oversigt over forskningsprojekter i hjertecentret ......the prognostic impact of supar on mortality...

Marts, 2018

Projekt titel Project title Kontakt/Contact (name, email)

NEO-Trail. A. radialis som graft. Randomiseret

undersøgelse af sekvelae efter skopisk vs åben høst

RCT on radial artery harvesting with open vs scopic technique.Peter Skov Olsen / C. Carranza / Louise Uth

[email protected]

SURTAVI Trial. Multicenter RCT. Stentklapper vs.

kirurgi.

SURTAVI Trial. Stentvalves vs surgery Peter Skov Olsen / L. Søndergaard / Gustav

Thyregod / Nikolaj Lilleør

[email protected]

CARPO. Radialis projekt RADIALIS Trial: Total arterial vs.conventional revascularisation: late outcome. Peter Skov Olsen / S. Damgård

[email protected]

FICS. Sammenholde de skrøbelige/svagelige patienter

i hjertekirurgi, i forhold til de ikke-skrøbelige/svagelige

patienter.

FICS - Frailty in Cardiac Surgery - Copenhagen StudyPeter Skov Olsen / Christian Møller / Caroline Beck

[email protected]

FAME 3: Patienterne randomiseres til FFR-guided PCI

til pt. med 3 VD vs. CABG best praxis.

Primær efekt mål: Efter 1 år - Død, MI, Stroke og

revaskularisering

Fractional Flow Reserve versus Angiography for Multivessel Evaluation (FAME) 3 TrialProjekt ansvarlig: Gustav Thyregod

Projektkoordinator: Camila Larsen

[email protected]

Glorius Glorius: Efficacy of GLP-1 agonists and restrictive vs. liberal FiO2 in patients undergoing open

heart surgery a 2-by-2 factorial designed, randomized clinical study.Projekt ansvarlig: Peter Skov Olsen/ Hanne Ravn /

mfl. [email protected]

Rivaroxaban vs. Asparin Rivaroxaban vs. Asparin Peter Skov Olsen / Nikolaj Lilleør / Camilla Larsen

[email protected]

NOTION II NOTION II Peter Skov Olsen / Lars Søndergaard / Gustav

Thyregod / Nikolaj Lilleør / Camilla Larsen

[email protected]

The Nordic experience with the Medtronic freestyle

stentles bioprotesis as a full root.

The Nordic experience with the Medtronic freestyle stentles bioprotesis as a full root. Morten Smerup, MD PHD -

[email protected] / Hanna

Dagnegård - [email protected]

TACSI trial Dual antiplatelet therapy with ticagrelor and acetylsalicylic acid (ASA) vs. ASA only after

isolated coronary artery bypass grafting in patients with acute conary syndrome (TACSI trial) Christian Møller MD PhD / Nikolaj Lilleør

[email protected]

Oversigt over forskningsprojekter i Hjertecentret / Research Projects, The Heart Centre

Thoraxkirurgisk klinik

Department of Cardiothoracic Surgery

Forskningsområde/subject: Hjertekirurgisk forskning/Cardiac surgical research

Forskningsområde/subject: Klassisk thoraxkirurgi (General thoracic surgery)


Værdien af kirurgi i behandlingen af malignt pleuralt

mesotheliomSurgical treatment of malignant pleural mesothelioma Jesper Ravn, Email:[email protected]

Værdien af lymfadenektomi ved pulmonal

metastasekiurgi ved Colo-rektal cancer Randomiseret studie Kåre Hornbech, Jesper Ravn, Rene Petersen,

Henrik Jessen HansenOsteosyntese til behandling af costafracturer Osteosynthesis in the treatment of rib fractures Jesper Ravn

Stratos osteosyntese til behandling af pseudartrose Stratos osetosynthesis in the treatment of pseudarthrosisBodil Brandt, Email:[email protected]

Respirationsstyrke m.m før og efter operation for

pectus excvavatum Respiratory strength and QOL before and after surgery for pectus excavatumBodil Brandt

Phd Projekt. Simulationsbaseret Læring af minimal

invasiv lungekirurgi PhD Project: Simulation based learning of minimal invasive lung surgery

Katrine Jensen, Email:[email protected]

PhD Projekt. Team træning af Ikke tekniske

færdigheder ved VATS kirurgi som en metode til at

forbedre resultater

PhD Project: Team training of non technical skils in VATS surgery as a method to improve

outcome

Kirsten Gjeraa, Email: [email protected],

Lars Konge. Email: [email protected], Rene

Horsleben Petersen

PhD projekt; Fast track VATS kirurgi PhD project: Fast track VATS surgery

Bo Laksafoss Holbek, Rene Horsleben Petersen

PROLUCA: Værdien af Perioperativ Rehabilitering ved

Operation for lungecancer- et randomiseret klinisk

forsøg med blindet effektmålsvurdering.

PROLUCA; Effect of perioperative rehabilitation in surgery for lung cancer- a randomised

clinical trial.

Jesper Holst,

Email:[email protected]

Det danske projekt med screening for lungecancer Danish Lung Cancer Screening Trial (DLCST) Jesper Holst

NSCLC stadie IIIA-N2 protokol NSCLC stage IIIA- N2 disease protocol Jesper Holst:

Prospektiv opfølgning af bronko- og angioplastiske

operationer ved lunge cancer

Prospective follow up of broncho- and angioplastic procedures for lung cancer Phillip Ryom, Jesper Holst

Multimodal behandling af maligne tumorer i thymus Multimodality treatment of thymic malignancies Jesper Holst, Rene Horsleben Petersen, Bodil

Brandt, Jesper Ravn

Forskningsområde/subject: Forskning i klinisk sygepleje / Clinical nursing research

Projekt titel Project title Kontakt/Contact

RAPIT - opfølgning af patienter efter intensiv terapi RAPIT - a follow-up of patients af intensive therapy Sanne Nielsen, Email:

(PhD projekt af Janet Froulund) [email protected]

mailto:[email protected]


Effekten af hyperoxi på coronar arteriel

blodgennemstrømning efter coronar bypass

The effect of hyperoxaemia on coronary artery bloodflow after coronary artery bypass grafting Hasse Møller Sørensen, (peter.hasse.moeller-

[email protected])

Stig Kofoed Jacobsen

Forskningsområde/subject: Højre ventrikel /dys-)funktion/Right ventricular (dys-)function


Ændringer i TAPSE under ukompliceret CABG Changes in TAPSE during uncomplicated CABG Andre Korshin, Hasse Møller Sørensen, Jens

Christian Nilsson, Hanne Berg Ravn, E-mail:

[email protected]

Hø. Ventrikel dysfunktion efter hjertekirurgi Right ventricular dysfunction af cardiac surgery Lars Grønlykke,Finn Gustafsson, Jens Christian

Nilsson, Hanne Berg Ravn, E-mail:

[email protected]

Forskningsområde/subject: Klassisk Thoraxanæstesiologi / Thoracic anaesthesia


Fast track video-assisteret thorakoskopisk kirurgi Fast track video assisted thoracoscopic surgery Lars Bjerregaard, Hasse Møller Sørensen, Henrik

Kehlet Email:[email protected]

Postoperative komplikationer og mortalitet hos

esophagusresecerede patienter

Outcome in patients with anastomosis leakage after surgery for c. esophagii Sebastian Roed Rasmussen, Rikke Vibeke Nielsen,

Mette Siemsen, Hasse Møller-Sørensen, Hanne

Berg Ravn, E-mail: [email protected]

Den prædiktive effekt af genom, biomarkør og

mikrobiom profil på graft kvalitet i human ex vivo lunge

perfusion

The effect of genome, biomarker and microbiome expression profiling on prediction of graft

performance in human ex vivo lung perfusion

Rikke Vibeke Nielsen, Hanne Berg Ravn, Hasse

Møller-Sørensen. E-mail:

[email protected]

Department of Cardiothoracic Anaesthesiology

Thoraxanæstesiologisk Klinik

Forskningsområde/subject: Basal fysiologi / Basic physiology

Forskningsområde/subject: Cardiopulmonal bypass / Cardiopulmonary bypass


Perfusion - Pressure - Cerebral - Infarct (PPCI) studiet Perfusion - Pressure - Cerebral - Infarct (PPCI) trial Anne G. Vedel, Jens Chr. Nilsson


Associationen mellem akut nyresvigt og hjertekirurgi Acute kidney injury and the association to cardiac surgery Cornelius Helbo Jakobsen, Rikke Vibeke Nielsen,

Kristian Kandler, Jens Christian Nilsson, Hanne

Berg Ravn, E-mail:

[email protected]

Effekten af MAP på hæmatokrit under CPB The effect of mean arterial pressure on haematocrit during CPB Anne-Sophie Fenger, Anne Grønborg Vedel,

Sebastian Roed Rassmussen, Frederik Holmgaard,

Jens Christian Nilsson, Hanne Berg Ravn, E-mail:

anne.grønborg. [email protected]

Near Infrared Spectroscopy under hjertekirurgi Evaluation and V alidation of Ne ar Infrared Spectroscopy for detection of N eurological

Complicat ions in Cardiac S urgery (EVeNtS) Frederik Holmgaard, Jens Chr Nilsson, Hanne Berg

Ravn, E-mail: [email protected]

PERSIST:Retrospektivt studie til identifikation af

risikopaitenter for SIRS efter CPB (del af

PERSIMUNE)

PERSIST: PERsonalised management of Systemic Inflammatory response using

cardiopulmonary bypasS Technique Post.doc Rikke Vibeke Nielsen, Hasse Møller-

Sørensen, Jens Christian Nilsson, Peter Skov

Olsen, Jens Lundgren, Søren Boesgaard, Hanne

Berg Ravn. E-mail: [email protected]

Potentialet i tarmens mikrobiom til at forudsige død og

komplikationer efter hjertekirurgi

Gut microbiome after cardiac surgery: The changes in gut microbiome composition after

cardiac surgery and differences between complicated and uncomplicated surgical courses

Chaoqun Zheng, [email protected],

Rikke Vibeke Nielsen,

[email protected]

Udvikling og validering af metaboliske biomarkører,

der kan identificere patienter med åndenød i risiko for

udvikling af akut lungeskade

Validation of new biomarker in patients following surgery-induced lung injury (VERIFY-LUNG-

INJURY)

Post. Doc Katrine Buggeskov, Raluca Maltesen,

Bodil Steen Rasmussen, Hanne Berg Ravn. E-mail:

[email protected]

GLP-1 agonist og ilt behandling til organbeskyttelse

ved hjerteoperation (GLORIOUS)

GLP-1 agOnist and Restrictive vs lIberal FiO2 in patients Undergoing open heart Surgery

(GLORIOUS)

Jens Christian Nilsson, Peter Skov Olsen, Christian

Hassager, Hanne Ravn, Jesper Kjærgaard, Lars

Køber.

Impact of health care system delay in patients with acute aortic dissection Raphaelle Chemtob, Hasse Møller-Sørensen, Lene

Holmvang, Peter Skov Olsen, Hanne Berg Ravn. E-

mail: [email protected]

Forskningsområde/subject: Kongenit Hjertekirurgi / Congenital Heart Surgery


Overlevelse, indlæringsvanskeligheder og kognitiv

funktion efter pædiatrisk kongenit hjertekirurgi

Neurodevelopmental outcome in adolescents after CHD surgery Line Holst, Morten Helvind, Niels Vejlstrup, Hanne

Ravn. Email:

[email protected]

Neurodevelopmental outcome in adolescents after CHD surgery - questionnaire Jonas Byriel Kronborg,

[email protected], Line Holst,

[email protected]

Forskningsområde/subject: Intensiv terapi / Critical care


Tidlig opsporing af akut lungesygdomEarly diagnosis of acute lung injury Emilie Risom, Katrine Buggeskov, Hanne Ravn, E-


Betydning af HSV reaktivering under kritisk sygdom

(Herpes ICU)

Influence of HSV reactivation during critical illness Søren Find Aalbæk Madsen, Praleene Sivapalan,

Jesper Brøndum Poulsen, Hanne Berg Ravn, E-


Gennemgang af litteratur vedrørende etiske

overvejelser om terapibegrænsninger på intensivAccepting the avoidable death, the philosphy of limiting intensive care Marc Sørensen, Lars Willy Andersen, E-mail:

[email protected]

Den prognostiske værdi af suPAR på mortalitet og

morbiditet efter hjertekirurgi

The prognostic impact of suPAR on mortality and major complications after cardiac surgery Maria Dons, Hanne Berg Ravn, Rasmus

Møgelvang, Rikke Vibeke Nielsen. E-mail:

[email protected]

Postoperative complications and survival after surgical resection of esophageal squamous cell

carcinoma

Sebastian Roed Rasmussen, Hanne Ravn, Mette

Siemsen, Email:

[email protected]

Forskningsområde/subject: Måleteknik / Measurement technique


Vektor Flow til estimering af blodets hastighed og flow-

kompleksitet omkring aorta- og mitralklapperne

Vektor Flow to estimate blood velocity and flow complexity at the aortic and mitral valves Hasse Møller Sørensen, Kristoffer Lindskov

Hansen, Jesper Kjærgaard (Kardiologisk Klinik)


Sammenligning af perifer versus centrale venøse

gasser

Central and peripheral measurements of venous oxygen saturation and lactate in cardiac

surgical patients"

Raphaelle Chemtob, Hasse Møller-Sørensen,Hanne

Berg Ravn, e-mail: [email protected]

Metodevalidering af TEG6S' platelet mapping i

sammenligning med Multiplate

Validation of a new technique with platelet mapping in comparison with Multiplate Praleene Sivapalan, Pär Johansson, Sisse

Ostrewski, Hanne Berg Ravn, E-mail:

[email protected]

PICCU vs. termodilutionsbaseret teknik til måling af

hjertets minutvolumen

PICCU vs. thermodilution technique for the measurement of cardiac output. Hasse Møller-Sørensen. E-mail: peter.hasse.moeller-

[email protected].

Systematic review of the association of venous oxygenation and outcome in adult hospitalized

patients

Raphaelle Chemtob, Hasse Møller-Sørensen,

Anders Perner, T.G. Eskesen, Hanne Berg Ravn, e-


Forskningsområde/subject: Forskning i klinisk sygepleje / Clinical nursing research


Anlæggelse af dobbeltløbet tube, Vivasigth-DL til

patienter der undergår lungeoperation

How does the staff perform with intubation using the Double Lumen Tube, Vivasight-DL; A

single center, prospective observational study Carsten Michel Pedersen

[email protected]

Effekt af tidlig intensiv mobilisering af den intuberede

patient

Effects of early mobilisation of the intubated patient Anne Langvad, Email:[email protected]

Pernille Fevejle Cromhout

([email protected])Department of Cardiothoracic Anaesthesiology

Risk assessment

Patient reported outcomes



Allogen mesenchymal stromal cellebehandling ved

iskæmisk hjertesvigt (MSC-HFII trial)

Allogeneic mesenchymal stromal cell therapy in patients with ischemic heart failure (MSC_HF

II trial)

Anders B. Mathiasen

Email:[email protected] Abbas

Ali Qayyum Email:[email protected]

Jens Kastrup MD, DMSc, Professor,


Serum YKL-40 som monitoreringsmarkør og

prognostisk biomarkør ved iskæmisk hjertesygdom

Serum YKL-40 as a biomarker for monitorering of treatment and prognosis in ischemic heart

disease

Jens Kastrup

Marina Harutyunyan-Bønsager <marina.harutyunyan-

[email protected]>

Allogen mesenchymal stromal cellebehandling ved

iskæmisk hjertesvigt (SCIENCE trial)

Allogeneic mesenchymal stromal cell therapy in patients with ischemic heart failure (SCIENCE

trial)

Anders B. Mathiasen

Email:[email protected] Abbas

Ali Qayyum Email:[email protected]

Jens Kastrup MD, DMSc, Professor,


Behandling med knoglemarvsceller ved STEMI (BAMI

trial)Treatment with mononuclear bone marrow cells in STEMI (BAMI)

Jens Kastrup

FLAWLESS: Finding LCX AMI with posterior ECG

LeadS

FLAWLESS: Finding LCX AMI with Posterior ECG LeadS Jens Kastrup Yama Said

Fakhri <[email protected]>

Immunosuppressive mekanismer af allogene humane

adipose-derived mesenchymal stromal celler for klinisk

terapi

Immunosuppressive Mechanisms of Allogenetic Human Adipose-derived Mesenchymal

Stromal Cell for Clinicla Therapy

Jens Kastrup Annette

Ekblond Email:[email protected]

Regenerative egenskaber af Humane Adipose Derived

Stomal Cells Mode of Action af et stamcelle produkt til

klinisk behandling

Regenerative properties of Human Adipose Derived Stromal Cells Mode of Action of a stem

cell product for clinical therapy.

Jens Kastrup Annette


At udvikle kliniske metoder til at identificere kvinder

med angina pectoris og mikrovaskulær sygdom og

belyse sygdommens betydning for venstre ventrikel og

atrium funktionen.

To establish new clinical methods to identify women with ngina pectoris and microvascular

disease and describe the influence of the disease on left ventricle and atrium function

Naja Dam Mygind


Jens Kastrup Email:[email protected]

Stamceller og alginat som ny regenerativ behandling

ved iskæmisk hjertesygdom.

Stem cells and alginate as a new regenerative therapy in case of ischemic heart disease. Bjarke Follin Larsen

Email:[email protected] Annette


Jens Kastrup

Hjertemedicinsk Klinik

Department of Cardiology

Forskningsområde/subject: Stamcellebehandling ved hjertesygdom - Biomarkører til prognosevurdering af patienter med hjertesygdom / Stem cell therapy in case of heart disease -

Biomarkers for prognosis evaluation of patients with heart disease


CATCH-2 trial: CT myokardieperfusion guidet

behandlingsstrategi hos patienter med nyligt

opstående akutte brystsmerter.

CATCH-2 trial: Cardiac CT in the treatment of acute chest pain Klaus F Kofoed,

Mathias Sørgaard

Email: [email protected]

CorSub: Validering af Koronar Subtraktions CT

skanning hos patienter med mistænkt eller kendt

iskæmisk hjertesygdom.

CorSub: Prospective International study af Coronary Substraction using 320 row-detector CT Klaus F. kofoed

Andreas Fuchs


Cad-risk: Risikostratificering for coronar arterie

sygdom hos type 2 diabetikere.

Cad-risk: Risk stratiefication for coranary artery disease with type 2 deabetic patients. Klaus F. kofoed

Mathias Sørgaard


Cocomo Cocomo: The Copenhagen co-mobidity in HIV infection study Klaus F Kofoed,

Judith M. Haissmann


Nøjagtighed af elektrokardiogafiske kriterier for

venstre atriumstørrelse, vurderet ved multidetektor

computer tomografi.

Accuracy of electrocardiographic criterias for left atrial enlargement, assessed by multidetector

computer tomography.

Klaus F. Kofoed

Julia Nilsson


Koronararterie Calcium Mass Score med Hjerte-CT Coronary Artery Calcium Mass Score by Cardiac

Computed TomographyKlaus F. Kofoed

Andreas Dehlbæk


Sammenhængen mellem ekko strain og myokardie-

tykkelse på 104 patienter med aortastenose The relationship between echo strain and myocardial wall thickness in 104 patients with aortic

stenosis

Klaus F. Kofoed

Per E. Sigvardsen


Evaluering af funktionel signifikans for stenose af

koronarkar vurderet ved transluminal attenuations

gradient ved koronar CT angiografi.

Evaluation of functional significance of coronary

stenosis using transluminal attenuation gradient by

coronary computed tomography angiography

Klaus F. Kofoed

Christian Pihl


Verdict-2: Forholdet mellem risikoprofil, klinisk

præsentation og morfologi i koronar aterosklerose i

asymptomatiske, præ-AKS og AKS patienter.

The relationship between risk profile, clinical presentation, and morphological features of

coronary atherosclerosis in asymptomatic, pre-ACS and ACS patients.

Klaus F. Kofoed

Martina Chantal De Knegt


Sammenhængen mellem koronararterie-volumen og

venstre ventrikelmasse, på tværs af varierende grader

af venstre ventrikel hypertrofi, vurderet med hjerte-CT.

Correlation between coronary artery volume and left ventricular mass, across varying degrees

of left ventricular hypertrophy, assessed by cardiac computed tomography.

Klaus F. Kofoed

Jakob Boesgaard Norsk


Discharge Discharge: Diagnostic Imaging strategies for patientes with stable chest pain and intermadiate Klaus F. Kofoed

Betydning af nefritis og andre risikofaktorer for

kardiovaskulær sygdom hos patienter med systemisk

lupus erythematous

Influence of and other risk Factors on cardiovascular disease in patients with systemic lupus

erythematosus

Marie-Louise From Hermansen, Email: marie-

[email protected]

Venstre ventrikels masse målt med MDCT

sammenligning med EKG kriterier for hypertrofi

Left ventricular mass in the general population assessed with multi detector computed

tomography and comparison with ecg criteria of left ventricular hypertrophy

Mads Mejdahl, Email:[email protected]

Forskningsområde/subject: CT Forskningsenheden / CT Research Unit

Varigheden af elektrokardiogrammets p-tak som en

risikomarkør for forkammerflimren med uddybende

analyser af sammenhænget mellem p-takkens

varighed og størrelsen på hjertets forkamre

P-wave duration and the risk of atrial fibrillation with a cardiac CT add-on on the relationship

between p-wave duration and left atrium end-diastolic volume

Jonas Bille Nielsen Email:

[email protected]

JAK2 V617F somatisk mutation for myeloproliferative

syndrom og forstørret milt størrelse

JAK2 V617F somatic mutation for myeloproliferative cancer and indcreased milt size in the

general population.

Børge Nordesgaard Email:

[email protected]

Koronar CT hos patienter NSTEMI - diagnostisk og prognostisk værdiCoronary CT angiography in patients with Non-ST segments elevation myocardial infarction –

Diagnostic accuracy and prognostic implications

Klaus F Kofoed Tobias

Kuhl Email: [email protected]

Hvile myokardie perfusion hos patienter med Non-STEMI bedømt med MDCTThe transmural extent of myocardial hyperperfusion predicts long-term outcome in patients with

non-ST segment elevation myocardial infarction – a multi-detector computed tomography study

Klaus F. Kofoed

Tobias Kuhl Email: [email protected]

Kadiovaskulær sygdom hos tilsyneladende raske

bedømt ved 320 MSCT. Et Hjerte-CT Herlev-Østerbro

substudium

Cardiovascular disease in apparently healthy subjects. A Copenhagen City population

substudy

Klaus F Kofoed, Email:[email protected]

Determinanter for myokardie flow reserve hos

patienter med brystsmerter og fravær af epikardiel

koronar sygdom

Determinants of myocardial perfusion reserve in patients without significant coronary artery

stenosis evaluated with 320 slice computed tomography

Klaus F.Kofoed Tobias

Kuhl Email: [email protected]

Gener og fedt lever sygdom Genes and fatty liver disease Stefan Stender Anne-Tybjerg-Hansen, Børgen

Nordestgaard [email protected]

Kadiovaskulær sygdom hos tilsyneladende raske

bedømt ved 320 MSCT. Et Hjerte-CT Herlev-Østerbro

substudium

Cardiovascular disease in apparently healthy subjects. A Copenhagen City population

substudy

Klaus F Kofoed, Email:[email protected]

Beta -3 antagonist behandling til patienter med

hjertesvigt

Beta 3 agonist treatment in heart failure (BEAT-HF) Henning Bundgaard: Email:

[email protected]

Hjerte-CT til optimering af behandlingsstrategi hos

patienter med atrieflimren. Betydningen af venstre

atriums vægstruktur og funktion for effekten af

ablationsbehandling hos patienter med paroxystiske

atrieflimren

IMPACT. Importance of left Atrial function and wall structure on outcome after ablation in

patients with paroxysmal atrial fibrillation. -assessed with -detector Computed Tomography.

Peter Karl jacobsen


ADVANCE trial. TAVI registry study ADVANCE Lars Søndergaard,


NOTION - randomiseret forsøg som sammenligner

outcome efter stentklapper med kirurgi

TAVI vs SAVR Lars Søndergaard




Profylaktisk ICD-behandling til patienter med non-

iskæmisk hjertesvigt

Prophylactic ICD treatment of patients with non-isshaemic heart failure Lars Køber, Email:[email protected]

Athmosphere: Randomiseret undersøgelse af

reninhæmmer til patienter med hjertesvigt

Athmosphere: Randomized analysis of renine inhibitor for patients with heart failure Lars Køber

Arts: Aldosteron antagonist til patienter med hjertesvigt Arts: Aldosteron antagonist for patients with heart failure Lars Køber

Strict versus lenient fluid restriction in HF and

hyponatremia: a randomized trial

Strict versus lenient fluid restriction in HF and hyponatremia: a randomized trial Louise Balling, Finn Gustafsson

Arts: Aldosteron antagonist til patienter med hjertesvigt Arts: Aldosteron antagonist for patients with heart failure Lars Køber

Takotsubo kardiomyopati Takotsubo cardiomyopathi Thomas Emil Christensen/Lene Holmvang/Philip

Hasbak/Lia E. Bang

PRomPT studiet: Forebyggende behandling mod

dannelse af arvæv efter blodprop i hjertet.

PRomPT study: Post-MI Remodeling Prevention Therapy Karen Thamsborg / Jesper Hastrup Svendsen,

Email:karen.thamsborg.rh.regionh.dk


Det Nordiske ICD studie: Et studie, hvor ICD patienter

med eller uden DF test under implantationen bliver

evalueret mhp behandling af ventrikulære arrytmier

Nordic ICD study: A study where ICD patients with or without DF test during the implant

procedure are evaluated regarding the treatment of ventricular arrythmias

Karen Thamsborg / Jesper Hastrup Svendsen

SLS: Medtronic's registerstudie over holdbarheden af

elektroder

SLS: System Longevity Study. Medtronic's register study on the longevity of leads Karen Thamsborg / Jesper Hastrup Svendsen /

Steen Pehrson, Email:[email protected]

Medicinsk antiarytmisk behandling eller

radiofrekvensablation af paroksystisk atrieflimren-et

prospektivt randomiseret multicenterstudie: MANTRA-

PAF

Antiarrhythmic medical threrapy or Catheter ablation in patients with paoroxystic atrial

fibrillation: The MANTRA-PAF study

Aslaug Karlsdottir / Steen Pehrson,


Lone atrial fibrillation in persons younger than 40 years

of age

Jesper Hastrup Svendsen,


EURObservational Research Programme: Atrial

Fibrillation Ablation Survey

EURObservational Research Programme: Atrial Fibrillation Ablation Survey Aslaug Karlsdottir / Steen Pehrson

Stereotaxis ablation registry Stereotaxis ablation registry Aslaug Karlsdottir / Steen Pehrson

Forskningsområde/subject: Kronisk hjerteinsufficiens/Chronic heart failure

DANSHOCK Danish Cardiogenic Shock Trial Danish Cardiogenic Shock Trial, effect of percutanous assist device in patients with acute

myocardial infarction complicated with cardiogenic shock

Matias Greve Linholm

[email protected]

Christian Hassager, [email protected]





DanAHF A nationwide retrospective cross-sectional study

of patients admitted for acute heart failure


[email protected]

REDUCE-LAP IASD device treatment in HFpEF Lene Larsen/Lars Søndergaard/Finn Gustafsson

Characterisation of CRT therapy Optimering af CRT behandling på baggrund af elektrodeplacering og ekg karakteristika Casper Lund-Andersen, Jesper Hastrup Svendsen

TEMPO Gilead study Effekt af nyt antiarytmikum til patienter med terapi fra ICD Jesper Hastrup Svendsen, Karen Thamsborg,

Aslaug Karslsdottir

The SCAUT Study Optimering af behandling af device patienter med anvendelse af App device Jesper Hastrup Svendsen, Helen Høgh Petersen

ELEVATE registry ELEVATE Finn Gustafsson ([email protected])

VANISH-CAV Effect of ivabradine on exercise capacity after heart transplantation Finn Gustafsson/Lærke Nelson

CARMAT study CARMAT (total artificial heart) CE mark study Finn Gustafsson/Peter S Olsen/Lene Larsen

RESHAPE 2 RESHAPE 2 (Mitraclip in heart failre) Finn Gustafsson/Lars Søndergaard


Evaluering af aorta stenose med Multi-Slice Computed

Tomography Assessment of aortic stenosis with Multi-Slice Computed Tomography

Linnea Hornbech Larsen,



Mitokondriefunktion hos overlevere efter hjertestop

behandlet med terapeutisk hypotermi

Mitochondrial function in survivors of cardiac arrest treated by therapeutic hypothermia Sebastian Wiberg <[email protected]> / John

Bro-Jeppesen / Jesper Kjærgaard / Nis Stride +

Flemming Dela (Panum Instituttet)

DANSHOCK Danish Cardiogenic Shock Trial Danish Cardiogenic Shock Trial, effect of percutanous assist device in patients with acute

myocardial infarction complicated with cardiogenic shock


[email protected]

Christian Hassager, [email protected]

Forskningsområde/subject: Aorta Stenose/Aortic stenosis

Forskningsområde/subject: Terapeutisk hypotermi/Therapeutic hypothermia

Centralisering af efterbehandling efter hjertestop uden

for hospital på hjertecentre - et follow-up studie

Centralization of Post-Resuscitation Care after Out-of-Hospital Cardiac

Arrest at Heart Centers – a Follow-up Study

Helle Søholm, Email:[email protected] Jesper

Kjærgaard, Email:[email protected]

Biobank på consecutive hjertestoppatienter Biobank on consecutive patients with out-of-hospital cardiac arrest Johannes Grand, Jesper Kjærgaard, Christian

Hassager Email: [email protected]

ICD-implantation hos patienter med hjertestop uden

for hospital og

den efterfølgende brug af ICD-shock samt

antitakypacing (ATP)

ICD-implantation in patients with out-of-hospital cardiac arrest, and the subsequent ICD-

shocks and antitachypacing (ATP)

H Søholm, [email protected], J Kjærgaard,

[email protected], B Philbert,

[email protected]

BOXBlood pressure and oxygenation targets in post resuscitation care

Johannes Grand, Christian Hassager, Jesper

Kjærgaard ([email protected])

CAMAP Hjernens perfusion og metabolisme ved ændringer i middelarterieblodtryk hos komatøse

patienter genoplivet efter hjertestop uden for hospital

Sebastian Wiberg, Johannes Grand, Jesper

Kjærgaard, Christian Hassager

([email protected])

Pupillometer på ITA Den prognostiske værdi af pupillometermåling ved OHCA Laust Obling, Jesper Kjærgaard

([email protected])

TAU subunits efter OHCA Prognostisk værdi af TAU subfragmenter efter OHCA Jesper Kjærgaard, Christian Hassager

([email protected])

TTM substudier Diverse substudier på TTM studiet Jesper Kjærgaard ([email protected]),

Christian Hassager ([email protected])

TOMAHAWK KAG ved OHCA m non-STEMI Jesper Kjærgaard, Christian Hassager

([email protected])

XePHOCAS Inhaled Xenon after OHCA Jesper Kjærgaard, Christian Hassager

([email protected])


RETROSHOCK Kardiogent shock database (RH+OUH)Jakob Josiassen, Christian Hassager

([email protected])

PREDICT Biomarkers in STEMI patients for Cardiogenic ShockMartin Frydland, Christian Hassager

([email protected])

DanShock: Effekt af avanceret kredsløbsstøtte til

patienter med akut myokardieinfarkt kompliceret af

kardiogent shock

DanShock: Effect of mechanical support in AKS-patient complicated by cardiogenic shock

Matias Greve Lindholm

(matias.greve.lindholm.region.dk), Jesper


Bipella ved CS RV Impella ved LV Impella med suctionproblemer

Jakob Josiassen, Matias Greve Lindholm, Jesper


([email protected])


Forskningsområde/subject: Cardiogent shock

Forskningsområde/subject: Molekylær Kardiologi

Elektrokardiografiske prædiktorer for pludselig

hjertedød og atrieflimren: the Copenhagen ECG

Study)

Electrocardiographic predictors for sudden cardiac death and atrial fibrillation: the Copenhagen

ECG Study)

Jonas Bille Nielsen og Anders Holst, Stig Haunsø.


Familiær forekomst af Lone AF Familial occurrence of Lone AF Lena Refsgaard, Mads Melby, (SSI), Stig Haunsø,

Morten Salling Olesen.


AVNRT, arv og mutation AVNRT, inheritance and mutation Laura Andresen, Jesper Hastrup Svendsen, Morten

Salling Olesen. Email:[email protected]

SCD 0-50 in the years old 2007-9 SCD 0-50 in the years old 2007-9 Bjarke Risgaard, Bo Gregers Winkel, Stig Haunsø,

Jacob Tfelt-Hansen. Email:

[email protected]

MI-RISK Risk factors SCD with first MI Jacob Tfelt-Hansen, email: [email protected]

Patienter ablateret for AF blev randomiseret til

dobbeltblindet studie

Patients ablated for AF were randomized for a double-blind study LMC Stine Darkner, Jesper Hastrup Svendsen


ST-segment ændringer og risiko for SCD ST-segment Deviations and the Risk of Cardiovascular Death Peter Vibe Rasmussen, Jonas Bille Nielsen, Anders

Holst, Stig Haunsø. Email:

[email protected]

LOOP study Påvisning af asymptomatisk Atrieflimren hos patienter med risiko for stroke Jesper Hastrup Svendsen; Email:

[email protected]

Genetiske årsager til supraventrikulær takyarytmi Genetisk variation hos patienter med SVT Jesper Hastrup Svendsen; Email:

[email protected]

Express studiet Genetisk variation i myokardievæv fra patienter med AF Jesper Hastrup Svendsen; Email:

[email protected]


LATE MI Effect of acute PCI in STEMI late presenters Lars Nepper-Christensen/Thomas Engstrøm

PROSEPCT IVUS/NIRS to characterize non-culprit vessels in patients with STEMI/NSTEMI Thomas Engstrøm

Impact of patient selection in clinical trials Peter Laursen/Thomas Engstrøm

Notion-3

Randomized study of full revascularization vs. no revascularization in patients with coronay

disease undergoing TAVI

Jacob Lønborg/Thomas Engstrøm/Lars

Søndergaard

Full revasc Full revasculatization vs. culprit only in patients with STEMI treated with primary PCI Thomas Engstrøm

IAMI Effect of influenza vaccination on morbidity and mortality in patients with myocardial infarction Thomas Engstrøm

DANAMI-3: Randomiseret undersøgelse af

postkonditionering ved STEMI

DANAMI-3 Thomas Engstrøm / Lars Køber/ Henning Kelbæk



Verdict: En dansk undersøgelse af betydningen af

hurtig behandling af patienter mistænkt for mindre

blodprop I hjertet, samt en undersøgelse af CT-

scanning som led i udredning af patienter med akutte

brystsmerter

Verdict: Very early versus deferred invasiv evaluation using computerized tomography in

patients with acute coronaty syndromes

Lars Køber/Christian Torp-Pedersen/Henning

Kelbæk, Thomas Engstrøm,


Etablering af kliniske metoder til at identificere kvinder

med angina pectoris og mikrovaskulær sygdom og

belyse sygdommens betydning for venstre ventrikel og

atrium funktionen

Establishment of methods to identify women with angina pectoris and microvascular disease,

and evaluate the impact of the disease on the left ventricle and atrium function

Naja Dam Mygind Email:[email protected] Jens

Kastrup

Forskningsområde/subject: Iskæmisk hjertesygdom / Ischemic heart disease

ODYSSEY ODYSSEY. A randomized, double blind, placebo controlled, parallel group study to evaluate

the effect of SAR236553/REGN727 on the occurrence of cardiovascular events in patients

who have recently experienced an acute coronar syndrome

Lia Bang Email: [email protected]

The Dal-GenE trial A phase III, double-blind, randomized placebo-controlled study to evaluate the effects of

dalcetrapib on cardiovascular (CV) risk in a genetically defined population with a recent Acute

Coronary Syndrome (ACS)


Intrakoronar trykvejledning før PCI FAME I + II + III Thomas Engstrøm,


STRENGHT STRENGHT. A long-term Outcomes Study to Assess STtin Residual risk reduction with

EpaNova in hiGh cardiovaskucular risk patienTs with Hypertriglyceridemia


GLP-1 og negativ remodellering efter STEMI Effects of liraglutide on cardiac remodeling following ST-elevation myocardial infarction Thomas Engstrøm

Plaquemorfologi hos patienter med aterosklerose i a.

carotis

Belyst ved brug ad 3D ultralyd Lia Bang Email: [email protected]

Reperfusionsprofiler hos rotter under GLP-1

stimulation

Profiles of reperfusion inury in rats after treatment with GLP-1 analogues Thomas Engstrøm

Additive effekter af forskellige typer cardioprotektion

hos grise

Additive effects in a pig model of RIPC, IPOST and framachological conditioning Thomas Engstrøm

EVOLVE II A Prospective Multicenter Trial to Assess the Safety and Effectiveness of the SYNERGYTM

Everolimus-Eluting Platinum Chromium Coronary Stent System (SYNERGYTM Stent System)

for the Treatment of Atherosclerotic Lesion(s)

Steffen Helqvist

Comfortable AMI Comparison of a biolimus-eluting stent with biodegradable polymer with a bare-metal stent

without coating in patients with acute ST-elevation myocardial infarction (STEMI)

Thomas Engstrøm

ABSORB II ABSORB II RANDOMIZED CONTROLLED TRIAL

A clinical evaluation to compare the safety, efficacy and performance of ABSORBTM

everolimus eluting bioresorbable vascular scaffold system against XIENCE PRIMETM

everolimus eluting coronary stent system in the treatment of subjects with ischemic heart

disease caused by de novo native coronary artery lesions

Steffen Helqvist

ST-STEMI Stent trombose efter STEMI Erik Jørgensen

PLATINUM A Prospective, Randomized, Multicenter Trial to Assess

an Everolimus-Eluting Coronary Stent System (PROMUS Element™) for the Treatment

of up to two De Novo Coronary Artery Lesions

Steffen Helqvist

PRIMULTI Primary PCI in Patients with ST-elevation Myocardial Infarction and Multivessel Disease:

Treatment of Culprit Lesion only or complete Revascularization

Steffen Helqvist / Henning Kelbæk / Thomas

Engstrøm

Global Leaders En sammenligning af effekten af 1 måneds behandling med ticagrelor plus acetylsalisylsyre

efterfulgt af monoterapi med ticagrelor og den aktuelt anvendte intensiv dobbelt antitrombocyt-

behandling til alle patienter, der gennemgår perkutant koronarindgreb med anvendelse af

bivalirudin og et produkt fra BioMatrix-serien af lægemiddelafgivende stenter.

Lene Holmvang - ongoing

Danegaptide En randomiseret undersøgesle af effekten af Danegaptide på infarktudvikling hos STEMI

patienter

Thomas Engstrøm

Prospect En prospektiv undersøgelse af udviklingen i koronasygdom bedømt med intrakoronar ulytralyd

og nær infra rød spektoskopi

Thomas Engstrøm

Leaders Free En prospektiv randomiseret sammenligning af BioFreedomTM Biolimus A9TM

lægemiddelcoated stent vs. GazelleTM bare metalstent hos patienter med høj

blødningsrisikoTM

Thomas Engstrøm

TARGET Sammenligning af Firehawk verses Xience stent. A prospective, multicenter, randomized,

two-arm, non-inferiority, open-label study with 1656 patients

Lene Holmvang

THEMIS Effect of Ticagrelor on Helalth outcomes in diabEtes Mellitus patients Intervention study. Lene Holmvang ongoing

TIGRIS A register study of patients with previus acute myocard Lene Holmvang ongoing

FFR-RUBIN Comparison of combined Rb-cardiac PET af CT versus coronary angiography/FFR to detect

ischemia in stable angina patients.

Lene Holmvang, Philip Hasbak, Thomas

Rasmussen (4011) ongoing

Projekt titel Project title Kontakt/ContactINHERIT: Undersøgelse af effekten af losartan på

hypertrofien ved hypertrofisk kardiomyopati

INHERIT: Assessment of the effect of losartan on the hypertrophy in hypertrophic

cardiomyopathyAnna Axelsson, Email:[email protected]

EVOLVE EVOLVE Anna Axelsson

SOHPIA-studiet: Fabry sygdom SOPHIA: Fabry disease Anna Axelsson

Undersøgelse af langtidsbehov for Long-term need for pacemaker after PTSMA Anna Axelsson

Undersøgelse af forekomsten af langt QT syndrom i Frequency and characteristics of long QT syndrome in Denmark Julie Theilade, Email:[email protected]

Mortalitet efter PTSMA Mortality after PTSMA Morten Jensen,


Undersøgelse af hjertepåvirkning ved arvelig primær

muskelsygdom

Heart involvement in primary peripheral muscular diseases Helle Petri Lauritsen,


Undersøgelse af familieophobning af hjertesygdom

ved SCD

Family clustering of cardiac diseases in relation to SCD patients

Mattis Flyholm Ranthe,


Undersøgelse af familieophobning af hjertesygdom

ved præmatur fødsel

Family clustering of cardiac diseases in women with pre-term labour Mattis Flyholm Ranthe

Undersøgelse af omfanget af arveligt betinget SCD i

en rutine retsmedicinsk opsætning

Extent of SCD due to inherited cardiac diseases in a routine forensic setting Laura Ferrero, Email:[email protected]

Molekylær autopsi og DNA sekventering af yngre med

SCD med mistænkt arvelig kardiomyopati eller primær

arytmi-sygdom

Molecular autopsy and DNA sequencing of heritable cardiomyopathic and channelopatric

causes of sudden cardiac death of young persons

Christin Løth Hertz,


Undersøgelse af ARVC patienter for mitokondrie

mutationer

Mitochontrial mutations in ARVC Alex Christensen,


Undersøgelse af forekomsten af ARVC syndrom i

Skandinavien

Frequency and characteristics of ARVC in Scandinavia Jesper Hastrup Svendsen, Anders Holst,


Resultater fra de første 1000 familier med arvelig

hjertesygdom henvist til REAH

Findings in the first 1000 families with an inherited cardiac disease referred to REAH Henning Bundgaard,


POET - partiel pereroral behandling af patienter med

infektiøs endocardit

POET - Partial oral treatment of patients with infectious endocarditis Kasper Iversen, Email:[email protected]

Forskningsområde/subject: Arvelige hjertesygdomme / Inherited cardiac diseases


Undersøgelse af hukommelse hos patienter indlagt

akut med ST-elevations myocardieinfarkt behandlet

med primær percutan coronar intervention – en

pilotundersøgelse

Investigation of memory of patients admitted urgently with ST-elevation myocardial infarction

and treated with primary percutane coronary intervention - a pilot investigation

Marianne N. Grum,


Patienter med aortastenose som gennemgår

Transcatheter Aortic Valve Implantation (TAVI)

behandling - hvilken behandling har de brug for på

medicinsik intensiv 2143?

Patients suffering from aortic stenosis who are treated with a Transcatheter Aortic Valve

Implantation (TAVI) - which care do they need at the medical intensive ward 2143?

Sanne Nielsen, Email:[email protected]

How can the nurse support a patient to develop knowledge and acting skills in order to master

life as a transplanted person?

Jytte Graarup, Email:[email protected]

CopenHeartRFA - et randomiseret projekt, der

undersøger effekten af et integreret rehabiliterings-

program versus vanlig opfølgning for patienter

behandlet for atrieflimren med ablation.

A randomised CopenHeartRFA trial. Examination of the effect of integrated cardiac

rehabilitation versus usual treatment for atrial febrillation patients treated with ablation.

Signe Risom, Email:[email protected]

Selina Kikkenborg Berg

CopenHeart SF - et randomiseret klinisk forsøg af et

integreret seksuelt rehabiliteringsprogram plus vanlig

behandling versus vanlig behandling hos mandlige

patienter med seksuel dysfunktion og ICD eller

iskæmisk hjertesygdom.

CopenHeart SF - a randomised clinical trial of a comprehensive sexual rehabilitation

programme plus usual care versus usual care in male patients with impaired sexual function

and implantable cardioverter defibrillator or ischaemic heart disease.

Pernille Palm Johansen,


Visualisering og struktureret opmærksom adfærd -

reducerer det patientens oplevelse af smerteintensitet

og angst under katheterablation af atrieflimren?

Marianne W. Nørgaard, Email:

[email protected]

National retningslinje for fase 2 rehabilitering til

patienter med atrieflimren, patienter med endokarditis

og patienter behandlet med en Implanterbar

Cardioverter Defibrillator (ICD)

Signe Risom, Email:[email protected]

Undersøgelse af patienters vurdering af

patientdeltagelse.

Jane Færch, Email: [email protected]

SAMOVAR, Umiddelbar mobilisering af patienter efter

koronar angiografi og perkutan intervention Immediate mobilization after coronary angiography and percutaneous coronary intervention

Marianne W. Nørgaard/Jane Færch Email:

[email protected]

Brugercentreret innovationsproces i PACE-

ambulatoriet User-centered innovation process in the outpatient clinic

Morten Arnfred, Email:

[email protected]

Identificering af Sygeplejefaglige behov og

problemstillinger hos patienter indlagt til TEVAR Nursing interventions to patients admitted to TEVAR

Marianne Grum, Email:

[email protected] Kan ændringer af risikofaktorer forbedre resultatet af

kateterablation for patienter med atrieflimren? Det

kliniske TOP AF Life program

Signe Risom, Email:

[email protected]

Forskningsområde/subject: Klinisk sygeplejeforskning/Clinical nursing research

MAT studiet: Mobilisering efter TAVI MAT study: Mobilisation after TAVI

Bettina H. Kirk, Marianne W. Nørgaard

[email protected]


Monitorering af sygdomsprogression med

transbronkiale biopsierTrans broncial biopsis for disease monitoring in inflmaatory lung disease

Thomas Kromann Lund:

[email protected]

Michael Perch ([email protected])

ScanCLAD: Et randomiseret multicenter Skandinavisk

studie til evaluering af om immunsupprimerende

behandling baseret på tacrolimus reducerer

incidensen af kronisk afstødning efter

lungetransplantation sammenlignet med standard

cyclosporin-baseret behandling

ScanCLAD: A randomized multi-center study evaluating if tacrolimus or cyclosporin de novo,

reduces the incidence of CLAD after lung transplantation

Thomas Kromann Lund

[email protected]

Pia Bredahl ([email protected])


EPOS: Et Europæisk multicenter studie til vurdering af

Pirfinidone til behandling af BOS efter

lungetransplantation

European Trial of Pirfenidone i BOS (EPOS) A European multi-center, randomised, double-

blind trial of pirfirenidone in bronchiolotis-obliterans-syndrome grade 1-3 in lung transplant

recipients

Michael Perch ([email protected]) Hans

Henrik Schultz

([email protected])

Lungeultralydskanning til vurdering af kronisk af

afstødning efter DLTx

Lung Ultrasound for evaluationg CLAD in lung transplant Receipients

Hans Henrik Schultz

[email protected]


Kroniske smerter og føleforstyrrelser efter

thoraxkirurgi: En undersøgelse af mekanismerChronic pain after thoracic surgery

Pia Bredahl [email protected] Michael

Perch (michael.perch€regionh.dk) Christan Holflod

Møller ([email protected])

Thomas Kromann Lund:

[email protected]


Forskningsområde/subject: Lungesygdomme & transplantation

Behandlingskonsekvens ved brug af transbronchial

biopsy til diagnostic af CVD

The clinical use of transbronchial biopsies in patients with collagen vascular tissue disease and

lung involvement

Forskningsområde/subject: Forskningsprojekter på tværs af klinikkerne i HJE


GLP-1 agonist og ilt behandling til organbeskyttelse

ved hjerteoperation (GLORIOUS)GLP-1 agOnist and Restrictive vs lIberal FiO2 in patients Undergoing open heart Surgery

(GLORIOUS)

Jens Christian Nilsson, Peter Skov Olsen, Christian

Hassager, Hanne Ravn, Jesper Kjærgaard, Lars

Køber.

PERSIST:Retrospektivt studie til identifikation af

risikopaitenter for SIRS efter CPB

PERSIST: PERsonalised management of Systemic Inflammatory response using

cardiopulmonary bypasS Technique Post.doc Rikke Vibeke Nielsen, Hasse Møller-

Sørensen, Jens Christian Nilsson, Peter Skov

Olsen, Jens Lundgren, Søren Boesgaard, Hanne

Berg Ravn. E-mail: [email protected]

oversigt over forskningsprojekter i hjertecentret ......the prognostic impact of supar on mortality...

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