nifedipine monotherapy controls essential hypertension

Nifedipine Monotherapy Controls Essential Hypertension When given as a slow release formulation in Nigerian patients Following a 2-week placebo washout period, 32 Nigerian patients, with mild to moderate essential hypertension (diastolic BP 95mm Hg but::!;; 120mm Hg) were randomly assigned to sustained release nifedipine 20mg bid (n = 16) or placebo (n = 16) in double-blind fashion for 6 weeks. The groups were comparable for age and weight. In the nifedipine group, there was a significant reduction in mean supine and standing systolic and diastolic BP compared with baseline and 10 of the 12 evaluable patients (83%) achieved goal BP at 90mm Hg. Although 5 of the 14 evaluable patients in the placebo group achieved goal BP the overall reduction was not significant. There was no significant change in heart rate, bodyweight or blood chemistry and one nifedipinetreated patient withdrew because of side effects. Thus ' ••• nlfedlplno In .u.talned-rel .... form, I •• fflc.clou • •• monoth.,.py for mild to mod.,.t ••••• ntl.1 hypert.n.lon In black (Nigerian) p.tlent.'. HNC. Ikeh va. Nguru EC, Offiah EC Current Therapeutic Research 40 196-202, Jul 1986 12 INPHARMA'"' 16 Aug 1986 0156-2703/86/0802-001 2/0$01.00/0 © ADIS Press

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Page 1: Nifedipine Monotherapy Controls Essential Hypertension

Nifedipine Monotherapy Controls Essential Hypertension When given as a slow release formulation in Nigerian patients

Following a 2-week placebo washout period, 32 Nigerian patients, with mild to moderate essential hypertension (diastolic BP ~ 95mm Hg but::!;; 120mm Hg) were randomly assigned to sustained release nifedipine 20mg bid (n = 16) or placebo (n = 16) in double-blind fashion for 6 weeks. The groups were comparable for age and weight.

In the nifedipine group, there was a significant reduction in mean supine and standing systolic and diastolic BP compared with baseline and 10 of the 12 evaluable patients (83%) achieved goal BP at 90mm Hg. Although 5 of the 14 evaluable patients in the placebo group achieved goal BP the overall reduction was not significant. There was no significant change in heart rate, bodyweight or blood chemistry and one nifedipinetreated patient withdrew because of side effects. Thus ' ••• nlfedlplno In .u.talned-rel .... form, I •• fflc.clou • •• monoth.,.py for mild to mod.,.t ••••• ntl.1 hypert.n.lon In black (Nigerian) p.tlent.'. Inenac~" HNC. Ikeh va. Nguru EC, Offiah EC Current Therapeutic Research 40 196-202, Jul 1986

12 INPHARMA'"' 16 Aug 1986 0156-2703/86/0802-0012/0$01.00/0 © ADIS Press

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