Microbial genome data resources

Reportor ： Zhou Xingrong

Introduction

Genome: All of the genetic information, the entire genetic complement, all of the hereditary material possessed by an organism.

Metagenome: the genomes of the total micro biota found in nature and involves cloning of total DNA isolated from an environment sample.

•Over 400 microbial genomes have been published to date, with over 1000 other projects ongoing and more in the process of being launched.

•Metagenome sequence data processing is in the early stages of development.

•We need assess the scientific value of microbial genome data.

Microbial genome data lifecycle

Figure 1 Microbial genome data lifecycle

• individual genomes NCBI’s Entrez Gene , EBI’s Integr8, UCSC G

enome Browser

• Multigenome

CMR, ERGO, Microbes Online, PUMA2, IMG, and MBGD

• Organism-specific annotation resources

PeerGAD, ASAP

• Integrated annotation resources

SEED, PUMA2

• Metagenome resources

GenBank, IMG/M, Megx.net

Microbial genome data management

1 、 data management characteristics

employ established technologiesinvolve organizing data according to a

data modelrequire integrating data from multiple

resources.

2 、 presents advantages

local data availability query performance ability to review curate data

Conclusions

I. aims at gradually improving the coherence and completeness of the functional characterization of microbial genomes.

II. contain different collections of genomes and annotations with different degrees of resolution regarding the same genomes.

III. Improving the organization and documentation of microbial genome data resources would benefit the maintenance of existing resources and the development of new resources.

IV. Mechanisms for funding together with a better oversight of resources are generally lacking at this time.

THANKS FOR YOUR ATTENTION!