Ointments suspension Ointments suspension and emulsionand emulsion(UNGUENTA)(UNGUENTA)

Author: as. Author: as. Yu.Yu. Yu.Yu.

PlaskonisPlaskonis

Ointments - suspensions are ointments, in the Ointments - suspensions are ointments, in the complement of which medicinal matters enter complement of which medicinal matters enter

soluble neither in basis nor in water.soluble neither in basis nor in water.

If the total amount of these substances If the total amount of these substances less less thanthan 5%, ground them with fluid, which is 5%, ground them with fluid, which is similar in characteristics to the base: similar in characteristics to the base: hydrophilic base – Aqua purificata, hydrophilic base – Aqua purificata, Vaselinum- olium vaselini, fatty base - stone Vaselinum- olium vaselini, fatty base - stone oil. Liquids are by rule Deryahina ½ the oil. Liquids are by rule Deryahina ½ the mass of dry matter. mass of dry matter.

If the total amount of these substances If the total amount of these substances more than 5%, they are ground by the rule more than 5%, they are ground by the rule DERYAGIN with ½ of the mass of dry matter DERYAGIN with ½ of the mass of dry matter molten basis.molten basis.

Ointments-suspension - this ointment containing solid Ointments-suspension - this ointment containing solid powder, crushed to the smallest size of drug substances powder, crushed to the smallest size of drug substances insoluble in water and the basis and distributed it to the insoluble in water and the basis and distributed it to the type of suspension (exceptions are Zinci sulphatis and type of suspension (exceptions are Zinci sulphatis and

Resorcini).Resorcini).

If the If the amountamount of insoluble substances in of insoluble substances in the ointment is from 5 to 20%, the ointment is from 5 to 20%, then then they were carefully ground in a mortar, they were carefully ground in a mortar, first in a dry form, and then with half first in a dry form, and then with half the quantity of the molten mass of dry the quantity of the molten mass of dry matter basis.matter basis.Use of auxiliary fluids in Use of auxiliary fluids in this case is pointless, because it will this case is pointless, because it will cause dilution of ointment and cause dilution of ointment and decrease the concentration of drugs.decrease the concentration of drugs.

Rp.: Unguenti Strеptocidi 3 % Rp.: Unguenti Strеptocidi 3 % 10,0 10,0 Da. Signa: Grease wounds. Da. Signa: Grease wounds. This suspension ointment containing This suspension ointment containing

solids less than 5% (3%). Streptocidi (0.3 solids less than 5% (3%). Streptocidi (0.3 g) as a substance that is difficult crushed, g) as a substance that is difficult crushed, crushed in the presence of a few drops of crushed in the presence of a few drops of Spiriti aethilici, and then carefully Spiriti aethilici, and then carefully ground with a few drops (0.15 g) Olei ground with a few drops (0.15 g) Olei Vaselini and Vaselini and received up to this mass received up to this mass obtained in 2-3 receptions give Vaselini obtained in 2-3 receptions give Vaselini with constant stirring to obtain a with constant stirring to obtain a homogeneous mass. homogeneous mass.

Rp.: Unguеnti Xеroformii Rp.: Unguеnti Xеroformii 100,0 100,0

Da. Signa: Ointment for Da. Signa: Ointment for bandages.bandages.

To prepare this ointment take 10.0 To prepare this ointment take 10.0 Xerophormi and 90.0 Vaselini. Xerophormi and 90.0 Vaselini. In a In a mortar mortar Xеroformii Xеroformii milled first in a dry milled first in a dry form, and then with half the quantity form, and then with half the quantity (5.0 g) melted Vaselini.(5.0 g) melted Vaselini.

After that, in several stages, with After that, in several stages, with careful careful ground ground add Vaselini, which add Vaselini, which remained.remained.

Rp.:Norsulfazoli-0,5Rp.:Norsulfazoli-0,5 LanoliniLanolini VaseliniVaselini -- ana 5,0ana 5,0 M., f. ung.M., f. ung. D. S. Smear of nasal D. S. Smear of nasal

inputs inputs 2 times a day.2 times a day.

Technology.Technology. In the mortar put 0.5 In the mortar put 0.5 Norsulfazoli and rubbing in dry form Norsulfazoli and rubbing in dry form first, then with 6 drops of Olei first, then with 6 drops of Olei Vaselini (per rule Deryahina). By Vaselini (per rule Deryahina). By mixing in the pulp obtained in 2-3 mixing in the pulp obtained in 2-3 receptions added 5.0 Lanolini receptions added 5.0 Lanolini hydricae, and 5.0 Vaselini until a hydricae, and 5.0 Vaselini until a homogeneous mixture.homogeneous mixture.

Written passport control (reverse side)Written passport control (reverse side)

% Norsulphazoli% Norsulphazoli

10,5 – 100%10,5 – 100%0,5 – х х = 4,8%0,5 – х х = 4,8%Olei VaseliniOlei Vaselini

1.0 - 23 drops1.0 - 23 drops0.25 - x =6 drops0.25 - x =6 drops

Written passport control (front side)Written passport control (front side)Date Number of prescriptionDate Number of prescriptionNorsulfazoli 0,5Norsulfazoli 0,5Olei Vaselini gtts. VI (1,0 – 23 drops.)Olei Vaselini gtts. VI (1,0 – 23 drops.)Lanolini hydrici 5,0Lanolini hydrici 5,0Vaselini 5,0Vaselini 5,0MM general= 10,5general= 10,5Prepared:Prepared:

Tested:Tested:

Pasta - this ointment containing more than Pasta - this ointment containing more than 20% (by SP Ukraine) solid phase. They are 20% (by SP Ukraine) solid phase. They are characterized by a dense consistency. characterized by a dense consistency.

When the human body temperature paste When the human body temperature paste only soften, not melt, and therefore may only soften, not melt, and therefore may be more time to linger on the skin.be more time to linger on the skin.

Depending on the destination of feed Depending on the destination of feed divided into: divided into: • Dermatological, • Dermatological, • • dental medicaldental medical• tooth. • tooth.

Dermatological pastes prepare by Dermatological pastes prepare by mixing of powdery medicinal matters mixing of powdery medicinal matters with molten basis.with molten basis.

Addition of liquid it follows to avoid Addition of liquid it follows to avoid for grinding of hard matters, so as it for grinding of hard matters, so as it results in dilution of paste.results in dilution of paste.

Medicinal nonsolutes which are Medicinal nonsolutes which are included in paste grind in shallow included in paste grind in shallow powder, mix up in the heated mortar powder, mix up in the heated mortar and gradually at the careful stirring and gradually at the careful stirring add molten basis to them add molten basis to them

Rp.: Acidi salicylici 0,4 Rp.: Acidi salicylici 0,4 Zinci oxydiZinci oxydiAmyli aa 5,0 Amyli aa 5,0 Vaselini 10,0 Vaselini 10,0 Misce, fiat pastaMisce, fiat pastaDa. Signa: Pasta Lassara.Da. Signa: Pasta Lassara.

Zinci oxydi, Acidi salicylici and Amyli did Zinci oxydi, Acidi salicylici and Amyli did not dissolve in water and Vaselini. Salicylic not dissolve in water and Vaselini. Salicylic acid in the friction creates dust that irritate acid in the friction creates dust that irritate mucous membranes. mucous membranes. In the porcelain cup in a water bath In the porcelain cup in a water bath melted melted Vaseline. In mortar warmed (50 ° Vaseline. In mortar warmed (50 ° C) milled Zinci oxydi, mixed with Acidi C) milled Zinci oxydi, mixed with Acidi salicylici and part of the molten Vaselini salicylici and part of the molten Vaselini (5.0 g). To add weight chilled parts starch (5.0 g). To add weight chilled parts starch (starch when mixed with hot Vaselini may (starch when mixed with hot Vaselini may form a starch paste), add the remaining form a starch paste), add the remaining melted Vaselini and mix until a melted Vaselini and mix until a homogeneous mixture. homogeneous mixture.

OintmentOintment -emulsion - a -emulsion - a heterogeneous system consisting heterogeneous system consisting of two phases and have a of two phases and have a surface section of the phase and surface section of the phase and environment. environment. This includes water solution or This includes water solution or water soluble drug substances, water soluble drug substances, which form the ointment basis which form the ointment basis emulsion, mainly type W / Oemulsion, mainly type W / O

Medicinal substances are easily Medicinal substances are easily soluble in water and prescribe in small soluble in water and prescribe in small quantities (less than 5%). Dissolved in quantities (less than 5%). Dissolved in a minimum amount of water. If they a minimum amount of water. If they are written in large quantities, they do are written in large quantities, they do not dissolve in water (except not dissolve in water (except Collargolum, Protargolum, Tanninum), Collargolum, Protargolum, Tanninum), and injected in ointment on the type and injected in ointment on the type of suspension. Dry and thick extract is of suspension. Dry and thick extract is injected into the ointments after injected into the ointments after preliminary rubbing them with preliminary rubbing them with alcohol-water-glycerol (1:6:3) mixturealcohol-water-glycerol (1:6:3) mixture

Ointments -type emulsion W / Ointments -type emulsion W / OO

RpRp.: .: Kalii iodidi 5.0Kalii iodidi 5.0

Natrii thiosulfatis 0.1 Natrii thiosulfatis 0.1

Aquae purificatae 4.4mlAquae purificatae 4.4ml

Lanolini anhydrici 13.5 Lanolini anhydrici 13.5

Axungiae porcinae 27.0Axungiae porcinae 27.0

Misce fiat unguentumMisce fiat unguentum Da. Signa. Da. Signa. For embracation.For embracation.

Kalii iodidi and Natrii thiosulfatis Kalii iodidi and Natrii thiosulfatis dissolved dissolved in water and the resulting solution is in water and the resulting solution is emulsified anhydrous lanolini.emulsified anhydrous lanolini.

By the obtained emulsion is added with By the obtained emulsion is added with stirring, thick emulsion based water / stirring, thick emulsion based water / Vaselinum.Vaselinum.

Ointment should have a yellowish colour. Ointment should have a yellowish colour. Adding Natrii thiosulfatis aims binding free Adding Natrii thiosulfatis aims binding free iodine, which can be distinguished even at iodine, which can be distinguished even at short storage. Presence of the brown colour short storage. Presence of the brown colour indicates the ointment selection of free indicates the ointment selection of free iodine, and in this case, an ointment for iodine, and in this case, an ointment for application useless. If a part of the iodine application useless. If a part of the iodine ointment is prescribed, it is prepared ointment is prescribed, it is prepared without adding Natrii thiosulfatis. without adding Natrii thiosulfatis.

Ointments -emulsions type Ointments -emulsions type O/W are typical cooling O/W are typical cooling ointments. Emulsifier in them ointments. Emulsifier in them is soap.is soap.

RpRp.:.: Stearini 10.0 Stearini 10.0 Kalii carbonatis 1.0 Kalii carbonatis 1.0

Natrii tetraboratis 0.5 Natrii tetraboratis 0.5 Olei Vaselini 15.0 Olei Vaselini 15.0

Aquae purificatae 70 ml Aquae purificatae 70 ml Misce fiat unguentumMisce fiat unguentum

Da. Signa. Da. Signa.

In warm aquatic solution of In warm aquatic solution of Kalii Kalii carbonatis carbonatis and and Natrii tetraboratis Natrii tetraboratis at at permanent interfusion add an alloy permanent interfusion add an alloy to the to the SteariniStearini a thin stream with a thin stream with butter. There is densifying of mass.butter. There is densifying of mass.