Cell Injury and Death Cell Injury and Death (Necrosis)(Necrosis)

Normal,kidney.GrossNormal,kidney.Gross Kidney,swelling.Gross.Note   Kidney,swelling.Gross.Note  

pallor compared to normal kidney pallor compared to normal kidney

Normal kidneyNormal kidney..  High power  High power..  Note   Note normal tubulesnormal tubules

Acute cellular oedema Acute cellular oedema ( cloudy swelling) Hydropic degeneration ( cloudy swelling) Hydropic degeneration

Electron micrograph of a renal tubular epithelial cellElectron micrograph of a renal tubular epithelial cell

Liver, Fatty ChangeLiver, Fatty Change

b. The fat vacuole distends the hepatocyte cytoplasm and b. The fat vacuole distends the hepatocyte cytoplasm and

displaces the nucleus off to one side displaces the nucleus off to one side

a. a. Normal liverNormal liver..  High power  High power.. The liver cell plates are apparentThe liver cell plates are apparent

Liver, fatty change. GrossLiver, fatty change. Gross

Normal Cell H&ENormal Cell H&E

Pyknotic NucleusPyknotic Nucleus

KaryorrhexicKaryorrhexic

KaryolysisKaryolysis

Coagulative Necrosis: HeartCoagulative Necrosis: Heart

Liquefactive Necrosis: BrainLiquefactive Necrosis: Brain

Caseous NecrosisCaseous Necrosis : : LungLung

•Granuloma Structure

Langhans giant cell Specific in tuberclosisLanghans giant cell Specific in tuberclosis

Foreign body giant cellForeign body giant cell

Pathology: the Hidden Science that Saves Lives Pathology: the Hidden Science that Saves Lives Pathology: is the Science behind the CurePathology: is the Science behind the Cure

• This pathology lab is prepared by, Dr. Omar Emad Ibrahim , Pathology Dep. Faculty of Medicine & Health Sciences, Thamar University .

• The images is taken from Pathology Second Edition by Alan Stevens .&, James Lowe.

• Atlas of Basic Histopathology.• The basis of Pathology Third Ed. by Neville Woolfe.

• Internet.