1.

• IntroPsych 1XX3 Live Lecture

Neuroscience I

When good neurons go bad 2. Introduction 3. 100 billion 4. Neurons are Communication Cells Dendrites Nucleus Axon Myelin Sheath Schwann Cell Node of Ranvier Axon Terminal Cell Body (Soma) 5. Thought and Behaviour 6. The Receptive Zone 7.

IntroPsych 1XX3 Live Lecture

Neuroscience I

Module 2: Receptor Trafficking 8. MOR Gene Disruption of MOR gene disrupts function of morphine Matthes et al., (1996); Sora et al., (1997); Loh et al., (1998); Monory et al., (2000) 9. The Life Cycle of a Receptor 10. Morphine Morphine Endorphin Mu-Opioid Peptide Receptor 11. MOP Receptors The fate of the MOP receptor depends on what binds to it. No Treatment Endorphin Heroin 12. Mice with designer genes RMOR s:R ecyclingM u- O pioidR eceptor Knock-in Mouse Line RMOR MOR 13. Knock-in vs. Wild-type 14. KI mice show reduced withdrawal behaviours. +/+ -/- 15.

IntroPsych 1XX3 Live Lecture

Neuroscience I

Module 3: Receptor Expression 16. Structural changes in the addicted neurons Robinson and Kolb (1997) 17. Dopamine and RewardCue Response Reward DOPAMINE (DA) 18. Chronic cocaine reduces DA receptor availability Healthy Brain Addicted Brain 19. Social Rank Morgan et al., (2002) Nat. Neurosci Social rank correlated with DA receptor function and subsequent vulnerability to addiction 20.

IntroPsych 1XX3 Live Lecture

Neuroscience I

Module 4: Myelin Sheath 21. The Action Potential 22. Multiple Sclerosis

A myelination disorder

Immune breakdown of myelin

Oligodendrocytes reproduce thinner, weaker myelin

Plaques and scars forms in the white matter

23. Prognosis Disease progression worsens throughout life 24. Life Expectancy Life expectancy 5-10 years lower than average There is no known cure 25. Causes and Therapies

Genetic and Environmental

Not explicitly hereditary, but influenced by genes

A number of environmental risk factors

Numerous Therapies

Drug therapies tend to target only specific symptoms

26.

IntroPsych 1XX3 Live Lecture

Neuroscience I

Module 5: Mirror Neurons 27. New Caledonian Crow http://www.sciencemag.org/feature/data/crow/weirmovie.mov 28. Motor Neurons 29. Prediction 30. Empathy 31. Child Development Awww, you know that tickles! 32. Theory of Mind 33. Monkey See, Monkey Do 34.