January 2016

Systems biology for the functional validation of genetic determinants of skeletal diseases

News Volume  III  

As   you   know   from   the   annual   mee2ng   in   Vienna,   and   the   2nd  periodic  Report  (which  puts  War  and  Peace  to  shame!),  we  have  had  a  very  busy  and  produc2ve  year  in  SYBIL  world!    However,  2016  promises  to  be  an  even  more  produc2ve  year  as  we   start   to   deep-­‐phenotype   a   broad   range   of   cell   and   animal  models  of  gene2c  skeletal  diseases   for  Systems  Biology  and   the  iden2fica2on  of  new  therapeu2c  targets  and  biomarkers.    We  can  even  achieve  11……………..        

SYBIL is committed to producing a range of webinars on specific topics of bone and cartilage pathophysiology. These can be a combination of basic concepts, in-d e p t h C o m m e n t a r y o r methodology. Please can you supply Kasia with a suitable topic that you are willing to ‘webinar’.

Following on from the very successful first training exchange – now is the time to make suggestions for the next visits! As a reminder these were the last visiting scientists:- Ella Dennis (UNEW to UNIVAQ) Relevant  techniques  for  osteoblast  and  osteoclast  culture  and  bone  metabolism  and  ac5vity  assays  Francesca Tonelli (UNIPV to UKK) Evalua5on   of   Hsp47   expression   in   zebrafish   WT  and  mutant  lines  using  novel  developed  an5body Kun Tian (UNIMAN to CERTUS) To   s ha r e   e x p e r i e n c e s   a nd   e x c hange  complementary  IT  skills

Mouse Model Generation We  are  gePng  close  to  the  3rd  phase  of  mouse   model   genera2on   for   SYBIL.   At  this   stage   please   can   you   submit  expressions   of   interest   to   Elodie   who  will  collate  and  distribute  to  the  OMICS  commiWee.  

Will   be   held   on   the   17th   February   in  Amsterdam  and  many  thanks  to  the  WP  leaders  who  will  be  aWending.  

Our  expert  reviewer  will  be  Gwenaelle  Fillon  who  is   a   Principal   Transla2onal   Medicine   Expert   at  Boehringer  Ingelheim�  Pharmaceu2cals.    We  look  forward  to  telling  Gwenaelle  all  about  the  successes  of  SYBIL.    

WP9 - Dissemination……………..

SYBIL @ ECTS 2016

………the most famous SY BIL of all, w i t h anot h e r h i s to r i cal Volume III…

ECTS  2016  to  be  held  in  Rome  on  14th-­‐17th   May   will   have   a   pre-­‐mee2ng   day   (May   13)   dedicated  to   EU   consor2a   and   will   include  several   ac2vi2es   including   New  Inves2gator   events.   Please   do  you  utmost  to  aWend.  

More details to follow……………………….

And finely…………….