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MYASTHENIA GRAVIS

Myasthenia gravis is a chronic neuromuscular autoimmune disorder of muscles and the nerves which are supplying them. Muscle weakness and fatigue are prominent features. Rapid muscle fatigue occurs as a result of autoantibodies created against acetylcholine receptors at postsynaptic neuromuscular junctions. Excitatory effect of acetylcholine is thus blocked at these junctions leading to progressive muscular weakness. Varying degrees of voluntary skeletal muscles weakness are present in the patients.

MYASTHENIA GRAVIS CAUSES:

It can affect an individual of any age however it most commonly affects the women below 40 and older men above 60 years of age. This disease is neither directly inherited nor is it contagious. Myasthenia gravis causes features the imperfection or miscommunication between the muscles and the nerves that are supplying it. Muscle contraction is brought about by binding of acetylcholine (Ach) at neuromuscular junctions. Sometime incorrect instructions by the body’s thymus gland leads to development of defective immune cells called autoantibodies which act against the body’s own Ach receptors ultimately altering or destroying them preventing the normal muscles to contract effectively.

MYASTHENIA GRAVIS SYMPTOMS:

Myasthenia gravis symptoms are produced as a result of faulty and inadequate contraction of voluntary muscle group (skeletal muscles). Onset may be sudden and not recognized immediately as myasthenia gravis. Damage to ocular muscles manifest as drooping of eyelids (ptosis) and blurring of vision. In face

and throat muscle, patient experiences difficulty in speaking, chewing, swallowing along with abnormal facial expressions. Patient may choke or gag as a result of weak pharyngeal muscles. In chest, breathing difficulties result. Weakness in arms, hands, fingers, neck and legs is felt. Person waddles when walk due to leg muscle weakness. Sometimes it becomes very difficult for the patient to hold up his head as a result of weakening of muscles in the neck.

MYASTHENIA GRAVIS DIAGNOSIS:

The important signs and symptom experienced by the patient helps in early Myasthenia Gravis diagnosis and treatment. Medical history along with adequate physical and neurological examinations is carried out. Special blood tests reveal Ach autoantibodies in the circulating blood. Edrophonium test using intravenous injection of edrophonium chloride briefly corrects muscle weakness hence an important diagnostic test. Impaired nerve-muscle transmission is diagnosed by single fibre electromyography. X-ray chest, CT and MRI should be done for presence and identification of thymoma.

MYASTHENIA GRAVIS TREATMENT:

No complete cure is yet present but it is an effectively manageable condition. Myasthenia gravis treatment is based on its control. Anticholinestrase agents such as neostigmine and physostigmine are prescribed to improve muscle strengths. Immunosuppressants are given to lower antibodies level thus improving muscle functions but it is associated with great amounts of side-effects and risk. Thymectomy is performed to surgically remove thymus in advanced uncontrollable cases or if a tumor of thymus is present. Myasthenia gravis herbal product, made up of pure natural herbs, helps to fight fatigue and immensely improves other associated symptoms. There are no size-effects of this herbal product. It also prevents the patient from going through painful surgical operation of thymus removal by efficiently controlling and curing the disease. The herbal mixture improves the neuromuscular transmission and serves as an amazing treatment for this ailment.

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