p783 effect of aspirin on endometrial receptivity and success of iui
TRANSCRIPT
Poster presentations / International Journal of Gynecology & Obstetrics 107S2 (2009) S413–S729 S635
measures in the form of all grains fortification and preconception
care and folic acid supplementation are needed.
Conclusion: National Flour fortification in Saudi Arabia did not
have the expected impact on reducing the incident of SB in Riyadh
area. Addition measures are needed.
P781
New directions in the provision of acute gynaecology services
for non-pregnant women in the UK
Y. Wan1, E. Edi-Osagie2. 1University of Manchester, 2St Mary’s
Hospital for Women & Children, Manchester
Background: Great strides have been made in the provision
of dedicated early pregnancy care, however acute gynaecology
services for non-pregnant women still suffer from a lack of
recognition.
Objectives: To explore the level of provision of acute gynaecological
care for non pregnant women in hospital trusts throughout the UK
and to identify effective care models.
Materials and Methods: A cross-sectional postal survey of health
care trusts providing pregnancy and gynaecological care in the UK
in 2008. A response rate of 38% (88/230) was achieved.
Results: 89% (78/88) of trusts provided acute gynaecology
services for non-pregnant women. 64% (50/78) of these
identified themselves as having dedicated acute gynaecological
assessment and/or treatment facilities. Early pregnancy and acute
gynaecological care was provided as joint units in 44% (22/50) and
separate units in 56% (28/50) of trusts.
Where there were separate premises, more out of hours care was
provided; 71% (17/24) versus 35% (8/23) provided 24 hour access
(p = 0.0199). 37% (29/78) of all trusts offering gynaecological care
had no dedicated ultrasound service compared with 1% of early
pregnancy units. 58% (45/78) of operating in acute gynaecology
occurs on emergency lists shared with other specialties whereas
36% (32/88) of early pregnancy lists are shared (p =0.0079).
Conclusions: There is a disparity in the provision of imaging and
theatre services for pregnant and non-pregnant patients despite
differing care models. This may lead to delays in diagnosis and
treatment for the non-pregnant patient. Opportunities for resource
sharing within acute gynaecology and early pregnancy services
need to be further explored in order to develop comprehensive and
accessible facilities.
P782
Evaluation of Sure Start Project – Providing specialised health
services to urban slums in Navi Mumbai
R. Wani1, U. Thanawala. 1FOGSI
Introduction: Navi Mumbai is a new township on the outskirts of
Mumbai having a population of 11 lakhs. As with any other city it
has its share of slums which houses 20% of the population.
This population generally, presents late for antenatal registrations,
has irregular follow ups & 10% of these women give birth at
home. This significantly contributes to morbidity and mortality
both maternal and neonatal.
Sure Start Project aims at targeting this population by way of
outreach antenatal clinics at Urban Health Post (UHP). 20 UHPs have
been selected where high risk patients are called for consultation
and examination by a senior specialist. This project aims at
providing regular antenatal care & immunization and thus creating
awareness of the importance of medical care among this population.
This hopes to bring about a behavioral change in the population
in terms of early ANC registrations, institutional deliveries which
would help in reducing maternal & neonatal mortality.
This public private partnership with Navi Mumbai Municipal
Corporation (NMMC), PATH International, Navi Mumbai Obstetric
and Gynecological Society (NMOGS), Indian Pediatric Association,
Sathi (NGO) and Yoga Niketan (For Yoga in ANC) was started in
February 2007.
Aim of our study: Analyse the Project to evaluate if the desired
impact has been made by the intervention in the last 12 months:
1. Induction of behavioral change in the population –
a. Awareness of health facility available
b. Early ANC registration and regular follow-up
c. Yoga exercises in ANC
d. No Home births
2. Health services provided –
a. Efficiency of link workers & UHP medical Officer in identifying
high risk cases in the population
b. Working and facilities at the High risk ANC clinic
c. Coordination with Mother and Child Health Centres (MCH) or
FRU (First Refferal Unit) to deal with high risk cases.
3. Parameters of health care in population
a. Maternal Mortality
b. Perinatal Mortality
c. Home deliveries
Results: It was observed that the recruitment of high risk cases
was not satisfactory in the first three months. This was because the
Link workers and the health officers were not used to the concept
of managing high risk antenatal at the UHP and all were sent to
MCH. But in the following months more cases were retained for
the clinics.
Awareness spread rapidly among the population and the women
were happy to receive specialist consultation at their doorstep.
Facilities available at the UHP (like a Doppler or basic ANC blood
investigations), which have now been sanctioned and we hope that
they will be available soon, so that the UHP is upgraded.
Analysis of the health parameters is pending on the collection of
population data from the registry.
Remarks of the Specialists – Obstetricians, Pediatricians, Yoga
trainers and NGO workers were also noted.
P783
Effect of aspirin on endometrial receptivity and success of IUI
A. Agarwal1, V. Das2, A. Pandey2, V. Jain2, S. Agarwal2, A. Ara2.1Dept. of Obs & Gynae, CSM Medical University (Former KGMC)
Lucknow, India, 2Dept. of Obs & Gynae, CSM Medical University
(Former KGMC), Lucknow, India
Objectives: To evaluate the effect of low dose aspirin on
endometrial receptivity and success of IUI.
Material and Methods: A double blind randomised controlled trial
was carried out in Deptt of Obs & Gynae, CSM Medical University
(former KGMC), Lucknow, India. 101 couple having undergone
intrauterine insemination without conception in at least 2 cycles
were enrolled after informed consent. They were randomised to
take either 150mg aspirin or placebo orally from Day 21 of cycle
prior to IUI cycle, for 2 months. All women underwent ovulation
induction with clomiphene citrate 100mg from day 2 to day 6. They
were followed for 2 cycles of IUI with aspirin/placebo. Pulsatility
index of uterine artery & endometrial thickness on Day 21 of IUI
cycles & conception rates of the two groups were compared using
SPSS software.
Results: There was statistically significant decrease in pulsatility
index and increase in endometrial thickness & folliculogenesis in
aspirin group as compared to placebo group.(p = 0.001, 0.001 &
0.023 respectively) The conception rate was 15.7% in aspirin group
as compared to 8% in placebo group.
Conclusion: Aspirin being a antiplatelet agent enhances uterine
and ovarian blood flow leading to better folliculogenesis and
improved endometrial receptivity thereby increasing conception
rates in patients having IUI failures.