most commonly used excipients

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Most Commonly Used Excipients

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  • S Soluble , FS Freely Soluble , SS Slightly Soluble , MIS Miscible , IS In Soluble

    SL NO

    NAME FUNCTION CONCENTRATION DESCRIPTION SOLUBILITY INCOMPATIBILITIES

    01 Avecil PH / Microcrystalline Cellulose / Pharmocel

    Diluent & Disintegrant Dilu.- 20% - 90% Dis.- 5 - 15%

    White, Odorless, Tasteless, Crystalline Powder

    SS 5% NaOH IS H2O, Dilute acids & Organic Solvents.

    With strong oxidizing agent.

    02 Cetrimide / Cetab Antiseptic, Preservative 0.005% Antiseptic 1 -3%

    White to Creamy White, Free Flowing, Bitter, Odor, Soapy Taste Powder

    S H2O, CHCL3, C2H5OH IS - Ether

    With Soap, I2, Alkali OH & Aquas solution React with metal.

    03 Cetyl Alcohol Coating & Emulsifying agent.

    Emu. agent- 2 - 5% Waxy ,White Flakes Granules Cubes or Casting.

    FS C2H5OH , Ether IS H2O MIS Fat, Liquid & Solid Paraffin.

    With strong oxidizing agent.

    04 Chlorhexidine / Chlorhexidine Gluconate Sol. / Hibiscrub

    Antimicrobial Preservative

    5% Odorless, Bitter Taste, Crystalline Powder

    MIS H2O S Acetone , C2H5OH

    -----------

    05 Chlorcresol / Parachlorometacresol

    Antimicrobial Preservative

    Cosmetic 0.1 - 0.2% Cream & Emulsion 0.075 - 0.12%

    Colorless , Crystalline Powder with fanolic odor.

    S Acetone , Alkali OH , CHCL3, C2H5OH , Glycerin.

    -----------

    06 Citric Acid / Citric Acid MH

    Antioxidant , Buffering agent

    Buffer Sol. 0.1 - 2% Colorless , Odorless, crystalline strong acidic taste powder

    S - H2O , C2H5OH , Ether With Potassium Tartarate , Alkali & alkaline Carbonate, Acetates ,Sulfides

    07

    Croscarmellose Sodium / Primellose / Solutab.

    Tab. & Cap. - Disintegrant

    Tablet 0.5 - 5 % Capsule 10 25 %

    Odorless, White or Grayish White Powder.

    IS H2O

    ------------

    08 Crospovidone Tablet - Disintegrant Tablet 2 - 5 %

    White to Creamy White, Free Flowing, Odorless, Tasteless Powder

    IS H2O & Common Organic Solvents.

    With organic & inorganic pharmaceutical ingredients.

    09 EDTA / Editic Acid / Tetracemic Acid

    Chelating Agent ------------

    White Crystalline Powder. S Solution of Alkali OH & 1 in 500 of Water.

    With oxidizing agent & strong base.

    10 Ethyl Acetate Solvent & Flavoring agent

    -----------

    Clear , Colorless , Volatile , Flammable Liquid.

    -----------

    -----------

    11 Liquid Glucose / Starch Syrup.

    Sweating agent , Tablet Binder , Coating Agent.

    Coating 10 - 20% Oral Syrup 20 - 60%

    MIS H2O With strong oxidizing agent.

    12 Glycerin / Glycerol Antimicrobial Preservative , Solvent & Sweating agent

    Preserv. < 20% Solvent 50% Sweating agent 20%

    Colorless , Odorless Sweating Hygroscopic Liquid.

    S H2O , C2H5OH IS Oil , Benzene , CHCL3

    -----------

    13 HPMC / HydroxyPropylMethylCellulose.

    Use for sustained release tablet.

    2 - 5% White to Creamy White, Odorless, Tasteless Granules

    S H2O ( Cold ) IS C2H5OH , CHCL3

    With oxidizing agent.

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  • Powder.

    14 IPA / Isopropanol / 2-Propanol / Iso Propyl Alcohol

    Solvent -----------

    Clear, Colorless, Volatile, Flammable Liquid.

    S Acetone MIS H2O , Glycerin C2H5OH , CHCL3 IS Salt Solution.

    With oxidizing agent.

    15 Magnesium Carbonate Tab. & Cap. Diluents. Tablet Excipient - 45%

    Light, White Colored, Bulky Odorless Powder.

    IS C2H5OH , H2O S H2O with CO2

    -----------

    16

    Aerosil / Colloidal Silicon di Oxide / Cab O - Sil

    Glidant, Lubricant, Suspending & Anticaking Agent.

    Glidant 0.1 0.5 % Suspending & Thickness Agent 2 10 %

    Bluish White Colored, Odorless, Tasteless, Light, Loose Powder.

    IS H2O, Organic Solvents except HF acid. S Solution in alkali OH.

    With diethylstilbestrol preparation.

    17 Lactose / Lactose MH / Microtose / Pharmatose / Milk of sugar.

    Tab. & Cap. Diluents. 65 85 % Odorless, White to off white crystalline particles or powder Slightly sweet testing.

    IS H2O ( 1 in 4.63 ) Ether , C2H5OH , CHCL3

    -----------

    18 Magnesium Sterate Tab. & Cap. Lubricant. 0.25 5.0 % Fine, White, Impalpable of low bulk density powder.

    IS H2O, Ether, C2H5OH. SS Warm Benzene & 95% C2H5OH.

    With strong acid, alkali & iron salt avoid mixing with strong oxidizing agent.

    19 Talc / Talcum / Talcum Powder

    Lubricant , Glidant , Tab. & Cap. Diluent.

    Glidant & Tab. Lubricant 1% - 10% T & C dilu. 5 - 30%

    -----------

    IS Dilute acid, dilute alkalis, organic solvents & water.

    With quaternary ammonium compounds.

    20 Glacial Acetic Acid / Acetic Acid / Ethanoic Acid / Vinegar Acid.

    Acidify agent, Antimicrobial & Antifungal Agent.

    -----------

    -----------

    MIS C2H5OH , H2O Ether , Glycerin & other fixed & volatile oils.

    With alkaline substances.

    21 Vitamin E / Alpha Tocopherol / Tocopherol

    Antioxidant & Therapeutic Agent.

    0.001 0.05 % Natural product, Odorless, Clear. Yellow, Yellowish Brown viscous Oil.

    IS H2O S C2H5OH, Ether, Acetone, vegetable Oil.

    With peroxide metal, Fe, Cu, Ag and its absorbed into plastic.

    22

    Vitamin C / Ascorbic Acid / Cevitamic Acid.

    Antioxidant & Therapeutic Agent.

    0.01 0.1 % White to light yellow color, odorless. nonhygroscopic , colorless , crystalline powder with acidic test.

    IS Ether, CHCL3 , Fixed Oils. S - C2H5OH, Propylene Glycol. FS H2O

    With alkalis, heavy metal ion Fe, Cu, oxidizing materials.

    23 Aspartame / Nutra Sweet. Sweating Agent. 200 times sweating powder from sugar.

    Off white, almost odorless, crystalline sweet test powder.

    SS - C2H5OH Sparingly Soluble H2O

    -----------

    24 Calcium Carbonate / Cal Carb / Pharma Carb / Pre Carb.

    Tab. & Cap. Diluents -----------

    Odorless, Tasteless, White Powder or Crystals.

    IS S H2O with ammonium salt or CO2.

    With Acid & Ammonium salts.

    25 Calcium Phosphate Tab. & Cap. Diluents ----------- S Dilute Acid.

    With indomithacin , aspirin ampicillin , cephalexin , erythromycin.

    26 Sodium CMC / Carboxymethyl cellulose

    Tab. & Cap. Disintigrant , Tab

    Tab Binder 1 6 % Oral Sol. 0.1 1.0 %

    Odorless, White or almost white granules Powder.

    S H2O IS Acetone, C2H5OH ,

    With strongly acidic solution.

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  • sodium / Sodium celloluse glycolate.

    Binder , Suspending & Water absorbing agent.

    Ether , Toluene.

    27 Mallic Acid / Apple Acid Antioxidant , Buffering , Flavoring , Therapeutic Agent.

    ----------- White crystalline powder with strong acidic test.

    FS, C2H5OH(95%) IS Benzene.

    With oxidizing solvents.

    28 Mannitol / Peppermint / Camphor

    Flavoring & Therapeutic Agent.

    Toothpaste 0.4 % Mouthwash 0.1 2%

    Colorless , Free Flowing , Shiny , Crystals Powder.

    FS SS Glycerine IS H2O

    With camphor , Phenol , Thymol , KMnO4

    29 Methocel / Methyl Cellulose

    Tab. & Cap. Disintigrant Tab Binder , Coating , Suspending Emulsifying agent.

    Disint. 2 10 % Binder 1 - 5 % Coating 0.5 5.0 % Emu. Agent 1 5 %

    Odorless, Tasteless , White Powder or Granules.

    S CH3COOH , H2O (cold) IS - Acetone , C2H5OH , Ether , CHCL3 , Toluene.

    With chlorocresol , mercuric chloride , phenol tannic acid , methyl paraben , propyl paraben.

    30 Methyl Paraben Sodium Antimicrobial preservative.

    0.18 0.20 % with propyl paraben sodium.

    White , Odorless , Hygroscopic , Crystals Powder.

    FS C2H5OH (95%), H2O IS Fixed oils.

    With talc , tragacanth , sodium alginate & sorbitol.

    31 Parrafin / Hard Parrafin Ointment Base

    -----------

    Odorless, Tasteless , Colorless White solid.

    S - Ether , CHCL3 , Volatile Oil SS - C2H5OH IS - Acetone , H2O C2H5OH(95%)

    -----------

    32 Phenol / Carbolic Acid / Hydroxy Benzene / Phenylic Alcohol.

    Antimicrobial preservative & Disinfectant.

    Mouth wash 1.4 % Disinfectant 5.0 %

    Colorless , Light Pink Caustic.

    S - H2O , Ether , Glycerine C2H5OH , CHCL3 , Volatile Oil.

    -----------

    33 Phosphoric Acid / Hydrogen Phosphate.

    Acidifying Agent ----------- Odorless, Colorless liquid. MIS - H2O , Alcohol with the evolution of heat.

    With alkaline substances.

    34 Povidone / Polyvinylpyrolidone / PVP

    Tab Disintigrant Tab Binder

    Tab Binder , Diluents 0.5 5.0 %

    Fine white to creamy white odorless hygroscopic powder.

    S - H2O , Acid , C2H5OH , CHCL3 , CH3OH IS - Ether

    ---------------

    35 Propyl Paraben Sodium Antimicrobial preservative.

    0.20 % with methyl paraben sodium 0.18%

    White , Odorless , Hygroscopic , Crystals Powder.

    S - H2O , C2H5OH (50 %) IS Fixed Oils.

    With talc , tragacanth , sodium alginate & sorbitol.

    36 Propylene Glycol / Methyl Glycol

    Antimicrobial preservative & Solvent.

    Solvent Oral Sol 10 25 % Parenteral 10 60 % Topical 5 80 %

    Clear , Colorless , Viscous , Odorless Liquid with sweet test.

    MIS Acetone , Glycerin , H2O , C2H5OH (95 %) , CHCL3

    With oxidizing reagents such as KMnO4

    37 Saccharine Sweating Agent 0.02 0.5 % Odorless , White Crystals or Crystal Powder.

    S Acetone , H2O (1000C) C2H5OH (95%) , Glycerin SS - CHCL3 , Ether

    --------------

    38 Saccharine Sodium Sweating Agent Oral Sol 0.075 0.6% Oral Syp 0.04 0.25%

    Odorless , White Crystals or Crystal Powder.

    S Acetone , H2O (1000C) C2H5OH (95%) , Glycerin SS - CHCL3 , Ether

    --------------

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  • 39 Simethicone Antifoaming Agent

    --------------- Translucent, Gray Colored, Viscous Fluid.

    S H2O, C2H5OH (95%), IS - CHCL3, Benzene.

    With oxidizing agent.

    40 Sodium Ascorate / Vitamin C Sodium

    Antioxidant & Therapeutic Agent

    ---------------

    White or Slightly Yellow Colored , Odorless crystalline Powder With Saline Test.

    S H2O , Glycerin IS - CHCL3, C2H5OH (95%)

    With oxidizing agent & heavy metal ion.

    41 Sodium Benzoate Antimicrobial preservative & Lubricant.

    Preservative Oral 0.02 - 05% Parenteral 0.5% Cosmetic 0.1 0.5% Lubricant 2 5%

    White granular crystalline, slightly hygroscopic, Odorless with saline test powder.

    S H2O, C2H5OH (90 -95%)

    With quaternary compounds , Gelatin , Ferric Salt , Ca salt.

    42 Sodium Bi Carbonate / Baking Soda

    Alkalizing & Therapeutic Agent.

    --------------- Odorless , White Crystalline Powder With saline Test.

    S H2O S C2H5OH (95%) , Ether

    Reacts with acid & acidic salt.

    43 Sodium Chloride / Hopper Salt / Rock Salt / Sea Salt / Table Salt.

    Tonicity Agent & Diluents.

    Tab. Diluent 5 - 20% Cap. Diluent 10 - 80%

    White Crystalline Powder With saline Test.

    S H2O , C2H5OH (95%) , Glycerin SS - C2H5OH

    ---------------

    44 Sodium Citrate DH Alkalizing, Buffering, Emulsifier, Sequestering Agent.

    Buffe. Agent- 0.3- 2% Seques. Agent- 0.3 - 2% Injection 0.02 - 4%

    Odorless , Colorless , White Crystalline Powder With a cooling saline Test.

    S H2O SS - C2H5OH (95%)

    With acidic substance

    45 Sodium Cyclamate Sweeting Agent 0.5 % White , Odorless or almost Odorless , Crystalline Powder With a sweet Test.

    S H2O , Propylene Glycol , C2H5OH (95%) IS - CHCL3 , Ether

    ---------------

    46 Sodium Hydroxide, Sodium Hydrate

    Buffering Agent ---- White or nearly white pellets or sticks.

    S Glycerine , H2O , C2H5OH , CHCL3IS - Ether.

    With acid , ester , ether

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    CrospovidoneIPA / Isopropanol / 2-Propanol / Iso Propyl AlcoholMagnesium Sterate Glacial Acetic Acid / Acetic Acid / Ethanoic Acid / Vinegar Acid.Methyl Paraben SodiumParrafin / Hard ParrafinPhenol / Carbolic Acid / Hydroxy Benzene / Phenylic Alcohol.Phosphoric Acid / Hydrogen Phosphate.Povidone / Polyvinylpyrolidone / PVPPropyl Paraben Sodium0.20 % with methyl paraben sodium 0.18%Propylene Glycol / Methyl GlycolSolvent SaccharineSaccharine SodiumSimethiconeSodium Ascorate / Vitamin C SodiumSodium BenzoatePreservative

    Sodium Bi Carbonate / Baking Soda Sodium Chloride / Hopper Salt / Rock Salt / Sea Salt / Table Salt.Sodium Citrate DHSodium CyclamateSodium Hydroxide, Sodium Hydrate