Inpharma 1294 - 30 Jun 2001

■ Low-dose thalidomide plus dexamethasone iseffective as salvage therapy for advanced myeloma,according to researchers from Italy. They treated 77patients with relapsed or refractory myeloma withthalidomide 100 mg/day continuously anddexamethasone 40mg on days 1–4 of each month.Myeloma protein was reduced by 75–100% in 14patients (18%), by 50–75% in 18 patients (23%) and by25–50% in 19 patients (25%); 26 patients (34%) hadno response (disease progression, stable disease orprotein reduction of < 25%). Median progression-freesurvival was 12 months after a median follow-up of 8months. Eight patients discontinued treatment becauseof adverse events.Palumbo A, et al. Low-dose thalidomide plus dexamethasone is an effectivesalvage therapy for advanced myeloma. Haematologica 86: 399-403, Apr2001 800867691

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Inpharma 30 Jun 2001 No. 12941173-8324/10/1294-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved