i

Pancreatic Cancer: A Summary of NCIs Portfolio

and Highlights of Recent Research Progress

September 2010

U.S. Department of Health and Human Services

National Institutes of Health

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Pancreatic Cancer: A Summary of NCIs Portfolio & Highlights of Recent Research Progress

Table of Contents

Highlights of NCIs Recent Progress in Pancreatic Cancer....................................... iv The Pancreatic Cancer Burden......................................................................................1

Pancreatic Cancer Incidence Rates......................................................................................................... 1 Pancreatic Cancer Mortality Rates ......................................................................................................... 3

NCI Planning for Pancreatic Cancer Research ............................................................4 Pancreatic Cancer Progress Review Group ..................................................................................... 4 Clinical Trials Planning Meeting on Pancreas Cancer Treatment ................................................... 5

NCIs Investment in Pancreatic Cancer Research .......................................................7 Health of the Field and Overarching Issues............................................................................ 7

NCI Funding for Pancreatic Cancer Research................................................................................. 7 Pancreatic-Cancer-Focused Research Projects and Trials............................................................... 8 Research Projects ............................................................................................................................ 8 Clinical Trials ................................................................................................................................ 10 Specialized Programs of Research Excellence .............................................................................. 11 Increased Capacity Building in Pancreatic Cancer Research ........................................................ 11 Growth in Number of Investigators............................................................................................... 11 Training ......................................................................................................................................... 14 Growth in Number of Publications................................................................................................ 15

Tumor Biology.......................................................................................................................... 16 Research Projects .......................................................................................................................... 16 Initiatives ....................................................................................................................................... 16 Research Highlights ...................................................................................................................... 17

Risk, Prevention, Screening, and Diagnosis......................................................................... 18 Research Projects .......................................................................................................................... 18 Clinical Trials ................................................................................................................................ 18 Initiatives ....................................................................................................................................... 18 Research Highlights ...................................................................................................................... 20

Therapy ..................................................................................................................................... 21 Research Projects .......................................................................................................................... 21 Clinical Trials ................................................................................................................................ 22 Initiatives ....................................................................................................................................... 23 Research Highlights ...................................................................................................................... 23

Health Services Research....................................................................................................... 24 Research Projects .......................................................................................................................... 24 Initiatives ....................................................................................................................................... 24 Research Highlights ...................................................................................................................... 25

Scientific Toolkit ...................................................................................................................... 25 Research Projects .......................................................................................................................... 25 Initiatives ....................................................................................................................................... 26 Research Highlights ...................................................................................................................... 26

Clinical Trials Planning Meeting on Pancreas Cancer Treatment ...................................... 26 American Recovery and Reinvestment Act of 2009............................................................. 27

Funding Mechanisms .................................................................................................................... 27 PRG Priority Areas........................................................................................................................ 28 Clinical Trials Planning Meeting Emphasis Areas........................................................................ 28

Conclusion.....................................................................................................................30 Appendix: NCI FY2009 Projects Coded to Pancreatic Cancer Progress Review

Group Recommendations ............................................................................................31

i

Pancreatic Cancer: A Summary of NCIs Portfolio & Highlights of Recent Research Progress

List of Figures

Figure 1. Estimated New Cases and Deaths for Pancreatic Cancer by Year, 2004-2010 ................1

Figure 2. Incidence Rate Trends for Pancreatic Cancer by Racial/Ethnic Group, 1982-2007.........2

Figure 3. Male-Female Incidence Rate Trends for Pancreatic Cancer, 1982-2007 .........................2

Figure 4. Mortality Rate Trends for Pancreatic Cancer, 1982-2007 ................................................3

Figure 5. Male-Female Mortality Rate Trends for Pancreatic Cancer, 1982-2007..........................3

Figure 6. Trends in NCI Funding for Pancreatic Cancer, FY2000-FY2009 ....................................7

Figure 7. Dollar Estimates for Extramural Research in Pancreatic Cancer by Scientific Area,

FY2007-FY2009..........................................................................................................9

Figure 8. Total Number of NCI-Sponsored Research Projects Relevant to Pancreatic Cancer, FY2000-FY2009..........................................................................................................9

Figure 9. Pancreatic Cancer Research by PRG Category, FY2000-FY2009 .................................10

Figure 10. NCI-Sponsored Clinical Trials Related to Pancreatic Cancer by Phase, July FY2010 ..............................................................................................................10

Figure 11. NCI-Sponsored Clinical Trials Related to Pancreatic Cancer by Focus, July FY2010 ..............................................................................................................11

Figure 12. Number of Investigators With at Least One R01 Grant Relevant to Pancreatic Cancer, FY2000-FY2009 ..........................................................................................13

Figure 13. Extramural Training Awards for Pancreatic Cancer Research, FY2005-FY2009........14

Figure 14. Percent by Mechanism of Extramural Training and Career Development Awards, FY2009 ......................................................................................................................15

Figure 15. Estimated Number of Scientific Articles on Pancreatic Cancer Research Acknowledging NCI Support, 2000-2009.................................................................16

Figure 16. Pancreatic Cancer Projects Related to Tumor Biology, FY2000 and FY2009.............17

Figure 17. Pancreatic Cancer Projects Related to Risk, Prevention, Screening, and Diagnosis, FY2000 and FY2009 .................................................................................................19

Figure 18. Pancreatic Cancer Projects Related to Therapy, FY2000 and FY2009 ........................22

Figure 19. Pancreatic Cancer Projects Related to Health Services Research, FY2000 and FY2009 ................................................