pancreatic cancer - national cancer institute pancreatic cancer is relatively rare (121/ 100,000...

Download Pancreatic cancer - National Cancer Institute Pancreatic Cancer is relatively rare (121/ 100,000 persons)

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  • Pancreatic cancer

  • Incidence and mortality

  • Deaths annually increasing

  • Risk factors

  • Types and stage

  • Early detection

  • Carbohydrate antigen 19-9

  • Glypican-1 positive exosomes

  • Carcinogenesis

  • Early stage disease

  • Neoantigen qualities

  • Cancer treatment

  • Immune checkpoint blockade

  • Novel immune therapies

  • Genetic alterations

  • Precision medicine

  • iExosomes

  • Complex microenvironment

  • Desmoplastic stroma

  • Cancer associated fibroblasts

  • Tumor heterogeneity

  • PDAC subtypes

  • Classical subtype

  • Chromosome structure

  • Stroma specific subtypes

  • Metabolic reprogramming

  • Stellate cells

  • RAS/MAPK

  • Trametinib plus HCQ

  • Drug delivery

  • Mouse model

  • Stroma targeting

  • Therapeutic response

  • Phase II trial

  • Hedgehog signaling

  • Tumor suppressor

  • Myoblast depletion

  • Overall survival

  • Anti-stromal therapy

  • Mesothelin

  • MSLN expression

  • MSLN threapeutics

  • Recombinant immunotoxin

  • Mechanism of action

  • LMB-100 plus paclitaxel

  • Active regimen

  • Anti-drug antibody

  • Decreasing ADA

  • Tofacitinib

  • Tocacitinib + LMB-100

  • Questions?

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