most commonly used excipients
DESCRIPTION
Most Commonly Used ExcipientsTRANSCRIPT
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S Soluble , FS Freely Soluble , SS Slightly Soluble , MIS Miscible , IS In Soluble
SL NO
NAME FUNCTION CONCENTRATION DESCRIPTION SOLUBILITY INCOMPATIBILITIES
01 Avecil PH / Microcrystalline Cellulose / Pharmocel
Diluent & Disintegrant Dilu.- 20% - 90% Dis.- 5 - 15%
White, Odorless, Tasteless, Crystalline Powder
SS 5% NaOH IS H2O, Dilute acids & Organic Solvents.
With strong oxidizing agent.
02 Cetrimide / Cetab Antiseptic, Preservative 0.005% Antiseptic 1 -3%
White to Creamy White, Free Flowing, Bitter, Odor, Soapy Taste Powder
S H2O, CHCL3, C2H5OH IS - Ether
With Soap, I2, Alkali OH & Aquas solution React with metal.
03 Cetyl Alcohol Coating & Emulsifying agent.
Emu. agent- 2 - 5% Waxy ,White Flakes Granules Cubes or Casting.
FS C2H5OH , Ether IS H2O MIS Fat, Liquid & Solid Paraffin.
With strong oxidizing agent.
04 Chlorhexidine / Chlorhexidine Gluconate Sol. / Hibiscrub
Antimicrobial Preservative
5% Odorless, Bitter Taste, Crystalline Powder
MIS H2O S Acetone , C2H5OH
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05 Chlorcresol / Parachlorometacresol
Antimicrobial Preservative
Cosmetic 0.1 - 0.2% Cream & Emulsion 0.075 - 0.12%
Colorless , Crystalline Powder with fanolic odor.
S Acetone , Alkali OH , CHCL3, C2H5OH , Glycerin.
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06 Citric Acid / Citric Acid MH
Antioxidant , Buffering agent
Buffer Sol. 0.1 - 2% Colorless , Odorless, crystalline strong acidic taste powder
S - H2O , C2H5OH , Ether With Potassium Tartarate , Alkali & alkaline Carbonate, Acetates ,Sulfides
07
Croscarmellose Sodium / Primellose / Solutab.
Tab. & Cap. - Disintegrant
Tablet 0.5 - 5 % Capsule 10 25 %
Odorless, White or Grayish White Powder.
IS H2O
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08 Crospovidone Tablet - Disintegrant Tablet 2 - 5 %
White to Creamy White, Free Flowing, Odorless, Tasteless Powder
IS H2O & Common Organic Solvents.
With organic & inorganic pharmaceutical ingredients.
09 EDTA / Editic Acid / Tetracemic Acid
Chelating Agent ------------
White Crystalline Powder. S Solution of Alkali OH & 1 in 500 of Water.
With oxidizing agent & strong base.
10 Ethyl Acetate Solvent & Flavoring agent
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Clear , Colorless , Volatile , Flammable Liquid.
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11 Liquid Glucose / Starch Syrup.
Sweating agent , Tablet Binder , Coating Agent.
Coating 10 - 20% Oral Syrup 20 - 60%
MIS H2O With strong oxidizing agent.
12 Glycerin / Glycerol Antimicrobial Preservative , Solvent & Sweating agent
Preserv. < 20% Solvent 50% Sweating agent 20%
Colorless , Odorless Sweating Hygroscopic Liquid.
S H2O , C2H5OH IS Oil , Benzene , CHCL3
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13 HPMC / HydroxyPropylMethylCellulose.
Use for sustained release tablet.
2 - 5% White to Creamy White, Odorless, Tasteless Granules
S H2O ( Cold ) IS C2H5OH , CHCL3
With oxidizing agent.
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Powder.
14 IPA / Isopropanol / 2-Propanol / Iso Propyl Alcohol
Solvent -----------
Clear, Colorless, Volatile, Flammable Liquid.
S Acetone MIS H2O , Glycerin C2H5OH , CHCL3 IS Salt Solution.
With oxidizing agent.
15 Magnesium Carbonate Tab. & Cap. Diluents. Tablet Excipient - 45%
Light, White Colored, Bulky Odorless Powder.
IS C2H5OH , H2O S H2O with CO2
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16
Aerosil / Colloidal Silicon di Oxide / Cab O - Sil
Glidant, Lubricant, Suspending & Anticaking Agent.
Glidant 0.1 0.5 % Suspending & Thickness Agent 2 10 %
Bluish White Colored, Odorless, Tasteless, Light, Loose Powder.
IS H2O, Organic Solvents except HF acid. S Solution in alkali OH.
With diethylstilbestrol preparation.
17 Lactose / Lactose MH / Microtose / Pharmatose / Milk of sugar.
Tab. & Cap. Diluents. 65 85 % Odorless, White to off white crystalline particles or powder Slightly sweet testing.
IS H2O ( 1 in 4.63 ) Ether , C2H5OH , CHCL3
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18 Magnesium Sterate Tab. & Cap. Lubricant. 0.25 5.0 % Fine, White, Impalpable of low bulk density powder.
IS H2O, Ether, C2H5OH. SS Warm Benzene & 95% C2H5OH.
With strong acid, alkali & iron salt avoid mixing with strong oxidizing agent.
19 Talc / Talcum / Talcum Powder
Lubricant , Glidant , Tab. & Cap. Diluent.
Glidant & Tab. Lubricant 1% - 10% T & C dilu. 5 - 30%
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IS Dilute acid, dilute alkalis, organic solvents & water.
With quaternary ammonium compounds.
20 Glacial Acetic Acid / Acetic Acid / Ethanoic Acid / Vinegar Acid.
Acidify agent, Antimicrobial & Antifungal Agent.
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MIS C2H5OH , H2O Ether , Glycerin & other fixed & volatile oils.
With alkaline substances.
21 Vitamin E / Alpha Tocopherol / Tocopherol
Antioxidant & Therapeutic Agent.
0.001 0.05 % Natural product, Odorless, Clear. Yellow, Yellowish Brown viscous Oil.
IS H2O S C2H5OH, Ether, Acetone, vegetable Oil.
With peroxide metal, Fe, Cu, Ag and its absorbed into plastic.
22
Vitamin C / Ascorbic Acid / Cevitamic Acid.
Antioxidant & Therapeutic Agent.
0.01 0.1 % White to light yellow color, odorless. nonhygroscopic , colorless , crystalline powder with acidic test.
IS Ether, CHCL3 , Fixed Oils. S - C2H5OH, Propylene Glycol. FS H2O
With alkalis, heavy metal ion Fe, Cu, oxidizing materials.
23 Aspartame / Nutra Sweet. Sweating Agent. 200 times sweating powder from sugar.
Off white, almost odorless, crystalline sweet test powder.
SS - C2H5OH Sparingly Soluble H2O
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24 Calcium Carbonate / Cal Carb / Pharma Carb / Pre Carb.
Tab. & Cap. Diluents -----------
Odorless, Tasteless, White Powder or Crystals.
IS S H2O with ammonium salt or CO2.
With Acid & Ammonium salts.
25 Calcium Phosphate Tab. & Cap. Diluents ----------- S Dilute Acid.
With indomithacin , aspirin ampicillin , cephalexin , erythromycin.
26 Sodium CMC / Carboxymethyl cellulose
Tab. & Cap. Disintigrant , Tab
Tab Binder 1 6 % Oral Sol. 0.1 1.0 %
Odorless, White or almost white granules Powder.
S H2O IS Acetone, C2H5OH ,
With strongly acidic solution.
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sodium / Sodium celloluse glycolate.
Binder , Suspending & Water absorbing agent.
Ether , Toluene.
27 Mallic Acid / Apple Acid Antioxidant , Buffering , Flavoring , Therapeutic Agent.
----------- White crystalline powder with strong acidic test.
FS, C2H5OH(95%) IS Benzene.
With oxidizing solvents.
28 Mannitol / Peppermint / Camphor
Flavoring & Therapeutic Agent.
Toothpaste 0.4 % Mouthwash 0.1 2%
Colorless , Free Flowing , Shiny , Crystals Powder.
FS SS Glycerine IS H2O
With camphor , Phenol , Thymol , KMnO4
29 Methocel / Methyl Cellulose
Tab. & Cap. Disintigrant Tab Binder , Coating , Suspending Emulsifying agent.
Disint. 2 10 % Binder 1 - 5 % Coating 0.5 5.0 % Emu. Agent 1 5 %
Odorless, Tasteless , White Powder or Granules.
S CH3COOH , H2O (cold) IS - Acetone , C2H5OH , Ether , CHCL3 , Toluene.
With chlorocresol , mercuric chloride , phenol tannic acid , methyl paraben , propyl paraben.
30 Methyl Paraben Sodium Antimicrobial preservative.
0.18 0.20 % with propyl paraben sodium.
White , Odorless , Hygroscopic , Crystals Powder.
FS C2H5OH (95%), H2O IS Fixed oils.
With talc , tragacanth , sodium alginate & sorbitol.
31 Parrafin / Hard Parrafin Ointment Base
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Odorless, Tasteless , Colorless White solid.
S - Ether , CHCL3 , Volatile Oil SS - C2H5OH IS - Acetone , H2O C2H5OH(95%)
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32 Phenol / Carbolic Acid / Hydroxy Benzene / Phenylic Alcohol.
Antimicrobial preservative & Disinfectant.
Mouth wash 1.4 % Disinfectant 5.0 %
Colorless , Light Pink Caustic.
S - H2O , Ether , Glycerine C2H5OH , CHCL3 , Volatile Oil.
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33 Phosphoric Acid / Hydrogen Phosphate.
Acidifying Agent ----------- Odorless, Colorless liquid. MIS - H2O , Alcohol with the evolution of heat.
With alkaline substances.
34 Povidone / Polyvinylpyrolidone / PVP
Tab Disintigrant Tab Binder
Tab Binder , Diluents 0.5 5.0 %
Fine white to creamy white odorless hygroscopic powder.
S - H2O , Acid , C2H5OH , CHCL3 , CH3OH IS - Ether
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35 Propyl Paraben Sodium Antimicrobial preservative.
0.20 % with methyl paraben sodium 0.18%
White , Odorless , Hygroscopic , Crystals Powder.
S - H2O , C2H5OH (50 %) IS Fixed Oils.
With talc , tragacanth , sodium alginate & sorbitol.
36 Propylene Glycol / Methyl Glycol
Antimicrobial preservative & Solvent.
Solvent Oral Sol 10 25 % Parenteral 10 60 % Topical 5 80 %
Clear , Colorless , Viscous , Odorless Liquid with sweet test.
MIS Acetone , Glycerin , H2O , C2H5OH (95 %) , CHCL3
With oxidizing reagents such as KMnO4
37 Saccharine Sweating Agent 0.02 0.5 % Odorless , White Crystals or Crystal Powder.
S Acetone , H2O (1000C) C2H5OH (95%) , Glycerin SS - CHCL3 , Ether
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38 Saccharine Sodium Sweating Agent Oral Sol 0.075 0.6% Oral Syp 0.04 0.25%
Odorless , White Crystals or Crystal Powder.
S Acetone , H2O (1000C) C2H5OH (95%) , Glycerin SS - CHCL3 , Ether
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39 Simethicone Antifoaming Agent
--------------- Translucent, Gray Colored, Viscous Fluid.
S H2O, C2H5OH (95%), IS - CHCL3, Benzene.
With oxidizing agent.
40 Sodium Ascorate / Vitamin C Sodium
Antioxidant & Therapeutic Agent
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White or Slightly Yellow Colored , Odorless crystalline Powder With Saline Test.
S H2O , Glycerin IS - CHCL3, C2H5OH (95%)
With oxidizing agent & heavy metal ion.
41 Sodium Benzoate Antimicrobial preservative & Lubricant.
Preservative Oral 0.02 - 05% Parenteral 0.5% Cosmetic 0.1 0.5% Lubricant 2 5%
White granular crystalline, slightly hygroscopic, Odorless with saline test powder.
S H2O, C2H5OH (90 -95%)
With quaternary compounds , Gelatin , Ferric Salt , Ca salt.
42 Sodium Bi Carbonate / Baking Soda
Alkalizing & Therapeutic Agent.
--------------- Odorless , White Crystalline Powder With saline Test.
S H2O S C2H5OH (95%) , Ether
Reacts with acid & acidic salt.
43 Sodium Chloride / Hopper Salt / Rock Salt / Sea Salt / Table Salt.
Tonicity Agent & Diluents.
Tab. Diluent 5 - 20% Cap. Diluent 10 - 80%
White Crystalline Powder With saline Test.
S H2O , C2H5OH (95%) , Glycerin SS - C2H5OH
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44 Sodium Citrate DH Alkalizing, Buffering, Emulsifier, Sequestering Agent.
Buffe. Agent- 0.3- 2% Seques. Agent- 0.3 - 2% Injection 0.02 - 4%
Odorless , Colorless , White Crystalline Powder With a cooling saline Test.
S H2O SS - C2H5OH (95%)
With acidic substance
45 Sodium Cyclamate Sweeting Agent 0.5 % White , Odorless or almost Odorless , Crystalline Powder With a sweet Test.
S H2O , Propylene Glycol , C2H5OH (95%) IS - CHCL3 , Ether
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46 Sodium Hydroxide, Sodium Hydrate
Buffering Agent ---- White or nearly white pellets or sticks.
S Glycerine , H2O , C2H5OH , CHCL3IS - Ether.
With acid , ester , ether
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CrospovidoneIPA / Isopropanol / 2-Propanol / Iso Propyl AlcoholMagnesium Sterate Glacial Acetic Acid / Acetic Acid / Ethanoic Acid / Vinegar Acid.Methyl Paraben SodiumParrafin / Hard ParrafinPhenol / Carbolic Acid / Hydroxy Benzene / Phenylic Alcohol.Phosphoric Acid / Hydrogen Phosphate.Povidone / Polyvinylpyrolidone / PVPPropyl Paraben Sodium0.20 % with methyl paraben sodium 0.18%Propylene Glycol / Methyl GlycolSolvent SaccharineSaccharine SodiumSimethiconeSodium Ascorate / Vitamin C SodiumSodium BenzoatePreservative
Sodium Bi Carbonate / Baking Soda Sodium Chloride / Hopper Salt / Rock Salt / Sea Salt / Table Salt.Sodium Citrate DHSodium CyclamateSodium Hydroxide, Sodium Hydrate