macop-b + radiotherapy effective in nhl

Inpharma 1285 - 28 Apr 2001 MACOP-B + radiotherapy effective in NHL Combination treatment with the MACOP-B * chemotherapy regimen plus radiotherapy is effective in patients with primary mediastinal large B cell lymphoma with sclerosis, according to results of a multicentre study conducted in Italy. 89 such patients received MACOP-B; 4–6 weeks after completing chemotherapy, they received mediastinal radiotherapy with a tumour dose of 30–36Gy over 4–5 weeks. After completing the MACOP-B regimen, an overall response rate of 92% was obtained; a complete response (CR) was achieved by 23 patients (26%) and a partial response (PR) by 59 (66%). Two months after radiotherapy, 55/59 patients who had previously achieved a PR after chemotherapy obtained CR status. After a median follow-up duration of 45 months, 71/78 patients (91%) who achieved a CR remained in continuous CR. * The MACOP-B regimen consists of methotrexate, doxorubicin, cyclophosphamide, vincristine, prednisone and bleomycin. Zinzani PL, et al. Primary mediastinal large B-cell lymphoma with sclerosis: a clinical study of 89 patients treated with MACOP-B chemotherapy and radiation therapy. Haematologica 86: 187-191, Feb 2001 800832372 1 Inpharma 28 Apr 2001 No. 1285 1173-8324/10/1285-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved

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Inpharma 1285 - 28 Apr 2001

MACOP-B + radiotherapy effectivein NHL

Combination treatment with the MACOP-B*

chemotherapy regimen plus radiotherapy is effective inpatients with primary mediastinal large B cell lymphomawith sclerosis, according to results of a multicentrestudy conducted in Italy.

89 such patients received MACOP-B; 4–6 weeks aftercompleting chemotherapy, they received mediastinalradiotherapy with a tumour dose of 30–36Gy over 4–5weeks.

After completing the MACOP-B regimen, an overallresponse rate of 92% was obtained; a completeresponse (CR) was achieved by 23 patients (26%) and apartial response (PR) by 59 (66%). Two months afterradiotherapy, 55/59 patients who had previouslyachieved a PR after chemotherapy obtained CR status.

After a median follow-up duration of 45 months,71/78 patients (91%) who achieved a CR remained incontinuous CR.* The MACOP-B regimen consists of methotrexate, doxorubicin,cyclophosphamide, vincristine, prednisone and bleomycin.

Zinzani PL, et al. Primary mediastinal large B-cell lymphoma with sclerosis: aclinical study of 89 patients treated with MACOP-B chemotherapy and radiationtherapy. Haematologica 86: 187-191, Feb 2001 800832372

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