orientation handbook

Basic Cardiovascular Research Training Grant 5T32-HL007284The Robert M. Berne Cardiovascular Research Center434-243-9943, [email protected]

Basic Cardiovascular Research Training Grant5T32-HL007284

Ruth L. Kirchstein National Research Service AwardDepartment of Health and Human ServicesNational Institutes of HealthNational Heart, Lung, and Blood Institute

Orientation Manual, edited 2008

Contents Page

Important Contacts 2Goals and Objectives 3Program Descriptions and Events 4Requirements and Opportunities for Trainees 5Predoctoral Trainee Stipends and Benefits 6Postdoctoral Trainee Stipends and Benefits 7All Trainees’ Benefits and Information:

Travel Funds 9Book Funds 9Journal Subscriptions 9Association memberships 9Special Courses 9CVRC Website 9UVa Research Website 10Library Access 10ID Badges and Email 10Mail 11Parking and Transportation 11Telephone Directory 11Mentors on Training Grant 12

Trainee Related ActivitiesResearch in Progress 14Translational Research Enhancement Program 17Translational Research Clinician List 18Annual Trainee Update Requirements 20

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mailto:[email protected]


IMPORTANT CONTACTS

Brian R. Duling, Ph.D.Program DirectorBasic Cardiovascular Research Training GrantPO Box 801394MR-4, Room [email protected] FAX: 434-924-2828

Janice Munson, Grant AccountantGraduate Programs OfficePO Box 800738Jordan Hall, Room [email protected] FAX: 434-924-0140

Andrea McNeelyProgram AdministratorCardiovascular Research CenterPO Box 801394MR-5, Room [email protected], [email protected] FAX:434-924-2828

Beckie ChamberlinGrants Management SpecialistNHLBIOffice of Grants Management6701 Rockledge Drive, Room #7044Bethesda, MD 20892-7926 (Express 20817) [email protected] 301-435-0183, FAX: 301-451-5462

Morgan Angulo, PhDTrainee Representative – Postdoc2008-2009Owens [email protected]

Scott Smith, MDTrainee Representative – Graduate Student2008-2009French [email protected]

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GOALS AND OBJECTIVES

Goal: to provide a environment in which young scientists are offered access to the finest research minds and superb equipment; and are given the support, encouragement and

training that will assure that the become future leaders in cardiovascular research

We have assembled a group of approximately 43 mentors from 7 training programs and 3 divisions in the School of Medicine. All are committed to training young investigators and teachers interested in the study of the heart and vasculature. Focus areas for faculty research include: biophysics and molecular biology of receptors and ion channels, cell signaling, growth control of vascular smooth muscle, microvascular regulation, molecular basis of leukocyte-endothelial cell interactions, and genetic engineering of the vascular system. Our laboratories are supplemented by a superb array of shared-instrumentation and core facilities.

The training program supports 15 pre-doctoral and post-doctoral trainees. The first year of graduate training is guided by one of the 7 programs after which the trainee chooses an advisor and a department to complete training. For pre-doctoral students, the departments establish criteria for professional excellence in the particular discipline, whereas the training grant Executive Committee focuses on the competencies necessary for quality cardiovascular research. Post-doctoral fellow training is primarily under the direction of their mentor(s), aided by consultation with the Training Grant Executive Committee. The central aim of the post-doctoral program is to complete the training of independent scientist-scholars. Accordingly, the fellows are treated as colleagues, and commonly interact with more than one faculty member during the training period.

Didactic education of both pre- and post-doctoral fellows is supplemented by a cardiovascular research-in-progress presentation series (the RIP’s), laboratory discussion groups, and an outstanding seminar program hosted by the Cardiovascular Research Center in conjunction with the participating centers, departments, and divisions. Preparation for translational research is fostered by the blend of faculty from clinical and basic science departments. We have also formalized a plan for PhD training for a selected group of our MD fellows.

Our training program is strongly backed by the University of Virginia, School of Medicine, which has established the Cardiovascular Research Center (CVRC) as a focus for coordinating cardiovascular research and training throughout the Medical School. In the spring of 2002 the CVRC and many of its associated trainees moved into new space, thus fostering stronger relations between faculty and trainees, and stimulating our interdisciplinary and translational research programs.

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TRAINING OF PREDOCTORAL FELLOWS

Predoctoral fellows have a broad range of undergraduate backgrounds and research interests while in graduate school. Their training is a combination of laboratory experience, coursework, mentoring, special events, and professional development. Admission is via the BIMS programs (http://www.healthsystem.virginia.edu/internet/bims/), and at the end of the first year students choose an advisor and department, meeting their requirements and ours in their training process.

Only citizens and permanent residents of the United States are eligible for training grant support, according to regulations set forth by the National Institutes of Health, the funding agency for this program.

TRAINING OF POSTDOCTORAL FELLOWS

Postdoctoral fellows come from a broad range of disciplines (both MD’s and PhD’s), and their training is based primarily on laboratory experience. Early in the training process (preferably within the first year), postdoctoral fellows are encouraged to apply for external funding to support their own research activities. The success rate for our trainees in these grant applications is remarkably high, due to the quality of the trainees, the efforts of the faculty to guide the trainees, and a formal instruction in grant writing. Working in conjunction with their advisors, these grants provide fellows with a learning experience in grant writing and in the development of hypothesis-driven scientific research. Postdoctoral fellows also have the opportunity for teaching experience in the graduate and medical curriculum.

DURATION OF TRAINING GRANT TENURE

The National Institutes of Health provides support for an individual student for a maximum duration of 5 years for a predoc and 3 years for a postdoc. The Cardiovascular Research Training Grant tries to limit support for our trainees to 2 years with the anticipation that they will obtain independent support within the first 2 years on the grant. Continued support beyond 2 years requires reapplication to the training grant and assessment by the Executive Committee of demonstrated effort to obtain external support and strong recommendation of his/her mentors(s).

TRAINING GRANT EVENTS

Fall Party – October/HalloweenRobert M. Berne Lecture – October 28, 2009: Marlene Rabinovitch, M.D.Winter Party – January or February, At Brian Duling’s homeTrainee Speakers – February 27, 2009: Mukesh Jain, M.D., May 8, 2009: Michael Gimbrone, M.D., coordinated by Trainee Representatives and includes happy hour, lunch, meetings, seminar Spring Picnic – Pavilion VIII, May or June

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Recruiting Fairs – please come with us on recruiting trips! See the program coordinator.

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REQUIREMENTS FOR ALL TRAINEES

Participation in the following is required by each Trainee:

1) Ethics course (a short course offered twice every spring)2) Vascular Biology course (BIMS 852, offered every other spring – next in 2009)3) Cardiovascular Research Center Seminar Series (selected Thursdays at noon with special

seminars other days and times) followed by lunch with external speakers4) Cardiovascular Research Center trainees’ Research-in-Progress presentation (third Mondays

at 5 p.m.)5) Translational Research Enhancement Program (scheduled individually)6) Course and Lab work as required by your department

Participation in the following is recommended for each Trainee:

1) Medical School Cardiovascular Physiology Course or equivalent2) Medical School Cardiovascular Pharmacology Course or equivalent

OPPORTUNITIES FOR TRAINEES

While interacting with the CVRC Training Grant, you will have opportunities to: Present a Research in Progress Seminar in the CVRC Seminar Series Make use of CVRC facilities such as poster printing and the library and attend CVRC

functions Be nominated for and perhaps receive a Robert M. Berne Trainee Achievement Award (two

awarded each year, one postdoctoral and one predoctoral) Teach a section of the BIMS 853/4 Modern Literature in Cardiovascular Research Present in progress research during the monthly Research-in-Progress presentations Go on recruiting trips up and down the eastern seaboard Meet with the dedicated training grant speaker at happy hours, lunches, and office

meetings Serve as trainee representative for the training grant Meet with Brian Duling as needed to talk about your scientific progress and challenges Progress to alumni status, where as long as you’re at UVa, you can continue to participate

in events!

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PREDOCTORAL STIPENDS AND BENEFITS2008-2009

1. STIPEND – NIH provides stipends for trainees at $20,772/year. We recognize that our trainees are exceptional and that they make major contributions to our research programs and therefore, the office of the Dean or mentors supplement the training grant stipends to bring them to the current level of $25,000. Additionally, special recognition of accomplishment is sometimes provided in the form of merit scholarship stipends may be awarded by departments and mentors.

2. Tuition and Fees – The Training Grant will cover tuition costs for all courses needed for and directly related to the PhD for 3 semesters a year.

3. Health Insurance/ Dental – The Training Grant will cover the Student Health plan or up to $2,297. Students receiving Chickering Insurance will have it paid directly by the grant. Dental Insurance is paid for by student, receipts are submitted to the BIMS administrator, and the BIMS administrator reimburses from the CVRC Training Grant.

4. Gym Membership -- Full-Time Students with valid UVa IDs are automatically members through payment of tuition & fees. If you are research-only for the summer, you are a member of the gym. If you are not registered for classes, there is a small charge for the summer.

If other expenses arise that your advisor is unable to cover, submit your needs in writing to the CVRC office, and we will do our best to meet them.

Good resources for graduate student information are http://www.healthsystem.virginia.edu/internet/gpo/enrolled.cfm and http://www.virginia.edu/graduateguide/.

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http://www.virginia.edu/graduateguide/

http://www.healthsystem.virginia.edu/internet/gpo/enrolled.cfm


POSTDOCTORAL STIPENDS* AND BENEFITS

1. Stipend Levels (set by NIH for FY09)

*If advisors want to pay at a higher level than what is allotted by the Training Grant they may supplement with non-NIH funds only.

Please see

http://www.nationalpostdoc.org/site/c.eoJMIWOBIrH/b.3790739/ for information about postdoctoral tax issues.

2. Health Insurance – (from the Office of the Vice President for Research and Graduate Studies: http://www.virginia.edu/vpr/postdoc/postdocinsurance.html)

The departmental Research Administrator (or other designee) and the Postdoctoral Fellow must take the following steps to ensure proper enrollment in the Postdoctoral Fellow Health Insurance Plan and begin insurance coverage:

a. Prior to the start of the fellowship, the Research Administrator (or other designee) must provide documentation of the funding source and the amount of funds that are designated for health insurance purchase to the Office of the Vice President for Research. Grant budget pages are a common example of such documentation.

Please be aware that in 2006 the National Institutes of Health increased the allowance for postdoctoral training expenses to $7850 to cover health insurance. Please email documentation to Wendy Perry, Director of Postdoctoral Programs, at [email protected] or fax to 434.924.8720.

b. The Research Administrator (or other departmental designee) must fill out an online form with account and enrollee information for the office management of the Vice President for Research. Charges will be made immediately following the appointment end date, or annually, whichever comes first.

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Years Experience

Stipend Amount*

0 $36,996.001 38,976.002 41,796.003 43,428.004 45,048.005 46,992.006 48,852.007 51,036.00


http://www.virginia.edu/vpr/postdoc/docs/2009%20postdoc%20health%20care%20premiums%20(2).xls

http://www.virginia.edu/vpr/postdoc/insuranceform.html


http://grants.nih.gov/grants/guide/notice-files/NOT-OD-06-093.html

http://www.virginia.edu/vpr/postdoc/postdocinsurance.html

http://www.nationalpostdoc.org/site/c.eoJMIWOBIrH/b.3790739/


c. After receiving email confirmation of Step 1 from the Office of the Vice President for Research, the Research Administrator (or other designee) must instruct the Postdoctoral Fellow to complete the necessary insurance enrollment forms available from the Benefits Division of Human Resources (924-4392). Completed forms must be received at the Benefits Division within 31 days of the beginning of the fellowship.

Questions concerning how to add dependent and family coverage, cost of additional coverage, deductibles, etc., should be directed to the Benefits Division at [email protected].

d. The Research Administrator (or other designee) must notify [email protected] of any change in status (e.g. change in grant number, family status, termination, renewal).

3. Intramural Sports and Athletic Facilities

A request for a letter of authorization identifying the postdoctoral fellow who would like to use these facilities should be sent to Andrea McNeely, the Program Coordinator. The annual charge for using these facilities is approximately $300. The Training Grant can reimburse you for this charge but only if requested . Details about all the facilities available and their hours of operation are available by visiting http://www.virginia.edu/ims/index.html or calling 924-3791. The authorization letter should be taken to The Director, Intra-Mural Sports and Recreation, Aquatic and Fitness Center, Whitehouse Road from 8:00 am – 5:00 pm Monday through Friday.

If other expenses arise that your advisor is unable to cover, submit a description of your needs in writing to the CVRC office, and we will do our best to meet them.

Postdoctoral trainees have to agree to “pay back” the first 12 months only of their postdoctoral stipend. This payback can be in the form of one month of work in the field of science (including teaching and industry) for every month up to 12 months that they received an NRSA postdoctoral fellow stipend. Note that the second year of a post-doctoral fellowship qualifies as a payback.

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http://www.virginia.edu/ims/index.html



http://www.hrs.virginia.edu/benefits.html

http://www.hrs.virginia.edu/benefits.html


ALL TRAINEES BENEFITS AND INFORMATION

1. Travel Funds

For the current project period, the Training Grant will pay up to $1,100.00/year in travel expenses.

Reminders: Please let the Training Grant Administrator know when you are going on a trip. This

information is useful if trying to locate you but also in planning for your expenses and reimbursement. International travel must have prior approval by the Dean. Please allow at least 2 weeks before the trip for this or your costs may not be covered.

Flights and conference registration can be paid for ahead of time by the Administrator or can be reimbursed after a trip with receipts and boarding passes.

Lodging, meals, and car rental will be reimbursed after the trip (with receipts, of course). Lodging receipts must be itemized. Meals can be reimbursed either with all itemized receipts or a set per diem but not a mixture of the two. If renting a vehicle, do not purchase the extra insurance as the University has coverage. Also, gas must be purchased before turning the vehicle in instead of added to the rental charge and a receipt from the gas station must accompany request for reimbursement.

Submit receipts and all trip information to the Administrator within 5 business days of trip completion.

More information about travel can be obtained through http://www.procurement.virginia.edu/pagetravel or asking the Administrator.

2. Books

The Training Grant will pay up to $200/year to defray the costs of books or journals related to research activities. Books can be purchased by the Administrator by providing a list or can be reimbursed by turning in a receipt.

3. Journals

One journal subscription is allowed per year (includes subsets and online access). Journal subscription can be paid by the Administrator or reimbursed.

4. Membership – One student or trainee type membership in a professional society is allowed per year. Memberships can be paid by the Administrator or reimbursed. If reimbursed, make sure to select graduate student, post-doctoral, or trainee cost as opposed to full membership cost.

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http://www.procurement.virginia.edu/pagetravel


5. Special Courses – Registration and travel for special courses (such as summer courses at Cold Spring Harbor Laboratory) will be considered in addition to allotted travel funds. Application should be made to the Training Grant Executive Committee through the Training Grant Administrator. A syllabus and cost structure of the proposed course should be provided with a short statement of how this course will be especially significant to the trainee’s progress.

6. CVRC Website

The Cardiovascular Research Center has a site on the Web at http://www.cvrc.virginia.edu. This website provides the ability to: Understand the history and organization of the training program Complete an application online Review the work of participating faculty and make an informed decision on program area and

mentor View a listing of current trainees and their biographies Access and edit your profile Review the orientation process and print out an orientation handbook View information regarding the Outstanding Trainee Award Search the CVRC web pages prior to the WWW.

7. UVa Research Website

The University of Virginia has an extensive site on the Web at http://www.virginia.edu/research. It includes information about all research faculty at the University including their principal field of research, their phone numbers and e-mail addresses. Other resources on this site include visa information; information about how to disclose intellectual property; links to NIH and NSF grant directories on-line; information about courier services available to deliver grant proposals to federal agencies and more. This site is updated weekly, and we encourage you to bookmark it in your browser program.

8. Library Access

Alderman Library and the other eleven libraries in the University System are state libraries, and all residents of Charlottesville and surrounding counties are eligible to use their driver’s license or a similar form of identification as a library card.

The Claude Moore Health Sciences Library is not a state library and is dedicated to Health System Center faculty, staff, students and those affiliated with the Health System Center, such as health care providers in this region. An active University ID card is used to access materials and

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http://www.virginia.edu/research

http://www.cvrc.virginia.edu/


for borrowing privileges. To use online materials through the library and its website, an active UVa email account is necessary.

9. University of Virginia Health System ID Badges and Email

Your primary department (eg, CVRC if you work in a laboratory located in CVRC space including MR-4 and MR-5; Radiology if you are a CVRC trainee but working for a Radiology PI) is responsible for providing trainees with ID badges, email access, door access, HR support, etc.

Speak to the Administrative Director in the Cardiovascular Research Center Offices (MR5, Suite 1010) to establish that you have access to the appropriate doors in the CVRC. The administrative director of any other department can provide similar services.

10. Messenger Mail and U.S. Mail

To facilitate delivery of express mail (FedEx, UPS) on the grounds of the University, your department name should be given as your return address, along with your lab’s building name and room number.

For US Mail and University personnel (referred to as “Messenger Mail”), the department’s name and box number must be used. If the user is located in MR5 building, assigned box numbers for the building should be given as your return address, along with Charlottesville, VA 22908. Check with your Department contact for your box number. The CVRC Box number is PO Box 801394, Charlottesville, VA 22908.

11. Parking and Transportation Services

The Parking and Transportation Office is located on Millmont Street, behind Barracks Road Shopping Center. Their hours are 7:30am – 5:00pm, Monday – Friday. Phone 924-7231 for more information. Permits can be issued immediately for lots at Scott Stadium West and U-Hall.

The University provides bus service to limited areas of the grounds and Charlottesville. There are several bus lines that service different areas as well as a Hospital/Scott Stadium and Hospital/U-Hall shuttle service. Refer to http://www.virginia.edu/parking/bus/bus.html

Charlottesville Transit Service buses are free with your University ID. Refer to http://www.charlottesville.org/Index.aspx?page=662 for bus lines.

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http://www.charlottesville.org/Index.aspx?page=662

http://www.virginia.edu/parking/bus/bus.html


12. Telephone Directory

This is revised annually. To include the names of new faculty, postdoctoral research fellows, and classified staff, complete a Directory Update Form on-line at https://whois.virginia.edu/cgi-local/whois_wrap The cut-off date for inclusion in the new phone book, which is circulated at the end of November, is September 1.

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https://whois.virginia.edu/cgi-local/whois_wrap


CVRC TRAINING GRANT MENTORS

PROGRAM FACULTY

DEPARTMENTAL AFFILIATION

EXECUTIVE COMMITTEE

PAULA Q. BARRETT PHARMACOLOGY MEMBERSTUART S. BERR RADIOLOGYBRETT BLACKMAN BIOMEDICAL ENGINEERING

THOMAS BRACIALEPATHOLOGY AND MICROBIOLOGY

BRIAN R. DULINGMOLECULAR PHYSIOLOGY AND BIOLOGICAL PHYSICS

PRINCIPLE INVESTIGATOR

FRED H. EPSTEIN RADIOLOGYBRENT A. FRENCH BIOMEDICAL ENGINEERING

JAMES C. GARRISON PHARMACOLOGY

BENJAMIN M. GASTON PEDIATRICS

ADRIAN GEAR BIOCHEMISTRYARIEL GOMEZ PEDIATRICSWILLIAM H. GUILFORD BIOMEDICAL ENGINEERINGPATRICE G. GUYENET PHARMACOLOGY

CATHERINE HEDRICKENDOCRINOLOGY AND METABOLISM

BRIAN P. HELMKE BIOMEDICAL ENGINEERINGJEFFREY HOLMES BIOMEDICAL ENGINEERINGJOHN A. HOSSACK BIOMEDICAL ENGINEERING

BRANT E. ISAKSONMOLECULAR PHYSIOLOGY AND BIOLOGICAL PHYSICS MEMBER

CHRISTOPHER KRAMER RADIOLOGY

IRVING KRON SURGERY

VICTOR LAUBACH SURGERYMICHAEL LAWRENCE BIOMEDICAL ENGINEERINGKEVIN S. LEE NEUROLOGYNORBERT LEITINGER PHARMACOLOGY

JOEL LINDENCARDIOVASCULAR RESEARCH

KEVIN LYNCH PHARMACOLOGYPAUL MATHERNE PEDIATRICS

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COLEEN MCNAMARACARDIOVASCULAR RESEARCH

CRAIG MEYER BIOMEDICAL ENGINEERINGRANDALL MOORMAN CARDIOLOGY

JERRY L. NADLERENDOCRINOLOGY AND METABOLISM

TOM OBRIG NEPHROLOGYMARK OKUSA INTERNAL MEDICINE

GARY OWENSMOLECULAR PHYSIOLOGY AND BIOLOGICAL PHYSICS

MANOJ PATEL ANESTHESIOLOGYSHAYN PEIRCE-COTTLER BIOMEDICAL ENGINEERING MEMBERRICHARD J. PRICE BIOMEDICAL ENGINEERING

JEFFREY SAUCERMAN BIOMEDICAL ENGINEERING

MARTIN A. SCHWARTZ MICROBIOLOGY MEMBER

THOMAS C. SKALAK BIOMEDICAL ENGINEERING

AVRIL V SOMLYOMOLECULAR PHYSIOLOGY AND BIOLOGICAL PHYSICS MEMBER

AMY L. TUCKERCARDIOVASCULAR RESEARCH

KENNETH S. TUNG PATHOLOGYBRIAN WAMHOFF CARDIOLOGY MEMBER

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TRAINING PROGRAM ACTIVITIES

RESEARCH IN PROGRESS

DAY: 3rd Monday of every month.TIME: 5:00 PM, food & drinks provided.PLACE: BME lecture room MR5 1041.

Roundtable presentations (January and July):

At a ROUNDTABLE each person gives a brief 4-6 minute synopsis of their ongoing research through oral description, no slides. We will then just go around the table. The goal is for each trainee to gain experience in explaining your research to a diverse audience, and for everyone to become familiarized with the research interests of their fellow CVTG trainees. We strongly encourage you to ask questions to help clarify your peer’s presentation and to supplement the questions that we might ask. The goal is to help you recognize how you might have done a better job at explaining what you are doing and why.

Here are some suggestions for you to think about in preparing what you are going to say.

1. Identify your audience and gear your presentation to the individuals in the group who know the least about your topic area. This is a critical skill for all effective communication including grant writing. Those more familiar will appreciate the refresher.

2. Identify who you are, what lab the work was done in, and perhaps a few words about your overall long term professional interests. For example, if you are a 2nd year student, where do you want to be headed after you receive your diploma?

3. When you begin the summary of your work (this applies to any research communication), you need to always open with a sentence that convinces your audience that what you are about to say is important and worth their attention.

4. Give one or two sentences (you cannot afford much more than this) of background that orients the audience regarding your project and clearly identifies the problem, question, or hypothesis that you hope to address.

5. Tell them how you intend to address the problem/question/hypothesis and if possible the rationale for selecting the experimental approach you selected.

6. Tell them your major findings (if any so far).

7. Give a conclusion that summarizes your findings and what is next.

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8. Identify the “best thing” and “worst thing” about your research.

It is a real challenge to communicate in this fashion but is a skill you must develop to be a successful independent investigator.

RIP sessions (February-June, August-December)

We will assign trainees to these slots. Everyone will present at least once during the year.

Guidelines:

1. Make your presentation approximately 20 minutes long.

2. Two research presentations are usually scheduled for one RIP session.

3. During or following your talk, pose 3-5 questions to stimulate trainee participation.

4. Any attending faculty will be asked to not ask questions at the end of your presentation until there have been at least 2 student questions. Faculty of course can ask points of clarification during talks. However, because of the short time frame, only clarification questions can be asked.

5. Please include material in your RIP presentation that is incomplete or controversial. This could be presented toward the end of your talk and might conclude with a slide summarizing future directions. Don't feel like you should have a complete story before presenting data - take advantage of the great input your trainee colleagues can provide early in a project.

6. Consider presenting a last slide to address the questions, "How does this research project relate to my long term plans of being a successful scientist?"

6. The RIP is intended to be a trainee’s primary forum for exchange of research ideas so please let us know if you have additional suggestions.

All attendees will be expected to fill out an evaluation sheet for each presentation to give feedback to the presenter.

If you have questions about the CVRC Research-in-Progress presentation sessions, please contact Brian Wamhoff ([email protected]).

CVRC RIP Trainee Performance Evaluation Form

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Name of Speaker:

Suggestions for

improvement:

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Content: Excellent Good Poor

Clear statement of purpose

Familiarity with introductory material

Organization of presentation

Discussion of methodology

Discussion of experimental findings

Interpretation of results

Critical evaluation of results and conclusions

Comments:

Presentation: Excellent Good Poor

Clarity of speech

Clarity of slides

Appropriateness of figures

Ability to field questions

Comments:



TRANSLATIONAL RESEARCH ENHANCEMENT PROGRAM

With the increasing recognition of the importance of translational research and of the need for integrative studies for our trainees in cardiovascular biology, we have initiated a Translational Research Enhancement Program for our Cardiovascular Research Trainees. Many of our students are highly focused on cellular and molecular research programs in their laboratory work, and they are more and more likely to be separated from the ultimate product of NIH sponsored research, that is, the illness and the patient. To address this we have developed a program for exposure of basic scientists in training to clinical activities. We have brought together a group of clinician-scientist faculty members involved in both cardiovascular medicine and basic cardiovascular research (see appended table). Each trainee is asked to select an individual from this group and to spend a day in a cardiovascular-related clinical environment. Clinical activities include cardiology and pediatric cardiology clinics, cardiac catheterization laboratory, cardiac and vascular anesthesia, cardiac and vascular surgery, cardiovascular pathology, etc. Ideally, the clinical scientist chosen will have a parallel research interest with the student, but that is not required.

The student will meet with the faculty member for a preclinical orientation and didactic session which will inform the student of what to expect and what they might learn from this experience. During the clinical exposure, and in a didactic session following the clinical experience, the faculty member and student will discuss the relevance of the clinical observations to cardiovascular research issues.

We hope that you will participate in this experience and that you will let us know how it can be improved. Please contact me if you have any questions or if you just want to discuss a clinical activity.

Randall Moorman, [email protected]

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LIST OF CLINICIANS MENTORS FOR TRANSLATIONAL RESEARCH ENHANCEMENT PROGRAM

Name. Telephone, Email ID

Department and Title of Translational Research Experience

Research Interest Clinical Interest

Beller, George (MD), 4-2134; GAB4C

Cardiology Assessment of regional myocardial blood flow and viability using radiotracer techniques; Reperfusion imaging after prolonged ischemia.

Nuclear cardiology, stress testing, coronary artery disease, acute ischemic syndromes, cardiac rehabilitation, preventive cardiology, lipids

Barrett, Eugene (MD, PhD), 4-1175; EJB8X

Endocrinology: Instruction in assessing insulin action in vivo including insulin's action on glucose and protein metabolism and vascular responsiveness

Diabetes, insulin action, nutrition Diabetes, lipid disorders

Baum, Victor (MD)2-3889; VCB2N

Anesthesiology: hemodynamic effects of general and regional anesthesia

Effects of anesthetic agents on sarcolemmal ionic currents in immature myocardium, developmental cardiac electrophysiology.

Cardiac, thoracic and vascular anesthesia

Carey, Robert M. (MD)4-5510; RMC4C

Endocrinology: Hormonal regulation of blood pressure and hypertension

Hormonal control of blood pressure and hypertension

Cardiovascular and renal endocrinology

Dent, John (MD)2-1414; JMD5K

Cardiology: Echocardiography, valvular heart disease, thromboembolism

Valvular heart disease, technology assessment, contrast echocardiography

Echocardiography, valvular heart disease, thromboembolism

Gomez, Ariel D (PhD)2-0078; RG

Pediatric Nephrology Molecular developmental biology of the kidney

Pediatric Nephrology

Kern, John (MD)2-4301; JKERN

Cardiovascular Surgery Spinal cord protection during vascular surgery

Cardiovascular Surgery

Kramer, Christopher (MD)2-4270; CMK2N

Cardiology: Translational Cardiovascular Imaging

Cardiac MRI in ischemic heart disease in animal models and in man. Myocardial viability in acute and chronic ischemic heart disease. LV remodeling after myocardial infarction. Imaging of atherosclerosis and coronary artery disease

general cardiology, ischemic heart disease, cardiac imaging, cardiac MRI and CT, echocardiography

Lynch, Carl (MD, PhD)4-2283; CL7Y

Anesthesiology Myocyte physiology; physiology of excitable cells

Cardiothoracic Anesthesia

Mangrum, James (PhD)2-3817; JMM5V

Cardiology ablation strategies for atrial fibrillation.

Atrial fibrillation, ablation therapy, implantable cardioverter defibrillators, cardiac electrophysiology, biventricular pacing for

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heart failure, pacemakersMatherne, Paul G (PhD)4-5365; GPM2Y

Pediatric Cardiology Cardiac protection and heart failure; Ischemia reperfusion; Murine physiology

Pediatric Cardiology and Cardiac Catheterization

Matsumoto, Allan (MD)4-9279; AHM4D

Radiology: Application of drugs and devices for in vivo animal applications or Multidimensional imaging for assessing the in vivo effects of drugs and devices

Vascular stenting, restenosis, aneurysmal disease, thrombolysis, fibroid embolization, device evaluation, venous thromboembolic disease.

Vascular, biliary, genitourinary, venous thromboembolic and oncologic disease and interventions.

McDaniel, Nancy L (MD)4-9148; NLM9M

Pediatric Cardiology Growth and development in children with congenital heart disease

Cardiac transplantation

McGahren, Eugene D. (MD)4-5643; PIC 4157EDM6K

Surgery: Observation of clinical practice of Pediatric Surgery

Pulmonary microcirculation General pediatric surgery, including neck, chest, abdominal conditions

McNamara, Coleen (MD)2-3366; CAM8C

Cardiology: Understanding the role of helix-loop-helix transcription regulators in vascular lesion formation. Diabetes and Cardiovascular Disease

Understanding the role of helix-loop-helix transcription regulators in vascular lesion formation. Diabetes and Cardiovascular Disease

Adult CardiologyPreventionDiabetes and Cardiovascular Diseases

Moorman, J. Randall (MD)2-3367; RM3H

Cardiology Molecular biology of ion channels; Modulation of cardiac excitability by signal transduction processes; Heart rate variability.

Cardiology and Cardiac Catheterization; Ischemic Heart Disease

Mounsey, J Paul (PhD)4-2465; JM6A

Cardiology Cardiac myocyte electrophysiology Clinical Electrophysiology

Ragosta, Mike (MD)4-2420; MR8B

Cardiology: Application to Coronary Intervention

Coronary physiology, interventional cardiology, myocardial infarction, novel training programs, chronic coronary occlusion, ischemic heart disease

General cardiology;interventional cardiology including angioplasty, stents, atherectomy and coronary brachytherapy; diagnostic catheterization; periperhal interventions

Rembold, Christopher (MD)4-2825; CR2G

Cardiology: Prevention of athrerosclerosis by treating hypertension, dyslipidemia, and the metabolic syndrome

Signal transduction in smooth muscle relaxation and contraction, specifically the mechanism of NO induced relaxation. Risk factors for atherosclerosis and their treatment.

Hypertension, Atherosclerosis and Hyperlipidemia

Theodorescu, Dan (MD, PhD)4-0042; DT9D

Urology Tumor biology and angiogenesis Urology

Tucker, Amy (MD)2-3366; ALT8T

Cardiology The role of adenosine in cardiac protection and angiogenesis

Adult Cardiology

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ANNUAL TRAINEE STATUS REPORT

This form should be completed by each trainee each year in March and submitted to the Training Grant Executive Committee. Continued support of the Training Grant will depend on timely progress including identification of committees, submission of grants, completions of required courses, etc.

I. ANNUAL TRAINEE STATUS REPORTRobert M. Berne Cardiovascular Research Center Basic Cardiovascular Research Training Grant 5T32-HL007284

Biographical Data:

Full Name: _______________________________________________________________________

Year of Entry to Grant: _________________ Date completing this form: ____________________

Local Address: ___________________________________________________________________

________________________________________________________________________________

Local Phone Number: _____________________________________________________________

Permanent (Non-UVa) Email: _______________________________________________________

Permanent (eg, parents’) Address and phone number (to be used to try to locate you for trainee updates for grant renewals): _________________________________________________

________________________________________________________________________________

Report Instructions: Students: complete Sections A and B

Postdocs: complete Section B.

Section A: Students Only

1. Courses Remaining to Complete Your PhD:

2. Lab Rotations Completed or in Progress:

3. Ph.D. Department Candidacy Exam (date of completion or date scheduled):

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4. Title or Working Title of Dissertation

5. Dissertation Committee Members (indicate Mentor):

6. Anticipated thesis defense date (or year):

7. Anticipated date of graduation

Section B. All Trainees:

1. Courses taken in the last year and grades. If none, please indicate.

2. Time with Mentor: How much one-on-one time (amount and frequency) do you spend with your mentor per month?

3. Publications:Please include a citation list with the following categories: published, submitted manuscripts, manuscripts in preparation, and abstracts. Please indicate if authored or co-authored. If none, please indicate.

4. Grants Applied for and Grants Awarded: Please list. All trainees must have applied for a grant by the end of their second year on the CVRC Training Grant; Postdoctoral fellows are highly encouraged to apply for a grant before the end of their first year of support.

5. Presentations at Scientific Meetings or Seminars Given:List the meeting, where it was held, the date of your presentation, the type of your presentation, and the title of your talk or poster.

6. Research Summary:Please provide a brief description of the research conducted during the current grant year. (For those predocs who have yet to select a specific project, a statement of research worked on in different mentors’ labs will suffice.) Additionally, provide a summary of the work to be conducted during the upcoming appointment year.

7. Modern Literature in Cardiovascular Research (BIMS 853/854) Please indicate if you have participated in the last year and frequency of participation. If you taught a section, please indicate.

8. Translational Research Program:

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If you participated in the translational research program during the current grant year, please provide the name and department of the clinician you worked with, dates, and a brief summary of the experience.

9. CV Training Grant Journal Club/RIP:How many of the monthly journal club or RIP meetings did you attend during the current grant year? Did you present any articles?

10.Awards and Honors If none, please indicate.

11.Other Significant Activity (course sections taught, leadership positions, students mentored, sessions chaired). If none, please indicate.

12.Suggestions for Grant Improvement. Where should we improve? Have you noticed something about the Training Grant experience that you would like us to know?

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orientation handbook

Documents

faculty research

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phd training

complete training

training period

finest research minds

cardiovascular researchwe

year of graduate training