metopimazine easing in emesis

Reactions 1083 - 7 Jan 2006 Metopimazine easing in emesis Metopimazine is an effective alternative to ondansetron in the prophylaxis of delayed chemotherapy-induced nausea and vomiting, report researchers from France. In their open-label study, 99 patients were randomised into two groups: group 1 received sublingual metopimazine 15mg three times daily and oral methylprednisolone 48 mg/day for 5 days after the first chemotherapy session, then ondansetron lyophilisate 8mg twice daily and methylprednisolone for 5 days the second chemotherapy session; group 2 received the treatments in the reverse order. * Treatment with metopimazine/methylprednisolone was associated with significantly higher success rates nausea and vomiting prophylaxis, compared with ondansetron/methylprednisolone (73.6% vs 57.5%). Separate analysis of nausea and vomiting showed that, of 29 pairs discordant for nausea, 21 were successfully treated with metopimazine; of 15 pairs discordant for vomiting, 13 responded to metopimazine. There were no significant differences between the two groups in overall quality of life. However, two individual components of the Functional Living Index Emesis questionnaire (‘Has vomiting prevented you from carrying out your normal leisure activities?’ and ‘Has nausea prevented you from preparing meals or other housework?’) were scored significantly in favour of metopimazine (2.07 vs 2.79 and 0.94 vs 1.24). Adverse events were mostly GI in nature and were significantly more common in patients receiving ondansetron. Constipation was twice as frequent and more severe during ondansetron treatment, compared with metopimazine. * This study was supported by a grant from Schwarz Pharma. Bloch J, et al. Comparison of the efficacy and safety of combinations of metopimazine or ondansetron with methylprednisolone in the prevention of delayed emesis in patients receiving chemotherapy. Current Medical Research and Opinion 21: 1763-1771, No. 11, Nov 2005 801027091 1 Reactions 7 Jan 2006 No. 1083 0114-9954/10/1083-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved

Upload: buidien

Post on 16-Mar-2017

214 views

Category:

Documents

0 download

Report

Download

Embed Size (px):

TRANSCRIPT

Reactions 1083 - 7 Jan 2006

Metopimazine easing in emesisMetopimazine is an effective alternative to

ondansetron in the prophylaxis of delayedchemotherapy-induced nausea and vomiting, reportresearchers from France.

In their open-label study, 99 patients wererandomised into two groups: group 1 receivedsublingual metopimazine 15mg three times daily andoral methylprednisolone 48 mg/day for 5 days after thefirst chemotherapy session, then ondansetronlyophilisate 8mg twice daily and methylprednisolone for5 days the second chemotherapy session; group 2received the treatments in the reverse order.*

Treatment with metopimazine/methylprednisolonewas associated with significantly higher success ratesnausea and vomiting prophylaxis, compared withondansetron/methylprednisolone (73.6% vs 57.5%).Separate analysis of nausea and vomiting showed that,of 29 pairs discordant for nausea, 21 were successfullytreated with metopimazine; of 15 pairs discordant forvomiting, 13 responded to metopimazine.

There were no significant differences between the twogroups in overall quality of life. However, two individualcomponents of the Functional Living Index Emesisquestionnaire (‘Has vomiting prevented you fromcarrying out your normal leisure activities?’ and ‘Hasnausea prevented you from preparing meals or otherhousework?’) were scored significantly in favour ofmetopimazine (2.07 vs 2.79 and 0.94 vs 1.24).

Adverse events were mostly GI in nature and weresignificantly more common in patients receivingondansetron. Constipation was twice as frequent andmore severe during ondansetron treatment, comparedwith metopimazine.* This study was supported by a grant from Schwarz Pharma.

Bloch J, et al. Comparison of the efficacy and safety of combinations ofmetopimazine or ondansetron with methylprednisolone in the prevention ofdelayed emesis in patients receiving chemotherapy. Current Medical Research andOpinion 21: 1763-1771, No. 11, Nov 2005 801027091

Aprepitant in Emesis Induced by Leptomeningeal ...which emesis was not controlled, except for a few days following the administration of aprepitant, which was given as off-label CINV

SURAT PERMINTAAN MENJADI RESPONDENrepository.poltekkes-kdi.ac.id/1331/8/LAMPIRAN.pdf · Emesis gravidarum umumnya terjadi pada primigravida atau kehamilan pertama 10. Emesis gravidarum

Quantitative Easing, Changes in Global Liquidity and ... · Quantitative Easing, Changes in Global Liquidity and Financial Instability ... changes in global liquidity and financial

Hiper emesis gravidica

PEPTIDE-INDUCED EMESIS IN DOGS · blue, or neutral red for evaluation of spatial distribution of lesions. RESULTS Systemic administration of many peptides induced emesis. Figure 1

Hyper emesis

Jamilah Alsaidan, Msc. The three consecutive phases of emesis are: Emesis NauseaRetchingVomiting

양적완화 금융학회발표자료 성태윤(연세대 경제학부)160604발표용 · uQuantitative Easing (QE) in the United States ØQuantitative Easing (QE) in the United States

Empirical Examination of Quantitative Easing in Monetary

Quantitative Easing: Impact on the US dollar - IG UK · Quantitative easing ... The collapse of Lehman Brothers in September 2008 ... IG Index plc Quantitative Easing: Impact on the

Solution Languages: Easing Pattern Composition in

Emesis e Hiperemesis Gravídica