membrane membrane receptors. single-pass membrane receptors membrane

membrane Membrane receptors

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membrane

Membrane receptors

Single-pass membrane receptors

membrane

Multi-pass membrane receptors

Ion channel membrane receptors

membranemembrane

Ion channel membrane receptors

Page 6: Membrane Membrane receptors. Single-pass membrane receptors membrane

Receptor kinases

Page 7: Membrane Membrane receptors. Single-pass membrane receptors membrane

Kinase activities associated with receptors

intrinsic tyrosine kinase activity

JAK tyrosine kinase activity

Page 8: Membrane Membrane receptors. Single-pass membrane receptors membrane

G-protein-linked receptors

GTP

hormone

membrane

G-protein-linked receptors

GDP

Page 10: Membrane Membrane receptors. Single-pass membrane receptors membrane

G-protein-linked receptors

adapter

adenylate adenylate cyclasecyclase

Page 11: Membrane Membrane receptors. Single-pass membrane receptors membrane

Insulin activation of glucose response

IRS-1

PP P P

GLUT

Page 12: Membrane Membrane receptors. Single-pass membrane receptors membrane

Follicle Stimulating Hormone & Receptor

Page 13: Membrane Membrane receptors. Single-pass membrane receptors membrane

FSH subunit mRNAs

Huhtaniemi and Aittomaki (1998) Eur.J.Endo. 138: 473– 481

Page 14: Membrane Membrane receptors. Single-pass membrane receptors membrane

FSH subunit polypeptides

Huhtaniemi and Aittomaki (1998) Eur.J.Endo. 138: 473– 481

Page 15: Membrane Membrane receptors. Single-pass membrane receptors membrane

FSH

Fox, et al. Mol Endocrinol (2001) 15:378-389

Page 16: Membrane Membrane receptors. Single-pass membrane receptors membrane

FSH Receptor

Huhtaniemi and Aittomaki (1998) Eur.J.Endo. 138: 473– 481

mRNA

Page 17: Membrane Membrane receptors. Single-pass membrane receptors membrane

FSH Receptor

Huhtaniemi and Aittomaki (1998) Eur.J.Endo. 138: 473– 481

Page 18: Membrane Membrane receptors. Single-pass membrane receptors membrane

FSH Receptor

(C, cysteine; S, serine; K, lysine; R, arginine; N, asparagine; A, alanine; D, aspartic acid; F, phenylalanine).

Mann, et al. (2000) Biol. Reprod. 62: 1240-1247

Page 19: Membrane Membrane receptors. Single-pass membrane receptors membrane

FSH Receptor

Mann, et al. (2000) Biol. Reprod. 62: 1240-1247

Page 20: Membrane Membrane receptors. Single-pass membrane receptors membrane

FSH Receptor

Sohn, et al. (2003) J. Biol. Chem. 278: 47868 –47876

Page 21: Membrane Membrane receptors. Single-pass membrane receptors membrane

FSH Receptor

Sohn, et al. (2003) J. Biol. Chem. 278: 47868 –47876

Page 22: Membrane Membrane receptors. Single-pass membrane receptors membrane

FSH Receptor

Gay et al. (2006) Nature Reviews Immunology 6: 693-698

Page 23: Membrane Membrane receptors. Single-pass membrane receptors membrane

Natural mutations of FSH & Receptor

Huhtaniemi and Aittomaki (1998) Eur.J.Endo. 138: 473– 481

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