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OPHTHALMOLOGY DIABETES MBChB 4 Prof P Roux 2012

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OPHTHALMOLOGY DIABETES. MBChB 4 Prof P Roux 2012. DIABETIC RETINOPATHY. 1. Adverse risk factors. 2. Pathogenesis. 3. Background diabetic retinopathy. 4. Diabetic maculopathies Focal Diffuse Ischaemic. 5. Clinically significant macular oedema. - PowerPoint PPT Presentation

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Page 1: OPHTHALMOLOGY DIABETES

OPHTHALMOLOGYDIABETES

MBChB 4Prof P Roux

2012

Page 2: OPHTHALMOLOGY DIABETES

DIABETIC RETINOPATHY

1. Adverse risk factors2. Pathogenesis

5. Clinically significant macular oedema6. Preproliferative diabetic retinopathy

3. Background diabetic retinopathy4. Diabetic maculopathies• Focal• Diffuse• Ischaemic

7. Proliferative diabetic retinopathy

Page 3: OPHTHALMOLOGY DIABETES

Adverse Risk Factors1. Long duration of diabetes

• Obesity• Hyperlipidaemia

2. Poor metabolic control

3. Pregnancy

4. Hypertension

5. Renal disease

6. Other

• Smoking• Anaemia

Page 4: OPHTHALMOLOGY DIABETES

Pathogenesis of diabetic retinopathy

Page 5: OPHTHALMOLOGY DIABETES

Consequences of retinal ischaemia

Page 6: OPHTHALMOLOGY DIABETES

Consequences of chronic leakage

Page 7: OPHTHALMOLOGY DIABETES

Location of lesions in background diabetic retinopathy

Page 8: OPHTHALMOLOGY DIABETES

Signs of background diabetic retinopathy

Microaneurysms usually temporal to fovea

Intraretinal dot and blot haemorrhages

Hard exudates frequentlyarranged in clumps or rings

Retinal oedema seen asthickening on biomicroscopy

Page 9: OPHTHALMOLOGY DIABETES

Focal diabetic maculopathy

• Circumscribed retinal thickening• Associated complete or incomplete circinate hard exudates

• Focal leakage on FA• Focal photocoagulation• Good prognosis

Page 10: OPHTHALMOLOGY DIABETES

Diffuse diabetic maculopathy

• Diffuse retinal thickening • Generalized leakage on FA

• Guarded prognosis• Grid photocoagulation• Frequent cystoid macular oedema

• Variable impairment of visual acuity

Page 11: OPHTHALMOLOGY DIABETES

Ischaemic diabetic maculopathy

• Macula appears relatively normal • Capillary non-perfusion on FA• Poor visual acuity • Treatment not appropriate

Page 12: OPHTHALMOLOGY DIABETES

Clinically significant macular oedema

Hard exudates within 500 m of centre of fovea with adjacent oedema which may be outside 500 m limit

Retinal oedema one disc area or larger any part of which is within one disc diameter (1500 m) of centre of fovea

Retinal oedema within 500 m of centre of fovea

Page 13: OPHTHALMOLOGY DIABETES

Treatment of clinically significant macular oedema

• For microaneurysms in centre of hard exudate rings located 500-3000 m from centre of fovea

Focal treatment

• Gentle whitening or darkening of microaneurysm (100-200 m, 0.10 sec)

• For diffuse retinal thickening located more than 500 m from centre of fovea and 500 m from temporal margin of disc

Grid treatment

• Gentle burns (100-200 m, 0.10 sec), one burn width apart

Page 14: OPHTHALMOLOGY DIABETES

Preproliferative diabetic retinopathy

Treatment - not required but watch for proliferative disease

• Cotton-wool spots• Venous irregularities

• Dark blot haemorrhages• Intraretinal microvascular abnormalities (IRMA)

Signs

Page 15: OPHTHALMOLOGY DIABETES

Proliferative diabetic retinopathy

• Flat or elevated• Severity determined by comparing with area of disc

Neovascularization

Neovascularization of disc = NVD

• Affects 5-10% of diabetics• IDD at increased risk (60% after 30 years)

Neovascularization elsewhere = NVE

Page 16: OPHTHALMOLOGY DIABETES

Indications for treatment of proliferativediabetic retinopathy

NVD > 1/3 disc in area Less extensive NVD + haemorrhage

NVE > 1/2 disc in area + haemorrhage

Page 17: OPHTHALMOLOGY DIABETES

• Spot size (200-500 m) depends on contact lens magnification

• Gentle intensity burn (0.10-0.05 sec)

• Follow-up 4 to 8 weeks

• Area covered by complete PRP• Initial treatment is 2000-3000 burns

Laser panretinal photocoagulation

Page 18: OPHTHALMOLOGY DIABETES

Assessment after photocoagulation

• Persistent neovascularization• Haemorrhage

Poor involution

• Re-treatment required

• Regression of neovascularization• Residual ‘ghost’ vessels or fibrous tissue

Good involution

• Disc pallor

Page 19: OPHTHALMOLOGY DIABETES

Indications for vitreoretinal surgery

Retinal detachment involving macula

Severe persistent vitreous haemorrhage

Dense, persistent premacular haemorrhage

Progressive proliferation despite laser therapy