monsanto 08-23-05

15
Soybean Breeding at Monsanto Overview of Soybean Breeding High Yielding, Diverse Germplasm Pool Screening Capabilities and Markers Roundup Ready™ 2 nd Generation Food Traits Comprehensive Approach to Soy Improvements

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Page 1: monsanto 08-23-05

Soybean Breeding at Monsanto

• Overview of Soybean Breeding• High Yielding, Diverse Germplasm Pool• Screening Capabilities and Markers• Roundup Ready™ 2nd Generation• Food Traits• Comprehensive Approach to Soy Improvements

Page 2: monsanto 08-23-05

Soy Breeding is a Key Component of Our Integrated Pipeline

ObjectivesEnhance germplasm competitivenessOutstanding germplasm key to delivering value added traits

Germplasm ResourcesSuperior Yield• Disease

resistance• Yield stability

Composition• Protein • Oil

Breeding Technology• Marker Ass’ted Breeding• Markers for Key Traits• Chromosome mapping

Soy varieties with increased value• Higher yields

• Improved consumer uses• Improvements in feed efficiency

Increased value for Monsanto and our stakeholders

Biotechnology• RR2G & Yield• Food & Feed Traits

Success: Integration of Conventional Breeding, Breeding Technology, Biotechnology, & Crop Analytics

Key DriversTop yielding varieties Increased genetic gain through germplasm & technology High value opportunities in food & feedPipeline support

Crop Analytics• HighThroughput• Essential for

Marker Development

Page 3: monsanto 08-23-05

• Ames• Beaman

• Bloomington

• Redwood Falls

•Glyndon

• Janesville • Guelph

• Stuttgart

• Stonington• Oxford

• Haubstadt

• Marion

• Mt Olive

• Galena

Global Soybean BreedingNorth America Variety Development

Northern RegionCentral RegionSouthern Region

2005 North America2005 North AmericaSoybean BreedingSoybean BreedingTesting & PurityTesting & Purity

• Findlay

Each station positioned to cover 5 million acresTypical station: 1 Breeder

+ 2-4 RA’s

Page 4: monsanto 08-23-05

Soybean Breeding at Monsanto:Excellent Germplasm from Multiple, Complementary Sources

World Class Germplasm Pool

HartzSouthern US

Food

AsgrowElite Varieties in NA & SA

YieldDefensive traits

DeKalbYield

Midwestern US

MonSoyBrazil

High Yield

Germplasm ProvidersHigh Yields

Complementary

First LineCanada

Food

Public SourcesUSDA, AVRDC

Disease, SCN, Diversity

UniversityCollaborations

Disease, Diversity

Experienced, Dedicated Breeding Staff15 Variety Development Breeders in N. America3 Breeders for South America2 Trait Breeders4 Pathology/Nematology Experts9 Leads with avg 15 years industry experienceBreeding Tech expertise

Outstanding GermplasmYield from multiple sources in

North & South AmericaPest tolerance for Yield StabilityUseful variability for protein & oil

quality and quantity Aggressive development of markers

for food, feed, and agronomic traits

Industry Collaborations

Germplasm Diversity

Elite Soy Varieties w/ Value Added

Traits

Page 5: monsanto 08-23-05

0

5

10

15

20

25

30

35

40

45

1920 1930 1940 1950 1960 1970 1980 1990 2000

Year

US

Gra

in Y

ield

(Bu/

Acr

e)

Goals• Identify what genes

control agronomic traits

• Implement new breeding procedures that improve our ability to select for these genes

• Increase the rate of genetic gain in our breeding programs

Goals• Identify what genes

control agronomic traits

• Implement new breeding procedures that improve our ability to select for these genes

• Increase the rate of genetic gain in our breeding programs

DNA markers improve the efficiency of plant breeding proceduresDNA markers improve the efficiency of plant breeding procedures

Plant Breeding Improvement for Soybeans

Page 6: monsanto 08-23-05

Mon Soybean RM012345678

Soybean Relative Maturity

Page 7: monsanto 08-23-05

Biotic and Abiotic Stresses Vary Across the Soy Belt; Diverse Germplasm, Hi Throughput Screening, and Markers are

the Foundation for Success

Scale: +++++ = severe, +++ = moderate, + = minor

+++++++++++++++++--6-8

+++++++++++++++++-+4-5

++++++++++++++++-+++3

--++++++++++++++++++++1-2

--++++++++++++++++++00-0

Root Knot Nema

StemCanker

Soy Cyst Nema

PhytopRoot Rot

Brown Stem Rot

IronDefic

White Mold

RM*

+++++++++++++++++--6-8

+++++++++++++++++-+4-5

++++++++++++++++-+++3

--++++++++++++++++++++1-2

--++++++++++++++++++00-0

Root Knot Nema

StemCanker

Soy Cyst Nema

PhytopRoot Rot

Brown Stem Rot

IronDefic

White Mold

R

RM = Relative Maturity

Page 8: monsanto 08-23-05

Broad Approach for Diseases, Nematodes, Insects & Nutritional Stresses Provides Yield Stability

• Breeding and Breeding Tech Provide Solutions for Stresses that Can Limit Yield

– Understand & prioritize key stresses by market

– Field and/or greenhouse screens for important stresses

– Automation to increase capacity – Continually search for new genes– Develop markers for useful

genes– Integrated approach across

Breeding, Breeding Tech, Biotech, Tech Development

– Prioritized application of markers

– Key partnerships with public institutions

Page 9: monsanto 08-23-05

Multiple Approaches to Identify Solutions for Asian Soybean Rust

• Monsanto Approach– Map Rpp genes– Utilize markers – Stack & evaluate major genes– Evaluate Soy Germplasm for new

sources– Validate screening protocols and

establish differential lines– Full operations of GC/GH

screening facilities in St. Louis and GH in Brazil

– Field screens in US and Brazil– Confirm USDA phenotypic

scores in FT. Detrick, MD• Identify immune PI accessions

Acquire & screengermplasm

Map genes & develop markers

Stack genes

Biotech solutions

Page 10: monsanto 08-23-05

Ag Challenge: Delivering Better Herbicide Tolerance & Increased Yields in Soybeans

DiscoveryDiscovery Phase 1Phase 1Proof of ConceptProof of Concept

Phase 2Phase 2Early DevelopmentEarly Development

Phase 3Phase 3Adv. DevelopmentAdv. Development

Phase 4Phase 4PrePre--LaunchLaunch

LaunchLaunch

Genomics

Biotechnology

MolecularBreeding

Roundup RReady2Yield® Soybeans

Yield estimates based on average yields of 64 bushels obtained in 2004.Lower yielding environments may not see the same level of yield increase

Compared with RRSB, this New Technology will deliver

better yield due to:

New Event

Breeding / Breeding Technology

Improved Tolerance

Up to+5 bu

ConventionalBreeding

Page 11: monsanto 08-23-05

Rich Pipeline of Soybean Products with Improved Food Uses

Near TermPursue commercialization of germplasm derived soy quality traits for near term profit opportunity, and development of business model

– Develop and enhance strategic relationships, and generate demand with food industry and supply chain to maximize value

– Oil composition– Improved Soy Protein

Soy Protein: Improved flavor profile

0.0

2.0

4.0

6.0

8.0

10.0

12.0

14.0

16.0

0.0 10.0 20.0 30.0 40.0 50.0

Off-Flavors Type A

Off-

Flav

or T

ype

BImproved

Soy

CommoditySoy

StandardSoybean

Low Lin

Linoleic18:2

Oleic18:1

Sats18:0 / 16:0

Linolenic18:3

Mid Oleic+ Low Lin

Zero Sat+ MO + LL

Progressive improvements in Oil Composition

Long TermContinue development of oil composition improvements to ensure strong position on soy trait business long term

– Multiple new traits with processing and health benefits

Page 12: monsanto 08-23-05

Low Linolenic AcidImproved Soybeans for Food

Benefits:• Cost competitive, widely available trans free

oil that doesn’t compromise taste or increase saturated fat

• A more stable soy oil requiring less hydrogenation; reduce/eliminate trans fats.

2005 technical milestones• Successful launch of AG2421V and

AG2321V• Rich Pipeline of new products to advanced

stage testing• Marker utilization for multiple traits

2006 technical milestones• More commercial varieties• Continued yield improvements• Expanded area of adaptation

Page 13: monsanto 08-23-05

Zero Sat + Mid Oleic + Low Lin Provides the Next Generation of Improvements

Product Concept: Biotech soybean with broad industry appeal that achieves reduced Sats, low linolenic, and mid oleic levels. Ideal for cooking and salad, frying segments of the oil market.

2005 Technical Milestones: Identify events that meet target composition,

Roundup® tolerance, other selection criteria

2006 Technical Milestones: Successful US field trials for most

promising transgenic events

Key Challenges for Breeding:Initiate crosses with Vistive™ as soon as

possible

Benefits: Compositional change results in healthier oil (lower sats, mid oleic – reduced cardiovascular risk) with improved functionality (low lin,mid oleic – enhanced flavor from improved stability, prolonged shelf life.)

Zero Sat + MO + LL

Zero Sat + MO + LL

Linolenic

SaturatesSaturates

CommoditySoy

CommoditySoy

Per

cent

of S

oy O

il C

ompo

sitio

nOleicOleic

LinoleicLinoleic

Page 14: monsanto 08-23-05

Lower affinity for odors, creates balanced flavors.

HBC less binding of off-flavorsGlycinin

β-conglycinin0

5

10

15

20

25

0.3 0.6 0.9 1.3 1.6 1.8 2.12 pentyl pyridine (mM)

Bou

nd 2

pen

tylp

yrid

ine

(mol

es/m

ole

prot

ein)

Highly soluble in beverages, creating smooth mouth feel

Soymilk protein sedimentation*________________________HBC soymilk: 2% sediment

Control soymilk: 15% sediment

*3 wk storage

Soymilk protein sedimentation*________________________HBC soymilk: 2% sediment

Control soymilk: 15% sediment

*3 wk storage

Benefits of High β-Conglycinin Soy Protein in Food

Page 15: monsanto 08-23-05

Genomics

ConventionalBreeding

Crop Analytics

MolecularBreeding

Chemistry

Fully Integrated Approach: High Yielding Germplasm, Multi-faceted Approach to Traits, Screening Capabilities, and Markers