Low-dose nifedipine/atenolol therapy for hypertension

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<ul><li><p>Low-dose nifedipine/atenolol therapy for hypertension </p><p> ... Us~ of a ollc~-dail}' ngim~II of t"~ fix~d combillatioll of atellolol 50mg pills slow-,~/~IIS~ IIifedipill~ 20mg pro,id~d a significant additional anti"y~rt~nsi,~ ~ff~ct U "OIlTS aft~' dosing compa,~d wit" atenolol 50mg alone.' A multicentre, double-blind study was conducted in which 153 evaluable patients with hypertension (sitting diastolic BP ~ 95mm Hg) randomly received ate nolo I 50mg/day or a fixed combination of ate nolo I 50mg/day and slow release nifedipine 20mg/day for 3 months. following a 4-week run-in period in which patients received atenolol 50mg/day. </p><p>Compared with patients who received atenolol alone. fixed combination recipients had a significant additional reduction in mean sitting and standing BP of 10/7 and 9/5mm Hg. respectively. at 24 hours. There was a similar incidence of adverse effects in both treatment groups, with headache being most commonly reported. FitLsimons TJ. Han W. von Frankenberg H. Sanderson JE. Joy MD. et al. Low-dosc atenolol and nifedipine for the treatment of hypenension. Journal of Drug Development 3: 13-19. Apr 1990 </p><p>16 ISSN 01S6-170J/90/0728-0001/0S01.00/0 e&gt; Adisl.terutiDlUII Ltd </p><p> /ColorImageDict &gt; /JPEG2000ColorACSImageDict &gt; /JPEG2000ColorImageDict &gt; /AntiAliasGrayImages false /CropGrayImages true /GrayImageMinResolution 150 /GrayImageMinResolutionPolicy /Warning /DownsampleGrayImages true /GrayImageDownsampleType /Bicubic /GrayImageResolution 150 /GrayImageDepth -1 /GrayImageMinDownsampleDepth 2 /GrayImageDownsampleThreshold 1.50000 /EncodeGrayImages true /GrayImageFilter /DCTEncode /AutoFilterGrayImages true /GrayImageAutoFilterStrategy /JPEG /GrayACSImageDict &gt; /GrayImageDict &gt; /JPEG2000GrayACSImageDict &gt; /JPEG2000GrayImageDict &gt; /AntiAliasMonoImages false /CropMonoImages true /MonoImageMinResolution 1200 /MonoImageMinResolutionPolicy /Warning /DownsampleMonoImages true /MonoImageDownsampleType /Bicubic /MonoImageResolution 600 /MonoImageDepth -1 /MonoImageDownsampleThreshold 1.50000 /EncodeMonoImages true /MonoImageFilter /CCITTFaxEncode /MonoImageDict &gt; /AllowPSXObjects false /CheckCompliance [ /PDFA1B:2005 ] /PDFX1aCheck false /PDFX3Check false /PDFXCompliantPDFOnly false /PDFXNoTrimBoxError true /PDFXTrimBoxToMediaBoxOffset [ 0.00000 0.00000 0.00000 0.00000 ] /PDFXSetBleedBoxToMediaBox true /PDFXBleedBoxToTrimBoxOffset [ 0.00000 0.00000 0.00000 0.00000 ] /PDFXOutputIntentProfile (sRGB IEC61966-2.1) /PDFXOutputConditionIdentifier () /PDFXOutputCondition () /PDFXRegistryName () /PDFXTrapped /False</p><p> /CreateJDFFile false /Description &gt;&gt;&gt; setdistillerparams&gt; setpagedevice</p></li></ul>