nifedipine gits: some action better than none in stable angina
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Inpharma 1454 - 11 Sep 2004
Nifedipine GITS: some ACTIONbetter than none in stable anginaWhile the addition of nifedipine GITS* to conventional
treatment for angina pectoris was not associated with animprovement in major cardiovascular event-freesurvival, it did reduce the need for coronary proceduresand interventions for symptoms, according to amultinational team of researchers.1
In the ACTION** study, 7665 patients aged ≥ 35 yearswho were being treated for stable angina pectoris wererandomised to receive additional treatment with oralnifedipine GITS starting at 30 mg/day and increasing to60 mg/day (n = 3825) or placebo.† There was a plannedfollow-up of 4.5–6 years.
There was no significant between-group difference inthe incidence of major cardiovascular event-freesurvival. However, there were significant reductions inthe rate of new overt heart failure and the need forcoronary angiography and bypass surgery in the groupthat received nifedipine, compared with the group thatreceived placebo; the respective values were 0.46versus 0.65, 5.46 versus 6.69 and 1.62 versus 2.06 per100 patient-years. While the frequency of any death,cardiovascular event or procedure was significantlylower for the nifedipine recipients than the placeborecipients, there was no significant between-groupdifference with regard to the frequency of cardiovascularevents alone. In addition, the group that receivednifedipine had a significantly reduced occurrence of anyvascular event.
In an accompanying editorial, Dr Bruce Psaty from theUniversity of Washington, Seattle, and Dr Curt Furbergfrom the Wake Forest University School of Medicine,Winston-Salem, US, state that "ACTION providessupport for the long-term treatment of the symptoms ofangina in patients already on β blockers and nitrates".2
* gastrointestinal therapeutic system** A Coronary disease Trial Investigating Outcome with NifedipineGITS† This study was funded by Bayer Healthcare AG, Germany.
1. Poole-Wilson PA, et al. Effect of long-acting nifedipine on mortality andcardiovascular morbidity in patients with stable angina requiring treatment(ACTION trial): randomised controlled trial. Lancet 364: 849-857, No. 9437, 4Sep 2004.
2. Psaty BM, et al. Contemplating ACTION-long-acting nifedipine in stableangina. Lancet 364: 817-818, No. 9437, 4 Sep 2004.
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Inpharma 11 Sep 2004 No. 14541173-8324/10/1454-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved