nutraceuticals : let food be ur medicine

PATEL BINDIYA RAMESH 1

NUTRACEUTICALS

“Let Food be Your Medicine”

Presented By

Patel Bindiya Ramesh

M.Pharm – (II semister)

(Pharmaceutics)

Under the guidance of

Dr. K. H. Ramteke

(M.Pharm, Ph.D.)

Dept. of Pharmaceutics

PE Society’sModern college of pharmacy (for ladies), Moshi,

Pune.


Content

Objective

History

Definition

Introduction

Classification

Scope

Area covered by nutraceuticals

Marketed products

Conclusion


Objective

To know what is nutracuetical?

To study various sources of nutraceuticals and its importance's.


History …

▪ The Greek physician Hippocrates, often known as the “father of

medicine” said “let food be your medicine”. The Philosophy behind is:

“Focus on Prevention”

▪ The term "Nutraceutical" was coined by combining the terms

"Nutrition" and "Pharmaceutical" in 1989 by Dr. Stephen De Felice.


▪ According to Dr. DeFelice , “Nutraceutical is any substance that

is a food or a part of food that provides medicinal or health

benefits including the prevention and treatment of disease.”

▪ Health ministry of Canada defines it “As a product isolated or

purified from the food generally sold in medicinal form not

assisted with food and demonstrated to have a physiological

benefit and provide protection against chronic disease.”


Definition Of Nutraceuticals…▪ A nutraceutical is any substance considered as a food, or its part which,

in addition to its normal which, in addition to its normal nutritional value

provides health benefits including the prevention of disease or

promotion of health.

▪ It is “any non-toxic food component that has scientifically proven

health benefits, including disease treatment or prevention” .

▪ The functional component of the food must be standardized in the

nutraceutical product and produced under good manufacturing

practices (GMPs).


Food As……Medicine

▪ Nearly two thirds of the world’s 6.1 billion people

rely on the healing power of plant based materials

for many reasons- availability, affordability, safety

or their belief in traditional affordability, or belief in

traditional cures.

▪ Medical benefits of food have been explored for

thousands of years Modern nutraceutical industry

began to develop during the 1980s.


Nutrition Required for

health

Pharmaceuticals Remedy for

sickness/injury

Nutraceuticals Preventative

medical approach

Figure : Concept of nutraceuticals


Nutraceuticals can be classified as…

1. Potential Nutraceuticals - One which has promising approach

towards particular health or medicinal benefit.

2. Established Nutraceuticals – A Potential Nutraceutical becomes

established nutraceutical only after there are sufficient clinical

use to demonstrate a benefit.


Nutraceuticals mainly consists of …

1. Nutrients: Substances which have established Nutritional

functions e.g. Vitamins, Minerals, Amino Acids, Fatty acids, etc.

2. Herbals/ Phytochemicals: Herbs or Botanical products.

3. Dietary Supplements: Probiotics, Prebiotics, Antioxidents,

Enzymes, etc.


Scope Of Nutraceuticals Disease Nutraceuticals Source

1) Joint health Glucosamine

Chondroitin

Found in ligaments ,cartilages,tissue, tendons Proteoglycans of articular cartilage

2) Cardiovascular health

Co Q-10

Melatonin

DHA

Soyabean ,olive oil

Bone marrow ,pineal glands

Fish oil

Reseveratrol

Caretonoids

Catechin

Grapes, red wine

Carrot ,sweet potato

Tea extracts


Disease Nutraceuticals Scope

3) Eye health DHA

Pycnogeal

Linseed (flax oil),fish oil

Barley

Lotein

Caretonoids

Spinach

Carrot ,sweet potatoes

4) Cancer prevention DHA

Resveratrol

Flax seed,linseed,fish oil.Red wine,grapes

Lycopene

Tea extracts (ellagic acid)

Tomatoes ,grape fruit

Strawberry ,Raspberry


CLASSIFICATION OF NUTRACEUTICALS

Natural source

Pharmacological condition

Chemical constituent


Classification Based On The Chemical Groups


Classification based on source

Plant Tomato, garlic, momordica

Animal Shark liver oil, codeliver oil

Minerals Calcium ,magnesium, phosphorous

Microorganism Bifidobacterium, lactobacilli


Inorganic Mineral Supplement

Calcium

Magnesium

Manganese

Boron

Copper

Zinc

Phosphorus


Calcium: Essential for bone and teeth, maintaining bone strength,

nerve, muscle and glandular function, blood clotting.

Iron: Energy production, Hb, oxygen transport.

Magnesium: For healthy nerve and muscle function, bone

formation.

Phosphorous: Energy production, phosphorylation process, bone

and teeth, for genetic material.


o Cobalt: Component of vit. B 12 and B 12 coenzymes.

o Copper: Hb and collagen production, function of heart, energy

production, absorption of iron.

o Iodine: Proper function of thyroid gland.

o Chromium: With insulin it helps in conversion of carbohydrate and fat

into energy, treatment of diabetes.

o Selenium: Antioxidant, functioning of heart muscle, part of GPX enzyme,

o Zinc: Essential for cell reproduction, for development in Neonates, wound

healing, production of sperm and testosterone hormone,


Vitamins Fat Soluble Vitamins

Vitamin A: Acts as antioxidant, essential for growth and

development, maintains healthy vision, skin and mucous

membranes, may aid in the prevention and treatment of certain

cancers and in the treatment of certain skin disorders.

Vitamin D: Essential for formation of bones and teeth, helps the

body to absorb and use calcium.

Vitamin E: Antioxidant, helps to form blood cells, boost immune

system.

Vitamin K: Essential for blood clotting


Water soluble vitamins

Vitamin C: Antioxidant, necessary for healthy bones, gums, teeth and skin.

Helps in wound healing, prevent from common cold.

Vitamin B1: Helps in carbohydrate metabolism, essential for neurological

function.

Vitamin B2: Energy metabolism, maintain healthy eye, skin and nerve

function.

Vitamin B3: Energy metabolism, brain function.

Vitamin B6: Helps to produce essential proteins, convert proteins to energy

Vitamin B12: Help in producing genetic material, formation of RBC,

maintenance of CNS, synthesis of amino acids, involved in metabolism of

protein, fat and carbohydrate.


Folic acid: Helps in RBC formation, formation of genetic

material of cell, very much essential during pregnancy.

Pantothenic acid: Aids in synthesis of cholesterol, steroids, and

fatty acids, crucial for intra neuronal synthesis of acetylcholine.


ProbiticsLive microorganisms which, when administered in adequate

amounts, confer a health benefit on the host

Species of Lactobacillus

Bifidobacterium

yeast Saccharomyces cerevisiae

some E. coli and Bacillus species are also used as probiotics


Shorten Duration of Intestinal Infections

Treat Diarrhea

Improve Symptoms of

Irritable Bowel Syndrome

Reduce Bladderand Urinary

Tract Infections

ManageLactose

Intolerance

PotentialBenefits ofProbiotics


Prebiotics Nondigestible substances that provide a beneficial physiological effect

for the host by selectively stimulating the favorable growth of a limited

number of indigenous bacteria.

Commonly known prebiotics are:

Oligofructose

Inulin

Galacto-oligosaccharides

Lactulose


Herbs

Aloe vera: Anti-inflammatory, emollient, wound healing,

Evening Primrose oil: Dietary supplement of linoleic acid,

treatment of atopic eczema.

Garlic: Antibacterial, antifungal, antithrombotic, antiinflammatory

Ginger: carminative, antiemetic, treatment of dizziness.

Ginseng: Adaptogen


Green tea: Antioxidant, reduces risk of CVD, enhances humoral

and cell mediated Immunity.

Vegetables, fruits, whole grain, herbs, nuts and various seeds

contain an abundance of phenolic compounds, terpenoids,

sulphur compounds, pigments etc. that has been associated

with protection / treatment of certain disease conditions.


Phytochemicals

Phytochemicals could provide health benefits as:

Substrate for biochemical reactions

Cofactors of enzymatic reactions

Inhibitors of enzymatic reactions

Absorbents that bind to & eliminate undesirable constituent

in the intestine

Scavengers of reactive or toxic chemicals


Enhance the absorption and / or stability of essential

nutrients

Selective growth factor for beneficial bacteria

Fermentation substrate for beneficial bacteria

Selective inhibitors of deleterious intestinal bacteria


Various phytochemicals

Phytochemicals Source Role Tocotrienols & tocopherols

Grains Suppressed the growth of diverse tumors cell lines via initiation of apoptosis and concomitant arrest of cells in the G1 phase of the cell cycle

Carotenoids Fruits & vegetables Antioxidants, protects against uterine, prostate, colorectal, lung and digestive tract cancers, and protection to other antioxidants.


Limonoids Citrus fruits Inhibiting phase I enzymes & inducing phase II detoxification enzymes in liver, provide protection to lung tissue.

Phytosterols Various plants Exhibit anti-inflammatory, anti-neoplastic, anti-pyretic & immune- modulating activity, decrease cholesterol.

Phenolic constituents

Various plants, wholegrain Antioxidants, lowers the risk of

CHD, diabetes, hypertension etc.


Flavonoids Grapes, wines Action against free radicals, free radicals mediated cellular signaling, inflammation, allergies, platelet aggregation, & hepatotoxins

Catechin & gallic acids

Grapes, berries, cocoa, green tea, acacia spp.

Antioxidants, free radical scavenging ability.

Isoflavonoids Soybeans Treating cancers & osteoporosis


Anthocyanidins Fruits & flowers Antioxidants & anti-mutagenic properties

Glucosinolates Cruciferous Activators of liver, detoxification enzymes, inhibit the neoplastic effect of various carcinogens.

Indoles Reduces estrogen dependent cancer risk,

Fiber Various vegetables, fruits, Protects against colorectal

diseases,


fruits

FRUITS BODY BENEFITS

1) Apples An apple’s 3 gm of fibre help you meet your fibre goal of 20g to 30 g daily.High fibre diets can lower high disease risk.

2) Apricots A good source of beta carotene(which is converted to vit-A by the body) providing the equivalent of 35% of RDA for vit-A

3) Bananas They are the great source of potassium ,which plays great role in heart and muscles function

4) Cherries Heart protective anthocyanins are present and also gives colour

5) Papayas Loaded with vit-C with b-carotene and calcium


vegetablesVEGETABLES BODY BENEFITS

1)Broccoli This food is loaded with sulphoraphane ,consisting 72 mg of calcium,78 mg of folic acid and vitamin C

2)Cabbage The indoles in a cabbage makes it a cancer fighter.

3)Carrots A stellar source of beta-carotene.one carrot contains twice unit of vit-A.

4)Tomatoes Technically consider as a fruit loaded with cancer fighting lycopene and a great source of vit-A.


Dietary fibre

• Structural carbohydrate of plants

• Neither digested nor absorbed

• Insoluble fibers - Predominant– Absorbs water in gastrointestinal tract– Promotes regular elimination– Increases stool weight – Speeds up digestion/elimination time

• Soluble fibers - Health benefits– Lowers serum cholesterol– Regulates blood sugar levels


Intake of Dietary Fiber

• Increased fiber intake may reduce risk of:– Gastrointestinal diseases– Hypertension– Diabetes– Heart disease– Several types of cancer (Colon)

• Recommended: 20-35 g daily

• Best sources: fruit, vegetables, whole grain breads/cereals, beans, rice, nuts, seeds.

• Adequate water intake is important.


Areas covered by Nutraceuticals

All therapeutic areas such as,

1. Anti- Arthritic (Rheumatoid Arthritis)

2. Sleeping disorders

3. Digestion problems

4. Prevention of certain cancers (Colorectal cancer)

5. Osteoporosis

6. Blood pressure

7. Cholesterol lowering (garlic)

8. Neurological disorders (Autism)

9. Diabetes etc..


NUTRACEUTICALS AVAILABLE IN MARKET

Brand name Components Function

Betatene Carotenoids Immune function

Xangold Lutein esters Eye health

Lipoec -lipoic acid Potent antioxidant

Generol Phytosterol CHD reduction

Premium probiotics probiotics Intestinal disorder

Soylife Soyabean phytoestrogen

Bone health


NUTRACEUTICALS AVAILABLE IN MARKET

Brand name Components Function

Z-trim Wheat Zero calorie fat replacer

Linumlife Lignan extract flax Prostate health

Fenulife Fenugreek galactomannon

Control blood sugar

Teamax Green tea extract Potent antioxidant

Marinol 3 FA, DHA, EPA Heart health protection

Clarinol CLA Weight loss ingredient

Cholestaid Saponin Reduce cholesterol


CONCLUSION Nutraceuticals are present in most of the food ingredients with varying

concentration.

Concentration, time and duration of supply of nutraceuticals influence

human health.

Manipulating the foods, the concentration of active ingredients can be

increased.

Diet rich in nutraceuticals along with regular exercise, stress reduction and

maintenance of healthy body weight will maximise health and reduce

disease risk.

“An Apple a Day Keeps the Doctor Away”.


REFERENCES1. Brower V. “Nutraceuticals: poised for a healthy slice of the healthcare market” Nat.

Biotechnol.1998, 16, 728-731.

2. http://www.hc-sc.gc.ca/sr-sr/biotech/about.apropor/gloss-eng.php(assessed on 23

sep 2010)

3. Raaz .M; Priyanka S; Bina R; Chauhan AK. “Healthy living with Nutraceuticals”

International Research Journal of Pharmacy 2011,2(12),12-14

4. Bahadoran Z; Parvin M; Fereidoun A. “Dietary polyphenols as potential Nutraceuticals

in management of diabetes” Journal of Diabetes & Metabolic Disorders 2013,12:43

5. Mahima ; Amit K; Ruchi T; K Karthik” Nutraceuticals from fruits and vegetables at

glance” . Journal of Biological sciences 2013,13(3):38-47

nutraceuticals : let food be ur medicine

Health & Medicine

prevention of disease

cardiovascular health

particular health

promotion of health

established nutraceuticals

disease nutraceuticals

disease nutraceuticals

proven health benefits