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Poster 15

Poster Presentations

Multicenter Evaluation of a New Daily Disposable ToricSoft Contact Lens

Kathy Osborn, O.D., Rose Franklin, BAppSc Optom,Jon Hansen, M.S., Terri L. Henderson, M.S., andYoussef Toubouti, M.S., Johnson & Johnson Vision CareInc., Jacksonville, Florida

Background: To evaluate the fit, vision, and comfortperformance of a new daily disposable toric soft contactlens (1-day Acuvue� Moist� for Astigmatism [1DAMfA)]vs Focus� Dailies� Toric All Day Comfort [FDTADC]).Method: This subject-masked, randomized, bilateral, and1-week dispensing crossover study was conducted in 7 USsites. Seventy subjects were enrolled in the study and wererequired to have a vertexed spherical power between–1.75DS to –5.00DS, with cylinder power between–1.25DC and –2.00DC, and refractive cylinder axis of180 6 30�.Results: With the 1DAMfA lenses, 95% of eyes weresuccessfully fit with the first lens. At 3 minutes afterinsertion, 98% of the 1DAMfA lenses were found to bewithin 10� of optimal orientation. There was less than 5�

rotation change from 3-15 minutes after insertion for 97%of the 1DAMfA lenses. Over 99% of the 1DAMfA lensesevaluated were found to have less than a 10� change fromfitting to the 1-week visit. Superiority of 1DAMfA overFDTADC was shown using a Patient Reported Outcomesquestionnaire in the domains of subjective comfort andvision (comfort, 55.9 for 1DAMfA vs 44.0 for FDTADC;difference (95% confidence interval [CI]) 12.0 (4.0, 19.8);p 5 0.003 and vision, 53.3 for 1DAMfA vs 45.6for FDTADC; difference [95% CI] 7.7 [0.58, 14.8];p 5 0.035).Conclusion: 1DAMfA was found to provide predictableorientation, a fast settling time and maintain stable rotationover time, as well as superior subjective comfort and visioncompared to FDTADC.(Study was sponsored by Johnson & Johnson Vision Care,

Inc.)

Poster 16

Management of Early Keratoconus With Specialty RigidGas Permeable Lenses

Brandi McGraw, O.D., Eye Associates of New Mexico,Gallup, New Mexico

Background: Keratoconus is a progressive corneal diseasewhich produces varying degrees of corneal steepening andthinning. Careful corneal examination and computerizedtopography analysis are important tools in the managementof this progression. Early keratoconus, or forme frustekeratoconus, often appears on topography as inferior cor-neal steepening and irregular astigmatism. Pellucid margi-nal degeneration, thought to be a variant of keratoconuswith similar pathology, appears similar in the early stage,

but has clinical variants with progression. While no con-crete hereditary link exists, there is a genetic component in10% of cases with a possible autosomal dominant trans-mission with incomplete penetrance.Case Summary: A 44-year-old Hispanic male was referredfrom a corneal specialist for a rigid gas permeable (RGP)lens fitting. The patient was diagnosed with a cornealdystrophy, right eye worse than left eye. The dystrophypresumed to have a congenital component since thepatient’s brother has a history of a corneal dystrophyresulting in a corneal transplant. The patient’s diseaseprocess is still in the early stages, but is suspected to beforme fruste keratoconus or pellucid marginal degenera-tion. Anterior segment examination appears normal in botheyes. However, topography reveals inferior steeping and adropped apex in the right cornea and irregular astigmatismwith a lesser dropped apex in the left eye. Best spectaclecorrected visual acuities are 20/50 O.D. and 20/20 O.S.After topography analysis, fitting with a diagnostic lens set,and conversations with the patient to understand visualdesires and expectations, RGP lenses were ordered. With acombination of 2 different specialty lenses, Naturalens anda bitoric design both from Advanced Vision Technologies,the patient is now 20/20 in both eyes and reports his visionis much sharper than in glasses.Conclusion: RGP contact lenses can be an essential tool inearly management of keratoconus. Since this is often not apermanent solution, proper patient education and reason-able long-term expectations are necessary. It is important toregularly evaluate a patient’s ocular health and cornealstatus through examination and topography analysis inorder to make appropriate RGP changes or surgical rec-ommendations as necessary.

Poster 17

Enhanced Optics for Contact Lenses Provide BetterClinical Outcomes

Gerard Cairns, Ph.D., Jeffery Schafer, O.D., Stephanie Su,O.D., and Gary Mosehauer, M.S., Bausch & Lomb,Incorporated, Rochester, New York

Purpose: Aspheric optics in contact lenses are designed toreduce inherent spherical aberration in the eye. Four studieswere conducted to evaluate spherical aberration and visualacuity of 2 marketed silicone hydrogel lenses (Test:balafilcon A with aspheric optics; Control: senofilcon Awith conventional spherical optics) across a range ofpowers.Methods: A single power was assessed in each study(+3.00D, -1.00D, -5.00D, and -9.00D). Cohorts of 22-25subjects were dilated with 1% tropicamide to achieve 6 mmpupils. Baseline spherical aberration readings and highcontrast logMAR visual acuities using a 6 mm artificialaperture were recorded and then repeated with lenses insitu. A linear mixed model was employed to analyze dataacross all studies and within each study, paired comparisons