m. villemin's experiments with the inoculation of tubercle

2
641 36,000 cases have been recorded, a certificate or extract from the book has never been asked for, and that the marks on the arm are always regarded as the best proof. THE Pathological Society held its last meeting for the season on Tuesday last. Mr. Simon, F.R.S., the President, observed that the promoters of the Society had originally determined that the study of pathology could not be agreeably carried on in hot weather, and they acquiesced in that view; but he felt sure that in the interim before their next meeting they would accumulate a vast stock of valuable material, and re-assemble with renewed appetites for pathological lore. Might we add the expression of a hope that what the communications gain in number they may lose in length ? THE Saxon, on its arrival at Table Bay with the Overland and Eastern Mails, was found to have on board nine of the crew convalescent from fever, which they appear to have caught whilst at Mauritius. On inspection, two children were also found in the same condition, their father having caught the fever at Mauritius, and died on the voyage before reaching Algoa Bay. One child died subsequently. No very accurate accounts have reached us as to the nature of the disease. It is described as a violent marsh fever, or swamp ague, rather than a true fever. It assumes the intermittent type, has nothing of a malignant character about it, and is known by the name of jungle fever. The sick have been removed to hospital, and no fear of its establishing itself in Cape Town is entertained. THE inhabitants of South Kensington and its neighbourhood have forwarded to the Secretary-at-War a petition, nume- rously and influentially signed, praying that the barracks at Knightsbridge may be removed. The reasons they urge for the removal are on the score of health, decency, and improve- ment of the high road leading to the most ornamental part of the metropolis. Earl de Grey, in 1863, had condemned the barracks as inimical to the health and comfort of the troops. Sir John Pakington cannot turn a deaf ear to the memorial. DR. HARE has resigned the Clinical Professorship and the Physicianship to University College Hospital. It is antici- pated that Dr. Russell Reynolds will succeed to the chair of Medicine vacated by Dr. Jenner, Dr. Wilsox Fox succeeding Dr. Hare as in-patient physician. IT has transpired, much to the astonishment of the public, that the counsel acting for the Metropolitan Board of Works before the Royal Commission on Water-supply is not instructed to cross-examine the witnesses who appear for the water com- panies. It may well be asked-What, then, are his duties ? Under these circumstances, it is evident that the water com- panies will have it "all their own way. " THE suggestion made by the Pall Mall Gazette—that the papers left in railway trains, and those which are purchased for merely temporary purposes, should be sent to the various hospitals in London for the use of the poor inmates-is an admirable one, and one that we hope to see put into effect. BILIOUS REMITTENT FEVER (erroneously termed-yellow fever in the daily press) seems to be decimating the population of Mauritius ; and the mortality there is said to be without precedent in any country. From the 10th to the 28th of February the deaths were 2061 ; on March 6th, 433 ; from the 1st to the 17th of April, 5070: making a total of 13,564. Port Louis has borne the brunt of the epidemic. The disease is now on the decrease. THE Report of the Commission on Venereal Disease will be signed by the members of the Committee next week. The book will then be printed, and the report and the evidence be published together, probably in about a month. THE Executive Committee of the Medical Council will meet on Tuesday next, previous to the meeting of the General Council on the following day. We have reason to believe that the consideration of the amended Medical Act will occupy the early attention of the Council. As yet the new Secretary of State-Mr. Gathorne Hardy-has not been applied to on the subject. M. VILLEMIN’S EXPERIMENTS WITH THE INOCULATION OF TUBERCLE. (Concluded from p. 583.) Second series of inoculations from man to rabbits. FIVE fine rabbits were inoculated on the 15th of January. One of these died three days, and two others eight days, after inoculation, with erysipelatous swelling of the head and neck. M. Villemin suggests that it is possible that the scalpel used had been tainted w ith some putrid principle, or that the inocu- lated matter had been contaminated by the septic fluid of a cavity. Of the two rabbits of this series that survived, one soon be- came greatly emaciated, and was on the point of sinking, when it was killed on the 16th of March. On the upper part of the left thigh were seen two bare scurfy patches, and a little higher up, nearer the gluteal region, there was an ulcer, involving the whole depth of the skin, which was sensibly thickened. Both lungs were filled with masses of tubercle, consisting of agglo- merated granulations. The spleen contained a large quantity of yellowish-white tubercle, slightly softened. In the cortical substance of one of the kidneys was found a piece of tuber- cular matter, the size of a bean. There were a few small granu- lations in the mesentery. Numerous tubercles were scattered over the lower part of the small intestine and the appendix vermiformis. One or two of the cervical and the parotidean glands were enlarged, and contained softened granulations of a yellowish colour. We have here an example of acute general tuberculosis. The second rabbit was killed on the 12th of July. It be- came much emaciated a short time after inoculation, and never regained flesh. The lungs contained numerous subpleural masses of softened tubercle; at other parts the tubercle was yellow, and of firm consistence. A few grey granulations were also observed in the lungs. A small number of transparent granulations were found in the mesentery. Third series of inoculations from man to rabbits. Two animals were inoculated at the Jardin d’Acclimatation on the 16th of March. Both were killed on the 7th of July. Tubercle in considerable amount was found in the lungs of both of them. M. Villemin’s inoculations from man to rabbits have been, in all, twenty-two. Of these, only two were unsuccessful, excepting, of course, those three animals which died shortly after inoculation. In the next experiments, the inoculation was from the cow to the rabbit. The inoculation was successful. Inoculation from rabbit to rabbit. Generally when inoculation from rabbit to rabbit has been = practised, tuberculisation advances with much greater rapidity than in the case of inoculation from man to rabbit. It is diffi- cult to say whether this is due to the fresh state of the inocu- lated matter, or whether the intensity of the virus varies according to the degree in which the animal from which the virus is taken is allied to the animal inoculated. In the rabbit tubercle does not seem to excite inflammation in the surrounding tissues so readily as in man. In some cases the granulations are surrounded by an areola of congestion; but this is evidently connected with the development of the granulations, and not an effect of their presence. In the chronic phthisis of rabbits the lung exhibits the same power of resist- ance. The tubercular matter becomes surrounded with a false membrane, in which bloodvessels are developed, and which,

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Page 1: M. VILLEMIN'S EXPERIMENTS WITH THE INOCULATION OF TUBERCLE

641

36,000 cases have been recorded, a certificate or extract fromthe book has never been asked for, and that the marks on thearm are always regarded as the best proof.

THE Pathological Society held its last meeting for the seasonon Tuesday last. Mr. Simon, F.R.S., the President, observedthat the promoters of the Society had originally determinedthat the study of pathology could not be agreeably carried onin hot weather, and they acquiesced in that view; but he feltsure that in the interim before their next meeting they wouldaccumulate a vast stock of valuable material, and re-assemblewith renewed appetites for pathological lore. Might we addthe expression of a hope that what the communications gainin number they may lose in length ?

THE Saxon, on its arrival at Table Bay with the Overlandand Eastern Mails, was found to have on board nine of thecrew convalescent from fever, which they appear to havecaught whilst at Mauritius. On inspection, two children werealso found in the same condition, their father having caughtthe fever at Mauritius, and died on the voyage before reachingAlgoa Bay. One child died subsequently. No very accurateaccounts have reached us as to the nature of the disease. Itis described as a violent marsh fever, or swamp ague, ratherthan a true fever. It assumes the intermittent type, hasnothing of a malignant character about it, and is known bythe name of jungle fever. The sick have been removed to

hospital, and no fear of its establishing itself in Cape Townis entertained.

__

THE inhabitants of South Kensington and its neighbourhoodhave forwarded to the Secretary-at-War a petition, nume-rously and influentially signed, praying that the barracks atKnightsbridge may be removed. The reasons they urge forthe removal are on the score of health, decency, and improve-ment of the high road leading to the most ornamental part ofthe metropolis. Earl de Grey, in 1863, had condemned thebarracks as inimical to the health and comfort of the troops.Sir John Pakington cannot turn a deaf ear to the memorial.

DR. HARE has resigned the Clinical Professorship and thePhysicianship to University College Hospital. It is antici-

pated that Dr. Russell Reynolds will succeed to the chair ofMedicine vacated by Dr. Jenner, Dr. Wilsox Fox succeedingDr. Hare as in-patient physician.

IT has transpired, much to the astonishment of the public,that the counsel acting for the Metropolitan Board of Worksbefore the Royal Commission on Water-supply is not instructedto cross-examine the witnesses who appear for the water com-

panies. It may well be asked-What, then, are his duties ?Under these circumstances, it is evident that the water com-panies will have it "all their own way."

THE suggestion made by the Pall Mall Gazette—that thepapers left in railway trains, and those which are purchasedfor merely temporary purposes, should be sent to the varioushospitals in London for the use of the poor inmates-is anadmirable one, and one that we hope to see put into effect.

BILIOUS REMITTENT FEVER (erroneously termed-yellow feverin the daily press) seems to be decimating the population ofMauritius ; and the mortality there is said to be without

precedent in any country. From the 10th to the 28th of

February the deaths were 2061 ; on March 6th, 433 ; from the1st to the 17th of April, 5070: making a total of 13,564.Port Louis has borne the brunt of the epidemic. The diseaseis now on the decrease.

THE Report of the Commission on Venereal Disease willbe signed by the members of the Committee next week. Thebook will then be printed, and the report and the evidence bepublished together, probably in about a month.

THE Executive Committee of the Medical Council will meeton Tuesday next, previous to the meeting of the GeneralCouncil on the following day. We have reason to believe thatthe consideration of the amended Medical Act will occupy the

early attention of the Council. As yet the new Secretary ofState-Mr. Gathorne Hardy-has not been applied to on thesubject.

M. VILLEMIN’S EXPERIMENTS WITH THEINOCULATION OF TUBERCLE.

(Concluded from p. 583.)

Second series of inoculations from man to rabbits.FIVE fine rabbits were inoculated on the 15th of January.

One of these died three days, and two others eight days, afterinoculation, with erysipelatous swelling of the head and neck.M. Villemin suggests that it is possible that the scalpel usedhad been tainted w ith some putrid principle, or that the inocu-lated matter had been contaminated by the septic fluid of acavity.

Of the two rabbits of this series that survived, one soon be-came greatly emaciated, and was on the point of sinking, whenit was killed on the 16th of March. On the upper part of theleft thigh were seen two bare scurfy patches, and a little higherup, nearer the gluteal region, there was an ulcer, involving thewhole depth of the skin, which was sensibly thickened. Bothlungs were filled with masses of tubercle, consisting of agglo-merated granulations. The spleen contained a large quantityof yellowish-white tubercle, slightly softened. In the corticalsubstance of one of the kidneys was found a piece of tuber-cular matter, the size of a bean. There were a few small granu-lations in the mesentery. Numerous tubercles were scatteredover the lower part of the small intestine and the appendixvermiformis. One or two of the cervical and the parotideanglands were enlarged, and contained softened granulations of ayellowish colour. We have here an example of acute generaltuberculosis.The second rabbit was killed on the 12th of July. It be-

came much emaciated a short time after inoculation, and neverregained flesh. The lungs contained numerous subpleuralmasses of softened tubercle; at other parts the tubercle wasyellow, and of firm consistence. A few grey granulations werealso observed in the lungs. A small number of transparentgranulations were found in the mesentery.

Third series of inoculations from man to rabbits.Two animals were inoculated at the Jardin d’Acclimatation

on the 16th of March. Both were killed on the 7th of July.Tubercle in considerable amount was found in the lungs ofboth of them.M. Villemin’s inoculations from man to rabbits have been,

in all, twenty-two. Of these, only two were unsuccessful,excepting, of course, those three animals which died shortlyafter inoculation.

In the next experiments, the inoculation was from the cowto the rabbit. The inoculation was successful.

Inoculation from rabbit to rabbit.Generally when inoculation from rabbit to rabbit has been =

practised, tuberculisation advances with much greater rapiditythan in the case of inoculation from man to rabbit. It is diffi-cult to say whether this is due to the fresh state of the inocu-lated matter, or whether the intensity of the virus variesaccording to the degree in which the animal from which thevirus is taken is allied to the animal inoculated.

In the rabbit tubercle does not seem to excite inflammationin the surrounding tissues so readily as in man. In some casesthe granulations are surrounded by an areola of congestion;but this is evidently connected with the development of thegranulations, and not an effect of their presence. In the chronic

phthisis of rabbits the lung exhibits the same power of resist-

ance. The tubercular matter becomes surrounded with a falsemembrane, in which bloodvessels are developed, and which,

Page 2: M. VILLEMIN'S EXPERIMENTS WITH THE INOCULATION OF TUBERCLE

642

perhaps, assists in the cure. Further, in the rabbit, tuberclehas not the same predilection for the apex which it shows inman. This may be explained by the difference in form of thelungs of the respective animals. In the rabbit the deposit oftubercular matter in serous membranes does not cause muchirritation.The results of inoculation from rabbit to rabbit were as

follows :-On the 30th of April two rabbits were inoculated with tubercle

taken from a rabbit which was killed immediately before theinoculation. The first was killed on the 16th of June. Tuberclein lungs, spleen, small intestine, and mesenteric glands. Thesecond was found dead on the 30th of June. Lungs infiltratedwith tubercle ; tubercle also on parietal pleura, and in liver,kidneys, and spleen.On the 12th of July a vigorous rabbit was inoculated. Killed

on the 30th of August. Lungs densely infiltrated with tubercle,which was also on the surface of the pleurae, in the mesentery,kidneys, and spleen. A small quantity was found on the smallintestine. A mass of enlarged and degenerated glands wasfound in front of the trachea, and the bronchial glands wereenlarged and tuberculous.

Inoculation from man to guinea-pig.On the 19th of December, two guinea-pigs were inoculated.

On the 21st February, one of them, a female, died. She hadbecome remarkably thin after the inoculation. Grey granula-tions were disseminated through the lungs. Tubercle wasalso found in the bronchial glands, liver, and spleen.On the 31st of March, the second animal, a male, died. The

lungs were densely infiltrated with tubercle. The bronchialglands were enlarged, and contained yellow matter. Most ofthe lymphatic glands of the body were enlarged. In eachaxilla was a gland the size of a bean, which had degeneratedinto a yellowish pulp. The liver and spleen also containedtubercle.

Inoculation from man to dog doubtful; and from man tocat, with little success. Man to sheep unsuccessful; man tobirds unsuccessful.The carnivora are much less liable to tubercle than the

rodents.Injection of tubercular matter into trachea doubtful.Inoculation of tubercular matter developed at seat of inocu-

lation. Performed successfully in two cases.

Appearance at seat of inoculation.Three or four days after the inoculation, a small nodule

appears, which resembles to the touch an indurated chancre ofthe prepuce. This enlarges for some time, and may at lastattain the size of a hazel-nut, or even of a small walnut. Thistakes place especially when the tubercular matter inoculatedis perfectly fresh, and taken from rabbits. These smalltumours are formed of a substance of a grey colour, fleshy, andrather resistant. On section, there are observed, at one periodof their evolution, small points of softening matter, of ayellowish-white colour. These points spread, become con-nuent, and lead to the softening of the whole tumour, and theevacuation of a cheesy matter, often mixed with pus.The development of tubercle internally seems to follow

inoculation in from ten to twenty days.It is possible that when phthisis is observed in several

members of the same family, it has spread by infection, not byhereditary transmission.

Inoculation has had the effect of producing abortion or thepremature death of the young. The young of animals inocu-lated, which survive a time, die with symptoms of inanition,but tubercles are not found in the body. The stomachs arefound very empty and milkless. Two such animals lived aboutfive months. Thev were thin. stunted. and scarcelvattainedmore than half the size of animals of their age. They presentedan excessive development of the abdomen, and their skin wasdull and ugly. They died of a sort of spinal meningitis, whichwas also fatal to several other rabbits previously in goodhealth which lived along with them. Neither of them pre-sented the slightest trace of tubercle.

CASES of contagious typhus having appeared amongsthorned cattle in several districts of Germany, especially atFrankfort, a ministerial ordinance, dated the 15th of May,has been issued, prohibiting the importation and transit ofruminating animals, fresh hides, or carcases along the wholelength of the French frontier, from Lauterbourg to the depart-ment of Savoy inclusive.

IMPORTANT PROSECUTION UNDER THEMEDICAL ACT.

MARLBOROUGH-STREET POLICE-COURT.

TUESDAY, MAY 21ST.

MR. ROBERT JACOB JORDAN appeared before Mr. Mansfieldin answer to a summons for having improperly assumed thetitle of "member of the Royal College of Surgeons of England."The Hon. F. Thesiger appeared for the prosecution; Mr.

Keane, Q.C., and Mr. Montague Williams appeared for thedefendant.The Hon. F. THESIGER in opening the case said,-I have

the honour to appear, Sir, on behalf of the Royal College ofSurgeons of England to support the information which waslaid by their secretary a week ago against Mr. Robert JacobJordan, who resides at 29, George-street, Hanover-square, foran offence against the provisions of the Medical Act, that ofhaving " wilfully and falsely pretended to be, and taken andused the name, title, or description, implying that he was re-cognised by law as a surgeon." I may state in the outset that

although those words which I have taken from the information,and which are contained in the 40th section of the Medical

Act, do express the offence with which the defendant is

charged, and with which you have to deal, they utterly fail toexpress the real nature and character of the offence of whichthe defendant has been guilty-an offence I may say that theRoyal College of Surgeons have every will to punish adequatelyas it deserves, but unfortunately as the law is at present con-stituted they have not the power. Sir, this is not an ordinarycase arising under this statute ; it is not the case of a manwho has merely infringed the provisions of the statute, whohas professed to possess the qualifications which the statuterequires him to possess as a guarantee of his knowledge and asa protection to the public ; it is not the case of such a mannever having possessed those qualifications, but it is the caseof a man who has been once a member of two honourable andlearned societies, the Royal College of Surgeons of Englandand the College of Physicians of Edinburgh ; a man who hashad opportunities of earning a name and a competency in anhonourable profession; but who has sacrificed that opportunityand disgraced his profession; a man who has been ignominiouslyexpelled from those societies; and what is more, a man who,after having been expelled from them, has openly braved them;who has carried on for years a trade which, I submit, outragesdecency in every possible way; a man who has kept for yearsa museum, a catalogue of which I hold in my hand, and the

particulars of which would I think shock the mind of any onepossessing a spark of refinement ; a man who at the entranceof that museum, so disgusting in its nature, has stuck up thediploma of the College of Surgeons.Mr. K:EANE. -I do not understand what this gentleman is

to be tried for. If he is to be tried for those things with regardto which my friend has been speaking with such extreme fer-vour, let him be charged accordingly. Have we anything todo with the Anatomical Museum ?The Hon. F. THESIGER.—I was quite prepared for this. You

will see, Sir, when I come to the section of the Act, that youhave a discretionary power as to the amount of penalty. Iwish to bring before you the conduct of this Mr. Robert JacobJordan, in order that you may, as I feel sure you will do ifthe facts are proved before you, inflict the very highest penaltywhich the law enables vou to inflict.Mr. KEANE.—You will not try him for one thing and punish

him for another.Mr. THESIGER.—I think I am not exceeding the duty I have

to perform as counsel, painful as that duty is. I say that foryears the defendant has been using the name of the College ofSurgeons and the name of the College of Physicians of Edin-burgh ; that he has professed to be a member of those societies;that he has used the diploma at all events of one of them inorder to publish and disseminate through this metropolis booksteeming with the foulest indecency, and in order to pander to