20032) on the efficacy on acute bronchitis.

Besides extract in powder form, Pel-argonium sidoides from Afriplex is also available as a liquid solution. Ap-plications: tablets, capsules, mixtures.

Irvingia extract for weight loss for the US and Asian marketIrvingia extract is now available from Afriplex, due to high demand from

emptying and allow for a more gra-dual absorption of dietary sugar. Ini-tial studies have suggested that the high fibre content of Irvingia account-ed for its beneficial metabolic effects, but recent animal studies suggest other factors as well. Researchers are studying Irvingia for its potential use in treating diabetes, metabolic syn-

drome and obesity.

In a study of 40 obese Cameroonian patients done in 2005, signifi-cant decreases of body weight, total cholesterol, LDL or ‘bad cholesterol’ and triglycerides were ob-served by the end of the 10 weeks’ study. A 2008 study based on 102 obese patients3) indicated similar results with lower dosages of Irvingia extract. 150 mg seed extract twice a day for 10 weeks reduces

weight by 13 kg compared to 0.7 kg for placebo. More evidence is needed about long term safety and efficacy, but already now Irvingia is a popular natural ingredient for weight loss es-pecially in the US.

Irvingia is available in powder form. Applications: tablets, capsules, chew-ing gum. Continues on page 6 ...>>

the US and the Asian slimming mar-ket. However, Irvingia is not formally approved in EU yet.

Irvingia garbodensis is the official name of the West African fruit tree commonly known as bush mango or African mango. The seeds of the bush mango contain water-soluble dietary fibres that delay stomach

Rose hip

IrvingiaPelargonium

Buchu

for treatment of diseases of the respi-ratory tract, thanks to its expectorant, bechic and antispasmodic properties.

JostEuropean regulations are getting more and more precise and restrictive regarding the levels of contaminants in food and nutritional products. As far as heavy metals are concerned,

there are a number of existing regula-tions that concern mineral salts.

Jost Chemical has been producing guaranteed high-purity minerals for nearly 25 years and is now also well-known for having developed a new technology for the manufacturing of ultra-pure calcium salts for infant for-mulations and drink applications.

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Article 354

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FoodNews No. 1 • February 2004 AlsianoPharma & Healthcare News No. 12 • June 2010 Alsiano

ageing. During World War II rose hip syrup was an important source of vi-tamin C for children.

Over time, several studies have been made. A human study of a rose hip remedy called LitoZin4) showed pos-sible benefits to rheumatoid arthritis sufferers. Seventy-four people, most-ly females, took part in the six-month trial. Just under half took the rose hip remedy LitoZin while the others took a placebo. Both groups conti-nued to take their usual medication. According to results, activity among the group taking the rose hip remedy improved by 20-25%. The number of joints causing pain or discomfort fell by 40%, but did not change for those treated with placebo.

Rose hip from Afriplex is available in powder form and as essential oil. Applications: tablets, capsules, bever-ages.

References1) Chuchalin, AG, Benan B, Lemacher, W : Ef-ficacy of Pelargonium sidoides preparation in patients with common cold, Explore 2007, 3: 573-84

2) Heinrich Matthys : Efficacy and safety of an extract of Pelargonium sidoides preparation in adults with acute bronchitis, International jour-nal of Phytotherapy and Phytopharmacology, May 1, 2003.

3) J.L. Ngondi, B.C. Etoundi et al : IGOB131, a novel seed extract of the West African plant Irvingi gabodensis, significantly reduces body weight and improves metablic parameters in overweight humans, Lipids in Health and Dis-ease, 2009, 8:7

4) Willich SN, Rossnagel K, Roll S, et al. “Rose hip herbal remedy in patients with rheumatoid arthritis - a randomised controlled trial”. Phy-tomedicine 17 (2), February 2010: 87–93.

No scientific evidence is available to justify Buchu´s herbal uses, but the diuretic and anti-inflammatoric ef-fect may be attributed to the vola-tile oil and flavonoid’s irritant nature. Despite the lack of evidence, buchu is still used today in western herbal medicine for urinary tract ailments. It is also used in combination with other herbs such as cornsilk, juniper, cranberry and uva-ursi.

Buchu from Afriplex is available as water extract spray-dried to malto-dextrin, essential oil and ethanolic ex-tract. Applications: tablets, capsules, cosmetics.

Rose hips for joint health applicationsRose hips are the fruit of the rose spe-cies Rosa canina. The fruit is ready to be harvested when it changes colour from green to bright red during early winter in South Africa.

The fruit contains mono- and digly-cerol (also known as G.O.P.O.) exhibit-ing anti-inflammatory properties and is therefore often used in joint health applications. Rose hip also contains an excellent source of vitamin C and antioxidant bioflavonoids. The carto-noids present in rose hips are beta-carotene, lycopene, betacryptoxan-thin, zeaxanthin, and lutein.

The benefits of rose hips have been known for centuries. Historians say the Vikings used rose hips to stave off scurvy on their long sea voyages and in the past, rose hips have been used across the world to treat a number of conditions, from arthritis, colds and flu to bladder stones and premature

Buchu for urinary tract infectionBuchu (Agathosma betulina) is a low growing shrub native to Cape Town, South Africa. It is part of the cultural heritage of the San and Khoi people as a stomach tonic and to treat uri-nary tract infections. Today, Buchu is widely used as a household medicine in South Africa, with a great repu-tation for treating kidney and uri-nary tract diseases. Buchu was first exported to Britain in 1790, and in 1821 it was listed in the British phar-macopoeia as a medicine for ‘cystitis, urethritis, nephritis and catarrh of the bladder’. Buchu is also listed in German Commission E Monographs and has moreover been consumed as herbal tea in Germany for decades.

The main compounds in the essential oils of Buchu are isomenthone and diosphenol (Buchu camphor). The fla-vour oil of Buchu has a characteristic blackcurrant smell and flavour. The essential oils are generally used be-cause of their antiseptic and diuretic properties. Buchu leaves also contain the flavonoids rutin, diosmin, hespe-ridin, and quecetin. The dry leaves are used in herbal preparations and contain around 3% essential oil.

Afriplex – the essence of AfricaAfriplex is a strong player in the international plant extract mar-ket, specialising in extracting the essence of Africa. The company specialises in providing high quality plant extracts for beverage, phar-maceutical, cosmetic and other applications. The extracts are pro-duced in client specific formats, thereby ensuring satisfactory prac-tical application to the client.

Name of extract

Pelargonium

Irvingia

Buchu

Rose hip

Baobab pulp

Rooibos

Kigelia

Aloe vera

Aloe ferox

Devil’s claw

Botanical name

Pelargonium sidoides

Irvingia gabodensis

Agathosma betulina

Rose canina

Adansonia digitata

Aspalathus linearis

Kigelia Africana

Aloe vera

Aloe ferox

Harpaghytum procumbens

Active

Coumarins, scopoletin

Seed fibre

Diosphenol, flavonoids

Vitamin C, GOPO

Pectin, amino acids, polyphenols, vitamin C

Asphilithin

Steroidal saponins

Aloin, polysaccharides

Aloin, polysaccharides

Harpagoside

Properties

Immune health/colds

Weight loss

Urinary tract infections,flavour enhancer

Joint health

Beauty from within, diges-tive health, energy booster

Antioxidant, skin nutrient

Suncare

Digestive health

Digestive health

Joint health

Article 355

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New innovative ingredient for ODTPEARLITOL® Flash is a new innovative compound excipient from Roquette for successful development of fast disintegration formulations such as orodisper-sible tablets

Directly compressibleThanks to its excellent compactibility, PEARLITOL® Flash makes possible the manufacture of good mechanically resistant tablets by direct compres-sion.

Under studied conditions, Korsch XP1 press fitted with 13 mm diame-ter flat bevelled-edge punches, 15kN compression force was sufficient to obtain 500 mg orodispersible tablets with acceptable hardness, friability and disintegration time characteris-tics.

Regulatory statusThe use of PEARLITOL® Flash in fast disintegrating tablets or orodispers-ible formulation tablets is suitable for both pharmaceutical and nutraceuti-cal applications. PEARLITOL® Flash is a compound of mannitol and extra white maize starch. Both ingredients comply with pharmaceutical com-pendial standards and food regula-tions. A US DMF type IV (excipient) is registered at the FDA.

PEARLITOL® Flash – ideal for ODT To sum up, the requirements for the ideal excipient in ODTs are good compatibility, fast disintegration and a nice mouth-feel (sweetener). PEARLITOL® Flash is an excipient that possesses all these abilities.

By Anders Hager, Sales Manager Healthcare, Alsiano, & Elham Blouet, Pharmaceutical Project and Develop-ment Manager, Roquette.

What kind of technology can achieve a fast delivery of active ingredients inside the mouth in 2 ml of water? The orodispersible dosage form has the characteristic feature of requiring neither water nor chewing during its administration - orodispersible tab-lets (ODT) disintegrates in the pres-ence of saliva.

ODT are uncoated tablets intended to be placed in the mouth where they disperse rapidly before being swallowed. Besides the fact that the ODT dosage form is one among oth-er means of extending the product lifecycle, this modern medication de-livery system offers various benefits:

• Easy to swallow – e.g. geriatric and paediatric populations

• On-the-go use – does not require drinking water as with a conven-tional tablet

• Better patient compliance - e.g. at-tractive mouth-feel

PEARLITOL® Flash: An innovative compound excipientBased on their wide experience with mannitol (PEARLITOL®), Roquette has developed an innovative binary com-pound excipient, PEARLITOL® Flash, which is composed of mannitol and maize starch.

PEARLITOL® Flash offers a technol-ogy that enables successful develop-ment of fast disintegration formula-tions such as ODT by providing:

• A uniquely pleasing taste• Fast melting in the mouth• Smooth texture• An easy DC tabletting process• A robust DC excipient• A surprisingly simple formulation

PEARLITOL® Flash provides a uniquely pleasing taste experience. The oro-dispersible tablets melt in the mouth with a very creamy and smooth tex-ture.

Contrary to usual orodispersible for-mulation tablets, no superdisinte-grant is needed, since PEARLITOL® Flash mannitol compound exhibits self-disintegration properties. In ad-dition, a low lubricant level (0.4%) is sufficient to achieve good compres-sion performance. This low level is beneficial to maintain the pleasant taste of PEARLITOL® Flash, whereas a high level of lubricant could compro-mise it.

Fast melting in the mouthOrodispersible tablets formulated with PEARLITOL® Flash, 0.4% of lu-bricant (magnesium stearate) and active substances from 2% up to 30%, display a very quick disintegra-tion time (Eur.Ph. method): 50-80 sec onds. This disintegration time is far below the “within 3 minutes” disin-tegration time required by the Eur.Ph. for orodispersible tablets.

Article 356

© - Roquette Fréres

Nice mouth-feelSweeteners

RobustnessHighly compres-

sible filler

Rapid disintegrantDisintegrant

PEARLITOL® Flash

8


The Alsiano Healthcare teamIt is always nice to be able to put a face on the person you talk to over the telephone or e-mail. So here we are ...

Lene Baldasano del Valle

Logistics manager

E-mail: [email protected]. dir.: +45 8230 0015

Logistics

Key accounts

Anders Hager

M.Sc. Chem.Sales manager

E-mail: [email protected]. dir.: +45 8230 0026Mobile: +45 2618 8545

Pharmaceuticals - cosmeticshealth & nutrition

Lene Aarøe Nissen

B. Chem. Eng.Area sales manager


Sales support

Birgitte Falkensteen

Sales assistant


Malene Rask Harder

Sales assistant


Sales support

Pharmaceuticals - cosmeticshealth & nutrition

Annette Strarup

B.Sc. (Hons.) Chem. Eng.Area sales manager


Pharmaceuticals - Fermentation

Annette Jarlskov

M.Sc. Food ScienceArea sales manager


Signe Mørck

Sales assistant


Sales support

We are pleased to announce that all our stock facili-ties in Denmark have now been united at one location at our warehouse in Karlslunde, south of Copenhagen. This warehouse will from now on function as the cen-tral warehouse for Alsiano Healthcare and Alsiano Food in the Nordic countries. The stock for Alsiano Industry is still located in Gothenburg. This new structure will secure a more efficient distribution of goods.

News in brief:Centralisation of stock activities at Karlslunde

Have a nice summer!

pharma & healthcare news june 2010

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