metabolism of zinc and its clinical significance

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Metabolism of Zinc and its clinical significance Dr. Rohini C Sane

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MetabolismofZincanditsclinicalsignificanceDr.Rohini CSane

ZincMetabolism

Rohini CSane

ZincMetabolism

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BODYZINCCONTENT-2gm

SERUMZINCLEVELS(physiological ):100micrograms/dl

ZincMetabolism

absorption ofdietaryZinc:DUODENUMInhibitorsofabsorptionofdietaryZinc: Copper,Calcium,Cobalt,Iron,PhytatesZinc&Coppercompetitors(ZincusedinWilson’sDiseaseasitdecreasesdietaryCopperabsorptioninduodenum)Zincstorageinhumanbody:LIVER(Metallothionein)

DietarysourcesofZinc:ØDietarysourcesofZinc:

a) Beansb) Cheesec) Grainsd) Nutse) Meats

FunctionsofZinc

ZincMetabolism

qDailydietaryRequirement-ForAdults:15mgForchildren:10mgqDailydietaryRequirementincreases–PregnancyLactation

ZincMetabolismvCauses ofZinc deficiencya) Nephroticsyndromeb) Hemolyticanemia‘myocardialinfarction’c) Infectiond) Achrodermititis (Zincabsorptiondefective)vSymptomsofZinc deficiencya) Poorwoundhealingb) Lesionsinskin(ofmouth,nose,fingers)c) Spermatogenesisd) Dermatitis/dementia/depressione) Alopecia

Zinctoxicity:causesandsymptomsqZinctoxicity:1. Welders:inhalationofZincoxidefumes2. RatpoisonscontainZinccompounds3. symptomsofZinctoxicity:a) Ulcerb) Pancreatitisc) anemiad) vomitinge) PulmonaryfibrosisqsymptomsofsevereofZinctoxicity:a) Headacheb) Feverc) Leukocytosisd) Anemiae) Plateletaggregationf) Phagocytosis

Zincexcess(toxicity)anddeficiency

Functions of ZincqFunctionsofZinc1.for>300enzymesZincisacofactorofenzymes(LDH,Alkalinephosphatase,Carbonicanhydrase,SOD,Carboxypeptidase )2. RNApolymeraserequiresZnforproteinbiosynthesis.3. ExtracellularSuperoxidedismutaseisZndependent.4.Zn–functionsasanantioxidant.5.synthesisofretinolbindingproteinrequireZinc6.Zincrequiredforimmunologicalfunctions.7.Zincsupplementationusefulfortreatingacutediarrhea.8.Zincsupplementationimprovesbirthweightofbabies.9.Zincplaysimportantrolein“Insulin“storageinbetapancreaticcells10.(commercialProtamine=Zincinsulate).11.Gusten –Salivatastesensation

Functions of Zinc –cofactorofRNApolymerase

RNApolymeraserequiresZnforproteinbiosynthesis

Zinc –asanantioxidant

3ExtracellularSuperoxidedismutaseisZndependent.4. Zn–functionsasanantioxidant.

Functions of Zincasanantioxidant

Functions of Zincasanantioxidant

ChaperonproteinsandZinc

Zinc andinsulinstorageinbetapancreaticcells

9.Zincplaysimportantrolein“Insulin“storageinbetapancreaticcells10.(commercialProtamin =Zincinsulate).

Zincasananti-canceragent