MCMP 441 DOR 101 PharmacologyDOR 101 Pharmacology

Abdelkader Ashour, Ph.D.Abdelkader Ashour, Ph.D.

33rdrd Lecture Lecture

MCMP 441

Autonomic Nervous SystemAutonomic Nervous System

MCMP 407

Organization of The Nervous SystemOrganization of The Nervous System

Central Nervous System: Brain and spinal cord

Peripheral Nervous System

Somatic Nervous SystemAutonomic Nervous System

Sympathetic Parasympathetic

Efferent DivisionAfferent Division

MCMP 407 Efferent division of the peripheral nervous system

MCMP 407

MCMP 407 Some anatomic and neurotransmitter features of Some anatomic and neurotransmitter features of autonomic and somatic motor nervesautonomic and somatic motor nerves

MCMP 407

Mimic or block the effects of the two primary neurotransmitters, Acetylcholine and Norepinephrine/Epinephrine

Drugs that mimic neurotransmitters are referred to as “receptor agonists” These drugs activate receptors

Drugs that block neurotransmitters are referred to as “receptor antagonists” These drugs block the endogenous neurotransmitters from

activating receptors

How do drugs influence the ANS?How do drugs influence the ANS?

MCMP 407

Parasympathetic nervous systemMimic acetylcholine = cholinergic = muscarinic agonists = parasympathomimetic

Block acetylcholine = anticholinergic = muscarinic antagonist = parasympatholytic

Sympathetic nervous systemMimic norepinephrine = adrenergic = adrenergic agonist = sympathomimetic

Block norepinephrine = antiadrenergic = adrenergic antagonist = sympatholytic

Classification of drugs affecting the ANSClassification of drugs affecting the ANS