mbbs ims msu
DESCRIPTION
physiologyTRANSCRIPT
![Page 1: mbbs ims msu](https://reader033.vdocuments.site/reader033/viewer/2022061213/54966beab47959774e8b4616/html5/thumbnails/1.jpg)
Cell Structure & Function
![Page 2: mbbs ims msu](https://reader033.vdocuments.site/reader033/viewer/2022061213/54966beab47959774e8b4616/html5/thumbnails/2.jpg)
Cell Theory
• All living things are made up of cells.
• Cells are the smallest working units of all living things.
• All cells come from preexisting cells through cell division.
![Page 3: mbbs ims msu](https://reader033.vdocuments.site/reader033/viewer/2022061213/54966beab47959774e8b4616/html5/thumbnails/3.jpg)
Definition of Cell
A cell is the smallest unit that is capable of performing life
functions.
![Page 4: mbbs ims msu](https://reader033.vdocuments.site/reader033/viewer/2022061213/54966beab47959774e8b4616/html5/thumbnails/4.jpg)
Cell Classified to function
1. Muscle cell2. Nerve cell3. Epithelial cell4. Connective tissue cell
![Page 5: mbbs ims msu](https://reader033.vdocuments.site/reader033/viewer/2022061213/54966beab47959774e8b4616/html5/thumbnails/5.jpg)
Examples of Cells
Amoeba Proteus
Plant Stem
Red Blood Cell
Nerve Cell
Bacteria
![Page 6: mbbs ims msu](https://reader033.vdocuments.site/reader033/viewer/2022061213/54966beab47959774e8b4616/html5/thumbnails/6.jpg)
Two Types of Cells
•Prokaryotic
•Eukaryotic
![Page 7: mbbs ims msu](https://reader033.vdocuments.site/reader033/viewer/2022061213/54966beab47959774e8b4616/html5/thumbnails/7.jpg)
Prokaryotic
• Do not have structures surrounded by membranes
• Few internal structures
• One-celled organisms, Bacteria
![Page 8: mbbs ims msu](https://reader033.vdocuments.site/reader033/viewer/2022061213/54966beab47959774e8b4616/html5/thumbnails/8.jpg)
Eukaryotic• Contain organelles (little organs) surrounded by
membranes• Most living organisms
Plant Animal
![Page 9: mbbs ims msu](https://reader033.vdocuments.site/reader033/viewer/2022061213/54966beab47959774e8b4616/html5/thumbnails/9.jpg)
“Typical” Animal Cell
![Page 10: mbbs ims msu](https://reader033.vdocuments.site/reader033/viewer/2022061213/54966beab47959774e8b4616/html5/thumbnails/10.jpg)
• Cells are surrounded by cell membrane
• The interior of the cell is divided:1. Nucleus
2. Cytoplasm
The Cytoplasm contains two components
1. Cell organelles
2. Cytosol
![Page 11: mbbs ims msu](https://reader033.vdocuments.site/reader033/viewer/2022061213/54966beab47959774e8b4616/html5/thumbnails/11.jpg)
Cell Parts
Surrounding the Cell
![Page 12: mbbs ims msu](https://reader033.vdocuments.site/reader033/viewer/2022061213/54966beab47959774e8b4616/html5/thumbnails/12.jpg)
Cell Membrane
Function of cell membrane
1. Regulate the passage of substance into and out of cell and between cell organelles and cytosol.
2. Link adjacent cells together3. Detect chemical
messengers arriving at the cell surface
![Page 13: mbbs ims msu](https://reader033.vdocuments.site/reader033/viewer/2022061213/54966beab47959774e8b4616/html5/thumbnails/13.jpg)
The Cell Membrane Structure
![Page 14: mbbs ims msu](https://reader033.vdocuments.site/reader033/viewer/2022061213/54966beab47959774e8b4616/html5/thumbnails/14.jpg)
Overview• Cell membrane separates living cell from
nonliving surroundings– thin barrier = 8nm thick
• Made of phospholipids, proteins & other macromolecules
![Page 15: mbbs ims msu](https://reader033.vdocuments.site/reader033/viewer/2022061213/54966beab47959774e8b4616/html5/thumbnails/15.jpg)
Phospholipids
Fatty acid
Phosphate
• Fatty acid tails– hydrophobic
• Phosphate group head – hydrophilic
• Arranged as a bilayer
![Page 16: mbbs ims msu](https://reader033.vdocuments.site/reader033/viewer/2022061213/54966beab47959774e8b4616/html5/thumbnails/16.jpg)
Phospholipid bilayer
polarhydrophilic
heads
nonpolarhydrophobic
tails
polarhydrophilic
heads
![Page 17: mbbs ims msu](https://reader033.vdocuments.site/reader033/viewer/2022061213/54966beab47959774e8b4616/html5/thumbnails/17.jpg)
More than lipids… • In 1972, S.J. Singer & G. Nicolson proposed that membrane
proteins are inserted into the phospholipid bilayer• Two types of membrane protein1. Integral membrane2. Peripheral membrane
![Page 18: mbbs ims msu](https://reader033.vdocuments.site/reader033/viewer/2022061213/54966beab47959774e8b4616/html5/thumbnails/18.jpg)
Membrane is a collage of proteins & other molecules embedded in the fluid matrix of
the lipid bilayerExtracellular fluid
Cholesterol
Cytoplasm
Glycolipid
Transmembraneproteins
Filaments ofcytoskeleton
Peripheralprotein
Glycoprotein
Phospholipids
![Page 19: mbbs ims msu](https://reader033.vdocuments.site/reader033/viewer/2022061213/54966beab47959774e8b4616/html5/thumbnails/19.jpg)
Membrane Proteins• Proteins determine membrane’s specific functions
– cell membrane & organelle membranes each have unique collections of proteins
• Membrane proteins:– peripheral proteins
• loosely bound to surface of membrane
– integral proteins • penetrate lipid bilayer, usually across whole membrane
• transmembrane protein
![Page 20: mbbs ims msu](https://reader033.vdocuments.site/reader033/viewer/2022061213/54966beab47959774e8b4616/html5/thumbnails/20.jpg)
Proteins domains anchor molecule
• Within membrane– nonpolar amino acids
• hydrophobic • anchors protein
into membrane
• On outer surfaces of membrane– polar amino acids
• hydrophilic• extend into extracellular
fluid & into cytosol
Polar areasof protein
Nonpolar areas of protein
![Page 21: mbbs ims msu](https://reader033.vdocuments.site/reader033/viewer/2022061213/54966beab47959774e8b4616/html5/thumbnails/21.jpg)
Many Functions of Membrane ProteinsOutside
Plasmamembrane
InsideTransporter Cell surface
receptorEnzymeactivity
Cell surface identity marker
Attachment to thecytoskeleton
Cell adhesion
![Page 22: mbbs ims msu](https://reader033.vdocuments.site/reader033/viewer/2022061213/54966beab47959774e8b4616/html5/thumbnails/22.jpg)
Membrane carbohydrates • Play a key role in cell-cell recognition
– ability of a cell to distinguish one cell from another
– important in organ & tissue development
![Page 23: mbbs ims msu](https://reader033.vdocuments.site/reader033/viewer/2022061213/54966beab47959774e8b4616/html5/thumbnails/23.jpg)
Membrane Junctions
• Some cell not anchored to other cells but suspend in the fluid.
• Most cells are packaged into tissues and are not free to move.
• Many cells physically joined by specialized types:
1. Desmosomes2. Tight junctions3. Gap junctions
![Page 24: mbbs ims msu](https://reader033.vdocuments.site/reader033/viewer/2022061213/54966beab47959774e8b4616/html5/thumbnails/24.jpg)
Inside the Cell
![Page 25: mbbs ims msu](https://reader033.vdocuments.site/reader033/viewer/2022061213/54966beab47959774e8b4616/html5/thumbnails/25.jpg)
Nucleus
• Almost all cells contain a single nucleus.• Directs cell activities• Separated from cytoplasm by nuclear membrane• Function-Stores and transmits genetic information in the
form of DNA. Genetic information passes from the nucleus to the cytoplasm
![Page 26: mbbs ims msu](https://reader033.vdocuments.site/reader033/viewer/2022061213/54966beab47959774e8b4616/html5/thumbnails/26.jpg)
Nuclear Membrane
• Surrounds nucleus• Made of two layers
Nuclear envelope
Nuclear pores• Openings allow
material to enter and leave nucleus
http://library.thinkquest.org/12413/structures.html
![Page 27: mbbs ims msu](https://reader033.vdocuments.site/reader033/viewer/2022061213/54966beab47959774e8b4616/html5/thumbnails/27.jpg)
Chromosomes
• In nucleus• Made of DNA• Contain instructions
for traits & characteristics
http://library.thinkquest.org/12413/structures.html
![Page 28: mbbs ims msu](https://reader033.vdocuments.site/reader033/viewer/2022061213/54966beab47959774e8b4616/html5/thumbnails/28.jpg)
Nucleolus
• Inside nucleus• Contains RNA to build
proteins
http://library.thinkquest.org/12413/structures.html
![Page 29: mbbs ims msu](https://reader033.vdocuments.site/reader033/viewer/2022061213/54966beab47959774e8b4616/html5/thumbnails/29.jpg)
Endoplasmic Reticulum• Moves materials around
in cell• Smooth type (Agranular):
lacks ribosomes. Site of lipid molecule synthesized
• Rough type (Granular): ribosomes embedded in surface. Packaging of proteins to be secreted or distributed.
http://library.thinkquest.org/12413/structures.html
![Page 30: mbbs ims msu](https://reader033.vdocuments.site/reader033/viewer/2022061213/54966beab47959774e8b4616/html5/thumbnails/30.jpg)
Ribosomes
• Composed of proteins and several RNA molecules
• Proteins factories of the cell
• Either bound to the organelle or found free in the cytoplasm
http://library.thinkquest.org/12413/structures.html
![Page 31: mbbs ims msu](https://reader033.vdocuments.site/reader033/viewer/2022061213/54966beab47959774e8b4616/html5/thumbnails/31.jpg)
Golgi Apparatus
• Most cells have single Golgi apparatus.
• Protein 'packaging plant'
• Move materials within the cell
• Move materials out of the cell
http://library.thinkquest.org/12413/structures.html
![Page 32: mbbs ims msu](https://reader033.vdocuments.site/reader033/viewer/2022061213/54966beab47959774e8b4616/html5/thumbnails/32.jpg)
Lysosome• Spherical or oval• Typical cell may contain
several hundreds• Digestive enzyme for
proteins, fats, and carbohydrates
• Transports undigested material to cell membrane for removal
• Cell breaks down if lysosome explodes
http://library.thinkquest.org/12413/structures.html
![Page 33: mbbs ims msu](https://reader033.vdocuments.site/reader033/viewer/2022061213/54966beab47959774e8b4616/html5/thumbnails/33.jpg)
Mitochondria
• Spherical rode like structure• Produces energy through
chemical reactions – breaking down fats & carbohydrates
• Controls level of water and other materials in cell
• Recycles and decomposes proteins, fats, and carbohydrates
http://library.thinkquest.org/12413/structures.html