neoplasia vi

Neoplasia VINeoplasia VI DR OSAMA I NASSIF FRCPCDR OSAMA I NASSIF FRCPC

CONSULTANT & ASSOCIATE CONSULTANT & ASSOCIATE PROFESSORPROFESSOR

DEPARTMENT OF PATHOLOGY, KAUHDEPARTMENT OF PATHOLOGY, KAUH

Neoplasia VI

DR OSAMA I NASSIF MD,FRCPCDR OSAMA I NASSIF MD,FRCPC

DEPARTMENT OF PATHOLOGYDEPARTMENT OF PATHOLOGY

KAUHKAUH

Etiology of cancer. Chemical carcinogens.

Radiation carcinogenesis.

Viral oncogenesis.

Biology of tumor growth.

• Kinetics of tumor cell growth.

• Tumor angiogenesis.

• Tumor progression and heterogeneity.

• Tumor invasion and spread.

Kinetics Of Tumor Cell Growth

Doubling time : equal or more than that of normal cells.

Growth fraction : cells in replicative pool , rarely >20%.

Production vz loss :

Tumor Angiogenesis

Tumor-associated angiogenic factors : -bFGF , VEGF……etc. Macrophage derived growth factors: -TNF-α. Weak angiogenic inhibitors: -Angiostatin , thrombospondin ( p53

upregulated) .

Kinetics Of Tumor Cell Growth

Clinical implications: 1- cancer therapey: Targeting cycling cells.

Effect of radiation & debulking.

2- latent period of tumors :

Months to years.

Tumor Progression and Heterogeneity.

Tumor Invasion and Spread.

Methods of spread : - Direct. -Through blood vessels. -Through lymph

vessels.

DEPARTMENT OF PATHOLOGY, KAUHDEPARTMENT OF PATHOLOGY, KAUHEtiology of Cancer.

Chemical carcinogens.

Radiation carcinogenesis.

Viral oncogenesis.

Chemical Carcinogens.

DEPARTMENT OF PATHOLOGY, KAUHDEPARTMENT OF PATHOLOGY, KAUHChemical Carcinogens.

DEPARTMENT OF PATHOLOGY, KAUHDEPARTMENT OF PATHOLOGY, KAUHChemical CarcinogensChemical Carcinogens

DEPARTMENT OF PATHOLOGY, KAUHDEPARTMENT OF PATHOLOGY, KAUHChemical Carcinogens

Chemical Carcinogens

Chemotherapy Induced Malignancies

neoplasia vi

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